364-98-7 | Diazoxide

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	in stock	$16.00	$11.00
100mg	95%	in stock	$24.00	$17.00
250mg	95%	in stock	$33.00	$23.00
1g	95%	in stock	$98.00	$68.00
5g	95%	in stock	$278.00	$194.00

Description

• Catalog Number: AB51934
• Chemical Name: Diazoxide
• CAS Number: 364-98-7
• Molecular Formula: C8H7ClN2O2S
• Molecular Weight: 230.6714
• MDL Number: MFCD00078578
• SMILES: Clc1ccc2c(c1)S(=O)(=O)NC(=N2)C

Computed Properties

• Complexity: 360
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 14
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.2

Literature

• Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.

  The Journal of biological chemistry 20171020

• Diazoxide prevents reactive oxygen species and mitochondrial damage, leading to anti-hypertrophic effects.

  Chemico-biological interactions 20170105

• Mitochondrial Channel Opener Diazoxide Attenuates Hypoxia-Induced sFlt-1 Release in Human Choriocarcinoma Cells.

  Journal of menopausal medicine 20140401

• Combined contributions of over-secreted glucagon-like peptide 1 and suppressed insulin secretion to hyperglycemia induced by gatifloxacin in rats.

  Toxicology and applied pharmacology 20130201

• Expression and regulation of nampt in human islets.

  PloS one 20130101

• Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms.

  Molecular biology reports 20121201

• Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?

  Diabetologia 20121101

• Diabetes triggers a PARP1 mediated death pathway in the heart through participation of FoxO1.

  Journal of molecular and cellular cardiology 20121101

• Octreotide for the treatment of sulfonylurea poisoning.

  Clinical toxicology (Philadelphia, Pa.) 20121101

• Late anti-apoptotic effect of K(ATP) channel opening in skeletal muscle.

  Clinical and experimental pharmacology & physiology 20121101

• Agelaia MP-I: a peptide isolated from the venom of the social wasp, Agelaia pallipes pallipes, enhances insulin secretion in mice pancreatic islets.

  Toxicon : official journal of the International Society on Toxinology 20120915

• Prostatic relaxation induced by agmatine is decreased in spontaneously hypertensive rats.

  BJU international 20120901

• Effects of Aβ1‐42 on the current of KATP channels in cultured cholinergic neurons.

  Neurological research 20120901

• Mitochondrial ROMK channel is a molecular component of mitoK(ATP).

  Circulation research 20120803

• Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.

  European journal of medicinal chemistry 20120801

• Intractable absence seizures in hyperinsulinism-hyperammonemia syndrome.

  Pediatric neurology 20120801

• Effects of mitochondrial ATP-sensitive K(+) channel on protein kinase C pathway and airway smooth muscle cell proliferation in asthma.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20120801

• Nuciferine stimulates insulin secretion from beta cells-an in vitro comparison with glibenclamide.

  Journal of ethnopharmacology 20120713

• Successful control of intractable hypoglycemia using radiopharmaceutical therapy with strontium-89 in a case with malignant insulinoma and bone metastases.

  Japanese journal of clinical oncology 20120701

• Mitochondrial K+ channels are involved in ischemic postconditioning in rat hearts.

  The journal of physiological sciences : JPS 20120701

• Enhancement of liver regeneration by adenosine triphosphate-sensitive K⁺ channel opener (diazoxide) after partial hepatectomy.

  Transplantation 20120615

• The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine.

  The Journal of physiology 20120615

• Role of connexin-43 in protective PI3K-Akt-GSK-3β signaling in cardiomyocytes.

  American journal of physiology. Heart and circulatory physiology 20120615

• Nutrient detection by incretin hormone secreting cells.

  Physiology & behavior 20120606

• Diazoxide inhibits aortic endothelial cell apoptosis in diabetic rats via activation of ERK.

  Acta diabetologica 20120601

• Quantitative pancreatic β cell MRI using manganese-enhanced Look-Locker imaging and two-site water exchange analysis.

  Magnetic resonance in medicine 20120601

• Protective effects of diazoxide against Aβ₂₅₋₃₅-induced PC12 cell apoptosis due to prevention of endoplasmic reticulum stress.

  Neuroreport 20120530

• Two neonatal diabetes mutations on transmembrane helix 15 of SUR1 increase affinity for ATP and ADP at nucleotide binding domain 2.

  The Journal of biological chemistry 20120525

• Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells.

  American journal of physiology. Endocrinology and metabolism 20120515

• Partial ABCC8 gene deletion mutations causing diazoxide-unresponsive hyperinsulinaemic hypoglycaemia.

  Pediatric diabetes 20120501

• Protective effect of delayed remote limb ischemic postconditioning: role of mitochondrial K(ATP) channels in a rat model of focal cerebral ischemic reperfusion injury.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501

• Polysaccharide isolated from Triticum aestivum stimulates insulin release from pancreatic cells via the ATP-sensitive K+ channel.

  International journal of molecular medicine 20120501

• Prolonged successful therapy for hyperinsulinaemic hypoglycaemia after gastric bypass: the pathophysiological role of GLP1 and its response to a somatostatin analogue.

  European journal of endocrinology 20120501

• A new mitochondrial pH biosensor for quantitative assessment of pancreatic β-cell function.

  Biochemical and biophysical research communications 20120427

• Diazoxide attenuates ischemia/reperfusion injury via upregulation of heme oxygenase-1 after liver transplantation in rats.

  World journal of gastroenterology 20120421

• Mice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.

  Diabetologia 20120401

• Diazoxide pretreatment enhances L6 skeletal myoblast survival and inhibits apoptosis induced by hydrogen peroxide.

  Anatomical record (Hoboken, N.J. : 2007) 20120401

• Anesthetic management of a 6 month-old infant for near total pancreatectomy with persistent hyperinsulinemic hypoglycemia.

  Korean journal of anesthesiology 20120401

• Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell.

  Molecular and cellular endocrinology 20120305

• Role of the amino-terminal transmembrane domain of sulfonylurea receptor SUR2B for coupling to K(IR)6.2, ligand binding, and oligomerization.

  Naunyn-Schmiedeberg's archives of pharmacology 20120301

• Some cannabinoid receptor ligands and their distomers are direct-acting openers of SUR1 K(ATP) channels.

  American journal of physiology. Endocrinology and metabolism 20120301

• Regulation of calcium in pancreatic α- and β-cells in health and disease.

  Cell calcium 20120301

• Glucose-induced nuclear shuttling of ChREBP is mediated by sorcin and Ca(2+) ions in pancreatic β-cells.

  Diabetes 20120301

• Ethanol causes endoplasmic reticulum stress and impairment of insulin secretion in pancreatic β-cells.

  Alcohol (Fayetteville, N.Y.) 20120201

• Successful treatment of congenital hyperinsulinism with long-acting release octreotide.

  European journal of endocrinology 20120201

• Disruption and stabilization of β-cell actin microfilaments differently influence insulin secretion triggered by intracellular Ca2+ mobilization or store-operated Ca2+ entry.

  FEBS letters 20120102

• Mitochondrial calcium homeostasis as potential target for mitochondrial medicine.

  Mitochondrion 20120101

• The heterogeneity of focal forms of congenital hyperinsulinism.

  The Journal of clinical endocrinology and metabolism 20120101

• Guidelines for the management of gastroenteropancreatic neuroendocrine (including carcinoid) tumours (NETs).

  Gut 20120101

• US-guided ethanol ablation of insulinomas: a new treatment option.

  Gastrointestinal endoscopy 20120101

• Non-classic androgen actions in Sertoli cell membrane in whole seminiferous tubules: effects of nandrolone decanoate and catechin.

  Steroids 20120101

• K(ATP) channel openers in the trigeminovascular system.

  Cephalalgia : an international journal of headache 20120101

• Activation of IL-11/STAT3 pathway in preconditioned human skeletal myoblasts blocks apoptotic cascade under oxidant stress.

  Regenerative medicine 20120101

• Glucose-induced O₂ consumption activates hypoxia inducible factors 1 and 2 in rat insulin-secreting pancreatic beta-cells.

  PloS one 20120101

• Hyperglycemia raises the threshold of levosimendan- but not milrinone-induced postconditioning in rat hearts.

  Cardiovascular diabetology 20120101

• Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats.

  Cardiovascular diabetology 20120101

• Acute and chronic animal models for the evaluation of anti-diabetic agents.

  Cardiovascular diabetology 20120101

• Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol.

  PloS one 20120101

• Rapid insulinotropic action of low doses of bisphenol-A on mouse and human islets of Langerhans: role of estrogen receptor β.

  PloS one 20120101

• High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels.

  Cardiovascular diabetology 20120101

• The diabetic heart: too sweet for its own good?

  Cardiology research and practice 20120101

• Effects of Extract from Solid-State Fermented Cordyceps sinensis on Type 2 Diabetes Mellitus.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.

  PloS one 20120101

• Insulinotropic effect of the non-steroidal compound STX in pancreatic β-cells.

  PloS one 20120101

• Metoclopramide-induced oculogyric crisis presenting as encephalitis in a young girl.

  Indian journal of pharmacology 20120101

• Hyperinsulinism presenting in childhood and treatment by conservative pancreatectomy.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

• [Effects of diazoxide on the mitochondrial membrane potential and ROS generation in rat uterus cells].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20120101

• Localized acquired hypertrichosis associated with the application of a splint.

  Case reports in pediatrics 20120101

• Prostatic relaxation induced by loperamide is reduced in spontaneously hypertensive rats.

  TheScientificWorldJournal 20120101

• Bariatric surgery in hypothalamic obesity.

  Frontiers in endocrinology 20120101

• Insulinoma and anaesthetic implications.

  Indian journal of anaesthesia 20120101

• Towards therapeutic applications of arthropod venom k(+)-channel blockers in CNS neurologic diseases involving memory acquisition and storage.

  Journal of toxicology 20120101

• Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells.

  PloS one 20120101

• Primary aldosteronism in pregnancy.

  Acta clinica Belgica 20120101

• Echocardiography monitoring for diazoxide induced pericardial effusion.

  BMJ case reports 20120101

• Drug-induced hepatitis following use of octreotide for long-term treatment of congenital hyperinsulinism.

  BMJ case reports 20120101

• Paclitaxel-induced endothelial dysfunction in living rats is prevented by nicorandil via reduction of oxidative stress.

  Journal of pharmacological sciences 20120101

• Seizure due to somatostatin analog discontinuation in a case diagnosed as congenital hyperinsulinism novel mutation.

  Journal of pediatric endocrinology & metabolism : JPEM 20120101

• [Neuroprotective effect of ischemic postconditioning and remote preconditioning. Prospective of clinical use].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20120101

• Cardiac subsarcolemmal and interfibrillar mitochondria display distinct responsiveness to protection by diazoxide.

  PloS one 20120101

• The effect of tempol administration on the aortic contractile responses in rat preeclampsia model.

  ISRN pharmacology 20120101

• Aquaporin-7 expression during coronary artery bypass grafting with diazoxide.

  Scandinavian cardiovascular journal : SCJ 20111201

• Protective effect of diazoxide against antimycin A-induced mitochondrial dysfunction in osteoblastic MC3T3-E1 cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20111201

• Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon.

  Biochimica et biophysica acta 20111201

• Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays.

  Pflugers Archiv : European journal of physiology 20111201

• Morphological mosaicism of the pancreatic islets: a novel anatomopathological form of persistent hyperinsulinemic hypoglycemia of infancy.

  The Journal of clinical endocrinology and metabolism 20111201

• Potential candidate genomic biomarkers of drug induced vascular injury in the rat.

  Toxicology and applied pharmacology 20111201

• Unique properties of the ATP-sensitive K⁺ channel in the mouse ventricular cardiac conduction system.

  Circulation. Arrhythmia and electrophysiology 20111201

• Activation of K(ATP) channels suppresses glucose production in humans.

  The Journal of clinical investigation 20111201

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Inhibitors of succinate: quinone reductase/Complex II regulate production of mitochondrial reactive oxygen species and protect normal cells from ischemic damage but induce specific cancer cell death.

  Pharmaceutical research 20111101

• Improved control of severe hypoglycemia in patients with malignant insulinomas by peptide receptor radionuclide therapy.

  The Journal of clinical endocrinology and metabolism 20111101

• Rapid signaling responses in Sertoli cell membranes induced by follicle stimulating hormone and testosterone: calcium inflow and electrophysiological changes.

  Life sciences 20111010

• Lessons in human biology from a monogenic pancreatic β cell disease.

  The Journal of clinical investigation 20111003

• In vitro insulin secretion by pancreatic tissue from infants with diazoxide-resistant congenital hyperinsulinism deviates from model predictions.

  The Journal of clinical investigation 20111003

• Treatment with somatostatin analogs and chemoembolization of liver metastases for severe hypoglycemia in malignant insulinomas.

  Journal of endocrinological investigation 20111001

• Advances in the etiology and management of hyperinsulinemic hypoglycemia after Roux-en-Y gastric bypass.

  Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20111001

• Hyperinsulinaemic hypoglycaemia and diabetes mellitus due to dominant ABCC8/KCNJ11 mutations.

  Diabetologia 20111001

• Mechanisms involved in the desflurane-induced post-conditioning of isolated human right atria from patients with type 2 diabetes.

  British journal of anaesthesia 20111001

• Mechanisms of control of the free Ca2+ concentration in the endoplasmic reticulum of mouse pancreatic β-cells: interplay with cell metabolism and [Ca2+]c and role of SERCA2b and SERCA3.

  Diabetes 20111001

• Positional cloning of a type 2 diabetes quantitative trait locus; tomosyn-2, a negative regulator of insulin secretion.

  PLoS genetics 20111001

• Mechanisms of p-methoxycinnamic acid-induced increase in insulin secretion.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20111001

• Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling.

  Aging 20111001

• Isoflurane decreases death of human embryonic stem cell-derived, transcriptional marker Nkx2.5(+) cardiac progenitor cells.

  Acta anaesthesiologica Scandinavica 20111001

• Glitazone-like action of glimepiride and glibenclamide in primary human adipocytes.

  Diabetes, obesity & metabolism 20110901

• Subsecond regulation of striatal dopamine release by pre-synaptic KATP channels.

  Journal of neurochemistry 20110901

• Diazoxide decreases ischemia-reperfusion injury in a rat model of lung transplantation.

  Transplantation proceedings 20110901

• Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells.

  Respiratory physiology & neurobiology 20110815

• Diazoxide suppresses hepatic ischemia/reperfusion injury after mouse liver transplantation by a BCL-2-dependent mechanism.

  The Journal of surgical research 20110801

• Interaction of morphine and potassium channel openers on experimental models of pain in mice.

  Fundamental & clinical pharmacology 20110801

• Current and future drug targets in weight management.

  Pharmaceutical research 20110801

• Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts.

  Journal of molecular and cellular cardiology 20110801

• Heat shock protein 90 mediates anti-apoptotic effect of diazoxide by preventing the cleavage of Bid in hypothermic preservation rat hearts.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110801

• Severity of diabetes governs vascular lipoprotein lipase by affecting enzyme dimerization and disassembly.

  Diabetes 20110801

• Treatment of congenital hyperinsulinism with lanreotide acetate (Somatuline Autogel).

  The Journal of clinical endocrinology and metabolism 20110801

• ATP-sensitive potassium (KATP) channel activation decreases intraocular pressure in the anterior chamber of the eye.

  Investigative ophthalmology & visual science 20110801

• [The effect of 5-HD on expression of PKC-alpha in rats of chronic hypoxic pulmonary hypertension].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20110801

• The effect of adrenergic β(2) receptor agonist on paraplegia following clamping of abdominal aorta.

  Archives of medical science : AMS 20110801

• Glucose regulates free cytosolic Zn²⁺ concentration, Slc39 (ZiP), and metallothionein gene expression in primary pancreatic islet β-cells.

  The Journal of biological chemistry 20110722

• Type-specific human papillomavirus detection in cervical smears in Romania.

  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20110701

• Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.

  Diabetologia 20110701

• Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium.

  Reproduction (Cambridge, England) 20110701

• Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.

  Bioorganic & medicinal chemistry 20110701

• Glucosensing in parvocellular neurons of the rat hypothalamic paraventricular nucleus.

  The European journal of neuroscience 20110701

• Dominantly acting ABCC8 mutations in patients with medically unresponsive hyperinsulinaemic hypoglycaemia.

  Clinical genetics 20110601

• The role of oxidized cytochrome c in regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia.

  The Biochemical journal 20110601

• Characterization of ABCC8 and KCNJ11 gene mutations and phenotypes in Korean patients with congenital hyperinsulinism.

  European journal of endocrinology 20110601

• Mitochondrial KATP channels participate in the limitation of infarct size by cariporide.

  Naunyn-Schmiedeberg's archives of pharmacology 20110601

• Diazoxide-unresponsive congenital hyperinsulinism in children with dominant mutations of the β-cell sulfonylurea receptor SUR1.

  Diabetes 20110601

• Adenosine triphosphate-sensitive potassium channel blockers attenuate the antiallodynic effect of R-PIA in neuropathic rats.

  Anesthesia and analgesia 20110601

• Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.

  Diabetes 20110601

• [Protective effects of mitochondrial ATP-sensitive potassium channel on A549 cell apoptosis induced by hyperoxia].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20110601

• Diazoxide preconditioning against seizure-induced oxidative injury is via the PI3K/Akt pathway in epileptic rat.

  Neuroscience letters 20110516

• Impact of the nature of the substituent at the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides on their opening activity toward ATP-sensitive potassium channels.

  Journal of medicinal chemistry 20110512

• Hypertensive emergencies in children.

  Indian journal of pediatrics 20110501

• Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110501

• The vasorelaxant effect of hydrogen sulfide is enhanced in streptozotocin-induced diabetic rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20110501

• Sex differences in the contribution of ATP-sensitive K+ channels in trigeminal ganglia under an acute muscle pain condition.

  Neuroscience 20110428

• Nucleo-cytosolic shuttling of FoxO1 directly regulates mouse Ins2 but not Ins1 gene expression in pancreatic beta cells (MIN6).

  The Journal of biological chemistry 20110415

• Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures.

  Brain research 20110406

• GSK-3β at the crossroads in the signalling of heart preconditioning: implication of mTOR and Wnt pathways.

  Cardiovascular research 20110401

• Treat the graft to improve the regenerative ability of the host.

  Medical hypotheses 20110401

• Glucose-dependent changes in SNARE protein levels in pancreatic β-cells.

  Endocrinology 20110401

• Partial inhibition of insulin secretion results in glucose intolerance but not hyperglucagonemia.

  Diabetes 20110401

• In vitro recovery of ATP-sensitive potassium channels in β-cells from patients with congenital hyperinsulinism of infancy.

  Diabetes 20110401

• Congenital hyperinsulinism: review of 12 Tunisian cases.

  La Tunisie medicale 20110401

• Transient neonatal hyperinsulinemic hypoglycemia and neurological outcome: a case report.

  Minerva pediatrica 20110401

• KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia.

  Cell death & disease 20110401

• Pancreatic endocrine tumors.

  North American journal of medical sciences 20110401

• The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia-ischemia-reperfusion in brain.

  Neuroscience letters 20110310

• Functional role of the activity of ATP-sensitive potassium channels in electrical behavior of hippocampal neurons: experimental and theoretical studies.

  Journal of theoretical biology 20110307

• [Malignant insulinoma].

  Orvosi hetilap 20110306

• Hyperinsulinemic hypoglycemia associated with ectopic Cushing's syndrome due to a pancreatic endocrine tumor in a Type 2 diabetes mellitus patient: clinical implications of a rare association.

  Journal of endocrinological investigation 20110301

• Inhibition of gastric motility by hyperglycemia is mediated by nodose ganglia KATP channels.

  American journal of physiology. Gastrointestinal and liver physiology 20110301

• Genome-wide homozygosity analysis reveals HADH mutations as a common cause of diazoxide-responsive hyperinsulinemic-hypoglycemia in consanguineous pedigrees.

  The Journal of clinical endocrinology and metabolism 20110301

• Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia.

  European journal of medicinal chemistry 20110301

• Postconditioning in focal cerebral ischemia: role of the mitochondrial ATP-dependent potassium channel.

  Brain research 20110223

• Induction of insulin secretion by an aqueous extract of Tabernanhte iboga Baill. (Apocynaceae) in rat pancreatic islets of Langerhans.

  Journal of ethnopharmacology 20110216

• Interactive medical case. Lying low.

  The New England journal of medicine 20110210

• Recognition of sulfonylurea receptor (ABCC8/9) ligands by the multidrug resistance transporter P-glycoprotein (ABCB1): functional similarities based on common structural features between two multispecific ABC proteins.

  The Journal of biological chemistry 20110204

• Levosimendan modulates programmed forms of cell death through K(ATP) channels and nitric oxide.

  Journal of cardiovascular pharmacology 20110201

• Genetics of congenital hyperinsulinemic hypoglycemia.

  Seminars in pediatric surgery 20110201

• KATP channel mutations in congenital hyperinsulinism.

  Seminars in pediatric surgery 20110201

• A specialized team approach to diagnosis and medical versus surgical treatment of infants with congenital hyperinsulinism.

  Seminars in pediatric surgery 20110201

• Rare forms of congenital hyperinsulinism.

  Seminars in pediatric surgery 20110201

• Glutamine triggers and potentiates glucagon-like peptide-1 secretion by raising cytosolic Ca2+ and cAMP.

  Endocrinology 20110201

• Role of vascular K(ATP) channels in blood pressure variability after sinoaortic denervation in rats.

  Acta pharmacologica Sinica 20110201

• Effect of glibenclamide on antinociceptive effects of antidepressants of different classes.

  Clinics (Sao Paulo, Brazil) 20110201

• AIF-mediated mitochondrial pathway is critical for the protective effect of diazoxide against SH-SY5Y cell apoptosis.

  Brain research 20110125

• Diazoxide attenuates indomethacin-induced small intestinal damage in the rat.

  European journal of pharmacology 20110110

• The pancreas in human type 1 diabetes.

  Seminars in immunopathology 20110101

• Reversal of rotenone-induced dysfunction of astrocytic connexin43 by opening mitochondrial ATP-sensitive potassium channels.

  Cellular and molecular neurobiology 20110101

• Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.

  Diabetes 20110101

• Familial focal congenital hyperinsulinism.

  The Journal of clinical endocrinology and metabolism 20110101

• Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management.

  Diabetes 20110101

• Cardiac glycosides are potent inhibitors of interferon-β gene expression.

  Nature chemical biology 20110101

• Isoflurane preconditioning increases endothelial cell tolerance to in-vitro simulated ischaemia.

  The Journal of pharmacy and pharmacology 20110101

• Elimination of hypoglycemia from the lives of people affected by diabetes.

  Diabetes 20110101

• TRP-ing down the path to insulin secretion.

  Diabetes 20110101

• Everolimus resolving hypoglycemia, producing hyperglycemia, and necessitating insulin use in a patient with diabetes and nonresectable malignant insulinoma.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

• Metastatic insulinoma in a patient with type 2 diabetes mellitus: case report and review of the literature.

  International journal of endocrinology 20110101

• Continuous glucose monitoring for evaluation of glycemic excursions after gastric bypass.

  Journal of obesity 20110101

• New developments in the treatment of hyperammonemia: emerging use of carglumic acid.

  International journal of general medicine 20110101

• Molecular mechanisms in exercise-induced cardioprotection.

  Cardiology research and practice 20110101

• Expression of ATP-sensitive potassium channels in human pregnant myometrium.

  Reproductive biology and endocrinology : RB&E 20110101

• Regulation of gap junctional communication by astrocytic mitochondrial K(ATP) channels following neurotoxin administration in in vitro and in vivo models.

  Neuro-Signals 20110101

• Evidence for presence and functional effects of Kv1.1 channels in β-cells: general survey and results from mceph/mceph mice.

  PloS one 20110101

• Nateglinide stimulates glucagon-like peptide-1 release by human intestinal L cells via a K(ATP) channel-independent mechanism.

  Biological & pharmaceutical bulletin 20110101

• Role of the nitric oxide on relaxation of the human umbilical artery during cooling.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

• Cardioprotective effect of nicorandil, a mitochondrial ATP-sensitive potassium channel opener, prolongs survival in HSPB5 R120G transgenic mice.

  PloS one 20110101

• Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury.

  Frontiers in physiology 20110101

• Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats.

  Molecular pain 20110101

• Pharmacological modulation of dopamine receptor D2-mediated transmission alters the metabolic phenotype of diet induced obese and diet resistant C57Bl6 mice.

  Experimental diabetes research 20110101

• Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy.

  International journal of pediatric endocrinology 20110101

• Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function.

  PloS one 20110101

• MicroRNAs in cardiovascular disease.

  F1000 medicine reports 20110101

• Evolving diagnostic and treatment strategies for pancreatic neuroendocrine tumors.

  Journal of hematology & oncology 20110101

• Preconditioning involves selective mitophagy mediated by Parkin and p62/SQSTM1.

  PloS one 20110101

• Modulation of myocardial mitochondrial mechanisms during severe polymicrobial sepsis in the rat.

  PloS one 20110101

• Lack of Restoration in Vivo by K-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge.

  Journal of tropical medicine 20110101

• Hypoglycemic syndrome in a patient with proinsulin-only secreting pancreatic adenoma (proinsulinoma).

  Case reports in medicine 20110101

• Stem cells for cardiac repair: status, mechanisms, and new strategies.

  Stem cells international 20110101

• Analysis of mitochondrial 3D-deformation in cardiomyocytes during active contraction reveals passive structural anisotropy of orthogonal short axes.

  PloS one 20110101

• Octreotide-treated diabetes accompanied by endogenous hyperinsulinemic hypoglycemia and protein-losing gastroenteropathy.

  Case reports in medicine 20110101

• [Congenital hyperinsulinism in the north-east Netherlands. Clinical features and DNA diagnostics in 22 children].

  Nederlands tijdschrift voor geneeskunde 20110101

• ATP-Sensitive Potassium Channel Currents in Eccentrically Hypertrophied Cardiac Myocytes of Volume-Overloaded Rats.

  International journal of cell biology 20110101

• [The influence of ATP-dependent K(+)-channel diazoxide opener on the opening of mitochondrial permeability transition pore in rat liver mitochondria].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20110101

• [Regulation of the mitochondrial ATP-sensitive potassium channel in rat uterus cells by ROS].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20110101

• Control of the intracellular redox state by glucose participates in the insulin secretion mechanism.

  PloS one 20110101

• Pulmonary hypertension and reopening of the ductus arteriosus in an infant treated with diazoxide.

  Journal of pediatric endocrinology & metabolism : JPEM 20110101

• Short- and long-term physiologic and pharmacologic control of blood pressure in pediatric patients.

  Integrated blood pressure control 20110101

• Congenital hyperinsulinism: current trends in diagnosis and therapy.

  Orphanet journal of rare diseases 20110101

• High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells.

  PloS one 20110101

• Oral administration of the KATP channel opener diazoxide ameliorates disease progression in a murine model of multiple sclerosis.

  Journal of neuroinflammation 20110101

• MiR-146a in Immunity and Disease.

  Molecular biology international 20110101

• Nicorandil prevents endothelial dysfunction due to antioxidative effects via normalisation of NADPH oxidase and nitric oxide synthase in streptozotocin diabetic rats.

  Cardiovascular diabetology 20110101

• Hyperinsulinism associated with gestational exposure to bupropion in a newborn infant.

  Journal of pediatric endocrinology & metabolism : JPEM 20110101

• Measurement of warfarin in the oral fluid of patients undergoing anticoagulant oral therapy.

  PloS one 20110101

• [Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium].

  Acta pharmaceutica Hungarica 20110101

• Clinical characteristics of recessive and dominant congenital hyperinsulinism due to mutation(s) in the ABCC8/KCNJ11 genes encoding the ATP-sensitive potasium channel in the pancreatic beta cell.

  Journal of pediatric endocrinology & metabolism : JPEM 20110101

• Long term sequelae of pediatric craniopharyngioma - literature review and 20 years of experience.

  Frontiers in endocrinology 20110101

• Effects of methylphenidate on weight gain and food intake in hypothalamic obesity.

  Frontiers in endocrinology 20110101

• Hypothalamic obesity after craniopharyngioma: mechanisms, diagnosis, and treatment.

  Frontiers in endocrinology 20110101

• Paternal Uniparental Isodisomy of Chromosome 11p15.5 within the Pancreas Causes Isolated Hyperinsulinemic Hypoglycemia.

  Frontiers in endocrinology 20110101

• Neonatal hyperinsulinism secondary to maternal intake of high-sugar drinks.

  BMJ case reports 20110101

• Rapidly progressing malignant insulinoma presented with multiple liver metastases: a case report.

  Journal of gastrointestinal cancer 20101201

• Diazoxide attenuates hypothermic preservation-induced renal injury via down-regulation of CHOP and caspase-12.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20101201

• Both mitochondrial KATP channel opening and sarcolemmal KATP channel blockage confer protection against ischemia/reperfusion-induced arrhythmia in anesthetized male rats.

  Journal of cardiovascular pharmacology and therapeutics 20101201

• Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.

  Molecular and cellular biochemistry 20101201

• Role of KATP and L-type Ca2+ channel activities in regulation of ovine uterine vascular contractility: effect of pregnancy and chronic hypoxia.

  American journal of obstetrics and gynecology 20101201

• Myocardial ischaemic and diazoxide preconditioning both increase PGC-1alpha and reduce mitochondrial damage.

  Acta cardiologica 20101201

• Hyperinsulinemic hypoglycemia evolving to gestational diabetes and diabetes mellitus in a family carrying the inactivating ABCC8 E1506K mutation.

  Pediatric diabetes 20101101

• Pharmacological preconditioning by diazoxide downregulates cardiac L-type Ca(2+) channels.

  British journal of pharmacology 20101101

• Discrimination between two possible reaction sequences that create potential risk of generation of deleterious radicals by cytochrome bc₁. Implications for the mechanism of superoxide production.

  Biochimica et biophysica acta 20101101

• ABCC8 and KCNJ11 molecular spectrum of 109 patients with diazoxide-unresponsive congenital hyperinsulinism.

  Journal of medical genetics 20101101

• Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel.

  Journal of molecular and cellular cardiology 20101101

• Management of intractable hypoglycemia with Yttirum-90 radioembolization in a patient with malignant insulinoma.

  The American journal of the medical sciences 20101101

• Hypoglycaemia following gastric bypass surgery--diabetes remission in the extreme?

  Diabetologia 20101101

• Diazoxide maintenance of myocyte volume and contractility during stress: evidence for a non-sarcolemmal K(ATP) channel location.

  The Journal of thoracic and cardiovascular surgery 20101101

• Microfluidic multi-analyte gradient generator.

  Analytical and bioanalytical chemistry 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• 3-(6-Fluoro-4-oxo-4H-chromen-3-yl)-3,4-dihydro-2H-1,2,4-benzothia-diazine-1,1-dione.

  Acta crystallographica. Section E, Structure reports online 20101101

• Mechanisms of the beneficial actions of ischemic preconditioning on subcellular remodeling in ischemic-reperfused heart.

  Current cardiology reviews 20101101

• Management of postgastric bypass noninsulinoma pancreatogenous hypoglycemia.

  Surgical endoscopy 20101001

• Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning.

  Cardiovascular research 20101001

• Endothelin signalling regulates volume-sensitive Cl- current via NADPH oxidase and mitochondrial reactive oxygen species.

  Cardiovascular research 20101001

• MicroRNA-21 is a key determinant in IL-11/Stat3 anti-apoptotic signalling pathway in preconditioning of skeletal myoblasts.

  Cardiovascular research 20101001

• Diazoxide preconditioning alleviates caspase-dependent and caspase-independent apoptosis induced by anoxia-reoxygenation of PC12 cells.

  Journal of biochemistry 20101001

• Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas.

  American journal of physiology. Heart and circulatory physiology 20101001

• Regulation of AMPA receptor currents by mitochondrial ATP-sensitive K+ channels in anoxic turtle neurons.

  Journal of neurophysiology 20101001

• The effect of 'Teucrium polium L.' extracts on insulin release from in situ isolated perfused rat pancreas in a newly modified isolation method: the role of Ca2+ and K+ channels.

  Iranian biomedical journal 20101001

• Potassium channel openers exhibit cross-tolerance with morphine in two experimental models of pain.

  The West Indian medical journal 20101001

• Targeting hypertension with a new adenosine triphosphate-sensitive potassium channel opener iptakalim.

  Journal of cardiovascular pharmacology 20100901

• Subplasmalemmal Ca(2+) measurements in mouse pancreatic beta cells support the existence of an amplifying effect of glucose on insulin secretion.

  Diabetologia 20100901

• Autonomic neuropathy predisposes to rosiglitazone-induced vascular leakage in insulin-treated patients with type 2 diabetes: a randomised, controlled trial on thiazolidinedione-induced vascular leakage.

  Diabetologia 20100901

• Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

  Diabetes 20100901

• Hyperinsulinemia precedes insulin resistance in mice lacking pancreatic beta-cell leptin signaling.

  Endocrinology 20100901

• 17 β-estradiol rapidly increases ATP-sensitive potassium channel activity in gonadotropin-releasing hormone neurons [corrected] via a protein kinase signaling pathway.

  Endocrinology 20100901

• Advanced diagnostic approaches and current medical management of insulinomas and adrenocortical disease in ferrets (Mustela putorius furo).

  The veterinary clinics of North America. Exotic animal practice 20100901

• Congenital hyperinsulinism due to mutations in HNF4A and HADH.

  Reviews in endocrine & metabolic disorders 20100901

• The hyperinsulinism/hyperammonemia syndrome.

  Reviews in endocrine & metabolic disorders 20100901

• Influence of ATP-dependent K(+)-channel opener on K(+)-cycle and oxygen consumption in rat liver mitochondria.

  Biochemistry. Biokhimiia 20100901

• Vascular dysfunctions following spinal cord injury.

  Journal of medicine and life 20100815

• Inhibition or deletion of soluble epoxide hydrolase prevents hyperglycemia, promotes insulin secretion, and reduces islet apoptosis.

  The Journal of pharmacology and experimental therapeutics 20100801

• Effects of high-density lipoproteins on pancreatic beta-cell insulin secretion.

  Arteriosclerosis, thrombosis, and vascular biology 20100801

• Autophagy induced by ischemic preconditioning is essential for cardioprotection.

  Journal of cardiovascular translational research 20100801

• AGI-1067, a novel antioxidant and anti-inflammatory agent, enhances insulin release and protects mouse islets.

  Molecular and cellular endocrinology 20100729

• Loss of AMP-activated protein kinase alpha2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia.

  The Biochemical journal 20100715

• Metabolic oscillations in pancreatic islets depend on the intracellular Ca2+ level but not Ca2+ oscillations.

  Biophysical journal 20100707

• Biotin increases glucokinase expression via soluble guanylate cyclase/protein kinase G, adenosine triphosphate production and autocrine action of insulin in pancreatic rat islets.

  The Journal of nutritional biochemistry 20100701

• Human K(ATP) channelopathies: diseases of metabolic homeostasis.

  Pflugers Archiv : European journal of physiology 20100701

• Mitochondria as a source of mechanical signals in cardiomyocytes.

  Cardiovascular research 20100701

• Transient anoxia and oxyradicals induce a region-specific activation of MAPKs in the embryonic heart.

  Molecular and cellular biochemistry 20100701

• Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells.

  Diabetes 20100701

• Persistent hyperinsulinemic hypoglycemia of infancy due to homozygous KCNJ11 (T294M) mutation.

  Indian journal of pediatrics 20100701

• A study of the relationship between pharmacologic preconditioning and adenosine triphosphate-sensitive potassium (KATP) channels on cultured cardiomyocytes using the microelectrode array.

  Journal of cardiovascular pharmacology 20100701

• [Effect of K-ATP channel opener diazoxide on islet cell apoptosis and the expressions of apoptosis-related genes].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100701

• Anemia and neutropenic fever with high dose diazoxide treatment in a case with hyperinsulinism due to Munchausen by proxy.

  Journal of pediatric endocrinology & metabolism : JPEM 20100701

• Two unrelated Chinese patients with hyperinsulinism /hyperammonemia (HI/HA) syndrome due to mutations in glutamate dehydrogenase gene.

  Journal of pediatric endocrinology & metabolism : JPEM 20100701

• Effects of mitochondrial potassium channel and membrane potential on hypoxic human pulmonary artery smooth muscle cells.

  American journal of respiratory cell and molecular biology 20100601

• Low-level arsenic impairs glucose-stimulated insulin secretion in pancreatic beta cells: involvement of cellular adaptive response to oxidative stress.

  Environmental health perspectives 20100601

• Octreotide's role in the management of sulfonylurea-induced hypoglycemia.

  Journal of medical toxicology : official journal of the American College of Medical Toxicology 20100601

• Signaling pathways involved in postconditioning-induced cardioprotection of human myocardium, in vitro.

  Experimental biology and medicine (Maywood, N.J.) 20100601

• Mechanisms of hydrogen peroxide-induced vasoconstriction in the isolated perfused rat kidney.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100601

• The phosphatidylinositol-3 kinase/Akt pathway mediates geranylgeranylacetone-induced neuroprotection against cerebral infarction in rats.

  Brain research 20100512

• Connexin 43 acts as a cytoprotective mediator of signal transduction by stimulating mitochondrial KATP channels in mouse cardiomyocytes.

  The Journal of clinical investigation 20100503

• Diazoxide reduces status epilepticus neuron damage in diabetes.

  Neurotoxicity research 20100501

• Progression of diet-induced diabetes in C57BL6J mice involves functional dissociation of Ca2(+) channels from secretory vesicles.

  Diabetes 20100501

• Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations.

  European journal of endocrinology 20100501

• Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma.

  European journal of endocrinology 20100501

• Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.

  American journal of physiology. Endocrinology and metabolism 20100501

• Congenital hyperinsulinism.

  Early human development 20100501

• Involvement of mitochondrial ATP-sensitive potassium channels in etomidate preconditioning-induced protection in human myeloid HL-60 cells.

  Environmental toxicology and pharmacology 20100501

• A lethargic neonate and an infant with seizure.

  Clinical pediatrics 20100401

• Opening of the mitoKATP channel and decoupling of mitochondrial complex II and III contribute to the suppression of myocardial reperfusion hyperoxygenation.

  Molecular and cellular biochemistry 20100401

• Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women With polycystic ovary syndrome.

  Metabolic syndrome and related disorders 20100401

• Effects of substitution of Cx43 by Cx32 on myocardial energy metabolism, tolerance to ischaemia and preconditioning protection.

  The Journal of physiology 20100401

• The intracellular localization and function of the ATP-sensitive K+ channel subunit Kir6.1.

  The Journal of membrane biology 20100401

• [Influence of diazoxide on mitochondrial apoptosis in human renal tubular cells induced by serum obtained from neonates with asphyxia].

  Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20100401

• Inhibition of endogenous hydrogen sulfide synthesis by PAG protects against ethanol-induced gastric damage in the rat.

  European journal of pharmacology 20100325

• Preconditioning promotes survival and angiomyogenic potential of mesenchymal stem cells in the infarcted heart via NF-kappaB signaling.

  Antioxidants & redox signaling 20100315

• Six months of diazoxide treatment at bedtime in newly diagnosed subjects with type 1 diabetes does not influence parameters of {beta}-cell function and autoimmunity but improves glycemic control.

  Diabetes care 20100301

• The KATP channel is a molecular sensor of atrophy in skeletal muscle.

  The Journal of physiology 20100301

• Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts.

  Journal of Korean medical science 20100301

• Recurrent hypoglycaemia in a type 2 diabetes patient - diagnostic difficulties.

  Archives of medical science : AMS 20100301

• [Akt involved in diazoxide preconditioning against rat hippocampal neuronal apoptosis induced by anoxia-reoxygenation injury].

  Zhonghua yi xue za zhi 20100223

• K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production.

  Journal of neuroscience research 20100201

• Variable effects of the mitoK(ATP) channel modulators diazoxide and 5-HD in ATP-depleted renal epithelial cells.

  Molecular and cellular biochemistry 20100201

• Coupling of liquid chromatography/tandem mass spectrometry and liquid chromatography/solid-phase extraction/NMR techniques for the structural identification of metabolites following in vitro biotransformation of SUR1-selective ATP-sensitive potassium channel openers.

  Drug metabolism and disposition: the biological fate of chemicals 20100201

• Inhibition of oxygen consumption in skeletal muscle-derived mitochondria by pinacidil, diazoxide, and glibenclamide, but not by 5-hydroxydecanoate.

  Journal of bioenergetics and biomembranes 20100201

• Sevoflurane pre- and post-conditioning protect the brain via the mitochondrial K ATP channel.

  British journal of anaesthesia 20100201

• Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels.

  British journal of pharmacology 20100201

• Transplantation of mesenchymal stem cells preconditioned with diazoxide, a mitochondrial ATP-sensitive potassium channel opener, promotes repair of myocardial infarction in rats.

  The Tohoku journal of experimental medicine 20100201

• [Effects of diazoxide on the mitochondrial ultrastructure and permeability in donor rat myocardium].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20100201

• Ischemic postconditioning may not influence early brain injury induced by focal cerebral ischemia/reperfusion in rats.

  Korean journal of anesthesiology 20100201

• Improved insulin sensitivity and islet function after PPARdelta activation in diabetic db/db mice.

  European journal of pharmacology 20100125

• [Effect of diazoxide on oxygen free radicals and cell apoptosis in brain tissue after deep hypothermia cerebral ischemia reperfusion injury in young rats].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20100115

• Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.

  Journal of medicinal chemistry 20100114

• Preconditioning with diazoxide prevents reoxygenation-induced rigor-type hypercontracture.

  Journal of molecular and cellular cardiology 20100101

• Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel.

  Biochemical pharmacology 20100101

• Terminalia bellirica stimulates the secretion and action of insulin and inhibits starch digestion and protein glycation in vitro.

  The British journal of nutrition 20100101

• Differential K(ATP) channel pharmacology in intact mouse heart.

  Journal of molecular and cellular cardiology 20100101

• ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivation.

  Diabetes 20100101

• Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume.

  The Journal of biological chemistry 20100101

• Modeling mitochondrial bioenergetics with integrated volume dynamics.

  PLoS computational biology 20100101

• Direct effects of K(ATP) channel openers pinacidil and diazoxide on oxidative phosphorylation of mitochondria in situ.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Defective secretion of islet hormones in chromogranin-B deficient mice.

  PloS one 20100101

• Congenital hyperinsulinism due to a compound heterozygous ABCC8 mutation with spontaneous resolution at eight weeks.

  Hormone research in paediatrics 20100101

• Novel neuroprotective strategies in ischemic retinal lesions.

  International journal of molecular sciences 20100101

• Insulinoma in a patient with MEN 1 syndrome--9-year follow-up: case report.

  Endokrynologia Polska 20100101

• Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.

  PloS one 20100101

• Diazoxide promotes oligodendrocyte precursor cell proliferation and myelination.

  PloS one 20100101

• Hypoglycaemia following upper gastrointestinal surgery: case report and review of the literature.

  BMC gastroenterology 20100101

• Nonclassic congenital adrenal hyperplasia.

  International journal of pediatric endocrinology 20100101

• Dual role of nNOS in ischemic injury and preconditioning.

  BMC physiology 20100101

• Mitochondrial preconditioning: a potential neuroprotective strategy.

  Frontiers in aging neuroscience 20100101

• The KATP channel activator diazoxide ameliorates amyloid-β and tau pathologies and improves memory in the 3xTgAD mouse model of Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20100101

• Electrical short-circuit in β-cells from a patient with non-insulinoma pancreatogenous hypoglycemic syndrome (NIPHS): a case report.

  Journal of medical case reports 20100101

• Neuroprotective properties of levosimendan in an in vitro model of traumatic brain injury.

  BMC neurology 20100101

• Hyperinsulinemic hypoglycemias in infancy and childhood--diagnostic therapeutic algorithm with contribution of two cases.

  Folia medica 20100101

• Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.

  PloS one 20100101

• Endocrinology of hirsutism.

  International journal of trichology 20100101

• [Effect of mitochondrial ATP-dependent potassium channel effectors diazoxide and glybenclamide on hydrodynamic diameter and membrane potential of the myometrial mitochondria].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20100101

• Magnesium Lithospermate B Protects Cardiomyocytes from Ischemic Injury Via Inhibition of TAB1-p38 Apoptosis Signaling.

  Frontiers in pharmacology 20100101

• Adverse drug effects in hospitalized elderly: data from the healthcare cost and utilization project.

  Clinical pharmacology : advances and applications 20100101

• Congenital hyperinsulinism with hyperammonaemia.

  BMJ case reports 20100101

• Diazoxide protects against hydrogen peroxide-induced toxicity in the osteoblastic MC3T3-E1 cells.

  European journal of pharmacology 20091210

• Chronic palmitate exposure inhibits insulin secretion by dissociation of Ca(2+) channels from secretory granules.

  Cell metabolism 20091202

• Congenital disorder of glycosylation type Ia: heterogeneity in the clinical presentation from multivisceral failure to hyperinsulinaemic hypoglycaemia as leading symptoms in three infants with phosphomannomutase deficiency.

  Journal of inherited metabolic disease 20091201

• Diazoxide reverses the enhanced expression of KATP subunits in cholinergic neurons caused by exposure to Aβ₁₋₄₂.

  Neurochemical research 20091201

• Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells.

  Diabetes 20091201

• Galanin potentiates supramaximal caerulein-stimulated pancreatic amylase secretion via its action on somatostatin secretion.

  American journal of physiology. Gastrointestinal and liver physiology 20091201

• Mitochondrial KATP opening confers protection against lethal myocardial injury and ischaemia-induced arrhythmias in the rat heart via PI3K/Akt-dependent and -independent mechanisms.

  Canadian journal of physiology and pharmacology 20091201

• Bistability of mitochondrial respiration underlies paradoxical reactive oxygen species generation induced by anoxia.

  PLoS computational biology 20091201

• Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis.

  British journal of pharmacology 20091201

• Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing.

  Circulation research 20091120

• New R/S-3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans as K(ATP) channel openers: modulation of the 4-position.

  Bioorganic & medicinal chemistry 20091115

• Early preconditioning protection against stunning in conscious sheep. Role of KATP channels.

  Molecular and cellular biochemistry 20091101

• Mitogen-activated protein kinase p38alpha and retinal ischemic preconditioning.

  Experimental eye research 20091101

• Hyperinsulinism-hyperammonaemia syndrome: novel mutations in the GLUD1 gene and genotype-phenotype correlations.

  European journal of endocrinology 20091101

• Synthesis of modified 4H-1,2,4-benzothiadiazine-1,1-dioxides and determination of their affinity and selectivity for different types of K(ATP) channels.

  ChemMedChem 20091101

• Beneficial effects of K-ATP channel openers in diabetes: an update on mechanisms and clinical experiences.

  Diabetes, obesity & metabolism 20091101

• The role of KATP channels on propofol preconditioning in a cellular model of renal ischemia-reperfusion.

  Anesthesia and analgesia 20091101

• Quantitative measurement of zinc secretion from pancreatic islets with high temporal resolution using droplet-based microfluidics.

  Analytical chemistry 20091101

• Immunotherapy for the prevention and treatment of type 1 diabetes: human trials and a look into the future.

  Diabetes care 20091001

• [Persistent hyperinsulinemic hypoglycemia of infancy: clinical analysis of 12 cases].

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20091001

• Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state.

  Cardiovascular research 20090901

• Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure.

  Cardiovascular research 20090901

• Successful medical management of status post-Roux-en-Y-gastric-bypass hyperinsulinemic hypoglycemia.

  Obesity surgery 20090901

• Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases.

  The Journal of clinical endocrinology and metabolism 20090901

• Radiofrequency ablation of solitary pancreatic insulinoma in a patient with episodes of severe hypoglycemia.

  European journal of gastroenterology & hepatology 20090901

• ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury.

  Neuroscience 20090818

• Lysosomal and proteasome-dependent proteolysis are differentially regulated by insulin and/or amino acids following feeding in young, mature and old rats.

  The Journal of nutritional biochemistry 20090801

• Deletion of PKCepsilon selectively enhances the amplifying pathways of glucose-stimulated insulin secretion via increased lipolysis in mouse beta-cells.

  Diabetes 20090801

• Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loop.

  Diabetes 20090801

• Somatostatin release, electrical activity, membrane currents and exocytosis in human pancreatic delta cells.

  Diabetologia 20090801

• Isoflurane induces a postconditioning effect on bovine pulmonary arterial endothelial cells exposed to oxygen-glucose deprivation.

  European journal of pharmacology 20090801

• Plasma membrane depolarization as a determinant of the first phase of insulin secretion.

  American journal of physiology. Endocrinology and metabolism 20090801

• Galanin inhibits caerulein-stimulated pancreatic amylase secretion via cholinergic nerves and insulin.

  American journal of physiology. Gastrointestinal and liver physiology 20090801

• Glucose sensing during hypoglycemia: lessons from the lab.

  Diabetes care 20090801

• Hypoglycemia: from the laboratory to the clinic.

  Diabetes care 20090801

• [Diabetes counteracts the protective effect of the diazoxide preconditioning on ischemic reperfused rat heart].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20090801

• Role of mitochondrial ATP-sensitive potassium channels on fatigue in mouse muscle fibers.

  Biochemical and biophysical research communications 20090717

• Evidence for an ATP-sensitive K+ channel in mitoplasts isolated from Trypanosoma cruzi and Crithidia fasciculata.

  International journal for parasitology 20090715

• Inhibitory effects of leptin on pancreatic alpha-cell function.

  Diabetes 20090701

• 3-Hydroxyacyl-coenzyme A dehydrogenase deficiency and hyperinsulinemic hypoglycemia: characterization of a novel mutation and severe dietary protein sensitivity.

  The Journal of clinical endocrinology and metabolism 20090701

• Sesquiterpenoids from antidiabetic Psacalium decompositum block ATP sensitive potassium channels.

  Journal of ethnopharmacology 20090625

• Hyperinsulinaemic hypoglycaemia.

  Archives of disease in childhood 20090601

• The phenomenon of seasonal pseudohypokalemia: effects of ambient temperature, plasma glucose and role for sodium-potassium-exchanging-ATPase.

  Clinical biochemistry 20090601

• Extremes of clinical and enzymatic phenotypes in children with hyperinsulinism caused by glucokinase activating mutations.

  Diabetes 20090601

• Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain complexes I and III.

  Biochimica et biophysica acta 20090601

• Role of the nitric oxide on diazoxide-induced relaxation of the calf cardiac vein and coronary artery during cooling.

  Fundamental & clinical pharmacology 20090601

• Intermittent adenosine at the beginning of reperfusion does not trigger cardioprotection.

  The Journal of surgical research 20090515

• ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity.

  Carcinogenesis 20090501

• Oleic acid directly regulates POMC neuron excitability in the hypothalamus.

  Journal of neurophysiology 20090501

• Possible role of JAK-2 in attenuated cardioprotective effect of ischemic preconditioning in hyperhomocysteinemic rat hearts.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20090501

• Cardiac dysfunctions following spinal cord injury.

  Journal of medicine and life 20090415

• Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.

  The Journal of biological chemistry 20090403

• Iptakalim protects against MPP+-induced degeneration of dopaminergic neurons in association with astrocyte activation.

  The international journal of neuropsychopharmacology 20090401

• Iptakalim ameliorates MPP+-induced astrocyte mitochondrial dysfunction by increasing mitochondrial complex activity besides opening mitoK(ATP) channels.

  Journal of neuroscience research 20090401

• Glucose-dependent and -independent electrical activity in islets of Langerhans of Psammomys obesus, an animal model of nutritionally induced obesity and diabetes.

  General and comparative endocrinology 20090401

• Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets.

  Diabetologia 20090401

• Endothelial heparanase secretion after acute hypoinsulinemia is regulated by glucose and fatty acid.

  American journal of physiology. Heart and circulatory physiology 20090401

• Identification of a chemical probe for NAADP by virtual screening.

  Nature chemical biology 20090401

• Diazoxide protects myocardial mitochondria, metabolism, and function during cardiac surgery: a double-blind randomized feasibility study of diazoxide-supplemented cardioplegia.

  The Journal of thoracic and cardiovascular surgery 20090401

• The insulinotropic effect of fluoroquinolones.

  Biochemical pharmacology 20090315

• Involvement of hippocampal CA3 K(ATP) channels in contextual memory.

  Neuropharmacology 20090301

• Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.

  Diabetes 20090301

• The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning.

  Experimental eye research 20090301

• Nicorandil attenuates FeCl(3)-induced thrombus formation through the inhibition of reactive oxygen species production.

  Circulation journal : official journal of the Japanese Circulation Society 20090301

• A new mechanism and strategy for inhibiting thrombus formation in the artery.

  Circulation journal : official journal of the Japanese Circulation Society 20090301

• [Regulation of rat airway smooth muscle cell proliferation by mitochondrial ATP-sensitive K(+) channel in asthmic rats.].

  Sheng li xue bao : [Acta physiologica Sinica] 20090225

• Impaired mitochondria-dependent vasodilation in cerebral arteries of Zucker obese rats with insulin resistance.

  American journal of physiology. Regulatory, integrative and comparative physiology 20090201

• Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells.

  Diabetes 20090201

• Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice.

  Diabetes 20090201

• Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells.

  Diabetologia 20090201

• The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing.

  Diabetes 20090201

• Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090201

• Blockade of the erbB2 receptor induces cardiomyocyte death through mitochondrial and reactive oxygen species-dependent pathways.

  The Journal of biological chemistry 20090123

• Effect of obestatin on insulin, glucagon and somatostatin secretion in the perfused rat pancreas.

  Regulatory peptides 20090108

• Protection against ischemia-induced ventricular arrhythmias and myocardial dysfunction conferred by preconditioning in the rat heart: involvement of mitochondrial K(ATP) channels and reactive oxygen species.

  Physiological research 20090101

• Glucose controls cytosolic Ca2+ and insulin secretion in mouse islets lacking adenosine triphosphate-sensitive K+ channels owing to a knockout of the pore-forming subunit Kir6.2.

  Endocrinology 20090101

• Regulation of calcium-permeable TRPV2 channel by insulin in pancreatic beta-cells.

  Diabetes 20090101

• Diazoxide-mediated growth inhibition in human lung cancer cells via downregulation of beta-catenin-mediated cyclin D1 transcription.

  Lung 20090101

• Identification of antihypertensive drugs which inhibit amyloid-beta protein oligomerization.

  Journal of Alzheimer's disease : JAD 20090101

• Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy.

  Journal of pediatric surgery 20090101

• Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1.

  World journal of surgical oncology 20090101

• Connexins: a myriad of functions extending beyond assembly of gap junction channels.

  Cell communication and signaling : CCS 20090101

• Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation.

  Molecular pain 20090101

• Childhood craniopharyngioma: greater hypothalamic involvement before surgery is associated with higher homeostasis model insulin resistance index.

  BMC pediatrics 20090101

• Sweet taste receptor expressed in pancreatic beta-cells activates the calcium and cyclic AMP signaling systems and stimulates insulin secretion.

  PloS one 20090101

• The mitochondrial ATP-sensitive potassium channel blocker 5-hydroxydecanoate inhibits toxicity of 6-hydroxydopamine on dopaminergic neurons.

  Neurotoxicity research 20090101

• Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy.

  BMC pregnancy and childbirth 20090101

• [Effect of adenosine triphosphate-dependent potassium channel activators on electrical reactions of intact and cultured endothelial cells].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20090101

• The role of ATP-sensitive potassium channel blockers in ischemia-reperfusion-induced renal injury versus their effects on cardiac ischemia reperfusion in rats.

  European review for medical and pharmacological sciences 20090101

• Impact of modulators of mitochondrial ATP-sensitive potassium channel (mitoK(ATP)) on hypoxic pulmonary vasoconstriction.

  Advances in experimental medicine and biology 20090101

• Acute ablation of PERK results in ER dysfunctions followed by reduced insulin secretion and cell proliferation.

  BMC cell biology 20090101

• Beneficial effect of the oxygen free radical scavenger amifostine (WR-2721) on spinal cord ischemia/reperfusion injury in rabbits.

  Journal of cardiothoracic surgery 20090101

• [Diagnostics and treatment of organic hyperinsulinism--experience in 105 cases].

  Casopis lekaru ceskych 20090101

• Neuroprotective effects of diazoxide and its antagonism by glibenclamide in pyramidal neurons of rat hippocampus subjected to ischemia-reperfusion-induced injury.

  The International journal of neuroscience 20090101

• Acute dystonic reactions in a lady presenting with repetitive involuntary muscle twitching: a case report.

  Cases journal 20090101

• Glucose metabolism, islet architecture, and genetic homogeneity in imprinting of [Ca2+](i) and insulin rhythms in mouse islets.

  PloS one 20090101

• Role of potassium channels in stretch-promoted atrial natriuretic factor secretion.

  Journal of the American Society of Hypertension : JASH 20090101

• Possible role of an ischemic preconditioning-like response mechanism in K(ATP) channel opener-mediated protection against streptozotocin-induced suppression of rat pancreatic islet function.

  Biochemical pharmacology 20081215

• Differential structure of atrial and ventricular KATP: atrial KATP channels require SUR1.

  Circulation research 20081205

• Weight loss in obese men by caloric restriction and high-dose diazoxide-mediated insulin suppression.

  Diabetes, obesity & metabolism 20081201

• Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel.

  Cardiovascular research 20081201

• Amplified hormonal counterregulatory responses to hypoglycemia in rats after systemic delivery of a SUR-1-selective K(+) channel opener?

  Diabetes 20081201

• Na+/H+ exchanger-1 inhibitors decrease myocardial superoxide production via direct mitochondrial action.

  Journal of applied physiology (Bethesda, Md. : 1985) 20081201

• A peptide of the phylloseptin family from the skin of the frog Hylomantis lemur (Phyllomedusinae) with potent in vitro and in vivo insulin-releasing activity.

  Peptides 20081201

• Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.

  Bioorganic & medicinal chemistry 20081201

• Minimizing hypoglycemia while maintaining glycemic control in diabetes.

  Diabetes 20081201

• American College of Endocrinology Pre-Diabetes Consensus Conference: part three.

  Diabetes care 20081201

• Long lasting synchronization of calcium oscillations by cholinergic stimulation in isolated pancreatic islets.

  Biophysical journal 20081115

• Preconditioning by an in situ administration of hydrogen peroxide: involvement of reactive oxygen species and mitochondrial ATP-dependent potassium channel in a cerebral ischemia-reperfusion model.

  Brain research 20081113

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel.

  Journal of medicinal chemistry 20081113

• The L-Type Ca+ and KATP channels may contribute to pacing-induced protection against anoxia-reoxygenation in the embryonic heart model.

  Journal of cardiovascular electrophysiology 20081101

• Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels.

  Molecular pharmacology 20081101

• Chronic sustained and intermittent hypoxia reduce function of ATP-sensitive potassium channels in nucleus of the solitary tract.

  American journal of physiology. Regulatory, integrative and comparative physiology 20081101

• Diazoxide enhances basal metabolic rate and fat oxidation in obese Zucker rats.

  Metabolism: clinical and experimental 20081101

• Involvement of mitoKATP channel in protective mechanisms of cerebral ischemic tolerance.

  Brain research 20081031

• Diazoxide-induced beta-cell rest reduces endoplasmic reticulum stress in lipotoxic beta-cells.

  The Journal of endocrinology 20081001

• Protein kinase C subtypes and retinal ischemic preconditioning.

  Experimental eye research 20081001

• Mary, Mary, quite contrary, how do your beta-cells fail?

  Diabetes 20081001

• Chronic antidiabetic sulfonylureas in vivo: reversible effects on mouse pancreatic beta-cells.

  PLoS medicine 20081001

• Why treatment fails in type 2 diabetes.

  PLoS medicine 20081001

• Calcium uptake in rat liver mitochondria accompanied by activation of ATP-dependent potassium channel.

  Biochemistry. Biokhimiia 20081001

• Use of a continuous glucose monitor in the management of inoperable metastatic insulinoma: a case report.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20081001

• Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels.

  Journal of immunology (Baltimore, Md. : 1950) 20080915

• Diazoxide increases liver and kidney HSP25 and HSP70 after shock and stroke.

  The Journal of surgical research 20080901

• Influence of sedentary versus physically active conditions on regulation of plasma renin activity and vasopressin.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080901

• Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers.

  Molecular pharmacology 20080901

• Stimulation of contractions in human myometrium by serotonin is unmasked by smooth muscle relaxants.

  Reproductive sciences (Thousand Oaks, Calif.) 20080901

• Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

  Diabetologia 20080901

• Bringing light to the dark side of insulin: a journey across the blood-brain barrier.

  Diabetes 20080901

• Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation.

  Journal of cellular and molecular medicine 20080901

• [Hyperinsulinemic hypoglycemia in adults. Case reports and a short review].

  Orvosi hetilap 20080831

• The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells.

  European journal of pharmacology 20080820

• Brief femoral artery ischaemia provides protection against myocardial ischaemia-reperfusion injury in rats: the possible mechanisms.

  Experimental physiology 20080801

• Protein kinase C-delta mediates neuronal apoptosis in the retinas of diabetic rats via the Akt signaling pathway.

  Diabetes 20080801

• Mouth breathing increases the pentylenetetrazole-induced seizure threshold in mice: a role for ATP-sensitive potassium channels.

  Epilepsy & behavior : E&B 20080801

• Protein kinase D is a key regulator of cardiomyocyte lipoprotein lipase secretion after diabetes.

  Circulation research 20080801

• Intramitochondrial signaling: interactions among mitoKATP, PKCepsilon, ROS, and MPT.

  American journal of physiology. Heart and circulatory physiology 20080801

• Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.

  The Journal of clinical investigation 20080801

• Glucose and glucose transporters regulate lymphatic pump activity through activation of the mitochondrial ATP-sensitive K+ channel.

  The journal of physiological sciences : JPS 20080801

• [Bax is involved in K ATP-mediated protection of the hippocampal neurons against hypoxic exposure].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080801

• Non-islet-cell tumor hypoglycemia and lactic acidosis in a child with congenital HIV and Burkitt's lymphoma.

  Journal of pediatric endocrinology & metabolism : JPEM 20080801

• Pharmacological prevention of peri-, and post-procedural myocardial injury in percutaneous coronary intervention.

  Current cardiology reviews 20080801

• Novel de novo mutation in sulfonylurea receptor 1 presenting as hyperinsulinism in infancy followed by overt diabetes in early adolescence.

  Diabetes 20080701

• Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta.

  Placenta 20080701

• Insulinoma in a third-trimester pregnant woman combined with pre-eclampsia: a case report and review of the diagnostic strategies.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20080701

• Continuous glucose monitoring in patients with insulinoma.

  Clinical endocrinology 20080601

• Dual effect of nitric oxide on ATP-sensitive K+ channels in rat pancreatic beta cells.

  Pflugers Archiv : European journal of physiology 20080601

• Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations.

  Diabetes 20080601

• Gene duplications resulting in over expression of glucokinase are not a common cause of hypoglycaemia of infancy in humans.

  Molecular genetics and metabolism 20080601

• Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels.

  Molecular and cellular biochemistry 20080601

• Effects of the selective EET antagonist, 14,15-EEZE, on cardioprotection produced by exogenous or endogenous EETs in the canine heart.

  American journal of physiology. Heart and circulatory physiology 20080601

• Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

  Bioorganic & medicinal chemistry 20080601

• Is octreotide a risk factor in necrotizing enterocolitis?

  Journal of pediatric surgery 20080601

• Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?

  Current neuropharmacology 20080601

• Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia.

  Journal of the neurological sciences 20080515

• Redox properties of the adenoside triphosphate-sensitive K+ channel in brain mitochondria.

  Journal of neuroscience research 20080515

• New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (+/-)-cromakalim as tissue-selective pancreatic beta-cell K(ATP) channel openers.

  Bioorganic & medicinal chemistry 20080515

• KATP channel openers facilitate glutamate uptake by GluTs in rat primary cultured astrocytes.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080501

• Quebrachitol-induced gastroprotection against acute gastric lesions: role of prostaglandins, nitric oxide and K+ ATP channels.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080501

• Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes.

  Pflugers Archiv : European journal of physiology 20080501

• Non-insulinoma persistent hyperinsulinaemic hypoglycaemia caused by an activating glucokinase mutation: hypoglycaemia unawareness and attacks.

  Clinical endocrinology 20080501

• Ovarian steroids stimulate adenosine triphosphate-sensitive potassium (KATP) channel subunit gene expression and confer responsiveness of the gonadotropin-releasing hormone pulse generator to KATP channel modulation.

  Endocrinology 20080501

• Effect of diazoxide on flavoprotein oxidation and reactive oxygen species generation during ischemia-reperfusion: a study on Langendorff-perfused rat hearts using optic fibers.

  American journal of physiology. Heart and circulatory physiology 20080501

• A Kir6.2 mutation causing severe functional effects in vitro produces neonatal diabetes without the expected neurological complications.

  Diabetologia 20080501

• KATP channel openers have opposite effects on mitochondrial respiration under different energetic conditions.

  Journal of cardiovascular pharmacology 20080501

• Effect of pressure overload on cardioprotection of mitochondrial KATP channels and GSK-3beta: interaction with the MPT pore.

  American journal of hypertension 20080501

• [18F-fluoro-L-DOPA PET-CT imaging combined with genetic analysis for optimal classification and treatment in a child with severe congenital hyperinsulinism].

  Anales de pediatria (Barcelona, Spain : 2003) 20080501

• Life-threatening hyperkalemia following partial pancreatectomy for neonatal hyperinsulinism.

  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20080501

• Pulmonary hypertension, heart failure and neutropenia due to diazoxide therapy.

  Advances in therapy 20080501

• All-trans retinoic acid prevents angiotensin II- and mechanical stretch-induced reactive oxygen species generation and cardiomyocyte apoptosis.

  Journal of cellular physiology 20080401

• The paradigm of postconditioning to protect the heart.

  Journal of cellular and molecular medicine 20080401

• Involvement of amlodipine, diazoxide, and glibenclamide in development of morphine tolerance in mice.

  The International journal of neuroscience 20080401

• Correlates between hyperinsulinism and hyperandrogenemia?

  Fertility and sterility 20080401

• Differential increase of mitochondrial matrix volume by sevoflurane in isolated cardiac mitochondria.

  Anesthesia and analgesia 20080401

• 20(S)-ginsenoside Rg3 enhances glucose-stimulated insulin secretion and activates AMPK.

  Biological & pharmaceutical bulletin 20080401

• Amelioration of oxidative mitochondrial DNA damage and deletion after renal ischemic injury by the KATP channel opener diazoxide.

  American journal of physiology. Renal physiology 20080301

• [Protective effect of ischemia and diazoxide preconditioning on postischemic reperfused myocardium and possible mechanism thereof].

  Zhonghua yi xue za zhi 20080226

• [Effects of diazoxide on Fas/FasL protein expressions in rat myocardium suffered from long-term hypothermic preservation].

  Sheng li xue bao : [Acta physiologica Sinica] 20080225

• Mitochondrial ATP-sensitive K+ channels regulate NMDAR activity in the cortex of the anoxic western painted turtle.

  The Journal of physiology 20080215

• Delayed pharmacological pre-conditioning effect of mitochondrial ATP-sensitive potassium channel opener on neurologic injury in a rabbit model of spinal cord ischemia.

  Acta anaesthesiologica Scandinavica 20080201

• Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.

  British journal of pharmacology 20080201

• Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue.

  Biological chemistry 20080201

• Enhanced activation of phospholipase C and insulin secretion from islets incubated in fatty acid-free bovine serum albumin.

  Metabolism: clinical and experimental 20080201

• Sildenafil inhibits duodenal contractility via activation of the NO-K+ channel pathway.

  Fundamental & clinical pharmacology 20080201

• The spontaneous mechanical activity of the circular smooth muscle of the rabbit colon in vitro.

  Pharmacological research 20080201

• Association of malignant insulinoma and type 2 diabetes mellitus: a case report.

  Annales d'endocrinologie 20080201

• KATP channel openers: tissue selectivity of original 3-alkylaminopyrido- and 3-alkylaminobenzothiadiazine 1,1-dioxides.

  Biochemical pharmacology 20080115

• Glucose induces synchronous mitochondrial calcium oscillations in intact pancreatic islets.

  Cell calcium 20080101

• Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats.

  Neuromuscular disorders : NMD 20080101

• Acute diabetes moderates trafficking of cardiac lipoprotein lipase through p38 mitogen-activated protein kinase-dependent actin cytoskeleton organization.

  Diabetes 20080101

• Importance of timing of magnesium administration in the isolated ischemic-reperfused rat heart: role of K(ATP) channels.

  Physiological research 20080101

• Diazoxide prevents abdominal adiposity and fatty liver in obese OLETF rats at prediabetic stage.

  Journal of diabetes and its complications 20080101

• [Physiological properties and possible correction of adenosine triphosphate-sensitive potassium channel function].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20080101

• Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms.

  PloS one 20080101

• Long-term non-surgical therapy of severe persistent congenital hyperinsulinism with glucagon.

  Hormone research 20080101

• Pituitary hypoplasia and growth hormone deficiency in a woman with glycogen storage disease type Ia: a case report.

  Journal of medical case reports 20080101

• A pharmacological analysis of the possible role of vasoactive mediators in compensatory coronary blood flow.

  Experimental and clinical cardiology 20080101

• Membrane potential controls adipogenic and osteogenic differentiation of mesenchymal stem cells.

  PloS one 20080101

• Preoperative detection of insulinomas: two case reports.

  Cases journal 20080101

• Mutations in UCP2 in congenital hyperinsulinism reveal a role for regulation of insulin secretion.

  PloS one 20080101

• [Diazoxide-induced mitochondrial swelling in the rat myometrium as a consequence of the activation of the mitochondrial ATP-sensitive (K+)-channel].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20080101

• Amyloid deposition in transplanted human pancreatic islets: a conceivable cause of their long-term failure.

  Experimental diabetes research 20080101

• Episodic confusional state: Due to insulinoma.

  Indian journal of psychiatry 20080101

• Hirsutism: clinico-investigative profile of 50 Indian patients.

  Indian journal of dermatology 20080101

• Is beta-cell failure in type 2 diabetes mellitus reversible?

  International journal of diabetes in developing countries 20080101

• Compound K enhances insulin secretion with beneficial metabolic effects in db/db mice.

  Journal of agricultural and food chemistry 20071226

• epsilonPKC phosphorylates the mitochondrial K(+) (ATP) channel during induction of ischemic preconditioning in the rat hippocampus.

  Brain research 20071212

• Voltage-gated Ca(2+) influx and insulin secretion in human and mouse beta-cells are impaired by the mitochondrial Na(+)/Ca(2+) exchange inhibitor CGP-37157.

  European journal of pharmacology 20071208

• Connexin 43 in ischemic pre- and postconditioning.

  Heart failure reviews 20071201

• Nutrient control of insulin secretion in perifused adult pig islets.

  Diabetes & metabolism 20071201

• Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

  Diabetic medicine : a journal of the British Diabetic Association 20071201

• Modulation of acute visceral nociception and bladder inflammation by plant triterpene, alpha, beta-amyrin in a mouse model of cystitis: role of tachykinin NK(1)-receptors, and K(+)(ATP) channels.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20071201

• Involvement of glucose and ATP-sensitive potassium (K+) channels on morphine-induced conditioned place preference.

  European journal of pharmacology 20071114

• Potassium channel openers accelerate epidermal barrier recovery.

  The British journal of dermatology 20071101

• Gliclazide inhibits proliferation but stimulates differentiation of white and brown adipocytes.

  Journal of biochemistry 20071101

• From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation.

  European journal of pediatrics 20071001

• Role of insulin in the hyperandrogenemia of lean women with polycystic ovary syndrome and normal insulin sensitivity.

  Fertility and sterility 20071001

• Resveratrol-induced inhibition of insulin secretion from rat pancreatic islets: evidence for pivotal role of metabolic disturbances.

  American journal of physiology. Endocrinology and metabolism 20071001

• 5-Hydroxydecanoate inhibits proliferation of hypoxic human pulmonary artery smooth muscle cells by blocking mitochondrial K(ATP) channels.

  Acta pharmacologica Sinica 20071001

• Cardioplegia and diazoxide modulate STAT3 activation and DNA binding.

  The Annals of thoracic surgery 20071001

• Effective pharmacotherapy against oxidative injury: alternative utility of an ATP-sensitive potassium channel opener.

  Journal of cardiovascular pharmacology 20071001

• Ischemic preconditioning: protection against myocardial necrosis and apoptosis.

  Vascular health and risk management 20071001

• A review of pioglitazone HCL and glimepiride in the treatment of type 2 diabetes.

  Vascular health and risk management 20071001

• Gonadotropin-releasing hormone neurons express K(ATP) channels that are regulated by estrogen and responsive to glucose and metabolic inhibition.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20070919

• Systemic administration of diazoxide induces delayed preconditioning against transient focal cerebral ischemia in rats.

  Brain research 20070907

• The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

  FEBS letters 20070904

• In vitro evidences for glucosensing capacity and mechanisms in hypothalamus, hindbrain, and Brockmann bodies of rainbow trout.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070901

• Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescue.

  Diabetes 20070901

• Tissue-dependent loss of phosphofructokinase-M in mice with interrupted activity of the distal promoter: impairment in insulin secretion.

  American journal of physiology. Endocrinology and metabolism 20070901

• Effects of washout following indomethacin administration on electrical field stimulation-induced isolated rat gastric fundus strip contractions.

  Journal of gastroenterology and hepatology 20070901

• Maintenance of myocyte volume homeostasis during stress by diazoxide is cardioprotective.

  The Annals of thoracic surgery 20070901

• Invited commentary.

  The Annals of thoracic surgery 20070901

• Diazoxide is protective in the rat retina against ischemic injury induced by bilateral carotid occlusion and glutamate-induced degeneration.

  Neurotoxicity research 20070901

• Adenosine and TNF-alpha exert similar inotropic effect on heart cultures, suggesting a cardioprotective mechanism against hypoxia.

  Life sciences 20070816

• The actions of a novel potent islet beta-cell specific ATP-sensitive K+ channel opener can be modulated by syntaxin-1A acting on sulfonylurea receptor 1.

  Diabetes 20070801

• Activation of alpha1B-adrenoceptors alleviates ischemia/reperfusion injury by limitation of mitochondrial Ca2+ overload in cardiomyocytes.

  Cardiovascular research 20070801

• Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore.

  Cardiovascular research 20070801

• Iptakalim, a vascular ATP-sensitive potassium (KATP) channel opener, closes rat pancreatic beta-cell KATP channels and increases insulin release.

  The Journal of pharmacology and experimental therapeutics 20070801

• Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif.

  Diabetologia 20070801

• A novel mutation associated with congenital hyperinsulinism.

  American journal of perinatology 20070801

• A randomised comparison of hydralazine and mini-bolus diazoxide for hypertensive emergencies in pregnancy: the PIVOT trial.

  The Australian & New Zealand journal of obstetrics & gynaecology 20070801

• The role of mitochondria in protection of the heart by preconditioning.

  Biochimica et biophysica acta 20070801

• Development of pulmonary hypertension in an infant treated with diazoxide.

  Journal of pediatric endocrinology & metabolism : JPEM 20070801

• [Protection mechanisms of ATP-sensitive K channels on hippocampal CA1 neurons during chronic severe hypoxia].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070801

• NO mobilizes intracellular Zn2+ via cGMP/PKG signaling pathway and prevents mitochondrial oxidant damage in cardiomyocytes.

  Cardiovascular research 20070715

• Lack of effect of short-term diazoxide administration on luteinizing hormone secretion in women with polycystic ovary syndrome.

  Fertility and sterility 20070701

• ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damage.

  Journal of cellular physiology 20070701

• Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701

• Mitochondrial Ca2+-activated K+ channels more efficiently reduce mitochondrial Ca2+ overload in rat ventricular myocytes.

  American journal of physiology. Heart and circulatory physiology 20070701

• Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling.

  Cardiovascular research 20070701

• No effect of inhibition of insulin secretion by diazoxide on weight loss in hyperinsulinaemic obese subjects during an 8-week weight-loss diet.

  Diabetes, obesity & metabolism 20070701

• ATP-sensitive potassium channel in mitochondria of the eukaryotic microorganism Acanthamoeba castellanii.

  The Journal of biological chemistry 20070615

• Metabolic and ionic coupling factors in amino acid-stimulated insulin release in pancreatic beta-HC9 cells.

  American journal of physiology. Endocrinology and metabolism 20070601

• Regulation of KATP channel subunit gene expression by hyperglycemia in the mediobasal hypothalamus of female rats.

  American journal of physiology. Endocrinology and metabolism 20070601

• A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.

  PLoS biology 20070601

• Expression and function of ATP-dependent potassium channels in late post-infarction remodeling.

  Journal of molecular and cellular cardiology 20070601

• Metastatic insulinoma in an adult patient with underlying nesidioblastosis.

  Journal of endocrinological investigation 20070601

• Changes in rat myocardium associated with modulation of ischemic tolerance by diazoxide.

  General physiology and biophysics 20070601

• Glucose and hippocampal neuronal excitability: role of ATP-sensitive potassium channels.

  Journal of neuroscience research 20070515

• ATP-sensitive potassium currents reduce the PGE2-mediated enhancement of excitability in adult rat sensory neurons.

  Brain research 20070511

• Effects of propofol on intracellular Ca2+ homeostasis in human astrocytoma cells.

  Brain research 20070511

• Virtual screening for novel openers of pancreatic K(ATP) channels.

  Journal of medicinal chemistry 20070503

• Oleic acid glucose-independently stimulates glucagon secretion by increasing cytoplasmic Ca2+ via endoplasmic reticulum Ca2+ release and Ca2+ influx in the rat islet alpha-cells.

  Endocrinology 20070501

• The role of adenosine triphosphate-regulated potassium channels in propofol-induced beneficial effect on contractile function of hypercholesterolemic isolated rabbit hearts.

  Saudi medical journal 20070501

• [Effect of opening of mitochondrial ATP-sensitive K(+) channels on the expression of hypoxia inducible factor-1alpha and cell proliferation in pulmonary arterial smooth muscle cells of rats].

  Sheng li xue bao : [Acta physiologica Sinica] 20070425

• Effects of diazoxide on gene expression in rat pancreatic islets are largely linked to elevated glucose and potentially serve to enhance beta-cell sensitivity.

  Diabetes 20070401

• ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.

  Diabetes 20070401

• Mitochondrial ATP-sensitive K+ channels are redox-sensitive pathways that control reactive oxygen species production.

  Free radical biology & medicine 20070401

• beta-cell failure in diabetes and preservation by clinical treatment.

  Endocrine reviews 20070401

• R-type Ca(2+)-channel-evoked CICR regulates glucose-induced somatostatin secretion.

  Nature cell biology 20070401

• Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene.

  PLoS medicine 20070401

• Drug-induced pulmonary hypertension in newborns: a review.

  Current vascular pharmacology 20070401

• Extemporaneous compounding in a sample of New Zealand hospitals: a retrospective survey.

  The New Zealand medical journal 20070323

• Pharmacologically preconditioned skeletal myoblasts are resistant to oxidative stress and promote angiomyogenesis via release of paracrine factors in the infarcted heart.

  Circulation research 20070302

• Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.

  Molecular endocrinology (Baltimore, Md.) 20070301

• Age- and gender-related differences in mitochondrial oxygen consumption and calcium with cardioplegia and diazoxide.

  The Annals of thoracic surgery 20070301

• Invited commentary.

  The Annals of thoracic surgery 20070301

• Diazoxide, as a postconditioning and delayed preconditioning trigger, increases HSP25 and HSP70 in the central nervous system following combined cerebral stroke and hemorrhagic shock.

  Journal of neurotrauma 20070301

• Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes.

  Sheng li xue bao : [Acta physiologica Sinica] 20070225

• Pharmacological and molecular characterization of ATP-sensitive K(+) conductances in CART and NPY/AgRP expressing neurons of the hypothalamic arcuate nucleus.

  Neuroscience 20070209

• The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070201

• Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance.

  American journal of physiology. Regulatory, integrative and comparative physiology 20070201

• Preconditioning protects endothelium by preventing ET-1-induced activation of NADPH oxidase and xanthine oxidase in post-ischemic heart.

  Journal of molecular and cellular cardiology 20070201

• Electrophysiological and pharmacological characterization of the K(ATP) channel involved in the K+-current responses to FSH and adenosine in the follicular cells of Xenopus oocyte.

  The journal of physiological sciences : JPS 20070201

• Twelve weeks' treatment with diazoxide without insulin supplementation in Type 2 diabetes is feasible but does not improve insulin secretion.

  Diabetic medicine : a journal of the British Diabetic Association 20070201

• The possible mechanisms by which phanoside stimulates insulin secretion from rat islets.

  The Journal of endocrinology 20070201

• Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: a dual effect of the drug.

  American journal of physiology. Heart and circulatory physiology 20070201

• Role of NO/cGMP/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20070201

• [Effect of activation of mitochondrial ATP sensitive potassium channel and calcium activated potassium channel on the permeability transition of mitochondria from both normal and ischemic rat brain].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201

• Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes.

  Life sciences 20070102

• Nicorandil opens mitochondrial K(ATP) channels not only directly but also through a NO-PKG-dependent pathway.

  Basic research in cardiology 20070101

• Distinct KATP channels mediate the antihypertrophic effects of adenosine receptor activation in neonatal rat ventricular myocytes.

  The Journal of pharmacology and experimental therapeutics 20070101

• Diazoxide prevents diabetes through inhibiting pancreatic beta-cells from apoptosis via Bcl-2/Bax rate and p38-beta mitogen-activated protein kinase.

  Endocrinology 20070101

• Antagonism of the insulinotropic action of first generation imidazolines by openers of K(ATP) channels.

  Biochemical pharmacology 20070101

• Diazoxide-induced respiratory inhibition - a putative mitochondrial K(ATP) channel independent mechanism of pharmacological preconditioning.

  Molecular and cellular biochemistry 20070101

• Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells.

  The Journal of endocrinology 20070101

• Severe paraneoplastic hypoglycemia in a patient with a gastrointestinal stromal tumor with an exon 9 mutation: a case report.

  BMC cancer 20070101

• Involvement of alpha-receptors and potassium channels in the mechanism of action of sildenafil citrate.

  International journal of impotence research 20070101

• Effect of diazoxide and Ca2+ on rat heart mitochondria loaded with Na+.

  Doklady. Biochemistry and biophysics 20070101

• Involvement of SH-groups during interaction of diazoxide with the inner membrane of rat heart mitochondria.

  Doklady. Biochemistry and biophysics 20070101

• Rapid intraoperative insulin assay: a novel method to differentiate insulinoma from nesidioblastosis in the pediatric patient.

  Annals of surgical innovation and research 20070101

• NFU-Enabled FASTA: moving bioinformatics applications onto wide area networks.

  Source code for biology and medicine 20070101

• Serofendic acid, a substance extracted from fetal calf serum, as a novel drug for cardioprotection.

  Cardiovascular drug reviews 20070101

• Pitfalls in diagnosing a small cystic insulinoma: a case report.

  Journal of medical case reports 20070101

• Pharmacological preconditioning with diazoxide slows energy metabolism during sustained ischemia.

  Experimental and clinical cardiology 20070101

• New benzopyran-based openers of the mitochondrial ATP-sensitive potassium channel with potent anti-ischemic properties.

  Journal of medicinal chemistry 20061228

• Glucose and insulin synergistically activate phosphatidylinositol 3-kinase to trigger oscillations of phosphatidylinositol 3,4,5-trisphosphate in beta-cells.

  The Journal of biological chemistry 20061222

• Influence of ATP-dependent K+ channels on nicotine-induced inhibition of withdrawal in morphine-dependent mice.

  European journal of pharmacology 20061215

• Diazoxide acts more as a PKC-epsilon activator, and indirectly activates the mitochondrial K(ATP) channel conferring cardioprotection against hypoxic injury.

  British journal of pharmacology 20061201

• The atypical antipsychotic clozapine impairs insulin secretion by inhibiting glucose metabolism and distal steps in rat pancreatic islets.

  Diabetologia 20061201

• Nutrient control of insulin secretion in isolated normal human islets.

  Diabetes 20061201

• Contribution of calcium influx in mediating glucose-stimulated oxygen consumption in pancreatic islets.

  Diabetes 20061201

• Ischemic preconditioning prevents endothelial dysfunction, P-selectin expression, and neutrophil adhesion by preventing endothelin and O2- generation in the post-ischemic guinea-pig heart.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061201

• Mosaic Turner syndrome and hyperinsulinaemic hypoglycaemia.

  Journal of pediatric endocrinology & metabolism : JPEM 20061201

• Hypoglycemia in the neonate.

  Pediatric endocrinology reviews : PER 20061201

• Diabetes and hypoglycaemia in young children and mutations in the Kir6.2 subunit of the potassium channel: therapeutic consequences.

  Diabetes & metabolism 20061201

• Stimulus-secretion coupling of hypotonicity-induced insulin release in BRIN-BD11 cells.

  Endocrine 20061201

• K+ channels involved in contractility of rabbit small intestine.

  Journal of physiology and biochemistry 20061201

• Influence of ATP-sensitive potassium channels on lithium state-dependent memory of passive avoidance in mice.

  European journal of pharmacology 20061121

• Iptakalim protects PC12 cell against H2O2-induced oxidative injury via opening mitochondrial ATP-sensitive potassium channel.

  Biochemical and biophysical research communications 20061117

• Opening mitoKATP increases superoxide generation from complex I of the electron transport chain.

  American journal of physiology. Heart and circulatory physiology 20061101

• Mechanism of reactive oxygen species generation after opening of mitochondrial KATP channels.

  American journal of physiology. Heart and circulatory physiology 20061101

• Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation.

  Cardiovascular research 20061101

• FCCP is cardioprotective at concentrations that cause mitochondrial oxidation without detectable depolarisation.

  Cardiovascular research 20061101

• Actions of ZD0947, a novel ATP-sensitive K+ channel opener, on membrane currents in human detrusor myocytes.

  British journal of pharmacology 20061101

• Clinical features and morphological characterization of 10 patients with noninsulinoma pancreatogenous hypoglycaemia syndrome (NIPHS).

  Clinical endocrinology 20061101

• Prolonged hyperinsulinaemic hypoglycaemia in newborns with intrauterine growth retardation.

  Archives of disease in childhood. Fetal and neonatal edition 20061101

• European Academy of Paediatrics, Barcelona, Spain, October 7-10, 2006. Abstracts.

  European journal of pediatrics 20061101

• [The effect of mitochondrial membrane potential on changes of reactive oxygen species and on proliferation of hypoxic human pulmonary arterial smooth muscle cells].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20061101

• Diazoxide-induced cardioprotection via DeltaPsim loss depending on timing of application.

  Life sciences 20061012

• LPS from Escherichia coli protects against indomethacin-induced gastropathy in rats--role of ATP-sensitive potassium channels.

  European journal of pharmacology 20061010

• First molecular evidence that inositol trisphosphate signaling contributes to infarct size reduction with preconditioning.

  American journal of physiology. Heart and circulatory physiology 20061001

• Iptakalim modulates ATP-sensitive K(+) channels in dopamine neurons from rat substantia nigra pars compacta.

  The Journal of pharmacology and experimental therapeutics 20061001

• C16:0 sulfatide inhibits insulin secretion in rat beta-cells by reducing the sensitivity of KATP channels to ATP inhibition.

  Diabetes 20061001

• Hyperlipidemic mice present enhanced catabolism and higher mitochondrial ATP-sensitive K+ channel activity.

  Gastroenterology 20061001

• Pancreatic islets from hypothalamic obese rats maintain K+ATP channel-dependent but not -independent pathways on glucose-induced insulin release process.

  Endocrine 20061001

• Proteomic analysis of pharmacological preconditioning: novel protein targets converge to mitochondrial metabolism pathways.

  Circulation research 20060929

• Diazoxide protects against methylmalonate-induced neuronal toxicity.

  Experimental neurology 20060901

• Diazoxide preconditioning alleviates apoptosis of hippocampal neurons induced by anoxia-reoxygenation in vitro through up-regulation of Bcl-2/Bax protein ratio.

  Sheng li xue bao : [Acta physiologica Sinica] 20060825

• K+-independent actions of diazoxide question the role of inner membrane KATP channels in mitochondrial cytoprotective signaling.

  The Journal of biological chemistry 20060818

• The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography.

  The Journal of clinical endocrinology and metabolism 20060801

• K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability.

  Journal of cell science 20060801

• Total cellular calcium and magnesium content of cultured human peripheral blood mononuclear cells following exposure to antidiabetic drugs.

  Acta diabetologica 20060801

• Paradoxical stimulation of glucagon secretion by high glucose concentrations.

  Diabetes 20060801

• First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx.

  Journal of pharmacological sciences 20060801

• Hypertrichosis lanuginosa acquisita associated with autoimmune hepatitis.

  The Journal of dermatology 20060801

• Recurrent hyperinsulinemic hypoglycemia caused by an insulin-secreting insulinoma.

  Nature clinical practice. Endocrinology & metabolism 20060801

• [Role of gap junction in ischemic preconditioning].

  Zhonghua xin xue guan bing za zhi 20060801

• Hyperinsulinism in infancy--genetic aspects.

  Pediatric endocrinology reviews : PER 20060801

• The mechanism by which the mitochondrial ATP-sensitive K+ channel opening and H2O2 inhibit the mitochondrial permeability transition.

  The Journal of biological chemistry 20060728

• Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.

  Journal of medicinal chemistry 20060727

• It is AMPA receptor, not kainate receptor, that contributes to the NBQX-induced antinociception in the spinal cord of rats.

  Brain research 20060719

• Drugs for treatment of very high blood pressure during pregnancy.

  The Cochrane database of systematic reviews 20060719

• New 3-alkylamino-4H-thieno-1,2,4-thiadiazine 1,1-dioxide derivatives activate ATP-sensitive potassium channels of pancreatic beta cells.

  Journal of medicinal chemistry 20060713

• The neuroprotection conferred by activating the mitochondrial ATP-sensitive K+ channel is mediated by inhibiting the mitochondrial permeability transition pore.

  Neuroscience letters 20060710

• Translocation of connexin 43 to the inner mitochondrial membrane of cardiomyocytes through the heat shock protein 90-dependent TOM pathway and its importance for cardioprotection.

  Circulation research 20060707

• Regulation of plasma vasopressin and renin activity in conscious hindlimb-unloaded rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060701

• A novel approach to assess insulin sensitivity reveals no increased insulin sensitivity in mice with a dominant-negative mutant hepatocyte nuclear factor-1alpha.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060701

• Intravenous 6-hydroxydopamine attenuates vasopressin and oxytocin secretion stimulated by hemorrhage and hypotension but not hyperosmolality in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20060701

• No loss of cardioprotection by postconditioning in connexin 43-deficient mice.

  Basic research in cardiology 20060701

• Intracellular ATP-sensitive K+ channels in mouse pancreatic beta cells: against a role in organelle cation homeostasis.

  Diabetologia 20060701

• Age- and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide.

  The Annals of thoracic surgery 20060701

• ATP-sensitive potassium channels mediate the anti-ischemic properties of ischemic and pharmacologic preconditioning in rat random-pattern skin flap.

  Annals of plastic surgery 20060701

• [Effect of opening of mitochondrial ATP-sensitive K⁺ channel on the distribution of cytochrome C and on proliferation of human pulmonary arterial smooth muscle cells in hypoxia].

  Sheng li xue bao : [Acta physiologica Sinica] 20060625

• Selective inhibition of pinacidil effects by estrogen in guinea pig heart.

  International journal of cardiology 20060607

• Diazoxide preconditioning plus subsequent hypothermia increased resistance of rat cultured hippocampal neurons against hypoxia-reoxygenation injury.

  Chinese medical journal 20060605

• Levosimendan protects against experimental endotoxemic acute renal failure.

  American journal of physiology. Renal physiology 20060601

• Diphenylhydantoin suppresses glucose-induced insulin release by decreasing cytoplasmic H+ concentration in pancreatic islets.

  Endocrinology 20060601

• Cardiac protection by mitoKATP channels is dependent on Akt translocation from cytosol to mitochondria during late preconditioning.

  American journal of physiology. Heart and circulatory physiology 20060601

• EUS-guided alcohol ablation of an insulinoma.

  Gastrointestinal endoscopy 20060601

• The effect of pre- and posttreatment with diazoxide on the early phase of chronic cerebral hypoperfusion in the rat.

  Brain research 20060504

• Serofendic acid, a novel substance extracted from fetal calf serum, protects against oxidative stress in neonatal rat cardiac myocytes.

  Journal of the American College of Cardiology 20060502

• Nitric oxide-cGMP-protein kinase G signaling pathway induces anoxic preconditioning through activation of ATP-sensitive K+ channels in rat hearts.

  American journal of physiology. Heart and circulatory physiology 20060501

• Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro.

  American journal of physiology. Heart and circulatory physiology 20060501

• Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression.

  Neuroscience letters 20060501

• Combined modulation of the mitochondrial ATP-dependent potassium channel and the permeability transition pore causes prolongation of the biphasic calcium dynamics.

  Cell calcium 20060501

• MitoKATP channel activation suppresses gap junction permeability in the ischemic myocardium by an ERK-dependent mechanism.

  Cardiovascular research 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Antihypertensive drugs clonidine, diazoxide, hydralazine and furosemide regulate the production of cytokines by placentas and peripheral blood mononuclear cells in normal pregnancy.

  Journal of hypertension 20060501

• Noninvasive assessment of brain injury in a canine model of hypothermic circulatory arrest using magnetic resonance spectroscopy.

  The Annals of thoracic surgery 20060501

• Preservation of mitochondrial structure and function after cardioplegic arrest in the neonate using a selective mitochondrial KATP channel opener.

  The Annals of thoracic surgery 20060501

• A mysterious case of normalising blood sugar: insulinoma in a long-standing diabetic patient.

  Age and ageing 20060501

• Mitochondrial potassium ATP channels and retinal ischemic preconditioning.

  Investigative ophthalmology & visual science 20060501

• L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter.

  Diabetes 20060501

• The mitochondrial K-ATP channel opener, diazoxide, prevents ischemia-reperfusion injury in the rabbit spinal cord.

  The American journal of pathology 20060501

• Diazoxide provides maximal KATP channels independent protection if present throughout hypoxia.

  The Annals of thoracic surgery 20060401

• Invited commentary.

  The Annals of thoracic surgery 20060401

• Data and animal management software for large-scale phenotype screening.

  Mammalian genome : official journal of the International Mammalian Genome Society 20060401

• Ocimum sanctum leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic beta-cells.

  The Journal of endocrinology 20060401

• MitoK(ATP)-dependent changes in mitochondrial volume and in complex II activity during ischemic and pharmacological preconditioning of Langendorff-perfused rat heart.

  Journal of bioenergetics and biomembranes 20060401

• Different effects of optical isomers of the 5-HT1A receptor antagonist pyrapyridolol against postischemic guinea-pig myocardial dysfunction and apoptosis through the mitochondrial permeability transition pore.

  European journal of pharmacology 20060318

• Protein kinase G-induced activation of K(ATP) channels reduces contractility of human prostate tissue.

  The Prostate 20060301

• Changes in membrane cholesterol of pituitary tumor (GH3) cells regulate the activity of large-conductance Ca2+-activated K+ channels.

  The Chinese journal of physiology 20060227

• Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs.

  European journal of pharmacology 20060217

• The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.

  European journal of pharmacology 20060215

• The regulation of rotenone-induced inflammatory factor production by ATP-sensitive potassium channel expressed in BV-2 cells.

  Neuroscience letters 20060213

• Glucose-stimulated DNA synthesis through mammalian target of rapamycin (mTOR) is regulated by KATP channels: effects on cell cycle progression in rodent islets.

  The Journal of biological chemistry 20060210

• A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels.

  The Journal of biological chemistry 20060203

• Activation of mitochondrial ATP-sensitive potassium channels improves rotenone-related motor and neurochemical alterations in rats.

  The international journal of neuropsychopharmacology 20060201

• Mitochondrial dysfunction as the cause of the failure to precondition the diabetic human myocardium.

  Cardiovascular research 20060201

• Ischemic preconditioning requires increases in reactive oxygen release independent of mitochondrial K+ channel activity.

  Free radical biology & medicine 20060201

• Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism.

  The Journal of pediatrics 20060201

• P-1075 exerts diverse modulatory effects on mitochondrial ATP-sensitive K+ channels in rabbit ventricular myocytes.

  Journal of cardiovascular pharmacology 20060201

• A rare case of adult-onset nesidioblastosis treated successfully with diazoxide.

  Endocrine journal 20060201

• [The effects of diazoxide on myocardium function and the expressions of ERK and JNK in isolated spontaneous hypertension rat hearts].

  Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20060201

• KATP channels in mouse spermatogenic cells and sperm, and their role in capacitation.

  Developmental biology 20060115

• Acute and chronic effects of glucose and carbachol on insulin secretion and phospholipase C activation: studies with diazoxide and atropine.

  American journal of physiology. Endocrinology and metabolism 20060101

• Initiation of remote microvascular preconditioning requires K(ATP) channel activity.

  American journal of physiology. Heart and circulatory physiology 20060101

• Non-beating HL-1 cells for confocal microscopy: application to mitochondrial functions during cardiac preconditioning.

  Progress in biophysics and molecular biology 20060101

• The direct physiological effects of mitoK(ATP) opening on heart mitochondria.

  American journal of physiology. Heart and circulatory physiology 20060101

• Role of the sarcolemmal adenosine triphosphate-sensitive potassium channel in hyperkalemic cardioplegia-induced myocyte swelling and reduced contractility.

  The Annals of thoracic surgery 20060101

• Hyperkalemic cardioplegia-induced myocyte swelling and contractile dysfunction: prevention by diazoxide.

  The Annals of thoracic surgery 20060101

• Effect of phosphodiesterase 5 inhibitor on alteration in vascular smooth muscle sensitivity and renal function in rats with liver cirrhosis.

  American journal of physiology. Heart and circulatory physiology 20060101

• Effects of sulfonylureas on mitochondrial ATP-sensitive K+ channels in cardiac myocytes: implications for sulfonylurea controversy.

  Diabetes/metabolism research and reviews 20060101

• Possible role of potassium channel, big K in etiology of schizophrenia.

  Medical hypotheses 20060101

• Towards selective Kir6.2/SUR1 potassium channel openers, medicinal chemistry and therapeutic perspectives.

  Current medicinal chemistry 20060101

• Complete clinical remission and disappearance of liver metastases after treatment with somatostatin analogue in a 40-year-old woman with a malignant insulinoma positive for somatostatin receptors type 2.

  Hormone research 20060101

• Ischemic preconditioning: a novel target for neuroprotective therapy.

  Cerebrovascular diseases (Basel, Switzerland) 20060101

• [Pitfalls in the diagnosis of congenital hyperinsulinism: a case report and review of the literature].

  Klinische Padiatrie 20060101

• Comparative proteomics analysis of differentially expressed phosphoproteins in adult rat ventricular myocytes subjected to diazoxide preconditioning.

  Drug metabolism and drug interactions 20060101

• [The influence of the fluorine-containing activators of mitochondrial adenosine triphosphate sensitive potassium channels on the oxidative phosphorilation].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20060101

• Study of the mechanism of action of diazoxide on rat heart mitochondria under calcium loading.

  Doklady. Biochemistry and biophysics 20060101

• Cardioprotective effects of diazoxide on myocardial ischemia/reperfusion injury in rats.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20060101

• A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart.

  Biochemical and biophysical research communications 20051223

• Costello syndrome and hyperinsulinemic hypoglycemia.

  American journal of medical genetics. Part A 20051215

• [Diazoxide preconditioning combined with subsequent hypothermia alleviates anoxia-re-oxygenation injury: experiment with rat hippocampal neurons].

  Zhonghua yi xue za zhi 20051207

• Activation of KATP channels by H2S in rat insulin-secreting cells and the underlying mechanisms.

  The Journal of physiology 20051201

• Diazoxide attenuates insulin secretion and hepatic lipogenesis in zucker diabetic fatty rats.

  Medical science monitor : international medical journal of experimental and clinical research 20051201

• Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells.

  Endocrinology 20051101

• Late preconditioning with isoflurane in cultured rat cortical neurones.

  British journal of anaesthesia 20051101

• Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia.

  Diabetologia 20051101

• [Congenital hyperinsulinism in newborn and infant].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20051101

• Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats.

  Diabetes 20051101

• Synaptic activity becomes excitotoxic in neurons exposed to elevated levels of platelet-activating factor.

  The Journal of clinical investigation 20051101

• Persistent hyperinsulinaemic hypoglycaemia of infancy: 15 years' experience at the Royal Children's Hospital (RCH), Melbourne.

  Journal of pediatric endocrinology & metabolism : JPEM 20051101

• Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression.

  European journal of pharmacology 20051031

• Post-ischemic administration of diazoxide attenuates long-term microglial activation in the rat brain after permanent carotid artery occlusion.

  Neuroscience letters 20051028

• Antidiabetic activity and toxicity of Zizyphus spina-christi leaves.

  Journal of ethnopharmacology 20051003

• Lack of manifestations of diazoxide/5-hydroxydecanoate-sensitive KATP channel in rat brain nonsynaptosomal mitochondria.

  The Journal of physiology 20051001

• Transgenic overexpression of SUR1 in the heart suppresses sarcolemmal K(ATP).

  Journal of molecular and cellular cardiology 20051001

• Feedback activation of phospholipase C via intracellular mobilization and store-operated influx of Ca2+ in insulin-secreting beta-cells.

  Journal of cell science 20051001

• Sulphonylurea sensitivity and enriched expression implicate inward rectifier K+ channels in Drosophila melanogaster renal function.

  The Journal of experimental biology 20051001

• Multiple treatment approach to limit cardiac ischemia-reperfusion injury.

  The Annals of thoracic surgery 20051001

• Invited commentary.

  The Annals of thoracic surgery 20051001

• Serum glucagon counterregulatory hormonal response to hypoglycemia is blunted in congenital hyperinsulinism.

  Diabetes 20051001

• [Effects of iptakalim on intracellular calcium concentrations, PKA and PKC activities in rat tail artery smooth muscle cells].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051001

• Impairment of diazoxide-induced formation of reactive oxygen species and loss of cardioprotection in connexin 43 deficient mice.

  Circulation research 20050916

• Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility.

  Journal of cell science 20050915

• Effect of indomethacin on electrical field stimulation-induced contractions of isolated transverse and longitudinal rat gastric fundus strips.

  World journal of gastroenterology 20050914

• Different actions of cardioprotective agents on mitochondrial Ca2+ regulation in a Ca2+ paradox-induced Ca2+ overload.

  Circulation journal : official journal of the Japanese Circulation Society 20050901

• Gestational change of K+ channel opener effect is correlated with the expression of uterine KATP channel subunits.

  European journal of obstetrics, gynecology, and reproductive biology 20050901

• Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener.

  Circulation 20050830

• Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks.

  Circulation research 20050819

• Protein kinase G transmits the cardioprotective signal from cytosol to mitochondria.

  Circulation research 20050819

• Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues.

  Biochemical and biophysical research communications 20050805

• Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells.

  Molecular endocrinology (Baltimore, Md.) 20050801

• Integrated pharmacological preconditioning and memory of cardioprotection: role of protein kinase C and phosphatidylinositol 3-kinase.

  American journal of physiology. Heart and circulatory physiology 20050801

• Metamizol acts as an ATP sensitive potassium channel opener to inhibit the contracting response induced by angiotensin II but not to norepinephrine in rat thoracic aorta smooth muscle.

  Vascular pharmacology 20050801

• Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.

  Environmental health perspectives 20050801

• MitoKATP-channel opener protects against neuronal death in rat venous ischemia.

  Neurosurgery 20050801

• Effects of ATP-sensitive potassium channel activators diazoxide and BMS-191095 on membrane potential and reactive oxygen species production in isolated piglet mitochondria.

  Brain research bulletin 20050730

• 3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.

  Journal of medicinal chemistry 20050728

• Diazoxide preconditioning attenuates global cerebral ischemia-induced blood-brain barrier permeability.

  Brain research 20050727

• Malignant insulinoma: spectrum of unusual clinical features.

  Cancer 20050715

• Adenosine and ATP-sensitive potassium channels modulate dopamine release in the anoxic turtle (Trachemys scripta) striatum.

  American journal of physiology. Regulatory, integrative and comparative physiology 20050701

• Diazoxide preserves hypercapnia-induced arteriolar vasodilation after global cerebral ischemia in piglets.

  American journal of physiology. Heart and circulatory physiology 20050701

• K(ATP) channels and preconditioning: a re-examination of the role of mitochondrial K(ATP) channels and an overview of alternative mechanisms.

  Journal of molecular and cellular cardiology 20050701

• Mitochondrial K(ATP) channels in cell survival and death.

  Journal of molecular and cellular cardiology 20050701

• Cardioprotective effects of K ATP channel activation during hypoxia in goldfish Carassius auratus.

  The Journal of experimental biology 20050701

• Probing of specific binding of synthetic sulfonylurea with the insulinoma cell line MIN6.

  Journal of biochemistry 20050701

• [Protective effect of mitochondrial ATP-sensitive potassium channel opener on rat heart during hypothermic preservation].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20050701

• Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte homeostasis after mitochondrial respiratory chain injury.

  American journal of physiology. Heart and circulatory physiology 20050601

• Ketotic hypoglycaemia in children with diazoxide responsive hyperinsulinism of infancy.

  European journal of pediatrics 20050601

• SUR, ABC proteins targeted by KATP channel openers.

  Journal of molecular and cellular cardiology 20050601

• Mitochondria and ischemia/reperfusion injury.

  Annals of the New York Academy of Sciences 20050601

• Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.

  Journal of medicinal chemistry 20050519

• Reactive oxygen species mediate the neuroprotection conferred by a mitochondrial ATP-sensitive potassium channel opener during ischemia in the rat hippocampal slice.

  Brain research 20050503

• Prostacyclin attenuates oxidative damage of myocytes by opening mitochondrial ATP-sensitive K+ channels via the EP3 receptor.

  American journal of physiology. Heart and circulatory physiology 20050501

• Systematic administration of iptakalim, an ATP-sensitive potassium channel opener, prevents rotenone-induced motor and neurochemical alterations in rats.

  Journal of neuroscience research 20050501

• Diazoxide-mediated insulin suppression in obese men: a dose-response study.

  Diabetes, obesity & metabolism 20050501

• Effects of KATP channel modulation on myocardial glycogen content, lactate, and amino acids in nonischemic and ischemic rat hearts.

  Journal of cardiovascular pharmacology 20050501

• The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats.

  Kidney international 20050501

• 150-kD oxygen-regulated protein is an essential factor for insulin release.

  Pancreas 20050501

• Alterations in net glucose uptake and in the pancreatic B-cell GLUT2 transporter induced by diazoxide and by secretory stimuli.

  The Journal of endocrinology 20050501

• Hyperinsulinism of infancy associated with a novel splice site mutation in the SCHAD gene.

  The Journal of pediatrics 20050501

• Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050427

• Evidence that insulin secretion influences SNAP-25 through proteasomal activation.

  Biochemical and biophysical research communications 20050415

• mitoKATP channel activation in the postanoxic developing heart protects E-C coupling via NO-, ROS-, and PKC-dependent pathways.

  American journal of physiology. Heart and circulatory physiology 20050401

• Peptide blockers of PKG inhibit ROS generation by acetylcholine and bradykinin in cardiomyocytes but fail to block protection in the whole heart.

  American journal of physiology. Heart and circulatory physiology 20050401

• Are one or two dangerous? Sulfonylurea exposure in toddlers.

  The Journal of emergency medicine 20050401

• Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy.

  Clinical endocrinology 20050401

• Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles.

  The Journal of investigative dermatology 20050401

• Glucose triggers protein kinase A-dependent insulin secretion in mouse pancreatic islets through activation of the K+ATP channel-dependent pathway.

  European journal of endocrinology 20050401

• Pancreatic beta-cells expressing GLP-1 are resistant to the toxic effects of immunosuppressive drugs.

  Journal of molecular endocrinology 20050401

• Mitochondrial ATP-sensitive K+ channels prevent oxidative stress, permeability transition and cell death.

  Journal of bioenergetics and biomembranes 20050401

• Protective effects of sarpogrelate, a 5-HT2A antagonist, against postischemic myocardial dysfunction in guinea-pig hearts.

  Molecular and cellular biochemistry 20050401

• Remote preconditioning reduces ischemic injury in the explanted heart by a KATP channel-dependent mechanism.

  American journal of physiology. Heart and circulatory physiology 20050301

• Mitochondria-derived reactive oxygen species and vascular MAP kinases: comparison of angiotensin II and diazoxide.

  Hypertension (Dallas, Tex. : 1979) 20050301

• Loss of the decrement in intraislet insulin plausibly explains loss of the glucagon response to hypoglycemia in insulin-deficient diabetes: documentation of the intraislet insulin hypothesis in humans.

  Diabetes 20050301

• Differential effects of insulin and dietary amino acids on muscle protein synthesis in adult and old rats.

  The Journal of physiology 20050215

• Calcium-activated potassium channel triggers cardioprotection of ischemic preconditioning.

  The Journal of pharmacology and experimental therapeutics 20050201

• Genotype-phenotype correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes.

  The Journal of clinical endocrinology and metabolism 20050201

• Mitochondrial K(ATP) channels in respiratory neurons and their role in the hypoxic facilitation of rhythmic activity.

  Brain research 20050201

• Diagnostic difficulties in long-standing insulinoma with near-normal plasma insulin levels.

  Journal of endocrinological investigation 20050201

• 4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.

  Journal of medicinal chemistry 20050127

• Diazoxide and dimethyl sulphoxide alleviate experimental cerebral hypoperfusion-induced white matter injury in the rat brain.

  Neuroscience letters 20050120

• Mitochondrial Ca2+-activated K+ channels in cardiac myocytes: a mechanism of the cardioprotective effect and modulation by protein kinase A.

  Circulation 20050118

• Effect of mitochondrial KATP channel on voltage-gated K+ channel in 24 hour-hypoxic human pulmonary artery smooth muscle cells.

  Chinese medical journal 20050105

• Activation of ATP-sensitive potassium channels prevents the cleavage of cytosolic mu-calpain and abrogates the elevation of nuclear c-Fos and c-Jun expressions after hypoxic-ischemia in neonatal rat brain.

  Brain research. Molecular brain research 20050105

• Synthesis and pharmacological evaluation of 4H-1,4-benzothiazine-2-carbonitrile 1,1-dioxide and N-(2-cyanomethylsulfonylphenyl)acylamide derivatives as potential activators of ATP sensitive potassium channels.

  Bioorganic & medicinal chemistry 20050103

• Mechanism, temporal patterns, and magnitudes of the metabolic responses to the KATP channel agonist diazoxide.

  American journal of physiology. Endocrinology and metabolism 20050101

• Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide.

  Biochemical pharmacology 20050101

• Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature.

  BMC physiology 20050101

• Contemporary strategies in the diagnosis and management of neonatal hyperinsulinaemic hypoglycaemia.

  Early human development 20050101

• Hyperinsulinism in tyrosinaemia type I.

  Journal of inherited metabolic disease 20050101

• Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R-injured rat cremaster muscles.

  Journal of biomedical science 20050101

• Fatality after deliberate ingestion of the pesticide rotenone: a case report.

  Critical care (London, England) 20050101

• Severe hyperinsulinaemic hypoglycaemia in a baby born to a mother taking oral ritodrine therapy for preterm labour.

  Hormone research 20050101

• Effect of the degree of ischaemic injury and reoxygenation time on the type of myocardial cell death in man: role of caspases.

  BMC physiology 20050101

• Effects of diazoxide treatments on electrophysiologyic properties in guinea pig papillary muscles undergoing ischemia/reperfusion.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• ATP-sensitive potassium channel (KATP channel) expression in the normal canine pancreas and in canine insulinomas.

  BMC veterinary research 20050101

• Neuroprotective effect of KR-31378, a novel potassium channel activator, on spinal cord ischemic injury in rabbits.

  Journal of investigative surgery : the official journal of the Academy of Surgical Research 20050101

• Bench-to-bedside review: Antidotal treatment of sulfonylurea-induced hypoglycaemia with octreotide.

  Critical care (London, England) 20050101

• Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20050101

• Differing effects of cyclosporin a on swelling amplitude and time constant of mitochondria from normal and ischemic rat brain.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20050101

• Mitochondrial permeability transition dynamics: an indicator of mitochondrial potassium channel opener.

  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 20050101

• Ischemic preconditioning and diazoxide limit mitochondrial Ca overload during ischemia/reperfusion: Role of reactive oxygen species.

  Experimental and clinical cardiology 20050101

• 2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 K(ATP) channels.

  Bioorganic & medicinal chemistry letters 20041206

• Short-term intermittent exposure to diazoxide improves functional performance of beta-cells in a high-glucose environment.

  American journal of physiology. Endocrinology and metabolism 20041201

• Modulation of adipoinsular axis in prediabetic zucker diabetic fatty rats by diazoxide.

  Endocrinology 20041201

• Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators.

  Diabetes 20041201

• Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets.

  Diabetes 20041201

• P2Y purinergic potentiation of glucose-induced insulin secretion and pancreatic beta-cell metabolism.

  Diabetes 20041201

• Massive augmentation of stimulated insulin secretion induced by fatty acid-free BSA in rat pancreatic islets.

  Diabetes 20041201

• Myocardial impairment in chronic hypoxia is abolished by short aeration episodes: involvement of K+ATP channels.

  Experimental biology and medicine (Maywood, N.J.) 20041201

• Bimodal role of conventional protein kinase C in insulin secretion from rat pancreatic beta cells.

  The Journal of physiology 20041115

• Testosterone induces cytoprotection by activating ATP-sensitive K+ channels in the cardiac mitochondrial inner membrane.

  Circulation 20041109

• Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB.

  The Journal of biological chemistry 20041105

• Quinolizidine alkaloids isolated from Lupinus species enhance insulin secretion.

  European journal of pharmacology 20041103

• Opening of Ca2+-activated K+ channels triggers early and delayed preconditioning against I/R injury independent of NOS in mice.

  American journal of physiology. Heart and circulatory physiology 20041101

• Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration.

  American journal of physiology. Heart and circulatory physiology 20041101

• PKC-epsilon is upstream and PKC-alpha is downstream of mitoKATP channels in the signal transduction pathway of ischemic preconditioning of human myocardium.

  American journal of physiology. Cell physiology 20041101

• Fluctuations in mitochondrial membrane potential in single isolated brain mitochondria: modulation by adenine nucleotides and Ca2+.

  Biophysical journal 20041101

• Effect of diazoxide on regulation of vesicular and plasma membrane GABA transporter genes and proteins in hippocampus of rats subjected to picrotoxin-induced kindling.

  Neuroscience research 20041101

• A new ATP-sensitive K+ channel-independent mechanism is involved in glucose-excited neurons of mouse arcuate nucleus.

  Diabetes 20041101

• Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.

  Diabetes 20041101

• Palmitoyl lysophosphatidylcholine mediated mobilization of LPL to the coronary luminal surface requires PKC activation.

  Journal of molecular and cellular cardiology 20041101

• Inhibition of phenylephrine induced hypertrophy in rat neonatal cardiomyocytes by the mitochondrial KATP channel opener diazoxide.

  Journal of molecular and cellular cardiology 20041101

• Selective arterial calcium stimulation and hepatic venous sampling in the evaluation of hyperinsulinemic hypoglycemia: potential and limitations.

  Journal of vascular and interventional radiology : JVIR 20041101

• [Hyperinsulinism-hyperammonemia syndrome due to a de novo mutation in exon 7 (G979A) of the glutamate dehydrogenase gene with excellent response to diazoxide].

  Anales de pediatria (Barcelona, Spain : 2003) 20041101

• Medications used in the treatment of hypoglycemia due to congenital hyperinsulinism of infancy (HI).

  Pediatric endocrinology reviews : PER 20041101

• [The protective effect of diazoxide on long-term heart preservation].

  Sheng li xue bao : [Acta physiologica Sinica] 20041025

• KATP channel activation induces ischemic preconditioning of the endothelium in humans in vivo.

  Circulation 20041012

• Rebaudioside A potently stimulates insulin secretion from isolated mouse islets: studies on the dose-, glucose-, and calcium-dependency.

  Metabolism: clinical and experimental 20041001

• Activation of the ATP-dependent potassium channel attenuates norepinephrine-induced vasoconstriction in the human forearm.

  Shock (Augusta, Ga.) 20041001

• Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity.

  Environmental health perspectives 20041001

• Insulin secretion is stimulated by ethanol extract of Anemarrhena asphodeloides in isolated islet of healthy Wistar and diabetic Goto-Kakizaki Rats.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20041001

• Persistent hyperinsulinemic hypoglycemia presenting with a rare complication: West syndrome.

  Journal of pediatric endocrinology & metabolism : JPEM 20041001

• Does the mitochondrial permeability transition have a role in preconditioning?

  Circulation 20040914

• Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs.

  Brain research 20040903

• Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning.

  American journal of physiology. Heart and circulatory physiology 20040901

• Potassium-specific effects of levosimendan on heart mitochondria.

  Biochemical pharmacology 20040901

• Zinc inhibits glutamate release via activation of pre-synaptic K channels and reduces ischaemic damage in rat hippocampus.

  Journal of neurochemistry 20040901

• Temporary preservation of beta-cell function by diazoxide treatment in childhood type 1 diabetes.

  Diabetes care 20040901

• Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.

  Diabetologia 20040901

• Endothelial protection from reperfusion injury by ischemic preconditioning and diazoxide involves a SOD-like anti-O2- mechanism.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901

• Atypical Ca2+-induced Ca2+ release from a sarco-endoplasmic reticulum Ca2+-ATPase 3-dependent Ca2+ pool in mouse pancreatic beta-cells.

  The Journal of physiology 20040815

• Diazoxide and N omega-nitro-L-arginine counteracted A beta 1-42-induced cytotoxicity.

  Neuroreport 20040806

• Preconditioning protects by inhibiting the mitochondrial permeability transition.

  American journal of physiology. Heart and circulatory physiology 20040801

• Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose.

  American journal of physiology. Endocrinology and metabolism 20040801

• Severe persistent hyperinsulinemic hypoglycemia due to a de novo glucokinase mutation.

  Diabetes 20040801

• Testosterone modulates K(+)ATP channels in Sertoli cell membrane via the PLC-PIP2 pathway.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040801

• Functional distinctions between the mitochondrial ATP-dependent K+ channel (mitoKATP) and its inward rectifier subunit (mitoKIR).

  The Journal of biological chemistry 20040730

• Both triggering and amplifying pathways contribute to fuel-induced insulin secretion in the absence of sulfonylurea receptor-1 in pancreatic beta-cells.

  The Journal of biological chemistry 20040730

• Acute increases in arterial blood pressure do not reduce plasma vasopressin levels stimulated by angiotensin II or hyperosmolality in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20040701

• Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation.

  Molecular endocrinology (Baltimore, Md.) 20040701

• NO donor-activated PKC-delta plays a pivotal role in ischemic myocardial protection through accelerated opening of mitochondrial K-ATP channels.

  Journal of cardiovascular pharmacology 20040701

• Effect of classic preconditioning and diazoxide on endothelial function and O2- and NO generation in the post-ischemic guinea-pig heart.

  Cardiovascular research 20040701

• A case of severe diazoxide toxicity.

  Paediatric anaesthesia 20040701

• The anti-inflammatory effect of diazoxide in coronary artery bypass grafting.

  Shock (Augusta, Ga.) 20040701

• Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2+ influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/inwardly rectifying K+ channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets.

  Diabetes 20040701

• Insulin feedback alters mitochondrial activity through an ATP-sensitive K+ channel-dependent pathway in mouse islets and beta-cells.

  Diabetes 20040701

• Mutation at position -132 in the islet amyloid polypeptide ( IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.

  Diabetologia 20040701

• Preconditioning of the myocardium by volatile anesthetics.

  Current medicinal chemistry. Cardiovascular and hematological agents 20040701

• The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice.

  European journal of pharmacology 20040628

• Potassium channel openers are uncoupling protonophores: implication in cardioprotection.

  FEBS letters 20040618

• Palmitate increases L-type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic beta-cells.

  The Journal of physiology 20040615

• Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release.

  Journal of medicinal chemistry 20040603

• Regulation by glucose and calcium of the carboxylmethylation of the catalytic subunit of protein phosphatase 2A in insulin-secreting INS-1 cells.

  American journal of physiology. Endocrinology and metabolism 20040601

• Diazoxide preconditioning protects against neuronal cell death by attenuation of oxidative stress upon glutamate stimulation.

  Journal of neuroscience research 20040601

• Role of calcium in pancreatic islet cell death by IFN-gamma/TNF-alpha.

  Journal of immunology (Baltimore, Md. : 1950) 20040601

• Glucose and insulin treatment of insulinoma cells results in transcriptional regulation of a common set of genes.

  Diabetes 20040601

• Inhibition of insulin secretion as a new drug target in the treatment of metabolic disorders.

  Current medicinal chemistry 20040601

• Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition.

  Hepatology (Baltimore, Md.) 20040601

• Diazoxide and dimethyl sulphoxide prevent cerebral hypoperfusion-related learning dysfunction and brain damage after carotid artery occlusion.

  Brain research 20040522

• Diazoxide affects the IF1 inhibitor protein binding to F1 sector of beef heart F0F1ATPsynthase.

  Biochemical pharmacology 20040515

• Quinine inhibits mitochondrial ATP-regulated potassium channel from bovine heart.

  The Journal of membrane biology 20040515

• The human mitochondrial KATP channel is modulated by calcium and nitric oxide: a patch-clamp approach.

  Biochimica et biophysica acta 20040512

• Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.

  American journal of physiology. Endocrinology and metabolism 20040501

• Openers of ATP-dependent K+-channels protect against a signal-transduction-linked and not freely reversible defect of insulin secretion in a rat islet transplantation model of Type 2 diabetes.

  Diabetologia 20040501

• [The research method for investigating the role of the mitochondrial permeability transition pore in cell death].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040501

• Cardioprotective effects of mitochondrial KATP channels activated at different time.

  Chinese medical journal 20040501

• Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.

  Circulation 20040413

• Additive antinociceptive effect of the combination of diazoxide, an activator of ATP-sensitive K+ channels, and sodium nitroprusside and dibutyryl-cGMP.

  European journal of pharmacology 20040405

• Exogenous nitric oxide generates ROS and induces cardioprotection: involvement of PKG, mitochondrial KATP channels, and ERK.

  American journal of physiology. Heart and circulatory physiology 20040401

• A store-operated mechanism determines the activity of the electrically excitable glucagon-secreting pancreatic alpha-cell.

  Cell calcium 20040401

• Attenuation of hyperinsulinemia by NN414, a SUR1/Kir6.2 selective K-adenosine triphosphate channel opener, improves glucose tolerance and lipid profile in obese Zucker rats.

  Metabolism: clinical and experimental 20040401

• [Diagnosis and treatment of insulinoma].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20040401

• Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor.

  The Journal of biological chemistry 20040319

• Chromatographic multivariate quality control of pharmaceuticals giving strongly overlapped peaks based on the chromatogram profile.

  Journal of chromatography. A 20040312

• Influence of central administration ATP-dependent K+ channel on morphine state-dependent memory of passive avoidance.

  European journal of pharmacology 20040308

• Evidence for mitochondrial K+ channels and their role in cardioprotection.

  Circulation research 20040305

• ROS are required for rapid reactivation of Na+/Ca2+ exchanger in hypoxic reoxygenated guinea pig ventricular myocytes.

  American journal of physiology. Heart and circulatory physiology 20040301

• Diazoxide enhances adipose tissue protein kinase B activation and glucose transporter-4 expression in obese Zucker rats.

  Medical science monitor : international medical journal of experimental and clinical research 20040301

• ROS-mediated ERK activation in delayed protection from anoxic preconditioning in neonatal rat cardiomyocytes.

  Chinese medical journal 20040301

• Mechanism of apoptosis induced by diazoxide, a K+ channel opener, in HepG2 human hepatoma cells.

  Archives of pharmacal research 20040301

• Influence of potassium channel modulators on morphine state-dependent memory of passive avoidance.

  Behavioural pharmacology 20040301

• Adenosine and a nitric oxide donor enhances cardioprotection by preconditioning with isoflurane through mitochondrial adenosine triphosphate-sensitive K+ channel-dependent and -independent mechanisms.

  Anesthesiology 20040301

• Cyclooxygenase-2 mediates ischemic, anesthetic, and pharmacologic preconditioning in vivo.

  Anesthesiology 20040301

• Influence of fasting on the effects of diazoxide in the ischemic-reperfused rat heart.

  Journal of physiology and biochemistry 20040301

• Y-26763: ATP-sensitive K+ channel activation and the inhibition of insulin release from human pancreatic beta-cells.

  European journal of pharmacology 20040220

• Diazoxide causes early activation of cardiac sarcolemmal KATP channels during metabolic inhibition by an indirect mechanism.

  Cardiovascular research 20040215

• Delayed preconditioning of the human myocardium: signal transduction and clinical implications.

  Cardiovascular research 20040215

• Electro-acupuncture preconditioning abrogates the elevation of c-Fos and c-Jun expression in neonatal hypoxic-ischemic rat brains induced by glibenclamide, an ATP-sensitive potassium channel blocker.

  Brain research 20040213

• 3-trifluoromethyl-4-nitro-5-arylpyrazoles are novel K(ATP) channel agonists.

  Bioorganic & medicinal chemistry letters 20040209

• The mitochondrial K(ATP) channel opener BMS-191095 induces neuronal preconditioning.

  Neuroreport 20040209

• Syntaxin-1A binds the nucleotide-binding folds of sulphonylurea receptor 1 to regulate the KATP channel.

  The Journal of biological chemistry 20040206

• Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells.

  Endocrinology 20040201

• Autosomal-dominant hypertension with type E brachydactyly is caused by rearrangement on the short arm of chromosome 12.

  Hypertension (Dallas, Tex. : 1979) 20040201

• Molecular mechanisms of the inhibitory effects of propofol and thiamylal on sarcolemmal adenosine triphosphate-sensitive potassium channels.

  Anesthesiology 20040201

• Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes.

  Diabetologia 20040201

• Difference in the cardioprotective mechanisms between ischemic preconditioning and pharmacological preconditioning by diazoxide in rat hearts.

  Circulation journal : official journal of the Japanese Circulation Society 20040201

• Roles of mitochondria in health and disease.

  Diabetes 20040201

• Visualization of the specific interaction of sulfonylurea-incorporated polymer with insulinoma cell line MIN6.

  Journal of biochemistry 20040201

• Severe transient neonatal hyperinsulinism associated with hyperlactataemia in non-asphyxiated infants.

  Journal of pediatric endocrinology & metabolism : JPEM 20040201

• [Congenital hyperinsulinism in 15 infants, 1981-1999; experiences and new insights].

  Nederlands tijdschrift voor geneeskunde 20040117

• Modulation of the excitability of cholinergic basal forebrain neurones by KATP channels.

  The Journal of physiology 20040115

• Bradykinin induces mitochondrial ROS generation via NO, cGMP, PKG, and mitoKATP channel opening and leads to cardioprotection.

  American journal of physiology. Heart and circulatory physiology 20040101

• Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing.

  The Biochemical journal 20040101

• Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes.

  Journal of neurosurgical anesthesiology 20040101

• Binding of sulfonylurea by AtMRP5, an Arabidopsis multidrug resistance-related protein that functions in salt tolerance.

  Plant physiology 20040101

• Activation of mitochondrial ATP-sensitive potassium channels delays ischemia-induced cellular uncoupling in rat heart.

  Acta pharmacologica Sinica 20040101

• Nine weeks of bedtime diazoxide is well tolerated and improves beta-cell function in subjects with Type 2 diabetes.

  Diabetic medicine : a journal of the British Diabetic Association 20040101

• Hyperinsulinaemic hypoglycaemia in preterm neonates.

  Archives of disease in childhood. Fetal and neonatal edition 20040101

• Diazoxide provides protection to human myocardium in vitro that is concentration dependent.

  The Annals of thoracic surgery 20040101

• Subcellular heterogeneity in mitochondrial red-ox responses to KATP channel agonists in freshly isolated rabbit cardiomyocytes.

  Molecular and cellular biochemistry 20040101

• Nesidioblastosis treated successfully by 85% pancreatectomy.

  The Kurume medical journal 20040101

• [Study of the mechanism of action of novel fluoro-containing analogs of diazoxide on the vascular tonus].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20040101

• [Fluorine-containing analog of diazoxide prevented apoptosis in neonatal cardiomyocytes during anoxia-reoxygenation].

  Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20040101

• The aminoguanidine carboxylate BVT.12777 activates ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1.

  BMC pharmacology 20040101

• [The effect of K(ATP)-channel activation on the electrical stability of myocardium in rats with postinfarction cardiosclerosis].

  Eksperimental'naia i klinicheskaia farmakologiia 20040101

• [Persistent hyperinsulinemic hypoglycemia. Two case reports].

  Cirugia y cirujanos 20040101

• Hirsutism: common clinical problem or index of serious disease?

  MedGenMed : Medscape general medicine 20040101

• Mechanisms of cardioprotective effects of magnesium on hypoxia-reoxygenation-induced injury.

  Experimental and clinical cardiology 20040101

• Palmitate-induced Ca2+-signaling in pancreatic beta-cells.

  Molecular and cellular endocrinology 20031230

• Prolonged culture in low glucose induces apoptosis of rat pancreatic beta-cells through induction of c-myc.

  Biochemical and biophysical research communications 20031226

• Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain.

  Brain research 20031219

• Mitochondrial ATP-sensitive potassium channels in surgical cardioprotection.

  Archives of biochemistry and biophysics 20031215

• Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans.

  European journal of pharmacology 20031215

• ATP-sensitive K+ channels in renal mitochondria.

  American journal of physiology. Renal physiology 20031201

• Amiodarone inhibits sarcolemmal but not mitochondrial KATP channels in Guinea pig ventricular cells.

  The Journal of pharmacology and experimental therapeutics 20031201

• The cardioprotective effects of Na+/H+ exchange inhibition and mitochondrial KATP channel activation are additive in the isolated rat heart.

  Pflugers Archiv : European journal of physiology 20031201

• Novel pharmacological preconditioning with diazoxide attenuates myocardial stunning in coronary artery bypass grafting.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20031201

• Time course of vascular reactivity to contracting and relaxing agents after endothelial denudation by balloon angioplasty in rat carotid artery.

  Atherosclerosis 20031201

• Trimethoprim-sulfamethoxazole induced prolonged hypoglycemia in an infant with MHC class II deficiency: diazoxide as a treatment option.

  Journal of pediatric endocrinology & metabolism : JPEM 20031201

• Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells.

  Annals of the New York Academy of Sciences 20031201

• Early biochemical and histological alterations in rat corticoencephalic cell cultures following metabolic damage and treatment with modulators of mitochondrial ATP-sensitive potassium channels.

  Neurochemistry international 20031101

• Interactions of diazoxide with frusemide, spironolactone, and acetylsalicylic acid in a patient with hyperinsulinism of Infancy and Fallot tetralogy.

  European journal of pediatrics 20031101

• Enhanced cardioprotection of the rat heart during hypothermic storage with combined Na+ - H+ exchange inhibition and ATP-dependent potassium channel activation.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20031101

• Heart mitochondria contain functional ATP-dependent K+ channels.

  Journal of molecular and cellular cardiology 20031101

• Ca2+ influx does not trigger glucose-induced traffic of the insulin granules and alteration of their distribution.

  Experimental biology and medicine (Maywood, N.J.) 20031101

• Diazoxide induces delayed pre-conditioning in cultured rat cortical neurons.

  Journal of neurochemistry 20031101

• ATP-dependent K+ channels in renal ischemia reperfusion injury.

  Renal failure 20031101

• 1,5-Anhydroglucitol stimulates insulin release in insulinoma cell lines.

  Biochimica et biophysica acta 20031013

• Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues.

  Diabetologia 20031001

• Intracellular mechanism of mitochondrial adenosine triphosphate-sensitive potassium channel activation with isoflurane.

  Anesthesia and analgesia 20031001

• Isoflurane pretreatment has immediate and delayed protective effects against cytokine-induced injury in endothelial and vascular smooth muscle cells.

  Anesthesiology 20031001

• Intra-myocyte ion homeostasis during ischemia-reperfusion injury: effects of pharmacologic preconditioning and controlled reperfusion.

  The Annals of thoracic surgery 20031001

• Early ischemic preconditioning for spinal cord protection.

  The Annals of thoracic surgery 20031001

• A case of partial trisomy 13 presenting with hyperinsulinaemic hypoglycaemia.

  Hong Kong medical journal = Xianggang yi xue za zhi 20031001

• HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning.

  The Journal of surgical research 20031001

• Effectiveness of octreotide in a case of refractory sulfonylurea-induced hypoglycemia.

  The Journal of emergency medicine 20031001

• ATP-sensitive K+ channel openers: old drugs with new clinical benefits for the heart.

  Current vascular pharmacology 20031001

• Functional coupling between sulfonylurea receptor type 1 and a nonselective cation channel in reactive astrocytes from adult rat brain.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917

• Both metabolic inhibition and mitochondrial K(ATP) channel opening are myoprotective and initiate a compensatory sarcolemmal outward membrane current.

  Circulation 20030909

• Combined pharmacological preconditioning with a G-protein-coupled receptor agonist, a mitochondrial KATP channel opener and a nitric oxide donor mimics ischaemic preconditioning.

  Clinical and experimental pharmacology & physiology 20030901

• Chemical preconditioning prevents paradoxical increase in glutamate release during ischemia by activating ATP-dependent potassium channels in gerbil hippocampus.

  Experimental neurology 20030901

• ATP-sensitive potassium channels induced in liver cells after transfection with insulin cDNA and the GLUT 2 transporter regulate glucose-stimulated insulin secretion.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901

• The K+ channel openers diazoxide and NS1619 induce depolarization of mitochondria and have differential effects on cell Ca2+ in CD34+ cell line KG-1a.

  Experimental hematology 20030901

• P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts.

  Journal of molecular and cellular cardiology 20030901

• Evidence for rapid 'metabolic switching' through lipoprotein lipase occupation of endothelial-binding sites.

  Journal of molecular and cellular cardiology 20030901

• Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining.

  Cardiovascular research 20030901

• [Sevoflurane anesthesia for pancreatectomy in an infant with nesidioblastosis].

  Masui. The Japanese journal of anesthesiology 20030901

• Protective effects of the potassium channel opener-diazoxide against injury in neonatal rat ventricular myocytes.

  General physiology and biophysics 20030901

• Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.

  Circulation 20030812

• Activation of the KATP channel-independent signaling pathway by the nonhydrolyzable analog of leucine, BCH.

  American journal of physiology. Endocrinology and metabolism 20030801

• Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.

  Endocrinology 20030801

• N-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits.

  The EMBO journal 20030801

• K(ATP) channels and pancreatic islet blood flow in anesthetized rats: increased blood flow induced by potassium channel openers.

  Diabetes 20030801

• Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death.

  Journal of neurochemistry 20030801

• Insulin-like growth factor-1 prevents loss of electrochemical gradient in cardiac muscle mitochondria via activation of PI 3 kinase/Akt pathway.

  Molecular and cellular endocrinology 20030731

• Degradation of phosphatidylethanol counteracts the apparent phospholipase D-mediated formation in heart and other organs.

  Biochimica et biophysica acta 20030721

• Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.

  Journal of medicinal chemistry 20030717

• Diazoxide pretreatment induces delayed preconditioning in astrocytes against oxygen glucose deprivation and hydrogen peroxide-induced toxicity.

  Journal of neuroscience research 20030715

• Mitochondrial ATP-sensitive potassium channel activation protects cerebellar granule neurons from apoptosis induced by oxidative stress.

  Stroke 20030701

• Effects of fatty acids in isolated mitochondria: implications for ischemic injury and cardioprotection.

  American journal of physiology. Heart and circulatory physiology 20030701

• [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: characterization and pharmacology of binding.

  Molecular pharmacology 20030701

• Long-term follow-up of 114 patients with congenital hyperinsulinism.

  European journal of endocrinology 20030701

• Mitochondrial plasticity in classical ischemic preconditioning-moving beyond the mitochondrial KATP channel.

  Cardiovascular research 20030701

• Ischaemic preconditioning and a mitochondrial KATP channel opener both produce cardioprotection accompanied by F1F0-ATPase inhibition in early ischaemia.

  Basic research in cardiology 20030701

• Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells.

  Metabolism: clinical and experimental 20030701

• Integrated pharmacological preconditioning in combination with adenosine, a mitochondrial KATP channel opener and a nitric oxide donor.

  The Journal of thoracic and cardiovascular surgery 20030701

• Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.

  The Journal of physiology 20030615

• ATP-sensitive potassium channels in rat primary afferent neurons: the effect of neuropathic injury and gabapentin.

  Neuroscience letters 20030612

• Elevated dietary salt suppresses renin secretion but not thirst evoked by arterial hypotension in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20030601

• Diazoxide triggers cardioprotection against apoptosis induced by oxidative stress.

  American journal of physiology. Heart and circulatory physiology 20030601

• Antiangiogenic effect of KR-31372 by apoptosis via mediation of mitochondrial KATP channel opening and the phosphatase and tensin homolog deleted from chromosome 10 phosphorylation.

  The Journal of pharmacology and experimental therapeutics 20030601

• Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels.

  Neuropharmacology 20030601

• Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats.

  Endocrinology 20030601

• Mitochondrial ATP-sensitive potassium channel: a novel site for neuroprotection.

  Investigative ophthalmology & visual science 20030601

• Acetylcholine-induced production of reactive oxygen species in adult rabbit ventricular myocytes is dependent on phosphatidylinositol 3- and Src-kinase activation and mitochondrial K(ATP) channel opening.

  Journal of molecular and cellular cardiology 20030601

• Functional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels.

  British journal of pharmacology 20030601

• Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.

  Cardiovascular research 20030601

• Coronary endothelial dysfunction after ischemia and reperfusion and its prevention by ischemic preconditioning.

  Italian heart journal : official journal of the Italian Federation of Cardiology 20030601

• Differential activation of protein kinase C between ischemic and pharmacological preconditioning in the rabbit heart.

  The Japanese journal of physiology 20030601

• Surgery of persistent hyperinsulinaemic hypoglycaemia.

  Seminars in neonatology : SN 20030601

• Mechanisms of delayed electrical uncoupling induced by ischemic preconditioning.

  Circulation research 20030530

• Activation of peripheral ATP-sensitive K+ channels mediates the antinociceptive effect of Crotalus durissus terrificus snake venom.

  European journal of pharmacology 20030523

• Glucose regulates EF-2 phosphorylation and protein translation by a protein phosphatase-2A-dependent mechanism in INS-1-derived 832/13 cells.

  The Journal of biological chemistry 20030516

• Isoflurane activates rat mitochondrial ATP-sensitive K+ channels reconstituted in lipid bilayers.

  American journal of physiology. Heart and circulatory physiology 20030501

• Contrasting roles of a novel K+ channel blocker and a K+ channel opener on electro-mechanical activity in canine heart tissue.

  International journal of cardiology 20030501

• Binding and effect of K ATP channel openers in the absence of Mg2+.

  British journal of pharmacology 20030501

• Cellular uptake of a catechol iron chelator and chloroquine into Plasmodium falciparum infected erythrocytes.

  Biochemical pharmacology 20030415

• Imidazoline NNC77-0074 stimulates insulin secretion and inhibits glucagon release by control of Ca(2+)-dependent exocytosis in pancreatic alpha- and beta-cells.

  European journal of pharmacology 20030411

• Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels.

  Endocrinology 20030401

• Persistent hyperinsulinemic hypoglycaemia followed as benign infantile convulsion.

  Seizure 20030401

• Insulin does not mediate glucose stimulation of proinsulin biosynthesis.

  Diabetes 20030401

• Targeting nucleotide-requiring enzymes: implications for diazoxide-induced cardioprotection.

  American journal of physiology. Heart and circulatory physiology 20030401

• Activation of Akt is essential for acetylcholine to trigger generation of oxygen free radicals.

  Cardiovascular research 20030401

• Modulation of mitochondrial adenosine triphosphate-sensitive potassium channels and sodium-hydrogen exchange provide additive protection from severe ischemia-reperfusion injury.

  The Journal of thoracic and cardiovascular surgery 20030401

• Adenine nucleotide translocase mediates the K(ATP)-channel-openers-induced proton and potassium flux to the mitochondrial matrix.

  Journal of bioenergetics and biomembranes 20030401

• [Changes in cardiac resistance to arrhythmogenic effects during ATP-dependent K+ channel activation].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20030401

• Synthesis and biological activity of 3,3-diamino-sulfonylacrylonitriles as novel inhibitors of glucose induced insulin secretion from beta cells.

  Bioorganic & medicinal chemistry 20030320

• Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria.

  The Journal of physiology 20030315

• MCC-134, a single pharmacophore, opens surface ATP-sensitive potassium channels, blocks mitochondrial ATP-sensitive potassium channels, and suppresses preconditioning.

  Circulation 20030304

• Mechanism of inhibitory actions of oxidizing agents on calcium-activated potassium current in cultured pigment epithelial cells of the human retina.

  Investigative ophthalmology & visual science 20030301

• Activation of mitochondrial ATP-sensitive potassium channels increases cell viability against rotenone-induced cell death.

  Journal of neurochemistry 20030301

• Pharmacological agents that directly modulate insulin secretion.

  Pharmacological reviews 20030301

• The effects of KATP channel modulators on counterregulatory responses and cognitive function during acute controlled hypoglycaemia in healthy men: a pilot study.

  Diabetic medicine : a journal of the British Diabetic Association 20030301

• Modulation of the trafficking efficiency and functional properties of ATP-sensitive potassium channels through a single amino acid in the sulfonylurea receptor.

  The Journal of biological chemistry 20030227

• Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice.

  Circulation 20030211

• Differential actions of cardioprotective agents on the mitochondrial death pathway.

  Circulation research 20030207

• Receptor and non-receptor-dependent mechanisms of cardioprotection with adenosine.

  American journal of physiology. Heart and circulatory physiology 20030201

• Inhibition of vascular ATP-sensitive K+ channels does not affect reactive hyperemia in human forearm.

  American journal of physiology. Heart and circulatory physiology 20030201

• Differential sensitivity of atrial and ventricular K(ATP) channels to metabolic inhibition.

  Cardiovascular research 20030201

• Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.

  Fundamental & clinical pharmacology 20030201

• The mitochondrial K(ATP) channel and cardioprotection.

  The Annals of thoracic surgery 20030201

• Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish population.

  Diabetologia 20030201

• Prolonged hyperinsulinemic hypoglycemia in a small for date preterm.

  Minerva pediatrica 20030201

• Leptin fully suppresses acetylcholine-induced insulin secretion and is reversed by tolbutamide in isolated perfused chicken pancreas.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030201

• Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.

  The Biochemical journal 20030115

• Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels.

  Stroke 20030101

• Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts.

  Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20030101

• Involvement of mitogen-activated protein kinases and reactive oxygen species in the inotropic action of ouabain on cardiac myocytes. A potential role for mitochondrial K(ATP) channels.

  Molecular and cellular biochemistry 20030101

• Effects of sulfonylureas on K(ATP) channel-dependent vasodilation.

  Journal of diabetes and its complications 20030101

• Protection of rat pancreatic islets by potassium channel openers against alloxan, sodium nitroprusside and interleukin-1beta mediated suppression--possible involvement of the mitochondrial membrane potential.

  Diabetologia 20030101

• [Malignant insulinoma in an 84-year-old woman].

  Anales de medicina interna (Madrid, Spain : 1984) 20030101

• [Treatment of insulinoma with diazoxide].

  Medicina 20030101

• Ischemic and pharmacological induction of delayed cellular protection in iNOS gene-disrupted mice myocytes.

  Polish journal of pharmacology 20030101

• Role of mitochondrial KATP channels and protein kinase C in ischaemic preconditioning.

  Clinical and experimental pharmacology & physiology 20030101

• Gender differences in effects of pinacidil but not diazoxide on heart automatism in the isolated guinea pig right atria.

  Polish journal of pharmacology 20030101

• Persistent hyperinsulinemic neonatal hypoglycemia caused by focal nesidioblastosis. Preoperative diagnosis by pancreatic venous sampling.

  Hormones (Athens, Greece) 20030101

• Methyl pyruvate stimulates pancreatic beta-cells by a direct effect on KATP channels, and not as a mitochondrial substrate.

  The Biochemical journal 20021215

• The effects of ischaemic preconditioning, diazoxide and 5-hydroxydecanoate on rat heart mitochondrial volume and respiration.

  The Journal of physiology 20021215

• Opening of potassium channels modulates mitochondrial function in rat skeletal muscle.

  Biochimica et biophysica acta 20021202

• Expression and activity of potassium ion channels in human prostate cancer.

  Cancer letters 20021201

• Mitochondrial Ca2+ uptake is important over low [Ca2+]i range in arterial smooth muscle.

  American journal of physiology. Heart and circulatory physiology 20021201

• The role of mitochondrial K(ATP) channels in the antiarrhythmic effects of ischaemic preconditioning in dogs.

  British journal of pharmacology 20021201

• The role of mitochondrial K(ATP) channels in antiarrhythmic effects of ischaemic preconditioning in dogs.

  British journal of pharmacology 20021201

• Serum inhibin B in polycystic ovary syndrome: regulation by insulin and luteinizing hormone.

  The Journal of clinical endocrinology and metabolism 20021201

• Diazoxide in the treatment of schizophrenia: novel application of potassium channel openers in the treatment of schizophrenia.

  Journal of clinical pharmacy and therapeutics 20021201

• Rapid insulin assay for intraoperative confirmation of complete resection of insulinomas.

  Surgery 20021201

• Improved beta cell function after short-term treatment with diazoxide in obese subjects with type 2 diabetes.

  Diabetes & metabolism 20021201

• Uncontrolled insulin secretion from a childhood pancreatic beta-cell adenoma is not due to the functional loss of ATP-sensitive potassium channels.

  Endocrine-related cancer 20021201

• Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery.

  The Annals of thoracic surgery 20021201

• Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.

  The Journal of biological chemistry 20021122

• The cytoplasmic C-terminus of the sulfonylurea receptor is important for KATP channel function but is not key for complex assembly or trafficking.

  European journal of biochemistry 20021101

• Nicorandil and leukocyte activation.

  Journal of cardiovascular pharmacology 20021101

• BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

  The Journal of clinical endocrinology and metabolism 20021101

• 2-alkyl-3-Alkylamino-2H-Benzo- and pyridothiadiazine 1,1-dioxides: from K+ATP channel openers to Ca++ channel blockers?

  Biological chemistry 20021101

• Time and amplitude regulation of pulsatile insulin secretion by triggering and amplifying pathways in mouse islets.

  FEBS letters 20021023

• Synthesis and evaluation of 7-substituted-3-cyclobutylamino-4H-1,2,4-benzothiadiazine-1,1-dioxide derivatives as K(ATP) channel agonists.

  Bioorganic & medicinal chemistry letters 20021021

• Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes.

  European journal of pharmacology 20021018

• Dynamics of glucose-induced membrane recruitment of protein kinase C beta II in living pancreatic islet beta-cells.

  The Journal of biological chemistry 20021004

• Cardioprotection by multiple preconditioning cycles does not require mitochondrial K(ATP) channels in pigs.

  American journal of physiology. Heart and circulatory physiology 20021001

• Long-term administration of nicorandil abolishes ischemic and pharmacologic preconditioning of the human myocardium: role of mitochondrial adenosine triphosphate-dependent potassium channels.

  The Journal of thoracic and cardiovascular surgery 20021001

• Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life.

  Diabetes 20021001

• Cell-type specific depression of neuronal excitability in rat hippocampus by activation of ATP-sensitive potassium channels.

  European biophysics journal : EBJ 20021001

• Study of a glucose-activated anion-selective channel in rat pancreatic beta-cells.

  Pflugers Archiv : European journal of physiology 20021001

• [PHHI (persistent hyperinsulinemic hypoglycemia of infancy)].

  Nihon rinsho. Japanese journal of clinical medicine 20021001

• Rapid effect of testosterone on rat Sertoli cell membrane potential. Relationship with K+ATP channels.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20021001

• Persistent hyperinsulinaemic hypoglycaemia of infancy: case report.

  East African medical journal 20021001

• 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells.

  Journal of medicinal chemistry 20020912

• The elevation of glutamate content and the amplification of insulin secretion in glucose-stimulated pancreatic islets are not causally related.

  The Journal of biological chemistry 20020906

• MitoK(ATP) opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat.

  American journal of physiology. Heart and circulatory physiology 20020901

• Glucose-sensing in glucagon-like peptide-1-secreting cells.

  Diabetes 20020901

• Opening of ATP-sensitive potassium channels causes generation of free radicals in vascular smooth muscle cells.

  Basic research in cardiology 20020901

• Delta opioid agonists and volatile anesthetics facilitate cardioprotection via potentiation of K(ATP) channel opening.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020901

• Pharmacological preconditioning ameliorates neurological injury in a model of spinal cord ischemia.

  The Annals of thoracic surgery 20020901

• Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

  Cardiovascular research 20020815

• Acetylcholine leads to free radical production dependent on K(ATP) channels, G(i) proteins, phosphatidylinositol 3-kinase and tyrosine kinase.

  Cardiovascular research 20020815

• Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene.

  Cardiovascular research 20020815

• Effects of mitochondrial K(ATP) modulators on cardioprotection induced by chronic high altitude hypoxia in rats.

  Cardiovascular research 20020815

• Ischemic preconditioning protection against stunning in conscious diabetic sheep: role of glucose, insulin, sarcolemmal and mitochondrial KATP channels.

  Cardiovascular research 20020815

• The relative order of mK(ATP) channels, free radicals and p38 MAPK in preconditioning's protective pathway in rat heart.

  Cardiovascular research 20020815

• Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: a possible mechanism of action.

  Journal of ethnopharmacology 20020801

• Neonatal hyperinsulinemic hypoglycemia. Two case reports.

  Minerva pediatrica 20020801

• Evidence that the novel imidazoline compound FT005 is an alpha(2)-adrenoceptor agonist.

  British journal of pharmacology 20020801

• Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells.

  Diabetes 20020801

• K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart.

  The Journal of physiology 20020801

• Diazoxide for cerebral protection during deep hypothermic circulatory arrest: is it really safe?

  The Annals of thoracic surgery 20020801

• Pancreatectomy extension in persistent hyperinsulinaemic hypoglycaemia: a new strategy.

  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie 20020801

• Opening of mitochondrial K+ channels increases ischemic ATP levels by preventing hydrolysis.

  Journal of bioenergetics and biomembranes 20020801

• Persistent hyperinsulinemic hypoglycemia of infancy: experience at Siriraj Hospital.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20020801

• Glucagon is paradoxically secreted at high concentrations of glucose in rat pancreas perfused with diazoxide.

  Diabetes, nutrition & metabolism 20020801

• The role of myocardial KATP-channel blockade in the protective effects of glibenclamide against ischaemia in the rat heart.

  Pharmacology & toxicology 20020801

• Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats.

  Neuroscience letters 20020726

• Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism.

  American journal of physiology. Cell physiology 20020701

• Role of nitric oxide synthase isoforms in glucose-stimulated insulin release.

  American journal of physiology. Cell physiology 20020701

• Ketamine abolishes ischemic preconditioning through inhibition of K(ATP) channels in rabbit hearts.

  American journal of physiology. Heart and circulatory physiology 20020701

• Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart.

  American journal of physiology. Heart and circulatory physiology 20020701

• Opening of mitochondrial K(ATP) channel occurs downstream of PKC-epsilon activation in the mechanism of preconditioning.

  American journal of physiology. Heart and circulatory physiology 20020701

• Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels.

  British journal of pharmacology 20020701

• Suppression of human tumor cell proliferation through mitochondrial targeting.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020701

• Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways.

  Anesthesiology 20020701

• Differential effects of anesthetics on mitochondrial K(ATP) channel activity and cardiomyocyte protection.

  Anesthesiology 20020701

• Effect of pretreatment with adenosine, diazoxide or ischemic preconditioning on ischemia- reperfusion injury in the limbs of rats.

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20020701

• Oral hypoglycemic sulfonylurea glimepiride preserves the myoprotective effects of ischemic preconditioning.

  The Journal of surgical research 20020615

• Diazoxide opens the mitochondrial permeability transition pore and alters Ca2+ transients in rat ventricular myocytes.

  Circulation 20020604

• The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener.

  Diabetes 20020601

• Chronic suppression of insulin by diazoxide alters the activities of key enzymes regulating hepatic gluconeogenesis in Zucker rats.

  European journal of endocrinology 20020601

• Clinically relevant concentrations of propofol have no effect on adenosine triphosphate-sensitive potassium channels in rat ventricular myocytes.

  Anesthesiology 20020601

• Modulation of a plant mitochondrial K+ATP channel and its involvement in cytochrome c release.

  Journal of bioenergetics and biomembranes 20020601

• Identification of a familial hyperinsulinism-causing mutation in the sulfonylurea receptor 1 that prevents normal trafficking and function of KATP channels.

  The Journal of biological chemistry 20020510

• Troglitazone ameliorates lipotoxicity in the beta cell line INS-1 expressing PPAR gamma.

  Diabetes research and clinical practice 20020501

• High-performance liquid chromatographic method with ultraviolet detection for the determination of dapsone and its hydroxylated metabolite in human plasma.

  Biomedical chromatography : BMC 20020501

• Contribution of the endoplasmic reticulum to the glucose-induced [Ca(2+)](c) response in mouse pancreatic islets.

  American journal of physiology. Endocrinology and metabolism 20020501

• Mitochondrial ATP-sensitive K+ channels influence force development and anoxic contractility in a flatfish, yellowtail flounder Limanda ferruginea, but not Atlantic cod Gadus morhua heart.

  The Journal of experimental biology 20020501

• Effects of K(ATP) channel modulators on acetylcholine release from guinea-pig isolated atria and small intestine.

  Naunyn-Schmiedeberg's archives of pharmacology 20020501

• Cardiomyocyte resistance to doxorubicin mediated by A(3) adenosine receptor.

  Journal of molecular and cellular cardiology 20020501

• [Hirsutism and hypertrichosis in adults: investigations and treatment].

  Annales de dermatologie et de venereologie 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Alterations of purine and pyrimidine nucleotide contents in rat corticoencephalic cell cultures following metabolic damage and treatment with openers and blockers of ATP-sensitive potassium channels.

  Neurochemistry international 20020401

• Correlation between GABA release from rat islet beta-cells and their metabolic state.

  American journal of physiology. Endocrinology and metabolism 20020401

• Preconditioning blocks cardiocyte apoptosis: role of K(ATP) channels and PKC-epsilon.

  American journal of physiology. Heart and circulatory physiology 20020401

• Glucosamine-induced beta-cell dysfunction: a possible involvement of glucokinase or glucose-transporter type 2.

  Pancreas 20020401

• The second activating glucokinase mutation (A456V): implications for glucose homeostasis and diabetes therapy.

  Diabetes 20020401

• Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020401

• Effect of ischemic preconditioning and mitochondrial KATP channel openers on chronic left ventricular remodeling in the ischemic-reperfused rat heart.

  Circulation journal : official journal of the Japanese Circulation Society 20020401

• Radio-frequency ablation for symptom control in a patient with metastatic pancreatic insulinoma.

  Clinical endocrinology 20020401

• Functional roles of KATP channels in vascular smooth muscle.

  Clinical and experimental pharmacology & physiology 20020401

• Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts.

  Journal of molecular and cellular cardiology 20020401

• Compound heterozygosity for the common sulfonylurea receptor mutations can cause mild diazoxide-sensitive hyperinsulinism.

  Clinical pediatrics 20020401

• The reactivity of serotonin, acetylcholine and kcl-induced contractions to relaxant agents in the rat gastric fundus.

  Pharmacological research 20020401

• Diazoxide protects the rabbit heart following cardioplegic ischemia.

  Molecular and cellular biochemistry 20020401

• ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus.

  Neuroscience letters 20020301

• Vascular K(ATP) channel blockade by glibenclamide, but not by acarbose, in patients with Type II diabetes.

  Clinical science (London, England : 1979) 20020301

• Determination of the specific interaction between sulfonylurea-incorporated polymer and rat islets.

  Journal of biochemistry 20020301

• Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis.

  European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20020301

• AMPA-induced Ca(2+) influx in cultured rat cortical nonpyramidal neurones: pharmacological characterization using fura-2 microfluorimetry.

  European journal of pharmacology 20020301

• Membrane potential dependent modulations of calcium oscillations in insulin-secreting INS-1 cells.

  Cell calcium 20020301

• Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation.

  American journal of physiology. Heart and circulatory physiology 20020201

• Overexpression of the Na/Ca exchanger shapes stimulus-induced cytosolic Ca(2+) oscillations in insulin-producing BRIN-BD11 cells.

  Diabetes 20020201

• Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.

  Diabetes 20020201

• The effects of cerulenin, an inhibitor of protein acylation, on the two phases of glucose-stimulated insulin secretion.

  Diabetes 20020201

• Diazoxide and pinacidil uncouple pyruvate-malate-induced mitochondrial respiration.

  Journal of bioenergetics and biomembranes 20020201

• Vascular effects of glibenclamide vs. glimepiride and metformin in Type 2 diabetic patients.

  Diabetic medicine : a journal of the British Diabetic Association 20020201

• Persistent hyperinsulinaemic hypoglycaemia.

  Seminars in neonatology : SN 20020201

• ATP-sensitive K(+) channels composed of Kir6.1 and SUR2B subunits in guinea pig gastric myocytes.

  American journal of physiology. Gastrointestinal and liver physiology 20020101

• Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals.

  Diabetes 20020101

• ATP-independent anoxic activation of ATP-sensitive K+ channels in dorsal vagal neurons of juvenile mice in situ.

  Neuroscience 20020101

• Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases.

  European journal of pediatrics 20020101

• Anaesthetic management of a case of nesidioblastosis for subtotal pancreatectomy.

  Paediatric anaesthesia 20020101

• Pharmacological and ischemic preconditioning of the human myocardium: mitoK(ATP) channels are upstream and p38MAPK is downstream of PKC.

  BMC physiology 20020101

• Voltage-gated potassium ion channels in colon cancer.

  Oncology reports 20020101

• ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures.

  Journal of pediatric endocrinology & metabolism : JPEM 20020101

• Study of the insulinotropic effect of the novel antihyperglycemic agent KAD-1229 using HIT T15 cells, a hamster's insulinoma cell line.

  Arzneimittel-Forschung 20020101

• Drugs for treatment of very high blood pressure during pregnancy.

  The Cochrane database of systematic reviews 20020101

• On the effect of diazoxide on isolated mitochondria from rat myocardium.

  Doklady. Biochemistry and biophysics 20020101

• Desensitization of insulin secretory response to imidazolines, tolbutamide, and quinine. II. Electrophysiological and fluorimetric studies.

  Biochemical pharmacology 20011215

• Characteristics and superoxide-induced activation of reconstituted myocardial mitochondrial ATP-sensitive potassium channels.

  Circulation research 20011207

• Anesthetic effects on mitochondrial ATP-sensitive K channel.

  Anesthesiology 20011201

• Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection.

  The Annals of thoracic surgery 20011201

• Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channel.

  Diabetes, obesity & metabolism 20011201

• Hyperinsulinaemic hypoglycaemia--leading symptom in a patient with congenital disorder of glycosylation Ia (phosphomannomutase deficiency).

  Journal of inherited metabolic disease 20011201

• Opening of mitochondrial K(ATP) channels attenuates the ouabain-induced calcium overload in mitochondria.

  Circulation research 20011109

• Mitochondrial ATP-sensitive potassium channels attenuate matrix Ca(2+) overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection.

  Circulation research 20011109

• Management of hyperinsulinemia with diazoxide in an elderly hemodialysis patient.

  Nephron 20011101

• Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide.

  Journal of molecular and cellular cardiology 20011101

• The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists.

  Pharmacological research 20011101

• Mitochondrial ATP-sensitive channel opener does not induce vascular preconditioning, but potentiates the effect of a preconditioning ischemia on coronary reactive hyperemia in the anesthetized goat.

  Pflugers Archiv : European journal of physiology 20011101

• Ischemic and pharmacological preconditioning in Girardi cells and C2C12 myotubes induce mitochondrial uncoupling.

  Circulation research 20011026

• Contribution to glucose tolerance of insulin-independent vs. insulin-dependent mechanisms in mice.

  American journal of physiology. Endocrinology and metabolism 20011001

• Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.

  American journal of physiology. Heart and circulatory physiology 20011001

• Glucose effects on gastric motility and tone evoked from the rat dorsal vagal complex.

  The Journal of physiology 20011001

• The KATP channel opener diazoxide protects cardiac myocytes during metabolic inhibition without causing mitochondrial depolarization or flavoprotein oxidation.

  British journal of pharmacology 20011001

• [Properties of KATP channels in hippocampal CA1 pyramidal neurons from adult rats].

  Sheng li xue bao : [Acta physiologica Sinica] 20011001

• Ten years' experience of persistent hyperinsulinaemic hypoglycaemia of infancy.

  Journal of paediatrics and child health 20011001

• Identification and pharmacological correction of a membrane trafficking defect associated with a mutation in the sulfonylurea receptor causing familial hyperinsulinism.

  The Journal of biological chemistry 20010921

• Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain.

  The Journal of biological chemistry 20010907

• Amino acids and insulin are both required to regulate assembly of the eIF4E. eIF4G complex in rat skeletal muscle.

  American journal of physiology. Endocrinology and metabolism 20010901

• Mitochondrial K(ATP) channel activation reduces anoxic injury by restoring mitochondrial membrane potential.

  American journal of physiology. Heart and circulatory physiology 20010901

• Hepatothermic therapy of obesity: rationale and an inventory of resources.

  Medical hypotheses 20010901

• Hyperinsulinism and hyperammonemia syndrome: report of twelve unrelated patients.

  Pediatric research 20010901

• Contribution of both the sarcolemmal K(ATP) and mitochondrial K(ATP) channels to infarct size limitation by K(ATP) channel openers: differences from preconditioning in the role of sarcolemmal K(ATP) channels.

  Naunyn-Schmiedeberg's archives of pharmacology 20010901

• Diazoxide induced cardioprotection: what comes first, K(ATP) channels or reactive oxygen species?

  Cardiovascular research 20010901

• Mitochondrial K(ATP) channel opening protects a human atrial-derived cell line by a mechanism involving free radical generation.

  Cardiovascular research 20010901

• Synthesis and characterization of a quinolinonic compound activating ATP-sensitive K(+) channels in endocrine and smooth muscle tissues.

  British journal of pharmacology 20010901

• Lidocaine and mexiletine inhibit mitochondrial oxidation in rat ventricular myocytes.

  Anesthesiology 20010901

• [Activation of ATP-sensitive K+ channels by ADP and K+ channel openers: homology model of sulfonylurea receptor carboxyl-termini].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20010901

• Critical timing of mitochondrial K(ATP) channel opening for enhancement of myocardial tolerance against infarction.

  Basic research in cardiology 20010901

• Incorporation of sulfonylurea into N-isopropylacrylamide as an extracellular matrix for an artificial pancreas.

  Bioscience, biotechnology, and biochemistry 20010901

• Effects of bezafibrate on beta-cell function of rat pancreatic islets.

  European journal of pharmacology 20010831

• Modulation of islet ATP content by inhibition or stimulation of the Na(+)/K(+) pump.

  European journal of pharmacology 20010824

• Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.

  Journal of medicinal chemistry 20010802

• Laparoscopic pancreatectomy for persistent hyperinsulinemic hypoglycemia of infancy.

  Surgical endoscopy 20010801

• ATP-sensitive K+ channels and cellular actions of morphine in periaqueductal gray slices of neonatal and adult rats.

  The Journal of pharmacology and experimental therapeutics 20010801

• Hyperinsulinism in short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency reveals the importance of beta-oxidation in insulin secretion.

  The Journal of clinical investigation 20010801

• Acute insulin responses to leucine in children with the hyperinsulinism/hyperammonemia syndrome.

  The Journal of clinical endocrinology and metabolism 20010801

• Sulfonylurea receptors inhibit the epithelial sodium channel (ENaC) by reducing surface expression.

  Pflugers Archiv : European journal of physiology 20010801

• Inhibition of large-conductance calcium-activated potassium channel by 2-methoxyestradiol in cultured vascular endothelial (HUV-EC-C) cells.

  The Journal of membrane biology 20010801

• Increased calcium vulnerability of senescent cardiac mitochondria: protective role for a mitochondrial potassium channel opener.

  Mechanisms of ageing and development 20010731

• Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells.

  Bioorganic & medicinal chemistry letters 20010709

• Downregulation of protein kinase C inhibits activation of mitochondrial K(ATP) channels by diazoxide.

  Circulation 20010703

• Distinct effect of diazoxide on insulin secretion stimulated by protein kinase A and protein kinase C in rat pancreatic islets.

  Diabetes research and clinical practice 20010701

• Oral agents for the treatment of type 2 diabetes mellitus: pharmacology, toxicity, and treatment.

  Annals of emergency medicine 20010701

• Intrinsic optical signals in respiratory brain stem regions of mice: neurotransmitters, neuromodulators, and metabolic stress.

  Journal of neurophysiology 20010701

• Effect on insulin release of compounds structurally related to the potassium-channel opener 7-chloro-3-isopropylamino-4H-1,2,4-benzothiadiazine 1,1-dioxide (BPDZ 73): introduction of heteroatoms on the 3-alkylamino side chain of the benzothiadiazine 1,1-dioxide ring.

  The Journal of pharmacy and pharmacology 20010701

• Glimepiride, a novel sulfonylurea, does not abolish myocardial protection afforded by either ischemic preconditioning or diazoxide.

  Circulation 20010626

• Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells.

  Circulation research 20010622

• Role of intracellular Na(+) kinetics in preconditioned rat heart.

  Circulation research 20010608

• A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism.

  The Journal of pharmacology and experimental therapeutics 20010601

• Glucose-regulated pulsatile insulin release from mouse islets via the K(ATP) channel-independent pathway.

  European journal of endocrinology 20010601

• Diazoxide effects on hypothalamic and extra-hypothalamic NPY content in Zucker rats.

  Peptides 20010601

• Transient hyperinsulinism in an asphyxiated newborn infant with hypoglycemia.

  American journal of perinatology 20010601

• Store-operated influx of Ca(2+) in pancreatic beta-cells exhibits graded dependence on the filling of the endoplasmic reticulum.

  Journal of cell science 20010601

• When it is more than transient neonatal hypoglycemia: hyperinsulinemia--a case study challenge.

  Neonatal network : NN 20010601

• Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.

  Journal of medicinal chemistry 20010524

• Preconditioning limits mitochondrial Ca(2+) during ischemia in rat hearts: role of K(ATP) channels.

  American journal of physiology. Heart and circulatory physiology 20010501

• Increased intracellular calcium is required for spreading of rat islet beta-cells on extracellular matrix.

  Diabetes 20010501

• Chloride channels regulate HIT cell volume but cannot fully account for swelling-induced insulin secretion.

  Diabetes 20010501

• The role of cyclic AMP in the pathogenesis of glucose desensitization in rat pancreatic islets.

  Pancreas 20010501

• Opening of mitochondrial K(ATP) channels triggers cardioprotection. Are reactive oxygen species involved?

  Circulation research 20010427

• Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism.

  Circulation research 20010427

• Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction.

  The Journal of biological chemistry 20010413

• Diabetes and hyperglycemia impair activation of mitochondrial K(ATP) channels.

  American journal of physiology. Heart and circulatory physiology 20010401

• Opening of mitochondrial ATP-sensitive potassium channels enhances cardioplegic protection.

  The Annals of thoracic surgery 20010401

• Interaction of sulfonylurea-conjugated polymer with insulinoma cell line of MIN6 and its effect on insulin secretion.

  Journal of biomedical materials research 20010401

• Restoration of Ca2+-inhibited oxidative phosphorylation in cardiac mitochondria by mitochondrial Ca2+ unloading.

  Molecular and cellular biochemistry 20010401

• Functional roles of cardiac and vascular ATP-sensitive potassium channels clarified by Kir6.2-knockout mice.

  Circulation research 20010330

• Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells.

  The Journal of biological chemistry 20010302

• Methyl pyruvate initiates membrane depolarization and insulin release by metabolic factors other than ATP.

  The Biochemical journal 20010301

• Oxytocin antagonist disrupts hypotension-evoked renin secretion and other responses in conscious rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010301

• Pituitary adenylate cyclase-activating polypeptide activates K(ATP) current in rat atrial myocytes.

  American journal of physiology. Heart and circulatory physiology 20010301

• Neurologic outcomes of 90 neonates and infants with persistent hyperinsulinemic hypoglycemia.

  Pediatrics 20010301

• Continuous infusion of glucagon induces severe hyponatremia and thrombocytopenia in a premature neonate.

  Pediatrics 20010301

• Characterization of secretory and morphologic properties of primary cultured endocrine cells from porcine pancreata.

  Pancreas 20010301

• Diazoxide, a K(ATP) opener, accelerates restitution of ethanol or indomethacin-induced gastric ulceration in rats independent of polyamines.

  Journal of gastroenterology and hepatology 20010301

• Failure to precondition pathological human myocardium.

  Journal of the American College of Cardiology 20010301

• Mitochondrial ATP-sensitive K+ channels play a role in cardioprotection by Na+-H+ exchange inhibition against ischemia/reperfusion injury.

  Journal of the American College of Cardiology 20010301

• Potassium channel openers depolarize hippocampal mitochondria.

  Brain research 20010216

• Involvement of K(ATP) channels in diethylstilbestrol-induced relaxation in rat aorta.

  European journal of pharmacology 20010209

• Bioenergetic consequences of opening the ATP-sensitive K(+) channel of heart mitochondria.

  American journal of physiology. Heart and circulatory physiology 20010201

• Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels.

  Molecular pharmacology 20010201

• Diazoxide protects mitochondria from anoxic injury: implications for myopreservation.

  The Journal of thoracic and cardiovascular surgery 20010201

• [Cardioprotective mechanism of ischemic preconditioning is impaired by postinfarct ventricular remodeling through angiotensin II type 1 receptor activation].

  Journal of cardiology 20010201

• Effects of glucose and amino acids on free ADP in betaHC9 insulin-secreting cells.

  Diabetes 20010201

• Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

  Diabetes 20010201

• Hyperinsulinism of infancy: the regulated release of insulin by KATP channel-independent pathways.

  Diabetes 20010201

• Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.

  Diabetes 20010201

• Overstimulation and beta-cell function.

  Diabetes 20010201

• [Personal experience with surgical treatment of insulinoma].

  Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti 20010201

• Downregulation of the voltage-dependent calcium channel (VDCC) beta-subunit mRNAs in pancreatic islets of type 2 diabetic rats.

  Biochemical and biophysical research communications 20010126

• K(ATP) channel blockers selectively interact with A(1)-adenosine receptor mediated modulation of acetylcholine release in the rat hippocampus.

  Brain research 20010119

• Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic alpha -cells.

  The Journal of biological chemistry 20010112

• Direct activation of mitochondrial K(ATP) channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts.

  Cardiovascular research 20010101

• Dual roles of mitochondrial K(ATP) channels in diazoxide-mediated protection in isolated rabbit hearts.

  American journal of physiology. Heart and circulatory physiology 20010101

• Role of mitochondrial and sarcolemmal K(ATP) channels in ischemic preconditioning of the canine heart.

  American journal of physiology. Heart and circulatory physiology 20010101

• Acute hypertension inhibits thirst stimulated by ANG II, hyperosmolality, or hypovolemia in rats.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010101

• Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes.

  Journal of molecular and cellular cardiology 20010101

• Ischemic preconditioning with opening of mitochondrial adenosine triphosphate-sensitive potassium channels or Na/H exchange inhibition: which is the best protective strategy for heart transplants?

  The Journal of thoracic and cardiovascular surgery 20010101

• Insulin autoimmune syndrome: the second Dutch case.

  The Netherlands journal of medicine 20010101

• Diazoxide and trimethaphan used?

  Chest 20010101

• Mitochondrial ATP-sensitive potassium channel plays a dominant role in ischemic preconditioning of rabbit heart.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20010101

• Intracellular potassium and chloride channels: an update.

  Acta biochimica Polonica 20010101

• Disopyramide and its metabolite enhance insulin release from clonal pancreatic beta-cells by blocking K(ATP) channels.

  Cardiovascular drugs and therapy 20010101

• Consequences of haemolysis without haptoglobin.

  Redox report : communications in free radical research 20010101

• Cholelithiasis in a newborn following treatment with the somatostatin analogue octreotide.

  European journal of pediatrics 20000701

• Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway.

  American journal of physiology. Endocrinology and metabolism 20000501

• Drugs for rapid treatment of very high blood pressure during pregnancy.

  The Cochrane database of systematic reviews 20000101

• Modulation of beta-cell ouabain-sensitive 86Rb+ influx (Na+/K+ pump) by D-glucose, glibenclamide or diazoxide.

  International journal of experimental diabetes research 20000101

• NADH shuttle system regulates K(ATP) channel-dependent pathway and steps distal to cytosolic Ca(2+) concentration elevation in glucose-induced insulin secretion.

  The Journal of biological chemistry 19990903

• PIP2 and PIP as determinants for ATP inhibition of KATP channels.

  Science (New York, N.Y.) 19981106

• Glucose regulation of islet amyloid polypeptide gene expression in rat pancreatic islets.

  The American journal of physiology 19970401

• Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channel.

  The Journal of physiology 19970315

• A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel.

  The Journal of biological chemistry 19961004

• Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor.

  Science (New York, N.Y.) 19951117

• Involvement of potassium and calcium channels at the locus coeruleus in fentanyl-induced muscular rigidity in the rat.

  Neuroscience letters 19951027

• Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.

  Life sciences 19950101

• Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 19930901

• Drug-induced diabetes.

  Bailliere's clinical endocrinology and metabolism 19921001

• Hypertrophic cardiomyopathy after prolonged diazoxide therapy for hyperinsulinemic hypoglycemia.

  The Journal of pediatrics 19910601

• Relationship between thirst and diazoxide-induced hypotension in rats.

  The American journal of physiology 19900801

• Complications of diazoxide treatment in persistent neonatal hyperinsulinism.

  Archives of disease in childhood 19891001

• Reversal by hypothermia of vasodilator-induced tachycardia in anesthetized rats.

  Archives internationales de pharmacodynamie et de therapie 19870801

• Complications of diazoxide in the treatment of nesidioblastosis.

  Archives of disease in childhood 19850101

• Leucine-induced hypoglycemia in a family: effect of diphenylhydantoin, oxprenolol, and diazoxide.

  Hormone research 19840101

• Effect of diazoxide-induced hypotension on cerebral blood flow in hypertensive rats.

  European journal of clinical investigation 19830601

• Vasodilators in the treatment of hypertension.

  Comprehensive therapy 19821101

• Treatment of hypertensive emergencies of pregnancy.

  Clinical pharmacy 19820101

• Hazards of diazoxide in pulmonary hypertension.

  British heart journal 19811001

• [Prolonged hypotension after the first dose of atenolol (author's transl)].

  Medicina clinica 19810425

• Studies in the rat on endralazine, a new antihypertensive drug structurally related to hydralazine.

  Clinical and experimental pharmacology & physiology 19810101

• Blindness and malignant hypertension.

  Lancet (London, England) 19791013

• Individual titration of diazoxide dosage in the treatment of severe hypertension.

  The American journal of cardiology 19790301

• Comparison of effects on cerebral blood flow of rapid reduction in systemic arterial pressure by diazoxide and labetalol in hypertensive patients: preliminary findings.

  British journal of clinical pharmacology 19790101

• Plasma renin and angiotensin II measurement in hypertensive and normal subjects: correlation of basal and stimulated states.

  The Journal of clinical endocrinology and metabolism 19770701

• Hypotension and bradycardia following diazoxide and hydralazine therapy.

  JAMA 19770606

• Orthostatic hypotension due to prazosin.

  Lancet (London, England) 19770212

• Hazards in antihypertension therapy.

  Annals of internal medicine 19770101

• Haemodynamic effects of prazosin.

  Archives internationales de pharmacodynamie et de therapie 19761201

• Letter: Diazoxide and myocardial ischemia.

  Annals of internal medicine 19760901

• Angina-like syndrome with diazoxide therapy for hypertensive crisis.

  Annals of internal medicine 19760601

• Effect of antidiuretic drugs in rats with lithium-induced polyuria.

  Acta pharmacologica et toxicologica 19760201

• Side effects of diazoxide.

  JAMA 19760119

• Development and management of extrapyramidal symptoms in hypertensive patients treated with diazoxide.

  American heart journal 19750301

• Oral diazoxide in uncontrolled malignant hypertension.

  The Medical journal of Australia 19741026

• Development of extrapyramidal symptoms in hypertensive patients treated with diazoxide.

  British medical journal 19730901

• Diazoxide.

  JAMA 19730813

• Intravenous diazoxide in the treatment of severe pre-eclamptic toxaemia and eclampsia.

  The Australian & New Zealand journal of obstetrics & gynaecology 19730801

• [Hyperglycemic coma without ketoacidosis in 2 hypertensive patients treated with intravenous diazoxide].

  La Nouvelle presse medicale 19720909

• Treatment of hypertension in infancy with diazoxide: report of a case with arrhythmia as a complications of therapy.

  The Journal of pediatrics 19720401

• Hyperosmolar nonketotic coma associated with diazoxide therapy for hypoglycemia.

  The Journal of pediatrics 19710301

• Management of severe hypertension with intravenous injections of diazoxide.

  The American journal of cardiology 19691201

• Pluriglandular syndrome with hyperinsulinism. Cardiomegaly as a possible complication of diazoxide therapy.

  Proceedings of the Royal Society of Medicine 19681201

• Toxic effects of a chlorothiazide-diazoxide combination on adipose tissue and kidneys of intact rats.

  Diabetologia 19680601

• The therapeutic application of diazoxide in pediatric hypoglycemic states.

  Annals of the New York Academy of Sciences 19680411

• Experimental and clinical studies with diazoxide.

  Annals of the New York Academy of Sciences 19680411

• Influence of drugs, implanted into the hypothalamus, on the water consumption of rats.

  The Journal of pharmacology and experimental therapeutics 19680101