3644-61-9 | 2-methyl-1-(4-methylphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$25.00	$18.00
5g	95%	in stock	$42.00	$30.00
25g	95%	in stock	$90.00	$63.00
100g	95%	in stock	$299.00	$209.00

Description

• Catalog Number: AB79732
• Chemical Name: 2-methyl-1-(4-methylphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride
• CAS Number: 3644-61-9
• Molecular Formula: C16H24ClNO
• Molecular Weight: 281.82086
• MDL Number: MFCD00058211
• SMILES: CC(C(=O)c1ccc(cc1)C)CN1CCCCC1.Cl
• NSC Number: 757872

Computed Properties

• Complexity: 262
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• Undefined Atom Stereocenter Count: 1

Literature

• Fatal tolperisone poisoning: autopsy and toxicology findings in three suicide cases.

  Forensic science international 20120210

• A phase IV observational multi-centre, open-label study on efficacy and safety of tolperisone 150 mg in patients with painful muscle spasm associated with degenerative or inflammatory diseases of the musculoskeletal system.

  The Journal of the Association of Physicians of India 20110101

• An immediate hypersensitivity reaction caused by tolperisone hydrochloride.

  Journal of investigational allergology & clinical immunology 20110101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• [IGOST guideline for pharmacotherapy of low back pain].

  MMW Fortschritte der Medizin 20100812

• Tolperisone.

  The Journal of the Association of Physicians of India 20100201

• NMR analysis, protonation equilibria and decomposition kinetics of tolperisone.

  Journal of pharmaceutical and biomedical analysis 20091205

• [New therapies for spastic movement disorders].

  MMW Fortschritte der Medizin 20091001

• [Efficiency local injection therapy with preparation mydocalm in myofascial pain syndrome cervicobrachial region].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20090101

• Tolperisone: a typical representative of a class of centrally acting muscle relaxants with less sedative side effects.

  CNS neuroscience & therapeutics 20080101

• Considerable interindividual variation in the pharmacokinetics of tolperisone HCl.

  International journal of clinical pharmacology and therapeutics 20070201

• [Use of local injections of tolperisone (midocalm) in combination with tractional therapy in the treatment of vertebral static syndrome].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20070101

• [Post-operative pain therapy of a chronic pain patient].

  Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20061101

• [Comparative effciency of bakloferon and tolperizon central muscle relaxants in complex therapy of back pain].

  Voenno-meditsinskii zhurnal 20060901

• A comparative study of the action of tolperisone on seven different voltage dependent sodium channel isoforms.

  European journal of pharmacology 20060524

• HPLC determination of tolperisone in human plasma.

  Archives of pharmacal research 20060401

• [A randomized, double blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• Tolperisone-type drugs inhibit spinal reflexes via blockade of voltage-gated sodium and calcium channels.

  The Journal of pharmacology and experimental therapeutics 20051201

• A randomized, double-blind, placebo-controlled study of the efficacy and safety of tolperisone in spasticity following cerebral stroke.

  European journal of neurology 20050601

• Simple pharmacological test battery to assess efficacy and side effect profile of centrally acting muscle relaxant drugs.

  Journal of pharmacological and toxicological methods 20050101

• [Midocalm in complex therapy of chronic low back pain syndrome].

  Klinicheskaia meditsina 20050101

• [A study of mydocalm efficiency in the treatment of chronic headache of tension].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101

• [Restorative treatment of degenerative-dystrophic diseases of large joints].

  Vestnik khirurgii imeni I. I. Grekova 20040101

• Separation of basic drug enantiomers by capillary electrophoresis using chicken alpha1-acid glycoprotein: insight into chiral recognition mechanism.

  Electrophoresis 20030801

• Anaphylactic reactions to tolperisone (Mydocalm).

  Swiss medical weekly 20030628

• [Back aches often become a chronic problem. Sodium channel block against chronification].

  MMW Fortschritte der Medizin 20030619

• Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20030501

• [Fibromyalgia also has psychological origins. 'Often harmony seeking perfectionists'].

  MMW Fortschritte der Medizin 20030501

• Simultaneous micellar LC determination of lidocaine and tolperisone.

  Journal of pharmaceutical and biomedical analysis 20030326

• [To make easier everyday life of stroke patients. Muscle relaxants diminish spasms].

  MMW Fortschritte der Medizin 20030227

• [Spinal pain and its treatment with midocalm].

  Terapevticheskii arkhiv 20030101

• Prophylactic tolperisone for post-exercise muscle soreness causes reduced isometric force--a double-blind randomized crossover control study.

  European journal of pain (London, England) 20030101

• Effect of muscle relaxants on experimental jaw-muscle pain and jaw-stretch reflexes: a double-blind and placebo-controlled trial.

  European journal of pain (London, England) 20030101

• [Mydocalm causing anaphylaxis].

  Pneumonologia i alergologia polska 20030101

• [Patient with chronic backache. Disabled or muscle spasm patient?].

  MMW Fortschritte der Medizin 20021205

• [Muscular pain and fatigue: is fibromyalgia sticking behind? These points bring it to light].

  MMW Fortschritte der Medizin 20021031

• Protein domain of chicken alpha(1)-acid glycoprotein is responsible for chiral recognition.

  Biochemical and biophysical research communications 20020719

• [Preventing chronification. So pain isn't branded into memory].

  MMW Fortschritte der Medizin 20020516

• [Fibromyalgia problem case. Monotherapy is mostly insufficient].

  MMW Fortschritte der Medizin 20020425

• [Mydeton: a centrally acting muscle relaxant drug from Gedeon Richter LTD].

  Acta pharmaceutica Hungarica 20020101

• Simultaneous determination of tolperisone and lidocaine by high performance liquid chromatography.

  Journal of pharmaceutical and biomedical analysis 20011201

• Tolperisone--a novel modulator of ionic currents in myelinated axons.

  General physiology and biophysics 20011201

• Separation of basic drug enantiomers by capillary electrophoresis using ovoglycoprotein as a chiral selector: comparison of chiral resolution ability of ovoglycoprotein and completely deglycosylated ovoglycoprotein.

  Electrophoresis 20010901

• Method for recording spinal reflexes in mice: effects of thyrotropin-releasing hormone, DOI, tolperisone and baclofen on monosynaptic spinal reflex potentials.

  Japanese journal of pharmacology 20010501

• [Spastic syndrome. More mobile again after stroke].

  MMW Fortschritte der Medizin 20010308

• Use of vancomycin silica stationary phase in packed capillary electrochromatography I. Enantiomer separation of basic compounds.

  Electrophoresis 20010201

• [Two complex suicidal poisonings with drugs and their medicolegal aspects].

  Przeglad lekarski 20010101

• [Neuropharmacological studies on tolperisone hydrochloride (author's transl)].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19791001