367-29-3 | 5-Fluoro-2-methylaniline

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$16.00	$11.00
10g	98%	in stock	$20.00	$14.00
25g	98%	in stock	$25.00	$18.00
100g	98%	in stock	$40.00	$28.00
500g	98%	in stock	$145.00	$101.00

Description

• Catalog Number: AB69253
• Chemical Name: 5-Fluoro-2-methylaniline
• CAS Number: 367-29-3
• Molecular Formula: C7H8FN
• Molecular Weight: 125.1435
• MDL Number: MFCD00007764
• SMILES: Fc1ccc(c(c1)N)C
• NSC Number: 60730

Computed Properties

• Complexity: 94.9
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.9

Upstream Synthesis Route

5-Fluoro-2-methylaniline, also known as FMFMA, is a versatile chemical compound commonly used in chemical synthesis due to its unique properties and reactivity. As a substituted aniline derivative, FMFMA serves as a valuable building block in the creation of various pharmaceuticals, agrochemicals, and organic compounds.In chemical synthesis, 5-Fluoro-2-methylaniline is frequently employed as a key intermediate in the production of specialized dyes, polymers, and pharmaceutical ingredients. Its fluorine substituent enhances the compound's nucleophilic and directing properties, making it highly useful in reactions involving electrophilic aromatic substitution and nucleophilic substitution. Additionally, the methyl group on the amino nitrogen atom provides steric hindrance, influencing the compound's regioselectivity in certain reactions.Moreover, the presence of the fluorine atom in the molecule imparts unique properties to the resulting products, such as improved bioactivity in pharmaceuticals or altered dye characteristics in colorants. By carefully controlling the reaction conditions and choosing appropriate coupling partners, chemists can harness the synthetic potential of 5-Fluoro-2-methylaniline to access a wide range of structurally diverse compounds with tailored properties and functionalities.

Literature

• Isomer selective IR-UV depletion spectroscopy of 4-fluorotoluene-NH3: evidence for π-proton-acceptor and linear hydrogen-bonded complexes.

  Physical chemistry chemical physics : PCCP 20110914

• The role of the methyl group in stabilising the weak N-H...pi hydrogen bond in the 4-fluorotoluene-ammonia complex.

  Physical chemistry chemical physics : PCCP 20100107