371942-69-7 | YM-201636

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$34.00	$24.00
2mg	98%	in stock	$47.00	$33.00
5mg	98%	in stock	$68.00	$48.00
25mg	98%	in stock	$191.00	$134.00
50mg	98%	in stock	$324.00	$227.00
100mg	98%	in stock	$549.00	$384.00
250mg	98%	in stock	$1,098.00	$768.00

Description

• Catalog Number: AF57720
• Chemical Name: YM-201636
• CAS Number: 371942-69-7
• Molecular Formula: C25H21N7O3
• Molecular Weight: 467.47933999999987
• MDL Number: MFCD16038303
• SMILES: Nc1ccc(cn1)C(=O)Nc1cccc(c1)c1nc(N2CCOCC2)c2c(n1)c1cccnc1o2

Computed Properties

• Complexity: 738
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 2.5

Literature

• Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.

  Journal of medicinal chemistry 20121108

• The PIKfyve inhibitor YM201636 blocks the continuous recycling of the tight junction proteins claudin-1 and claudin-2 in MDCK cells.

  PloS one 20120101

• Identification of a novel signaling pathway and its relevance for GluA1 recycling.

  PloS one 20120101

• Genetic interaction between MTMR2 and FIG4 phospholipid phosphatases involved in Charcot-Marie-Tooth neuropathies.

  PLoS genetics 20111001

• Phosphoinositides direct equine infectious anemia virus gag trafficking and release.

  Traffic (Copenhagen, Denmark) 20110401

• Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.

  The EMBO journal 20100421

• YM201636, an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, halts glucose entry by insulin in adipocytes.

  Biochemical and biophysical research communications 20090508

• A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding.

  EMBO reports 20080201