37386-15-5 | Pyrrolidin-1-ylacetic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$10.00	$7.00
1g	95%	in stock	$25.00	$18.00
5g	95%	in stock	$92.00	$65.00
25g	95%	in stock	$385.00	$270.00

Description

• Catalog Number: AB58845
• Chemical Name: Pyrrolidin-1-ylacetic acid
• CAS Number: 37386-15-5
• Molecular Formula: C6H11NO2
• Molecular Weight: 129.157
• MDL Number: MFCD04114075
• SMILES: OC(=O)CN1CCCC1

Computed Properties

• Complexity: 108
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: -2.8

Upstream Synthesis Route

2-(Pyrrolidin-1-yl)acetic acid is a versatile compound widely utilized in chemical synthesis. As a key building block in organic chemistry, this compound serves as a crucial intermediate in the production of various pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure containing a pyrrolidine ring and a carboxylic acid functionality enables it to participate in a variety of synthetic reactions.In chemical synthesis, 2-(Pyrrolidin-1-yl)acetic acid plays a pivotal role in the formation of biologically active compounds and complex organic molecules. Its incorporation into the molecular structure of target compounds can lead to enhanced bioactivity, improved pharmacokinetic properties, and increased stability. This compound can undergo diverse transformation reactions such as esterification, amidation, and condensation to introduce specific functional groups or modify existing chemical moieties.Additionally, 2-(Pyrrolidin-1-yl)acetic acid is often used as a chiral building block, allowing for the creation of enantiomerically pure compounds. The presence of the pyrrolidine ring imparts stereochemical control during reactions, making it a valuable tool in asymmetric synthesis. This compound's versatility and reactivity make it a valuable asset in the synthesis of complex molecules with diverse applications in the fields of pharmaceuticals, materials science, and organic chemistry.

Literature

• New highly potent GABA uptake inhibitors selective for GAT-1 and GAT-3 derived from (R)- and (S)-proline and homologous pyrrolidine-2-alkanoic acids.

  European journal of medicinal chemistry 20060701

• Syntheses and SAR studies of 4-(heteroarylpiperdin-1-yl-methyl)-pyrrolidin-1-yl-acetic acid antagonists of the human CCR5 chemokine receptor.

  Bioorganic & medicinal chemistry letters 20040705

• Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.

  Bioorganic & medicinal chemistry letters 20040223

• Rapid fluorescent screening for bifunctional amine-acid catalysts: efficient syntheses of quaternary carbon-containing aldols under organocatalysis.

  Organic letters 20031113

• Determination of copper, nickel, cobalt, silver, lead, cadmium, and mercury ions in water by solid-phase extraction and the RP-HPLC with UV-Vis detection.

  Analytical and bioanalytical chemistry 20030301