37517-30-9 | N-(3-acetyl-4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butanamide

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$63.00	$45.00
250mg	95%	in stock	$151.00	$106.00
1g	95%	in stock	$153.00	$107.00
5g	95%	in stock	$432.00	$303.00
10g	95%	in stock	$712.00	$498.00

Description

• Catalog Number: AI49189
• Chemical Name: N-(3-acetyl-4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}phenyl)butanamide
• CAS Number: 37517-30-9
• Molecular Formula: C18H28N2O4
• Molecular Weight: 336.4259
• MDL Number: MFCD00599435
• SMILES: CCCC(=O)Nc1ccc(c(c1)C(=O)C)OCC(CNC(C)C)O

Computed Properties

• Complexity: 401
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 10
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.7

Literature

• Trace determination of β-blockers and β2-agonists in distilled and waste-waters using liquid chromatography-tandem mass spectrometry and solid-phase extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20121101

• Active components of frequently used β-blockers from the aspect of computational study.

  Journal of molecular modeling 20120901

• Determination of celiprolol in human plasma using high performance liquid chromatography with fluorescence detection for clinical application.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

• A trans-specific polymorphism in ZC3HAV1 is maintained by long-standing balancing selection and may confer susceptibility to multiple sclerosis.

  Molecular biology and evolution 20120601

• Successful and safe treatment of hemangioma with oral propranolol in a single institution.

  Korean journal of pediatrics 20120501

• Follow-up with exercise test of effort-induced ventricular arrhythmias linked to ryanodine receptor type 2 gene mutations.

  The American journal of cardiology 20120401

• Cardio classics revisited: focus on the role of amlodipine.

  Integrated blood pressure control 20120101

• Development of square-wave adsorptive stripping voltammetric method for determination of acebutolol in pharmaceutical formulations and biological fluids.

  Chemistry Central journal 20120101

• A mathematical model of mitotic exit in budding yeast: the role of Polo kinase.

  PloS one 20120101

• Performance scores in general practice: a comparison between the clinical versus medication-based approach to identify target populations.

  PloS one 20120101

• Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

  PLoS computational biology 20111201

• Infantile haemangioma and β-blockers in otolaryngology.

  European annals of otorhinolaryngology, head and neck diseases 20111101

• Recombination patterns in dicot-infecting mastreviruses mirror those found in monocot-infecting mastreviruses.

  Archives of virology 20110801

• Applicability of Greulich and Pyle method for age assessment in forensic practice on an Italian sample.

  International journal of legal medicine 20110501

• 1H and 13C NMR characteristics of β-blockers.

  Magnetic resonance in chemistry : MRC 20110501

• Propranolol as first-line treatment of head and neck hemangiomas.

  Archives of otolaryngology--head & neck surgery 20110501

• Population-based analysis of class effect of β blockers in heart failure.

  The American journal of cardiology 20110415

• Importance of physicochemical properties for the design of new pesticides.

  Journal of agricultural and food chemistry 20110413

• Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling.

  Trends in pharmacological sciences 20110401

• Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.

  Drug metabolism and disposition: the biological fate of chemicals 20110201

• Mechanisms of fibrinogen-acebutolol interactions: Insights from DSC, CD and LS.

  Colloids and surfaces. B, Biointerfaces 20110201

• Validated stability-indicating spectrofluorimetric methods for the determination of ebastine in pharmaceutical preparations.

  Chemistry Central journal 20110101

• Development of novel in silico model to predict corneal permeability for congeneric drugs: a QSPR approach.

  Journal of biomedicine & biotechnology 20110101

• The proteomic complexity and rise of the primordial ancestor of diversified life.

  BMC evolutionary biology 20110101

• Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent.

  International journal of analytical chemistry 20110101

• Dyslipidemia induced by drugs used for the prevention and treatment of vascular diseases.

  The open cardiovascular medicine journal 20110101

• Mammalian selenocysteine lyase is involved in selenoprotein biosynthesis.

  Journal of nutritional science and vitaminology 20110101

• Label-free integrative pharmacology on-target of drugs at the β(2)-adrenergic receptor.

  Scientific reports 20110101

• Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

  Healthcare informatics research 20101201

• Potential for biodegradation and sorption of acetaminophen, caffeine, propranolol and acebutolol in lab-scale aqueous environments.

  Journal of hazardous materials 20101115

• Occurrence and removal of estrogens and beta blockers by various processes in wastewater treatment plants.

  The Science of the total environment 20100901

• Management of infantile subglottic hemangioma: acebutolol or propranolol?

  International journal of pediatric otorhinolaryngology 20100801

• Seasonal variations in the occurrence and fate of basic and neutral pharmaceuticals in a Swedish river-lake system.

  Chemosphere 20100601

• Antibodies to piloerector muscle in a patient with lupus-lichen planus overlap syndrome.

  North American journal of medical sciences 20100601

• Fate of beta blockers in aquatic-sediment systems: sorption and biotransformation.

  Environmental science & technology 20100201

• Medicinal chemistry of drugs used in diabetic cardiomyopathy.

  Current medicinal chemistry 20100101

• Correlation effect of EGFR and CXCR4 and CCR7 chemokine receptors in predicting breast cancer metastasis and prognosis.

  Journal of experimental & clinical cancer research : CR 20100101

• Principal component analysis of HPLC retention data and molecular modeling structural parameters of cardiovascular system drugs in view of their pharmacological activity.

  International journal of molecular sciences 20100101

• Diagnosis and treatment of chronic insomnia.

  Annals of Indian Academy of Neurology 20100101

• Palmaria palmata (Dulse) as an unusual maritime aetiology of hyperkalemia in a patient with chronic renal failure: a case report.

  Journal of medical case reports 20100101

• Effect of antihypertensive therapy on cognitive functions of patients with hypertension.

  Annals of Indian Academy of Neurology 20100101

• Gesturing Meaning: Non-action Words Activate the Motor System.

  Frontiers in human neuroscience 20100101

• Comparison of the analysis of beta-blockers by different techniques.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091201

• Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

  Bioorganic & medicinal chemistry 20091001

• [Beta blockers in migraine prophylaxis].

  Brain and nerve = Shinkei kenkyu no shinpo 20091001

• The role of transporters in the pharmacokinetics of orally administered drugs.

  Pharmaceutical research 20090901

• Involvement of influx and efflux transport systems in gastrointestinal absorption of celiprolol.

  Journal of pharmaceutical sciences 20090701

• Beta-blocking agent for treatment of infantile hemangioma.

  Plastic and reconstructive surgery 20090601

• Application of ionic liquids in high performance reversed-phase chromatography.

  International journal of molecular sciences 20090601

• First record of Prorocentrum lima (Dinophyceae) inside harbor areas and along the Abruzzo region coast, W Adriatic.

  Marine pollution bulletin 20090401

• In-vitro relationship between protein-binding and free drug concentrations of a water-soluble selective beta-adrenoreceptor antagonist (atenolol) and its interaction with arsenic.

  Journal of health, population, and nutrition 20090201

• Using supported liquid extraction together with cellobiohydrolase chiral stationary phases-based liquid chromatography with tandem mass spectrometry for enantioselective determination of acebutolol and its active metabolite diacetolol in spiked human plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090115

• Determination of selected beta-receptor antagonists in biological samples by solid-phase extraction with cholesterolic phase and LC/MS.

  Analytical and bioanalytical chemistry 20090101

• Pharmaceutical cleaning validation using non-proximate large-area desorption electrospray ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

• Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

  Journal of medicinal chemistry 20081113

• Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.

  Journal of medicinal chemistry 20081009

• Simultaneous determination of beta-blockers in human plasma using liquid chromatography-tandem mass spectrometry.

  Biomedical chromatography : BMC 20080701

• Ozonation of reverse osmosis concentrate: kinetics and efficiency of beta blocker oxidation.

  Water research 20080601

• Stability of chosen beta-adrenolytic drugs of different polarity in basic environment.

  Journal of AOAC International 20080101

• Beta-blockers use in patients with chronic obstructive pulmonary disease and concomitant cardiovascular conditions.

  International journal of chronic obstructive pulmonary disease 20071201

• A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling.

  Proceedings of the National Academy of Sciences of the United States of America 20071016

• Cutaneous vasculitis induced by carvedilol.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20070801

• QSAR study on permeability of hydrophobic compounds with artificial membranes.

  Bioorganic & medicinal chemistry 20070601

• Determination of beta-blockers and beta2-agonists in sewage by solid-phase extraction and liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. A 20070504

• Elimination of pharmaceuticals in sewage treatment plants in Finland.

  Water research 20070301

• Antihypertensive and antioxidant action of amlodipine and vitamin C in patients of essential hypertension.

  Journal of clinical biochemistry and nutrition 20070301

• A population-based analysis of the class effect of beta-blockers after myocardial infarction.

  American heart journal 20070201

• Evaluation of chromatographic descriptors for the prediction of gastro-intestinal absorption of drugs.

  Journal of chromatography. A 20070105

• Spectrophotometric and spectrofluorimetric methods for analysis of acyclovir and acebutolol hydrochloride.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070101

• Clinical review: aggressive management and extracorporeal support for drug-induced cardiotoxicity.

  Critical care (London, England) 20070101

• Biopharmaceutics classification of selected beta-blockers: solubility and permeability class membership.

  Molecular pharmaceutics 20070101

• Evaluation of the impact on entomocoenosis of active agents allowed in organic olive farming against Bactrocera oleae (Gmelin, 1790).

  Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes 20070101

• [Interrelationship between changes of rate and variability of cardiac rhythm under influence of beta-adrenoblockers].

  Kardiologiia 20070101

• Abstracts of papers presented at the 2007 pittsburgh conference.

  Journal of automated methods & management in chemistry 20070101

• Amoxicillin-Induced Eosinophilic Pneumonia with Granulomatous Reaction: Discrepancy between Drug-Induced Lymphocyte Stimulation Test Findings and the Provocation Drug Test.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20070101

• Spectrophotometric and spectrofluorimetric methods for analysis of tramadol, acebutolol and dothiepin in pharmaceutical preparations.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061201

• Analysis of neutral and basic pharmaceuticals in sewage treatment plants and in recipient rivers using solid phase extraction and liquid chromatography-tandem mass spectrometry detection.

  Journal of chromatography. A 20061117

• Spectrophotometric and spectrofluorimetric methods for analysis of acyclovir and acebutolol hydrochloride.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20061101

• Smith-Magenis syndrome: a case report of improved sleep after treatment with beta1-adrenergic antagonists and melatonin.

  The Journal of pediatrics 20060901

• Arrhythmogenic right ventricular dysplasia in pregnancy: a case report.

  The Journal of reproductive medicine 20060901

• Spectrofluorimetric determination of drugs containing active methylene group using N1-methyl nicotinamide chloride as a fluorigenic agent.

  Chemical & pharmaceutical bulletin 20060701

• Transdermal delivery of beta-blockers.

  Expert opinion on drug delivery 20060501

• Transport of acebutolol through rabbit corneal epithelium.

  Biological & pharmaceutical bulletin 20060401

• UPLC/MS for the identification of beta-blockers.

  Journal of pharmaceutical and biomedical analysis 20060224

• Stability of atenolol, acebutolol and propranolol in acidic environment depending on its diversified polarity.

  Pharmaceutical development and technology 20060101

• Effects of grapefruit juice on the pharmacokinetics of acebutolol.

  British journal of clinical pharmacology 20051201

• [Antihypertensive therapy with left cardiac insufficiency].

  Medizinische Monatsschrift fur Pharmazeuten 20051201

• Prediction and experimental validation of acute toxicity of beta-blockers in Ceriodaphnia dubia.

  Environmental toxicology and chemistry 20051001

• Assay of acebutolol in pharmaceuticals by analytical capillary isotachophoresis.

  Journal of chromatography. A 20050715

• Treatment of high blood pressure and gain in event-free life expectancy.

  Vascular health and risk management 20050601

• Acebutolol-induced subacute cutaneous lupus erythematosus.

  Skin pharmacology and physiology 20050101

• [Cholinergic urticaria revealed by beta-blockers: case report and therapeutic management].

  Therapie 20050101

• Determination of stability constants of the inclusion complexes of beta-blockers in heptakis (2,3-dimethyl-6-sulfato)-beta-cyclodextrin.

  Archives of pharmacal research 20041201

• Medication error caused by confusing drug blisters.

  Lancet (London, England) 20040626

• Spectrophotometric determination of some beta-blockers in dosage forms based on complex formation with Cu(II) and Co(II).

  Farmaco (Societa chimica italiana : 1989) 20040601

• Isotachophoresis of beta-blockers in a capillary and on a poly(methyl methacrylate) chip.

  Electrophoresis 20040601

• Simultaneous determination of thirteen beta-blockers and one metabolite by gradient high-performance liquid chromatography with photodiode-array UV detection.

  Forensic science international 20040420

• Nodal and BMP2/4 signaling organizes the oral-aboral axis of the sea urchin embryo.

  Developmental cell 20040301

• Sleep-deprived mice show altered cytokine production manifest by perturbations in serum IL-1ra, TNFa, and IL-6 levels.

  Brain, behavior, and immunity 20031201

• Evaluation of teicoplanin chiral stationary phases of 3.5 and 5 microm inside diameter silica microparticles by polar-organic mode capillary electrochromatography.

  Electrophoresis 20030901

• Evaluation of an immortalized retinal endothelial cell line as an in vitro model for drug transport studies across the blood-retinal barrier.

  Pharmaceutical research 20030901

• Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro.

  Toxicological sciences : an official journal of the Society of Toxicology 20030801

• Changes in serum lipids and antioxidant status in west Algerian patients with essential hypertension treated with acebutolol compared to healthy subjects.

  Medical science monitor : international medical journal of experimental and clinical research 20030801

• Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.

  Pharmaceutical research 20030801

• Agonist actions of 'beta-blockers' provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor.

  Molecular pharmacology 20030601

• Pharmacokinetic changes of acebutolol after oral administration in rabbits with diabetes mellitus induced by alloxan.

  Archives of pharmacal research 20030601

• Influence of cimetidine co-administration on the pharmacokinetics of acebutolol enantiomers and its metabolite diacetolol in a rat model: the effect of gastric pH on double-peak phenomena.

  International journal of pharmaceutics 20030414

• Beta 1-adrenergic antagonists and melatonin reset the clock and restore sleep in a circadian disorder, Smith-Magenis syndrome.

  Journal of medical genetics 20030101

• Atrial fibrillation in chronic dialysis patients in the United States: risk factors for hospitalization and mortality.

  BMC nephrology 20030101

• [Acute poisoning with nifedipine and acebutol: two cases].

  Przeglad lekarski 20030101

• [Toxicologic analysis of some adrenergic-beta blockers in the diagnosis of intoxications].

  Archiwum medycyny sadowej i kryminologii 20030101

• Electrocardiographic changes associated with beta-blocker toxicity.

  Annals of emergency medicine 20021201

• The effect of selective beta1-blockade on EMG signal characteristics during progressive endurance exercise.

  European journal of applied physiology 20021201

• Beta-adrenergic-receptor blockade and myocardial ischemia: something old, something new.

  Journal of cardiothoracic and vascular anesthesia 20021201

• Beta-adrenergic blockade during severe ischemia.

  Journal of cardiothoracic and vascular anesthesia 20021201

• Pharmacokinetics of acebutolol and its main metabolite, diacetolol after oral administration of acebutolol in rabbits with carbon tetrachloride-induced hepatic failure.

  Archives of pharmacal research 20020801

• Isolation and properties of genetically defined strains of the methylotrophic yeast Hansenula polymorpha CBS4732.

  Archives of microbiology 20020201

• Screening drugs for metabolic stability using pulsed ultrafiltration mass spectrometry.

  Combinatorial chemistry & high throughput screening 20020201

• Mutations of muscle glycogen synthase that disable activation by glucose 6-phosphate.

  Archives of biochemistry and biophysics 20020115

• Propranolol and metoprolol enhance the anticonvulsant action of valproate and diazepam against maximal electroshock.

  Pharmacology, biochemistry, and behavior 20020101

• Cardioselective beta-blockers for reversible airway disease.

  The Cochrane database of systematic reviews 20020101

• [Acebutolol in the treatment of arterial hypertension in pregnancy--comparison with commonly used hypertensive agents].

  Ceska gynekologie 20020101

• Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosis.

  Microbiology (Reading, England) 20011201

• beta-Adrenoceptor blockade enhances the anticonvulsant effect of glutamate receptor antagonists against maximal electroshock.

  European journal of pharmacology 20011116

• beta(1)-adrenergic antagonists improve sleep and behavioural disturbances in a circadian disorder, Smith-Magenis syndrome.

  Journal of medical genetics 20010901

• ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds.

  Journal of medicinal chemistry 20010719

• Influence of carvedilol on the benefits of physical training in patients with moderate chronic heart failure.

  European journal of heart failure 20010601

• Effect of lipophilicity on in vivo iontophoretic delivery. II. Beta-blockers.

  Biological & pharmaceutical bulletin 20010601

• Effect of an alpha-blocker (Nicergoline) and of a beta-blocker (Acebutolol) on the in vitro biosynthesis of vascular extracellular matrix.

  Pathologie-biologie 20010501

• Quantitative structure-retention and retention-activity relationships of beta-blocking agents by micellar liquid chromatography.

  Journal of chromatography. A 20010406

• First derivative spectrophotometric, TLC-densitometric, and HPLC determination of acebutolol HCL in presence of its acid-induced degradation product.

  Journal of pharmaceutical and biomedical analysis 20010201

• Cardioselective beta-blocker use in patients with reversible airway disease.

  The Cochrane database of systematic reviews 20010101

• [Interaction between melilot and acenocoumarol? (Melilotruscus aculeatus)].

  Therapie 20010101

• Comparison of the effect of perindopril and acebutolol on cerebral hemodynamics in hypertensive patients.

  Cardiovascular drugs and therapy 20010101

• [The comparison of clinical effectiveness of perindopril and acebutolol in the primary hypertension treatment].

  Przeglad lekarski 20010101

• Affinities at the verapamil binding site of MDR1-encoded P-glycoprotein: drugs and analogs, stereoisomers and metabolites.

  International journal of clinical pharmacology and therapeutics 20000401

• Acebutolol-induced ventricular tachycardia reversed with sodium bicarbonate.

  Journal of toxicology. Clinical toxicology 19990101

• Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).

  The Journal of pharmacology and experimental therapeutics 19980701

• Long-term effects on sexual function of five antihypertensive drugs and nutritional hygienic treatment in hypertensive men and women. Treatment of Mild Hypertension Study (TOMHS).

  Hypertension (Dallas, Tex. : 1979) 19970101

• Autoantibodies associated with lupus induced by diverse drugs target a similar epitope in the (H2A-H2B)-DNA complex.

  The Journal of clinical investigation 19920701

• Fulminant myasthenia gravis soon after initiation of acebutolol therapy.

  European neurology 19900101

• [Monotherapy with acebutolol in hypertensive diabetic patients].

  Polski tygodnik lekarski (Warsaw, Poland : 1960) 19900101

• Effect of intravenous and oral acebutolol in patients with bundle branch block.

  International journal of cardiology 19860201

• Relative potency of a beta-blocking and a calcium entry blocking agent as antihypertensive drugs in black patients.

  European journal of clinical pharmacology 19860101

• Central action of beta-adrenoceptor antagonists on blood pressure after acute administration in rats.

  Journal de pharmacologie 19860101

• Acebutolol in essential hypertension: results of two multicenter studies against placebo and propranolol.

  American heart journal 19850501

• Comparison of acebutolol and hydrochlorothiazide in essential hypertension.

  American heart journal 19850501

• The psychological side effects of acebutolol and atenolol.

  British journal of clinical pharmacology 19840301

• [Antidotal treatment of acebutolol poisoning].

  Arzneimittel-Forschung 19840101

• Mechanisms of antihypertensive action of beta-adrenergic blocking drugs: evidence against potentiation of baroreflexes.

  European heart journal 19830701

• Pharmacological properties of diacetolol (M & B 16,942), a major metabolite of acebutolol.

  European journal of pharmacology 19820507

• [Dose-response relationship and duration of action of acebutolol / investigations on heart rate behaviour and ischemic ST-segment depression].

  Arzneimittel-Forschung 19820101

• Addition of acebutolol to diuretics in hypertension.

  Clinical pharmacology and therapeutics 19811201

• New drugs for treating cardiac arrhythmias.

  Postgraduate medicine 19810101

• Effects of beta-adrenergic blocking drugs in hypertensive rats.

  Journal of pharmacobio-dynamics 19800101

• [Electrophysiological properties of injectable acebutolol. A study of one case of auriculo-ventricular block observed under acebutolol per os (author's transl)].

  Annales de cardiologie et d'angeiologie 19790101

• Randomised study of six beta-blockers and a thiazide diuretic in essential hypertension.

  British medical journal 19780805

• Cutaneous vasculitis due to acebutolol.

  Lancet (London, England) 19770827

• Suppression of premature ventricular contractions by acebutolol.

  Circulation 19770501

• [Test with trinitrine. Clinical evaluation of the beta anti-adrenergic effect of acebutolol in arterial hypertension].

  La Nouvelle presse medicale 19751231

• [Pharmacology of acebutolol in animals].

  La Nouvelle presse medicale 19751231

• A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practolol.

  British journal of pharmacology 19740301