3811-73-2 | 2-Mercaptopyridine N-oxide sodium salt

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$25.00	$18.00
25g	97%	in stock	$26.00	$18.00
100g	97%	in stock	$57.00	$40.00
500g	97%	in stock	$167.00	$117.00

Description

• Catalog Number: AI49340
• Chemical Name: 2-Mercaptopyridine N-oxide sodium salt
• CAS Number: 3811-73-2
• Molecular Formula: C5H4NNaOS
• Molecular Weight: 149.1461
• MDL Number: MFCD01941547
• SMILES: [S-]c1cccc[n+]1[O-].[Na+]

Computed Properties

• Complexity: 162
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2

Upstream Synthesis Route

Sodium omadine, also known as sodium 2-pyridinethiol-1-oxide, is a versatile chemical compound widely used in various chemical synthesis applications. Its remarkable properties make it a popular choice for catalyzing reactions and providing antimicrobial properties in different chemical processes.In organic synthesis, sodium omadine acts as a catalyst for the oxidation of organic substrates. It efficiently promotes the oxidation of alcohols to aldehydes and ketones, making it a valuable tool in the production of pharmaceuticals, fragrances, and other fine chemicals. Additionally, it is used in the synthesis of heterocyclic compounds and other complex organic molecules.Furthermore, Sodium omadine is also utilized in polymer chemistry as a stabilizer and antimicrobial agent. By inhibiting the growth of bacteria, fungi, and algae, it helps extend the shelf life of various polymer products and prevents microbial contamination during production processes.Its effectiveness in promoting chemical reactions and its antimicrobial properties make sodium omadine an essential component in the toolkit of chemists and researchers working in the fields of organic synthesis and polymer chemistry.

Literature

• Species sensitivity distribution approach to primary risk analysis of the metal pyrithione photodegradation product, 2,2'-dipyridyldisulfide in the Inland Sea and induction of notochord undulation in fish embryos.

  Aquatic toxicology (Amsterdam, Netherlands) 20120815

• The versatile binding mode of transition-state analogue inhibitors of tyrosinase towards dicopper(II) model complexes: experimental and theoretical investigations.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20111125

• Single-substance and mixture toxicity of five pharmaceuticals and personal care products to marine periphyton communities.

  Environmental toxicology and chemistry 20110901

• Dense fouling in acid transfer pipelines by an acidophilic rubber degrading fungus.

  Biofouling 20110701

• Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum.

  Journal of agricultural and food chemistry 20110525

• Direct observation of the β-carotene reaction with hydroxyl radical.

  The journal of physical chemistry. B 20110310

• Zinc is a potential therapeutic for chemoresistant ovarian cancer.

  Journal of experimental therapeutics & oncology 20110101

• Activation of the orphan receptor tyrosine kinase ALK by zinc.

  Biochemical and biophysical research communications 20100806

• Zinc signals promote IL-2-dependent proliferation of T cells.

  European journal of immunology 20100501

• K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport.

  Respiratory research 20100101

• Leaching of hydrophobic Cu and Zn from discarded marine antifouling paint residues: evidence for transchelation of metal pyrithiones.

  Environmental pollution (Barking, Essex : 1987) 20091201

• Metal ionophores - an emerging class of anticancer drugs.

  IUBMB life 20091101

• Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action.

  Journal of inorganic biochemistry 20091001

• Pyrithione and 8-hydroxyquinolines transport lead across erythrocyte membranes.

  Translational research : the journal of laboratory and clinical medicine 20090901

• Molecular mechanism underlying Akt activation in zinc-induced cardioprotection.

  American journal of physiology. Heart and circulatory physiology 20090801

• Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+.

  Proceedings of the National Academy of Sciences of the United States of America 20090519

• Aryl-bridged 1-hydroxypyridin-2-one: sensitizer ligands for Eu(III).

  Inorganic chemistry 20080721

• Synthesis and anticancer properties of water-soluble zinc ionophores.

  Cancer research 20080701

• Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20080601

• In vitro-refolding of a single-chain Fv fragment in the presence of heteroaromatic thiols.

  Journal of biotechnology 20080430

• Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.

  American journal of physiology. Cell physiology 20080301

• Comparative effects of sodium pyrithione evoked intracellular calcium elevation in rodent and primate ventral horn motor neurons.

  Biochemical and biophysical research communications 20080201

• Thioperoxy derivative generated by UV-induced transformation of N-hydroxypyridine-2(1H)-thione isolated in low-temperature matrixes.

  The journal of physical chemistry. A 20080117

• NADPH-dependent coenzyme Q reductase is the main enzyme responsible for the reduction of non-mitochondrial CoQ in cells.

  BioFactors (Oxford, England) 20080101

• Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates.

  Molecular and cellular neurosciences 20070801

• Automated laser scanning cytometry: a powerful tool for multi-parameter analysis of drug-induced apoptosis.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070201

• Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3beta signaling.

  Experimental cell research 20070115

• Chemical genetics suggests a critical role for lysyl oxidase in zebrafish notochord morphogenesis.

  Molecular bioSystems 20070101

• Zinc induces ERK-dependent cell death through a specific Ras isoform.

  Apoptosis : an international journal on programmed cell death 20061101

• Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation.

  Journal of neuroscience research 20060101

• Product pharmacology and medical actives in achieving therapeutic benefits.

  The journal of investigative dermatology. Symposium proceedings 20051201

• A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos.

  The journal of investigative dermatology. Symposium proceedings 20051201

• S100A9 deficiency alters adenosine-5'-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils.

  The international journal of biochemistry & cell biology 20050601

• Activation of caspase-3 in HL-60 cells treated with pyrithione and zinc.

  Biological & pharmaceutical bulletin 20050401

• Effect of Zn2+ ions on ryanodine binding to sarcoplasmic reticulum of striated muscles in the presence of pyrithione.

  Acta pharmacologica Sinica 20041201

• Chromatographic behavior of pyrithiones.

  Journal of chromatography. A 20041015

• Activation of a calcium entry pathway by sodium pyrithione in the bag cell neurons of Aplysia.

  Journal of neurobiology 20040915

• Characterisation of zinc uptake into rat cultured cerebrocortical oligodendrocyte progenitor cells.

  Neuroscience letters 20031204

• Blocking NF-kappaB activation may be an effective strategy in the fever therapy.

  The Japanese journal of physiology 20031001

• Role of lipid-soluble complexes in targeted tumor therapy.

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030801

• Nuclear factor-kappaB inhibitors abolish hypoxic vasoconstriction in sheep-isolated pulmonary arteries.

  European journal of pharmacology 20030101

• Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.

  European journal of biochemistry 20021201

• Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20021201

• Zinc is involved in the expression of a nuclear-encoded alternative oxidase gene in the yeast Hansenula anomala.

  Bioscience, biotechnology, and biochemistry 20021201

• One-electron oxidation of 'photo-Fenton' reagents and inhibition of lipid peroxidation.

  Biochemical and biophysical research communications 20021122

• Studies on cytotoxic and genotoxic effects of N-hydroxypyridine-2-thione (Omadine) in L5178Y mouse lymphoma cells.

  Toxicology letters 20021115

• Delayed diagnosis of occupational contact dermatitis from sodium pyrithione in a metalworking fluid.

  Contact dermatitis 20021001

• The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715

• Antimicrobial susceptibility changes and T-OMP shifts in pyrithione-passaged planktonic cultures of Pseudomonas aeruginosa PAO1.

  Journal of applied microbiology 20020101

• Elevated intracellular zinc and altered proton homeostasis in forebrain neurons.

  Neuroscience 20020101

• Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells.

  Journal of neurochemistry 20010801

• Allergic contact dermatitis from sodium pyrithione in metalworking fluid.

  Contact dermatitis 20010701