383432-38-0 | CP-724714

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$15.00	$11.00
5mg	99%	in stock	$37.00	$26.00

Description

• Catalog Number: AD39406
• Chemical Name: CP-724714
• CAS Number: 383432-38-0
• Molecular Formula: C27H27N5O3
• Molecular Weight: 469.53497999999996
• MDL Number: MFCD15144738
• SMILES: COCC(=O)NC/C=C/c1ccc2c(c1)c(ncn2)Nc1ccc(c(c1)C)Oc1ccc(nc1)C

Computed Properties

• Complexity: 692
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 9
• XLogP3: 4.3

Literature

• Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

  European journal of medicinal chemistry 20110601

• Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

  Toxicological sciences : an official journal of the Society of Toxicology 20090401

• Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach.

  Journal of medicinal chemistry 20080626

• Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety.

  Cancer chemotherapy and pharmacology 20080601

• A quantitative analysis of kinase inhibitor selectivity.

  Nature biotechnology 20080101

• Population pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors.

  Cancer chemotherapy and pharmacology 20071101

• Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.

  Cancer research 20071015

• First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20070215