386715-33-9 | 5-(Chloromethyl)-2-(trifluoromethyl)pyridine

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$8.00	$5.00
250mg	97%	in stock	$18.00	$12.00
1g	97%	in stock	$25.00	$17.00
5g	97%	in stock	$99.00	$70.00
10g	97%	in stock	$182.00	$128.00

Description

• Catalog Number: AB51143
• Chemical Name: 5-(Chloromethyl)-2-(trifluoromethyl)pyridine
• CAS Number: 386715-33-9
• Molecular Formula: C7H5ClF3N
• Molecular Weight: 195.5695
• MDL Number: MFCD01862650
• SMILES: ClCc1ccc(nc1)C(F)(F)F

Computed Properties

• Complexity: 148
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• XLogP3: 2.2

Upstream Synthesis Route

The 5-(Chloromethyl)-2-(trifluoromethyl)pyridine compound is commonly utilized in chemical synthesis as a versatile building block. Its unique combination of functional groups, including a chloromethyl and trifluoromethyl group on a pyridine ring, imparts specific reactivity that enables its integration into a wide range of synthetic pathways. In organic synthesis, this compound serves as a key intermediate in the construction of various pharmaceuticals, agrochemicals, and materials. The chloromethyl group is particularly valuable for introducing nucleophilic substitution reactions, enabling the attachment of diverse functional groups. Additionally, the trifluoromethyl group enhances the compound's lipophilicity, biological activity, and stability, making it an essential component in drug discovery and development.Moreover, 5-(Chloromethyl)-2-(trifluoromethyl)pyridine can participate in transition metal-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Heck, and Sonogashira couplings, to form complex molecular architectures efficiently. This versatility in chemical transformations makes it a valuable tool for the synthesis of intricate organic molecules with diverse applications in medicinal chemistry, materials science, and other related fields.