3878-55-5 | Mono-methyl succinate

Packsize	Purity	Availability	Price	Discounted Price
25g	95%	in stock	$13.00	$9.00
100g	95%	in stock	$34.00	$24.00
500g	95%	in stock	$77.00	$54.00

Description

• Catalog Number: AB49537
• Chemical Name: Mono-methyl succinate
• CAS Number: 3878-55-5
• Molecular Formula: C5H8O4
• Molecular Weight: 132.1146
• MDL Number: MFCD00002788
• SMILES: COC(=O)CCC(=O)O
• NSC Number: 511

Computed Properties

• Complexity: 118
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4

Literature

• Repeated, selection-driven genome reduction of accessory genes in experimental populations.

  PLoS genetics 20120501

• Supplementation of pyruvate prevents palmitate-induced impairment of glucose uptake in C2 myotubes.

  Molecular and cellular endocrinology 20111015

• Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment.

  The Biochemical journal 20110801

• Phagocyte-like NADPH oxidase generates ROS in INS 832/13 cells and rat islets: role of protein prenylation.

  American journal of physiology. Regulatory, integrative and comparative physiology 20110301

• Development of an orthodontic elastic material using EMA-based resin combined with 1-butanol.

  Dental materials journal 20110101

• 2-Phenyl-biguanidinium hydrogen succinate methanol monosolvate.

  Acta crystallographica. Section E, Structure reports online 20101201

• Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.

  American journal of physiology. Endocrinology and metabolism 20090601

• Total synthesis of the natural succinate derivative of 5-(hydroxymethyl)furfural isolated from the Noni fruit (Morinda citrifolia).

  Natural product research 20090101

• Comprehensive proteomics of Methylobacterium extorquens AM1 metabolism under single carbon and nonmethylotrophic conditions.

  Proteomics 20080901

• [Studies on chemical constituents of Ranunculus ternatus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

• Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion.

  American journal of physiology. Cell physiology 20080201

• Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose.

  The Biochemical journal 20070401

• Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.

  British journal of pharmacology 20070401

• Synergistic potent insulin release by combinations of weak secretagogues in pancreatic islets and INS-1 cells.

  The Journal of biological chemistry 20070302

• Identification of monomenthyl succinate in natural mint extracts by LC-ESI-MS-MS and GC-MS.

  Journal of agricultural and food chemistry 20060628

• Fumarate reductase: structural and mechanistic insights from the catalytic reduction of 2-methylfumarate.

  FEBS letters 20060306

• Selective loss of glucose-induced amplification of insulin secretion in mouse pancreatic islets pretreated with sulfonylurea in the absence of fuels.

  Diabetologia 20051201

• P2Y purinergic potentiation of glucose-induced insulin secretion and pancreatic beta-cell metabolism.

  Diabetes 20041201

• Liquid chromatographic determination of oxaliplatin in blood using post-column derivatization in a microwave field followed by photometric detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005

• Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis.

  Cell death and differentiation 20030601

• Differences between mouse and rat pancreatic islets: succinate responsiveness, malic enzyme, and anaplerosis.

  American journal of physiology. Endocrinology and metabolism 20020801

• Differential effects of hyperlipidemia on insulin secretion in islets of langerhans from hyperglycemic versus normoglycemic rats.

  Diabetes 20020301

• A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion.

  Diabetes 20010601

• Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.

  Diabetes 20010201

• Differential acute and long term actions of succinic acid monomethyl ester exposure on insulin-secreting BRIN-BD11 cells.

  International journal of experimental diabetes research 20010101