-
Preconditioning with gabexate is superior to inosine for ameliorating acute renal ischemia-reperfusion injury in rats.
Transplantation proceedings 20140101
-
Clinical efficacy of gabexate mesilate for acute pancreatitis in children.
European journal of pediatrics 20131101
-
Reduced sodium transport with nasal administration of the prostasin inhibitor camostat in subjects with cystic fibrosis.
Chest 20130701
-
Effect of a serine protease inhibitor on the progression of chronic renal failure.
American journal of physiology. Renal physiology 20121015
-
In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats.
American journal of physiology. Renal physiology 20121001
-
Nafamostat mesilate, a noncalcium compound, as an anticoagulant, induces calcium-dependent haemolysis when infused with packed erythrocytes.
Transfusion medicine (Oxford, England) 20120601
-
An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice.
The Journal of clinical investigation 20120402
-
[Could nafamostat or gabexate prevent the post endoscopic retrograde cholangiopancreatography pancreatitis?].
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20120301
-
Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.
Clinical and experimental nephrology 20120201
-
Duodenal myotomy blocks reduction of meal size and prolongation of intermeal interval by cholecystokinin.
Physiology & behavior 20120201
-
Antitumoral efficacy of the protease inhibitor gabexate mesilate in colon cancer cells harbouring KRAS, BRAF and PIK3CA mutations.
PloS one 20120101
-
Effect of synthetic protease inhibitor gabexate mesilate on attenuation of coagulant activity and cytokine release in a rat model of islet transplantation.
Transplantation proceedings 20111101
-
Oral delivery system for two-pulse colonic release of protein drugs and protease inhibitor/absorption enhancer compounds.
Journal of pharmaceutical sciences 20110801
-
Role of TRPV1 in nociception and edema induced by monosodium urate crystals in rats.
Pain 20110801
-
The short term satiety peptide cholecystokinin reduces meal size and prolongs intermeal interval.
Peptides 20110601
-
Is entirely conservative management a correct strategy for hemodynamically stable patient with a grade IV blunt pancreatic injury?
World journal of surgery 20110401
-
ONO 3403, a synthetic serine protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-{alpha} and nitric oxide production and protects mice from lethal endotoxic shock.
Innate immunity 20110201
-
[Synthetic protease inhibitors for the treatment of DIC].
Rinsho byori. The Japanese journal of clinical pathology 20110201
-
Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury.
The Journal of surgical research 20110101
-
The effects of gabexate mesilate on the microsurgical reconstruction of the hepatic artery in living donor liver transplantation.
Transplantation proceedings 20101201
-
Effects of a synthetic protease inhibitor (gabexate mesilate) and a neutrophil elastase inhibitor (sivelestat sodium) on acid-induced lung injury in rats.
European journal of pharmacology 20100901
-
Regulator of calcineurin 1 controls growth plasticity of adult pancreas.
Gastroenterology 20100801
-
Release of interleukin-1 receptor antagonist by combining a leukocyte adsorption carrier with ulinastatin.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20100801
-
Refractory chronic urticaria treated effectively with the protease inhibitors, nafamostat mesilate and camostat mesilate.
Acta dermato-venereologica 20100701
-
Lack of therapeutic effects of gabexate mesilate on the hepatic encephalopathy in rats with acute and chronic hepatic failure.
Journal of gastroenterology and hepatology 20100701
-
Tumor-derived trypsin enhances proliferation of intrahepatic cholangiocarcinoma cells by activating protease-activated receptor-2.
International journal of oncology 20100401
-
Efficacy of camostat mesilate against dyspepsia associated with non-alcoholic mild pancreatic disease.
Journal of gastroenterology 20100301
-
Post-ERCP pancreatitis.
Journal of hepato-biliary-pancreatic sciences 20100101
-
[Treatment of disseminated intravascular coagulation].
[Rinsho ketsueki] The Japanese journal of clinical hematology 20100101
-
Stability of gabexate mesilate products: Influence of the addition of mannitol.
Bio-medical materials and engineering 20100101
-
C5a-inhibitory peptide combined with gabexate mesilate prevents the instant blood-mediated inflammatory reaction in a rat model of islet transplantation.
Transplantation proceedings 20100101
-
The specific inhibition of HepG2 cells proliferation by apoptosis induced by gabexate mesilate.
International journal of clinical and experimental pathology 20100101
-
[Treatment of DIC associated with myelogenous leukemia].
Nihon rinsho. Japanese journal of clinical medicine 20091001
-
Continuous regional arterial infusion therapy for acute necrotizing pancreatitis due to Mycoplasma pneumoniae infection in a child.
Cardiovascular and interventional radiology 20090501
-
Camostat attenuates airway epithelial sodium channel function in vivo through the inhibition of a channel-activating protease.
The Journal of pharmacology and experimental therapeutics 20090501
-
Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.
Protein science : a publication of the Protein Society 20090501
-
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Journal of hypertension 20090101
-
C5a inhibitory peptide combined with gabexate mesilate is a clinically available candidate for preventing the instant blood-mediated inflammatory reaction.
Transplantation proceedings 20090101
-
Modelling of tumour--host coexistence In vitro in the presence of serine protease inhibitors.
In vivo (Athens, Greece) 20090101
-
Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis.
World journal of gastroenterology 20081107
-
Choledochoscope manometry about different drugs on the Sphincter of Oddi.
World journal of gastroenterology 20081014
-
Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat.
Regulatory peptides 20081009
-
The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats.
International immunopharmacology 20080701
-
Protective effects of amino acids against gabexate mesilate-induced cell injury in porcine aorta endothelial cells.
Journal of pharmacological sciences 20080701
-
Pharmacological approach to acute pancreatitis.
World journal of gastroenterology 20080521
-
CCK-induced pancreatic growth is not limited by mitogenic capacity in mice.
American journal of physiology. Gastrointestinal and liver physiology 20080501
-
Characteristics of gabexate mesilate-induced cell injury in porcine aorta endothelial cells.
Journal of pharmacological sciences 20080301
-
Somatostatin bolus injection for post-ERCP pancreatitis prevention: a need for further study.
Gastrointestinal endoscopy 20080101
-
Synthetic serine protease inhibitor, gabexate mesilate, prevents nuclear factor-kappaB activation and increases TNF-alpha-mediated apoptosis in human pancreatic cancer cells.
Digestive diseases and sciences 20071001
-
Early successes and late failures in the prevention of post endoscopic retrograde cholangiopancreatography.
World journal of gastroenterology 20070714
-
Antiproteases in preventing post-ERCP acute pancreatitis.
JOP : Journal of the pancreas 20070709
-
Somatostatin and gabexate for post-endoscopic retrograde cholangiopancreatography pancreatitis prevention: meta-analysis of randomized placebo-controlled trials.
Journal of gastroenterology and hepatology 20070701
-
Efficacy of postprocedure administration of gabexate mesylate in the prevention of post-ERCP pancreatitis: a randomized, controlled, multicenter study.
Gastrointestinal endoscopy 20070601
-
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents.
Life sciences 20070501
-
Translocation of pancreatic juice after ischemia and reperfusion of the intestines and the effects of gabexate mesilate (FOY) in rats.
Transplantation proceedings 20070501
-
Prophylactic administration of somatostatin or gabexate does not prevent pancreatitis after ERCP: an updated meta-analysis.
Gastrointestinal endoscopy 20070401
-
Risk for post-ERCP pancreatitis after needle knife precut sphincterotomy following repeated cannulation attempts.
Journal of clinical gastroenterology 20070401
-
Pancreatic diabetes in a follow-up survey of chronic pancreatitis in Japan.
Journal of gastroenterology 20070401
-
Prophylaxis of post-ERCP pancreatic complications with gabexate.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20070301
-
[Typhoid fever and acute pancreatitis: two cases].
Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20070301
-
Induction of early response genes in trypsin inhibitor-induced pancreatic growth.
American journal of physiology. Gastrointestinal and liver physiology 20070201
-
Evaluation of serum amylase and gabexate mesilate with endoscopic papillary balloon dilatation.
The journal of medical investigation : JMI 20070201
-
Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials.
BMC gastroenterology 20070101
-
The papilla of Vater just below the pylorus presenting as recurrent duodenal ulcer bleeding.
Internal medicine (Tokyo, Japan) 20070101
-
Successful intermittent application of the Pringle maneuver for 30 minutes during human hepatectomy: a clinical randomized study with use of a protease inhibitor.
Hepato-gastroenterology 20070101
-
Successful liver transplantation across the ABO incompatibility barrier in 6 cases of biliary atresia.
Journal of pediatric surgery 20061201
-
A case of feline pancreatitis.
The Journal of veterinary medical science 20061201
-
Boerhaave syndrome treated conservatively following early endoscopic diagnosis: a case report.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 20061201
-
Frequency of post-ERCP pancreatitis in a single tertiary referral centre without and with routine prophylaxis with gabexate: a 6-year survey and cost-effectiveness analysis.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20060801
-
Pharmacological prevention of post-ERCP pancreatitis--an everlasting dream?
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20060801
-
Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma.
The Journal of allergy and clinical immunology 20060701
-
[Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20060701
-
Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice.
The Journal of physiology 20060615
-
Properties of poly(lactic-co-glycolic acid) nanospheres containing protease inhibitors: camostat mesilate and nafamostat mesilate.
International journal of pharmaceutics 20060511
-
Effects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats.
Pediatric surgery international 20060501
-
Calcineurin-dependent and calcineurin-independent signal transduction pathways activated as part of pancreatic growth.
Pancreas 20060401
-
Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective?
Journal of gastroenterology and hepatology 20060401
-
Evidence-based treatment of acute pancreatitis: a look at established paradigms.
Annals of surgery 20060201
-
Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
Cytokine 20060121
-
New approaches for the treatment of acute pancreatitis.
JOP : Journal of the pancreas 20060111
-
Evaluation of a protease inhibitor in the prevention of ischemia and reperfusion injury in hepatectomy under intermittent Pringle maneuver.
American journal of surgery 20060101
-
Clinical trial of gabexate in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060101
-
A case of severe acute pancreatitis, in overlap syndrome of systemic sclerosis and systemic lupus erythematosus, successfully treated with plasmapheresis.
Modern rheumatology 20060101
-
Beneficial effect of gabexate mesilate on microscopic polyangiitis with renal dysfunction and pulmonary hemorrhage: A case report.
Angiology 20060101
-
Pharmacological management of pancreatitis.
Current opinion in pharmacology 20051201
-
Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats.
Journal of gastroenterology and hepatology 20050601
-
Water and enzyme secretion are tightly coupled in pancreatic secretion stimulated by food or CCK-58 but not by CCK-8.
American journal of physiology. Gastrointestinal and liver physiology 20050501
-
Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats.
Metabolism: clinical and experimental 20050501
-
Effects of gabexate mesilate (FOY) on amylase and phospholipase A2 in human serum and pancreatic juice.
Digestive diseases and sciences 20050501
-
Gabexate mesilate and acute pancreatitis: an experience of evidence based drug information for improving rational drug use.
Pharmacy world & science : PWS 20050401
-
Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats.
Journal of gastroenterology 20050301
-
Effect of synthetic protease inhibitor gabexate mesilate on the attenuation of ischemia/reperfusion injury in canine kidney autotransplantation.
Surgery 20050201
-
Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats.
Pancreas 20050101
-
Antimetastatic activity of a synthetic serine protease inhibitor, FOY-305 (Foypan).
In vivo (Athens, Greece) 20050101
-
Gabexate mesilate hastens recovery from vecuronium-induced neuromuscular blockade.
European journal of anaesthesiology 20050101
-
Use of low dose dopamine, gabexate mesilate and ulinastatin reduces the water balance and pulmonary complication in thoracic esophagectomy patients.
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus 20050101
-
[Hepatic portal venous gas--a report of two cases successfully treated with conservative management].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20041210
-
[Essential therapeutic strategies for acute pancreatitis--guidelines for initial treatment and their significance].
Nihon rinsho. Japanese journal of clinical medicine 20041101
-
[Treatment of acute pancreatitis with protease inhibitor, H2 receptor antagonist and somatostatin analogue].
Nihon rinsho. Japanese journal of clinical medicine 20041101
-
Treatment of acute pancreatitis with protease inhibitors: a meta-analysis.
European journal of gastroenterology & hepatology 20041101
-
The effect of continuous arterial infusion of gabexate mesilate (FOY-007) on experimental acute pancreatitis.
The journal of medical investigation : JMI 20040801
-
Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research 20040701
-
Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas.
JOP : Journal of the pancreas 20040701
-
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.
American journal of physiology. Gastrointestinal and liver physiology 20040501
-
[Changes in coagulation, fibrinolysis and platelet functions during extracorporeal circulation].
Nihon rinsho. Japanese journal of clinical medicine 20040501
-
Gabexate mesilate and heparin responsiveness in coronary patients.
Medical science monitor : international medical journal of experimental and clinical research 20040301
-
[Autoimmune pancreatitis].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040110
-
Preparation and characterization of starch/cyclodextrin bioadhesive microspheres as platform for nasal administration of Gabexate Mesylate (Foy) in allergic rhinitis treatment.
Biomaterials 20040101
-
Circulating ethanol does not stimulate pancreatic secretion in conscious rats.
Pancreas 20031101
-
[A case of severe Chlamydia pneumoniae pneumonia requiring mechanical ventilation and complicated with disseminated intravascular coagulation].
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20031101
-
CCK-58 is the only detectable endocrine form of cholecystokinin in rat.
American journal of physiology. Gastrointestinal and liver physiology 20030801
-
Involvement of proteinase-activated receptor-2 in mast cell tryptase-induced barrier dysfunction in bovine aortic endothelial cells.
Cellular signalling 20030801
-
Nafamostat mesilate is an extremely potent inhibitor of human tryptase.
Journal of pharmacological sciences 20030801
-
[Prevention of hemorrhage occurring in patients with leukemia].
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20030610
-
Use of gabexate mesylate in Italian hospitals: a multicentre observational study.
Journal of clinical pharmacy and therapeutics 20030601
-
Effects of bioactive agents on biliary motor function.
Current gastroenterology reports 20030401
-
Gabexate mesilate, a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-alpha production by inhibiting activation of both nuclear factor-kappaB and activator protein-1 in human monocytes.
The Journal of pharmacology and experimental therapeutics 20030401
-
Gabexate mesilate, a synthetic anticoagulant, inhibits the expression of endothelial leukocyte adhesion molecules in vitro.
Critical care medicine 20030401
-
Systematic skepticism.
Critical care medicine 20030401
-
Changes in blood viscosity with synthetic protease inhibitors.
Journal of pharmacological sciences 20030401
-
Morphological relationship between intercalated duct and pancreatic islet in streptozotocin and/or camostat mesilate administrations in the chicken.
Anatomia, histologia, embryologia 20030401
-
Results of treating severe acute pancreatitis with gabexate is associated with neutrophil apoptosis activity.
Hepato-gastroenterology 20030101
-
Does gabexate mesilate affect serum concentrations of acute phase proteins after endoscopic retrograde cholangiopancreatography examination?
Hepato-gastroenterology 20030101
-
Acute pancreatitis occurring in the early postpartum period: a case report.
Journal of perinatal medicine 20030101
-
Gabexate mesilate (FOY) inhibition of amylase and phospholipase A(2) activity in sow pancreatic juice.
Journal of investigative surgery : the official journal of the Academy of Surgical Research 20030101
-
A possible defensive mechanism in the basal region of gastric mucosa and the healing of erosions.
Clinical hemorheology and microcirculation 20030101
-
Gabexate mesilate and/or octreotide in human immunodeficiency virus-associated pancreatic abnormalities.
Alimentary pharmacology & therapeutics 20021001
-
Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial.
Gastrointestinal endoscopy 20021001
-
Biological phenotype determination with ex vivo model in gastric cancer for matrix-metalloproteinase inhibitor treatment.
International journal of molecular medicine 20020901
-
Early capillary no-reflow during low-flow reperfusion after hind limb ischemia in the rat.
Annals of plastic surgery 20020801
-
Modulation of L-arginine transport and nitric oxide production by gabexate mesylate.
Biochemical pharmacology 20020715
-
Hepatocyte protection by a protease inhibitor against ischemia/reperfusion injury of human liver.
Journal of the American College of Surgeons 20020701
-
Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice.
Japanese journal of pharmacology 20020701
-
Predicting and preventing post-ERCP pancreatitis.
Current gastroenterology reports 20020401
-
Effects of gabexate mesilate, a protease inhibitor, on human sphincter of Oddi motility.
Digestive diseases and sciences 20020401
-
Novel trial for the treatment of steroid dependency in minimal change disease: combined therapy of camostat mesilate and glycyrrhizin.
Nephron 20020301
-
Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock.
Shock (Augusta, Ga.) 20020301
-
[Thoracic aortic aneurysm with chronic disseminated intravascular coagulation treated successfully with orally administered camostat mesilate, warfarin and aspirin].
[Rinsho ketsueki] The Japanese journal of clinical hematology 20020301
-
Differential cytokine response in host defence mechanisms triggered by gram-negative and gram-positive bacteria, and the roles of gabexate mesilate, a synthetic protease inhibitor.
The Journal of international medical research 20020101
-
A case of primary Sjögren's syndrome associated with low titer cold agglutinin disease.
Clinical and experimental rheumatology 20020101
-
Inhibition of natural killer cytotoxicity in vitro by clinical grade serine protease inhibitors.
Haematologia 20020101
-
Fatal cases of gabexate mesilate-induced anaphylaxis.
International journal of clinical pharmacology research 20020101
-
Combinatorial synthesis of SSAO inhibitors using sonogashira coupling: SAR of aryl propargylic amines.
Bioorganic & medicinal chemistry letters 20011008
-
Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid.
Anti-cancer drugs 20010901
-
Regional effects of nafamostat, a novel potent protease and complement inhibitor, on severe necrotizing pancreatitis.
Surgery 20010801
-
Successful treatment of DIC with a serine proteinase inhibitor.
The American journal of emergency medicine 20010701
-
Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta.
Gastroenterology 20010601
-
Effects of synthetic serine protease inhibitors on proliferation and collagen synthesis of human pancreatic periacinar fibroblast-like cells.
Pancreas 20010401
-
Selective inhibition of human mast cell tryptase by gabexate mesylate, an antiproteinase drug.
Biochemical pharmacology 20010201
-
Preparation and characterization of biodegradable or enteric-coated microspheres containing the protease inhibitor camostat.
The Journal of pharmacy and pharmacology 20010201
-
[Can post-ERCP acute pancreatitis be predicted and prevented?].
Gastroenterologie clinique et biologique 20010101
-
[Gabexate mesilate vs gabexate mesilate combined with octreotide in the prevention of postoperative complications of pancreatic surgery: preliminary results].
Chirurgia italiana 20010101
-
Gabexate mesilate in acute pancreatitis: miracle or mirage?
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20010101
-
Multicentre comparative study of two schedules of gabexate mesilate in the treatment of acute pancreatitis. Italian Acute Pancreatitis Study Group.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20010101
-
Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.
Journal of enzyme inhibition 20010101
-
Continuous regional arterial infusion (CRAI) therapy reduces the mortality rate of acute necrotizing pancreatitis: results of a cooperative survey in Japan.
Journal of hepato-biliary-pancreatic surgery 20010101
-
Gabexate mesilate in acute pancreatitis: neither a miracle nor a mirage, merely the search of optimal dosage.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20010101
-
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
Regulatory peptides 19990630
-
Gabexate mesylate inhibition of serine proteases: thermodynamic and computer-graphics analysis.
Journal of pharmaceutical sciences 19861201
-
Synthetic inhibitors of trypsin, plasmin, kallikrein, thrombin, C1r-, and C1 esterase.
Biochimica et biophysica acta 19771013
