399-51-9 | 6-Fluoroindole

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$9.00	$6.00
10g	98%	in stock	$16.00	$11.00
25g	98%	in stock	$36.00	$25.00
100g	98%	in stock	$135.00	$94.00

Description

• Catalog Number: AB45419
• Chemical Name: 6-Fluoroindole
• CAS Number: 399-51-9
• Molecular Formula: C8H6FN
• Molecular Weight: 135.1383
• MDL Number: MFCD00056933
• SMILES: Fc1ccc2c(c1)[nH]cc2
• NSC Number: 520436

Computed Properties

• Complexity: 126
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: 2.7

Upstream Synthesis Route

6-Fluoro-1H-indole is a valuable building block in chemical synthesis due to its unique reactivity and structural properties. This compound has found wide applications in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the synthesis of various biologically active compounds.One of the notable applications of 6-Fluoro-1H-indole is in the synthesis of novel drug candidates. The fluorine atom at the 6-position imparts distinct pharmacological properties to the resulting compounds, making them potentially more potent or selective compared to their non-fluorinated analogs. By incorporating 6-Fluoro-1H-indole into the molecular structure of drug candidates, researchers can tailor their properties to improve efficacy and reduce side effects.Furthermore, 6-Fluoro-1H-indole serves as a versatile precursor for the synthesis of heterocyclic compounds and natural products. Its ability to undergo various functional group transformations, including halogenation, alkylation, and condensation reactions, allows chemists to access a diverse array of complex molecules with interesting biological activities. The presence of the fluorine atom also offers opportunities for further diversification through fluorine-based chemistry strategies.In summary, the versatile reactivity and biological significance of 6-Fluoro-1H-indole make it a valuable tool in the hands of synthetic chemists seeking to develop new pharmaceuticals, agrochemicals, and materials. Its role as a key intermediate in the construction of molecular scaffolds underscores its importance in modern chemical synthesis strategies.

Literature

• Ionization potentials of fluoroindoles and the origin of nonexponential tryptophan fluorescence decay in proteins.

  Journal of the American Chemical Society 20050323

• Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.

  Journal of medicinal chemistry 20040603