4005-51-0 | 2-Amino-1,3,4-thiadiazole

Packsize	Purity	Availability	Price	Discounted Price
10g	97%	in stock	$8.00	$5.00
25g	97%	in stock	$18.00	$12.00
500g	97%	in stock	$133.00	$93.00

Description

• Catalog Number: AB43755
• Chemical Name: 2-Amino-1,3,4-thiadiazole
• CAS Number: 4005-51-0
• Molecular Formula: C2H3N3S
• Molecular Weight: 101.1303
• MDL Number: MFCD00003107
• SMILES: Nc1nncs1
• NSC Number: 4728

Computed Properties

• Complexity: 48.1
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• XLogP3: -0.6

Literature

• 2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.

  Bioorganic & medicinal chemistry letters 20120901

• 5-(Thio-phen-2-ylmeth-yl)-1,3,4-thia-diazol-2-amine.

  Acta crystallographica. Section E, Structure reports online 20120501

• Investigation of trypanothione reductase inhibitory activity by 1,3,4-thiadiazolium-2-aminide derivatives and molecular docking studies.

  Bioorganic & medicinal chemistry 20120301

• 4-(3,5-Dioxo-10-oxa-4-aza-tricyclo-[5.2.1.0]decan-4-yl)-10-oxa-4-aza-tricyclo-[5.2.1.0]decane-3,5-dione.

  Acta crystallographica. Section E, Structure reports online 20120201

• The in vivo activity of 1,3,4-thiadiazolium-2-aminide compounds in the treatment of cutaneous and visceral leishmaniasis.

  The Journal of antimicrobial chemotherapy 20120101

• catena-Poly[(μ-2-amino-1,3,4-thia-diazole-κN:N)di-μ-chlorido-cadmium].

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• Virtual screening identification of nonfolate compounds, including a CNS drug, as antiparasitic agents inhibiting pteridine reductase.

  Journal of medicinal chemistry 20110113

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  Journal of fluorescence 20110101

• The activity of a new 2-amino-1,3,4-thiadiazole derivative 4ClABT in cancer and normal cells.

  Folia histochemica et cytobiologica 20110101

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  Physical chemistry chemical physics : PCCP 20101028

• Selective determination of homocysteine at physiological pH using nanostructured film of aminothiadiazole modified electrode.

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  Acta crystallographica. Section E, Structure reports online 20090701

• Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibitory effects.

  Journal of enzyme inhibition and medicinal chemistry 20081201

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• Anticancer, neuroprotective activities and computational studies of 2-amino-1,3,4-thiadiazole based compound.

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• Probing Aspergillus niger glucose oxidase with pentacyanoferrate(III) aza- and thia-complexes.

  Journal of inorganic biochemistry 20061001

• Synthesis and spectroscopic studies of new Schiff bases.

  Molecules (Basel, Switzerland) 20060317

• 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole and a redetermination of 2-amino-1,3,4-thiadiazole, both at 120 K: chains of edge-fused R(2)(2)(8) and R(4)(4)(10) rings, and sheets of R(2)(2)(8) and R(6)(6)(20) rings.

  Acta crystallographica. Section C, Crystal structure communications 20060101

• Spectrophotometric and electrical studies of charge transfer complexes of 2-amino-1,3,4-thiadiazole with pi-acceptors.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

• Cytotoxic effect of a new 1,3,4-thiadiazolium mesoionic compound (MI-D) on cell lines of human melanoma.

  British journal of cancer 20040719

• Role of an aminothiazole derivative on ethanol- and thermally oxidized sunflower oil-induced toxicity.

  Polish journal of pharmacology 20040101

• Antibacterial Role of SO(4), NO(3), C(2)O(4) and CH(3)CO(2) Anions on Cu(II) and Zn(II) Complexes of a Thiadiazole-derived Pyrrolyl Schiff Base.

  Metal-based drugs 20020101

• 2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole.

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