4033-39-0 | L-2,3-Diaminopropionic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	96%	in stock	$106.00	$75.00
1g	96%	in stock	$251.00	$176.00
5g	96%	in stock	$713.00	$499.00

Description

• Catalog Number: AF68777
• Chemical Name: L-2,3-Diaminopropionic acid
• CAS Number: 4033-39-0
• Molecular Formula: C3H8N2O2
• Molecular Weight: 104.1078
• MDL Number: MFCD09265268
• SMILES: N[C@H](C(=O)O)CN

Computed Properties

• Complexity: 73.3
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2
• XLogP3: -4.3

Literature

• Capreomycin--a polypeptide antitubercular antibiotic with unusual binding properties toward copper(II).

  Journal of inorganic biochemistry 20120101

• Structure-activity relationship (SAR) of the α-amino acid residue of potent tetrahydroisoquinoline (THIQ)-derived LFA-1/ICAM-1 antagonists.

  Bioorganic & medicinal chemistry letters 20110101

• Mutation of L-2,3-diaminopropionic acid synthase genes blocks staphyloferrin B synthesis in Staphylococcus aureus.

  BMC microbiology 20110101

• Incorporation of 2,3-diaminopropionic acid into linear cationic amphipathic peptides produces pH-sensitive vectors.

  Chembiochem : a European journal of chemical biology 20100614

• Evaluation of [99mTc-(CO)3-X-Y-Bombesin(7-14)NH2] conjugates for targeting gastrin-releasing peptide receptors overexpressed on breast carcinoma.

  Anticancer research 20100101

• Molecular characterization of staphyloferrin B biosynthesis in Staphylococcus aureus.

  Molecular microbiology 20091101

• Highly enantioselective synthesis of (S)-alpha-alkyl-alpha,beta-diaminopropionic acids via asymmetric phase-transfer catalytic alkylation of 2-phenyl-2-imidazoline-4-carboxylic acid tert-butyl esters.

  Organic letters 20090820

• N-Terminal 2,3-diaminopropionic acid (Dap) peptides as efficient methylglyoxal scavengers to inhibit advanced glycation endproduct (AGE) formation.

  Bioorganic & medicinal chemistry 20090315

• Photoinduced linkage isomerism of {RuNO}(6) complexes with bioligands and related chelators.

  Dalton transactions (Cambridge, England : 2003) 20090214

• Small-molecule inhibitors of integrin alpha2beta1 that prevent pathological thrombus formation via an allosteric mechanism.

  Proceedings of the National Academy of Sciences of the United States of America 20090120

• L-2,3-diaminopropionate: one of the building blocks for the biosynthesis of Zwittermicin A in Bacillus thuringiensis subsp. kurstaki strain YBT-1520.

  FEBS letters 20080903

• A convenient route to enantiopure 3-aryl-2,3-diaminopropanoic acids by diastereoselective Mannich reaction of camphor-based tricyclic iminolactone with imines.

  The Journal of organic chemistry 20080502

• Small molecule inhibitors of integrin alpha2beta1.

  Journal of medicinal chemistry 20071101

• Asymmetric synthesis of beta2-amino acids: 2-substituted-3-aminopropanoic acids from N-acryloyl SuperQuat derivatives.

  Organic & biomolecular chemistry 20070907

• Variable stability heterodimeric coiled-coils from manipulation of electrostatic interface residue chain length.

  Journal of the American Chemical Society 20070822

• Chiroptical properties of diamino carboxylic acids.

  Chirality 20070701

• Orientation preferences of backbone secondary amide functional groups in peptide nucleic acid complexes: quantum chemical calculations reveal an intrinsic preference of cationic D-amino acid-based chiral PNA analogues for the P-form.

  Biophysical journal 20070201

• Novel parent structures for inhibitors of the murine GABA transporters mGAT3 and mGAT4.

  European journal of pharmacology 20050905

• Soluble MHC-peptide complexes induce rapid death of CD8+ CTL.

  Journal of immunology (Baltimore, Md. : 1950) 20050601

• Biochemical properties of new synthetic carnosine analogues containing the residue of 2,3-diaminopropionic acid: the effect of N-acetylation.

  Amino acids 20050201

• A conventional route for the synthesis of new oxazolidin-2-one derivatives with beta-aminoalanines.

  Chemical & pharmaceutical bulletin 20041001

• Synthesis of 9-membered dilactams derived from 1,3-diaminopropionic and glutamic acids.

  The journal of peptide research : official journal of the American Peptide Society 20040301

• An efficient synthesis of a probe for protein function: 2,3-diaminopropionic acid with orthogonal protecting groups.

  Organic letters 20040122

• Radiochemical investigations of gastrin-releasing peptide receptor-specific [(99m)Tc(X)(CO)3-Dpr-Ser-Ser-Ser-Gln-Trp-Ala-Val-Gly-His-Leu-Met-(NH2)] in PC-3, tumor-bearing, rodent models: syntheses, radiolabeling, and in vitro/in vivo studies where Dpr = 2,3-diaminopropionic acid and X = H2O or P(CH2OH)3.

  Cancer research 20030715

• Gene cloning, purification, and characterization of 2,3-diaminopropionate ammonia-lyase from Escherichia coli.

  Bioscience, biotechnology, and biochemistry 20021201

• Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.

  Biochemistry 20021112

• Novel spermine-amino acid conjugates and basic tripeptides enhance cleavage of the hairpin ribozyme at low magnesium ion concentration.

  Bioorganic & medicinal chemistry letters 20011203

• Does the activation of poly (ADP-ribose) synthetase mediate tissue injury in the sepsis induced by cecal ligation and puncture?

  Shock (Augusta, Ga.) 20010801

• Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.

  Biochemistry 20010626

• Glucosamine-6-phosphate synthase from Escherichia coli: determination of the mechanism of inactivation by N3-fumaroyl-L-2,3-diaminopropionic derivatives.

  Biochemistry 19900417