410536-97-9 | Sirtinol

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$28.00	$19.00
5mg	97%	in stock	$75.00	$52.00
10mg	97%	in stock	$113.00	$79.00
250mg	97%	in stock	$267.00	$187.00
1g	97%	in stock	$636.00	$445.00

Description

• Catalog Number: AF57570
• Chemical Name: Sirtinol
• CAS Number: 410536-97-9
• Molecular Formula: C26H22N2O2
• Molecular Weight: 394.4651
• MDL Number: MFCD00810186
• SMILES: O=C(c1ccccc1/N=C/c1c(O)ccc2c1cccc2)N[C@@H](c1ccccc1)C

Computed Properties

• Complexity: 586
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• Undefined Atom Stereocenter Count: 1
• XLogP3: 5.3

Literature

• Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control.

  Toxicology and applied pharmacology 20170801

• Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20160601

• The Effects of Class-Specific Histone Deacetylase Inhibitors on the Development of Limbs During Organogenesis.

  Toxicological sciences : an official journal of the Society of Toxicology 20151101

• Structural modification of resveratrol leads to increased anti-tumor activity, but causes profound changes in the mode of action.

  Toxicology and applied pharmacology 20150815

• Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.

  The Journal of physiology 20150415

• Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro.

  Toxicological sciences : an official journal of the Society of Toxicology 20141101

• Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols.

  Toxicology letters 20140902

• Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice.

  Journal of cellular and molecular medicine 20140801

• Attenuation of β-amyloid-induced tauopathy via activation of CK2α/SIRT1: targeting for cilostazol.

  Journal of neuroscience research 20140201

• Resveratrol restores sirtuin 1 (SIRT1) activity and pyruvate dehydrogenase kinase 1 (PDK1) expression after hemorrhagic injury in a rat model.

  Molecular medicine (Cambridge, Mass.) 20140101

• Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.

  Neuroscience letters 20131011

• Pleiotropic effects of the sirtuin inhibitor sirtinol involves concentration-dependent modulation of multiple nuclear receptor-mediated pathways in androgen-responsive prostate cancer cell LNCaP.

  Molecular carcinogenesis 20130901

• Growth inhibition and apoptosis-inducing effects of cudraflavone B in human oral cancer cells via MAPK, NF-κB, and SIRT1 signaling pathway.

  Planta medica 20130901

• S-allyl cysteine attenuates free fatty acid-induced lipogenesis in human HepG2 cells through activation of the AMP-activated protein kinase-dependent pathway.

  The Journal of nutritional biochemistry 20130801

• SIRT1 inhibits TNF-α-induced apoptosis of vascular adventitial fibroblasts partly through the deacetylation of FoxO1.

  Apoptosis : an international journal on programmed cell death 20130601

• Visfatin is expressed in human granulosa cells: regulation by metformin through AMPK/SIRT1 pathways and its role in steroidogenesis.

  Molecular human reproduction 20130501

• SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging.

  Biochemical pharmacology 20130501

• Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130401

• SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes.

  Osteoarthritis and cartilage 20130301

• Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms.

  The Journal of nutritional biochemistry 20121101

• SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway.

  Cytokine 20121101

• Red wine extract protects against oxidative-stress-induced endothelial senescence.

  Clinical science (London, England : 1979) 20121001

• Evaluation of sirtuin role in neuroprotection of retinal ganglion cells in hypoxia.

  Investigative ophthalmology & visual science 20120628

• Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells.

  Clinical and experimental immunology 20120401

• Resveratrol induces apoptosis MH7A human rheumatoid arthritis synovial cells in a sirtuin 1-dependent manner.

  Rheumatology international 20120101

• Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.

  Vascular pharmacology 20120101

• Hypoxia initiates sirtuin1-mediated vascular endothelial growth factor activation in choroidal endothelial cells through hypoxia inducible factor-2α.

  Molecular vision 20120101

• The role of sirtuin 1 in osteoblastic differentiation in human periodontal ligament cells.

  Journal of periodontal research 20111201

• Repression of P66Shc expression by SIRT1 contributes to the prevention of hyperglycemia-induced endothelial dysfunction.

  Circulation research 20110902

• Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells.

  Cardiovascular research 20110201

• Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants.

  International journal of obesity (2005) 20101001

• Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice.

  The Journal of pharmacology and experimental therapeutics 20101001

• Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.

  Current neurovascular research 20100501

• Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotype.

  Cardiovascular research 20100201

• SIRT1 confers protection against UVB- and H2O2-induced cell death via modulation of p53 and JNK in cultured skin keratinocytes.

  Journal of cellular and molecular medicine 20090901

• Hemeoxygenase-1 upregulation is critical for sirtinol-mediated attenuation of lung injury after trauma-hemorrhage in a rodent model.

  Anesthesia and analgesia 20090601

• Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.

  Neuromolecular medicine 20090101

• A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

  Nature 20081113

• Roles of PI3-K/Akt pathways in nanoparticle realgar powders-induced apoptosis in U937 cells.

  Acta pharmacologica Sinica 20080301

• SIRT1 activation confers neuroprotection in experimental optic neuritis.

  Investigative ophthalmology & visual science 20070801

• Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.

  American journal of physiology. Lung cellular and molecular physiology 20070201

• Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors.

  Journal of medicinal chemistry 20051201