4178-93-2 | H-Leu-pna

Packsize	Purity	Availability	Price	Discounted Price
250mg	96%	in stock	$16.00	$11.00
1g	96%	in stock	$43.00	$30.00
5g	96%	in stock	$189.00	$132.00
25g	96%	in stock	$791.00	$554.00

Description

• Catalog Number: AF57438
• Chemical Name: H-Leu-pna
• CAS Number: 4178-93-2
• Molecular Formula: C12H17N3O3
• Molecular Weight: 251.2817
• MDL Number: MFCD00063681
• SMILES: N[C@H](C(=O)Nc1ccc(cc1)[N+](=O)[O-])CC(C)C

Computed Properties

• Complexity: 293
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 1.7

Literature

• Prey digestion in the midgut of the predatory bug Podisus nigrispinus (Hemiptera: Pentatomidae).

  Journal of insect physiology 20120601

• The leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation.

  International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20120501

• Mechanism of peptide hydrolysis by co-catalytic metal centers containing leucine aminopeptidase enzyme: a DFT approach.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20120201

• Changes and induction of aminopeptidase activities in response to pathogen infection during germination of pigeonpea (Cajanas cajan) seeds.

  Journal of plant physiology 20111015

• LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo.

  Microvascular research 20110901

• LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin.

  Investigational new drugs 20110801

• Small-molecule probe using dual signals to monitor leucine aminopeptidase activity.

  Bioorganic & medicinal chemistry letters 20110415

• Technological characterization of lactococci isolated from traditional Chinese fermented milks.

  Journal of dairy science 20110401

• Comparative analyses of exoproteinases produced by three phytopathogenic microorganisms.

  Journal of pathogens 20110101

• An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin.

  PLoS genetics 20101201

• Immobilization of the aminopeptidase from Aeromonas proteolytica on Mg2+/Al3+ layered double hydroxide particles.

  ACS applied materials & interfaces 20101001

• Covalent immobilisation of protease and laccase substrates onto siloxanes.

  Chemosphere 20100801

• Targeting aminopeptidase N (APN/CD13) with cyclic-imide peptidomimetics derivative CIP-13F inhibits the growth of human ovarian carcinoma cells.

  Cancer letters 20100628

• Partial purification and characterization of Helicoverpa armigera (Lepidoptera: Noctuidae) active aminopeptidase secreted in midgut.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20100201

• Alteration of circulating Placental Leucine Aminopeptidase (P-LAP) activity in preeclampsia.

  Neuro endocrinology letters 20100101

• [B-, H- and L-cathepsin-like activity in blood plasma of patients with diseases of the thyroid, parathyroid and adrenal glands].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20100101

• Characterization of activity of a potential food-grade leucine aminopeptidase from kiwifruit.

  Enzyme research 20100101

• Purification and characterization of L-phenylalanine aminopeptidase from chick-pea cotyledons (Cicer arietinum L.).

  Protein and peptide letters 20090101

• Purification and properties of major midgut leucyl aminopeptidase of Morimus funereus (Coleoptera, Cerambycidae) larvae.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20080301

• Blocking binding of Bacillus thuringiensis Cry1Aa to Bombyx mori cadherin receptor results in only a minor reduction of toxicity.

  BMC biochemistry 20080101

• [Procedure for obtaining and catalytic properties of trypsin immobilized in cryogels of polyvinyl alcohol].

  Prikladnaia biokhimiia i mikrobiologiia 20080101

• Intestinal first-pass metabolism via carboxylesterase in rat jejunum and ileum.

  Drug metabolism and disposition: the biological fate of chemicals 20070701

• Inhibition of APN/CD13 leads to suppressed progressive potential in ovarian carcinoma cells.

  BMC cancer 20070101

• Identification of a new chromophoric substrate in the library of amino acid p-nitroanilides for continuous assay of VanX, a D,D-dipeptidase essential for vancomycin resistance.

  Analytical biochemistry 20060701

• Kinetic, spectroscopic, and X-ray crystallographic characterization of the functional E151H aminopeptidase from Aeromonas proteolytica.

  Biochemistry 20050913

• Metal ion modulation of cystinyl aminopeptidase.

  The Biochemical journal 20050815

• Detection and quantification of leucyl aminopeptidase after native electrophoresis using leucine-p-nitroanilide.

  Electrophoresis 20050601

• The leucyl aminopeptidase from Helicobacter pylori is an allosteric enzyme.

  Microbiology (Reading, England) 20050601

• Endogenous cystinyl aminopeptidase in Chinese hamster ovary cells: characterization by [125I]Ang IV binding and catalytic activity.

  Biochemical pharmacology 20040901

• A thermostable leucine aminopeptidase from Bacillus kaustophilus CCRC 11223.

  Extremophiles : life under extreme conditions 20040201

• Purification and properties of an aminopeptidase from the mid-gut gland of scallop (Patinopecten yessoensis).

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20031201

• Overexpression, purification, and characterization of the recombinant leucine aminopeptidase II of Bacillus stearothermophilus.

  Current microbiology 20030701

• Relationship of chloroquine-induced redistribution of a neutral aminopeptidase to hemoglobin accumulation in malaria parasites.

  Archives of biochemistry and biophysics 20030215

• Partial purification and characterization of midgut leucyl aminopeptidase of Morimus funereus (Coleoptera: Cerambycidae) larvae.

  Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20030201

• Purification, characterization, and genetic analysis of a leucine aminopeptidase from Aspergillus sojae.

  Biochimica et biophysica acta 20020607

• Evaluation of the inhibition effect of thiolated poly(acrylates) on vaginal membrane bound aminopeptidase N and release of the model drug LH-RH.

  The Journal of pharmacy and pharmacology 20020501

• Saccharomyces boulardii enhances N-terminal peptide hydrolysis in suckling rat small intestine by endoluminal release of a zinc-binding metalloprotease.

  Pediatric research 20020401

• The aminopeptidase from Aeromonas proteolytica can function as an esterase.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20020101

• A secreted aminopeptidase of Pseudomonas aeruginosa. Identification, primary structure, and relationship to other aminopeptidases.

  The Journal of biological chemistry 20011123

• Thiolation of polycarbophil enhances its inhibition of intestinal brush border membrane bound aminopeptidase N.

  Journal of pharmaceutical sciences 20011101

• Aminopeptidase-N from the Helicoverpa armigera (Hubner) brush border membrane vesicles as a receptor of Bacillus thuringiensis crylac delta-endotoxin.

  Current microbiology 20011001

• Purification and characterization of aminopeptidase B from Escherichia coli K-12.

  Bioscience, biotechnology, and biochemistry 20010701

• Binding specificity of Bacillus thuringiensis Cry1Aa for purified, native Bombyx mori aminopeptidase N and cadherin-like receptors.

  BMC biochemistry 20010101

• Carboxyl-modified amino acids and peptides as protease inhibitors.

  Journal of medicinal chemistry 19860101