4238-71-5 | 1-Benzylimidazole

Packsize	Purity	Availability	Price	Discounted Price
10g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$26.00	$18.00
100g	98%	in stock	$89.00	$62.00
500g	98%	in stock	$339.00	$237.00

Description

• Catalog Number: AB54063
• Chemical Name: 1-Benzylimidazole
• CAS Number: 4238-71-5
• Molecular Formula: C10H10N2
• Molecular Weight: 158.1998
• MDL Number: MFCD00005296
• SMILES: c1ccc(cc1)Cn1cncc1

Computed Properties

• Complexity: 130
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 1.6

Literature

• Gas-phase behaviour of Ru(II) cyclopentadienyl-derived complexes with N-coordinated ligands by electrospray ionization mass spectrometry: fragmentation pathways and energetics.

  Rapid communications in mass spectrometry : RCM 20120815

• The fatty acid 8,11-diol synthase of Aspergillus fumigatus is inhibited by imidazole derivatives and unrelated to PpoB.

  Lipids 20120701

• Multi-species comparison of the mechanism of biotransformation of MeO-BDEs to OH-BDEs in fish.

  Aquatic toxicology (Amsterdam, Netherlands) 20120615

• Functional characterization and substrate specificity of a novel gene encoding zinc finger-like protein, ZfLp, in Xenopus laevis oocytes.

  The Journal of toxicological sciences 20120101

• Synthesis and structure-activity relationship of 1- and 2-substituted-1,2,3-triazole letrozole-based analogues as aromatase inhibitors.

  European journal of medicinal chemistry 20110901

• Synthesis and spectroscopic studies on charge-transfer molecular complexes formed in the reaction of imidazole and 1-benzylimidazole with σ- and π-acceptors.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901

• Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.

  Journal of medicinal chemistry 20110714

• Hexa-kis-(1-benzyl-1H-imidazole-κN)manganese(II) bis-(perchlorate).

  Acta crystallographica. Section E, Structure reports online 20110701

• Structures of human Golgi-resident glutaminyl cyclase and its complexes with inhibitors reveal a large loop movement upon inhibitor binding.

  The Journal of biological chemistry 20110408

• N-benzylimidazole carboxamides as potent, orally active stearoylCoA desaturase-1 inhibitors.

  Bioorganic & medicinal chemistry letters 20110315

• DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands.

  Journal of inorganic biochemistry 20110201

• Thromboxane synthase suppression induces lung cancer cell apoptosis via inhibiting NF-κB.

  Experimental cell research 20101210

• Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes.

  Bioorganic & medicinal chemistry letters 20100901

• 3,3'-Dibenzyl-1,1'-ethyl-enediimidazolium dibromide.

  Acta crystallographica. Section E, Structure reports online 20100901

• Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).

  Journal of medicinal chemistry 20100225

• Linkage isomerism and spin frustration in heterometallic rings: synthesis, structural characterization, and magnetic and EPR spectroscopic studies of Cr(7)Ni, Cr(6)Ni(2), and Cr(7)Ni(2) rings templated about imidazolium cations.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20091207

• Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction.

  Journal of separation science 20090501

• Tetra-kis(1-benzyl-1H-imidazole)dichlorido-nickel(II).

  Acta crystallographica. Section E, Structure reports online 20090501

• Intramolecular hydrogen bonding as a determinant of the inhibitory potency of N-unsubstituted imidazole derivatives towards mammalian hemoproteins.

  Metallomics : integrated biometal science 20090301

• Toward prediction of alkane/water partition coefficients.

  Journal of medicinal chemistry 20080710

• 1-Benzyl-imidazolium hexa-fluoro-phosphate-1-benzyl-imidazole (1/1).

  Acta crystallographica. Section E, Structure reports online 20080201

• Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.

  Molecular pharmacology 20071101

• S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant.

  The Journal of pharmacology and experimental therapeutics 20070601

• Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel.

  PloS one 20070101

• Oxidative metabolism of seleno-L-methionine to L-methionine selenoxide by flavin-containing monooxygenases.

  Chemical research in toxicology 20061201

• Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

  Bioorganic & medicinal chemistry letters 20060915

• Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.

  Drug metabolism and disposition: the biological fate of chemicals 20060801

• Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).

  Bioorganic & medicinal chemistry letters 20060801

• Models of the cytochromes: crystal structures and EPR spectral characterization of low-spin bis-imidazole complexes of (OETPP)Fe(III) having intermediate ligand plane dihedral angles.

  Inorganic chemistry 20060710

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Conformational flexibility of mammalian cytochrome P450 2B4 in binding imidazole inhibitors with different ring chemistry and side chains. Solution thermodynamics and molecular modeling.

  The Journal of biological chemistry 20060324

• Supramolecular assemblies with calix[6]arenes and copper ions: from dinuclear to trinuclear linear arrangements of hydroxo-Cu(II) complexes.

  Inorganic chemistry 20060206

• Synthetic, structural, and biochemical studies of organotin(IV) with Schiff bases having nitrogen and sulphur donor ligands.

  Bioinorganic chemistry and applications 20060101

• Effect of cytochrome P450 inhibitors and anticonvulsants on the acute toxicity of acrylonitrile.

  Archives of toxicology 20051001

• The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.

  Mutation research 20050905

• Upregulation of cyclooxygenase-2 and thromboxane A2 production mediate the action of tumor necrosis factor-alpha in isolated rat myenteric ganglia.

  American journal of physiology. Gastrointestinal and liver physiology 20050901

• Five new zinc phosphite structures: tertiary building blocks in the construction of hybrid materials.

  Inorganic chemistry 20050418

• Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives.

  Life sciences 20041224

• 4-Phenyl-1H-imidazole (a low-temperature redetermination), 1-benzyl-1H-imidazole and 1-mesityl-1H-imidazole.

  Acta crystallographica. Section C, Crystal structure communications 20040801

• Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes.

  Journal of medicinal chemistry 20040701

• S-oxidation of S-methyl-esonarimod by flavin-containing monooxygenases in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20031201

• Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes.

  Drug metabolism and disposition: the biological fate of chemicals 20030501

• Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole.

  Environmental toxicology and chemistry 20030401

• A structure-permeability study of small drug-like molecules.

  Bioorganic & medicinal chemistry letters 20030224

• Exploration of the diaphorase activity of neutrophil NADPH oxidase.

  European journal of biochemistry 20020201

• Effects of salinity on aldicarb toxicity in juvenile rainbow trout (Oncorhynchus mykiss) and striped bass (Morone saxatilis x chrysops).

  Toxicological sciences : an official journal of the Society of Toxicology 20011201

• N-benzylimidazole for preparation of S9 fraction with multi-induction of metabolizing enzymes in short-term genotoxicity assays.

  Mutagenesis 20011101

• Characterization of moclobemide N-oxidation in human liver microsomes.

  Xenobiotica; the fate of foreign compounds in biological systems 20010701

• Metabolism of a disulfiram metabolite, S-methyl N,N-diethyldithiocarbamate, by flavin monooxygenase in human renal microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20010201

• Mechanism for benomyl action as a mitochondrial aldehyde dehydrogenase inhibitor in mice.

  Chemical research in toxicology 19980501

• N-benzylimidazole, a potent inducer of rat liver enzymes involved in mutagenic activation of various carcinogens.

  Mutation research 19930601

• Reduction by prostacyclin of acetaminophen-induced liver toxicity in the mouse.

  Hepatology (Baltimore, Md.) 19880101

• 1-Benzylimidazole, a thromboxane synthetase inhibitor acutely lowers blood pressure mainly by alpha-adrenoceptor blockade in spontaneously hypertensive rats (SHR).

  Prostaglandins, leukotrienes, and medicine 19831201

• Cardiovascular effects of 1-benzylimidazole.

  The Journal of pharmacology and experimental therapeutics 19750901