427-51-0 | Cyproteroneacetate

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$34.00	$24.00
200mg	97%	in stock	$39.00	$27.00
1g	97%	in stock	$115.00	$81.00

Description

• Catalog Number: AI67643
• Chemical Name: Cyproteroneacetate
• CAS Number: 427-51-0
• Molecular Formula: C24H29ClO4
• Molecular Weight: 416.9377
• MDL Number: MFCD00864671
• SMILES: CC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2C=C(C2=CC(=O)[C@H]3[C@@H]([C@]12C)C3)Cl)C(=O)C
• NSC Number: 81430

Computed Properties

• Complexity: 903
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 8
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• XLogP3: 3.6

Literature

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• Effects of two different oral contraceptives on homocysteine metabolism in women with polycystic ovary syndrome.

  Contraception 20060401

• Characterization of atrazine-induced gonadal malformations in African clawed frogs (Xenopus laevis) and comparisons with effects of an androgen antagonist (cyproterone acetate) and exogenous estrogen (17beta-estradiol): Support for the demasculinization/feminization hypothesis.

  Environmental health perspectives 20060401

• The efficacy of topical cyproterone acetate alcohol lotion versus placebo in the treatment of the mild to moderate acne vulgaris: a double blind study.

  Dermatology online journal 20060330

• Marked sexual dimorphism of lacrimal gland peroxidase in hamster: repression by androgens and estrogens.

  Biochemical and biophysical research communications 20060324

• Effects of two forms of combined oral contraceptives on carbohydrate metabolism in adolescents with polycystic ovary syndrome.

  Fertility and sterility 20060201

• Rosiglitazone and ethinyl estradiol/cyproterone acetate as single and combined treatment of overweight women with polycystic ovary syndrome and insulin resistance.

  Human reproduction (Oxford, England) 20060101

• Androgens induce increases in intracellular calcium via a G protein-coupled receptor in LNCaP prostate cancer cells.

  Journal of andrology 20060101

• Gene expression profiles in rat liver slices exposed to hepatocarcinogenic enzyme inducers, peroxisome proliferators, and 17alpha-ethinylestradiol.

  International journal of toxicology 20060101

• [Case report article: ovulation and Diane-35, current perspectives in detection and control of fertility].

  Revista de medicina de la Universidad de Navarra 20060101

• Effect of oral hormone replacement therapy on plasma homocysteine levels.

  Acta obstetricia et gynecologica Scandinavica 20060101

• [Effect of 6-month treatment with oral antiandrogen alone and in combination with insulin sensitizers on body composition, hormonal and metabolic parameters in women with polycystic ovary syndrome (PCOS) in order to determine therapeutic strategy].

  Akusherstvo i ginekologiia 20060101

• Disappearance of a virilizing adrenal tumor following therapy with cyproterone acetate.

  Endocrine-related cancer 20051201

• Co-activator and co-repressor interplay on the human androgen receptor.

  Andrologia 20051201

• Comparison of the clinical efficacy of flutamide and spironolactone plus Diane 35 in the treatment of idiopathic hirsutism: a randomized controlled study.

  Fertility and sterility 20051201

• Polycystic ovary syndrome.

  Clinical evidence 20051201

• Long-term androgen deprivation therapy improves survival in prostate cancer patients presenting with prostate-specific antigen levels > 20 ng/mL.

  International journal of radiation oncology, biology, physics 20051101

• Perspectives of contraceptive choices for men.

  Indian journal of experimental biology 20051101

• Antiandrogenic therapy can cause coronary arterial disease.

  International journal of urology : official journal of the Japanese Urological Association 20051001

• Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

  Journal of medicinal chemistry 20050908

• [Clinical research on combined therapy of diane-35 with modified yougui pill on polycystic ovarian syndrome].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050901

• CAR and PXR: xenosensors of endocrine disrupters?

  Chemico-biological interactions 20050815

• Antidiabetic activity of passive nonsteroidal glucocorticoid receptor modulators.

  Journal of medicinal chemistry 20050811

• Simultaneous determination of cyproterone acetate and ethinylestradiol in tablets by derivative spectrophotometry.

  Chemical & pharmaceutical bulletin 20050801

• Anti-androgen induced inhibition of testicular descent is associated with a decrease in sympathetic tonus.

  European journal of pediatric surgery : official journal of Austrian Association of Pediatric Surgery ... [et al] = Zeitschrift fur Kinderchirurgie 20050801

• The ErbB3-binding protein Ebp1 suppresses androgen receptor-mediated gene transcription and tumorigenesis of prostate cancer cells.

  Proceedings of the National Academy of Sciences of the United States of America 20050712

• Effectiveness of cyproterone acetate in achieving castration and preventing luteinizing hormone releasing hormone analogue induced testosterone surge in patients with prostate cancer.

  The Journal of urology 20050701

• Does neoadjuvant hormone therapy for early prostate cancer affect cognition? Results from a pilot study.

  BJU international 20050701

• Influence of exogenous oestrogen or (anti-) androgen administration on soluble transferrin receptor in human plasma.

  The Journal of endocrinology 20050701

• Cyproterone acetate in the therapy of prostate carcinoma.

  Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20050601

• Long term phenobarbital administration does not promote the multiplication of hepatocytes replicating after single cyproterone acetate administration.

  Life sciences 20050513

• Cyproterone acetate affects protamine gene expression in the testis of adult male rat.

  Contraception 20050501

• New insights into the mechanism of imposex induction in the dogwhelk Nucella lapillus.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050501

• [Systemic acne therapy].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20050501

• Intermittent androgen deprivation for biologic recurrence after radical prostatectomy: long-term experience.

  Urology 20050401

• Cyproterone acetate and ethinylestradiol-induced pill oesophagitis: a case report.

  International journal of clinical practice. Supplement 20050401

• Morphological abnormalities during early-life development of the estuarine mummichog, Fundulus heteroclitus, as an indicator of androgenic and anti-androgenic endocrine disruption.

  Aquatic toxicology (Amsterdam, Netherlands) 20050304

• Regulation of Sertoli-germ cell adherens junction dynamics via changes in protein-protein interactions of the N-cadherin-beta-catenin protein complex which are possibly mediated by c-Src and myotubularin-related protein 2: an in vivo study using an androgen suppression model.

  Endocrinology 20050301

• Treatment of female pattern hair loss with oral antiandrogens.

  The British journal of dermatology 20050301

• Short-term modification of sex hormones is associated with changes in ghrelin circulating levels in healthy normal-weight men.

  Journal of endocrinological investigation 20050301

• Rheology and NMR self-diffusion experiments as well as skin permeation of diclofenac-sodium and cyproterone acetate of new gel preparations.

  Journal of pharmaceutical sciences 20050201

• Genotoxic potential of cyproterone acetate: a possible role of reactive oxygen species.

  Toxicology in vitro : an international journal published in association with BIBRA 20050201

• Combined use of metformin and ethinyl estradiol-cyproterone acetate in polycystic ovary syndrome.

  European journal of obstetrics, gynecology, and reproductive biology 20050201

• Evaluation and treatment of male and female pattern hair loss.

  Journal of the American Academy of Dermatology 20050201

• Effects of metformin and ethinyl estradiol-cyproterone acetate on lipid levels in obese and non-obese women with polycystic ovary syndrome.

  European journal of endocrinology 20050201

• Anemia under androgen deprivation: influence of flutamide, cyproteroneacetate and orchiectomy on the erythropoietin system.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20050201

• Development of androgen- and estrogen-responsive bioassays, members of a panel of human cell line-based highly selective steroid-responsive bioassays.

  Toxicological sciences : an official journal of the Society of Toxicology 20050101

• Bicalutamide vs cyproterone acetate in preventing flare with LHRH analogue therapy for prostate cancer--a pilot study.

  Prostate cancer and prostatic diseases 20050101

• Receptor isoform and ligand-specific modulation of dihydrotestosterone-induced prostate specific antigen gene expression and prostate tumor cell growth by estrogens.

  Journal of andrology 20050101

• [Acceptability of continuous combined versus cyclical HRT: a French multicentric randomized clinical study].

  Gynecologie, obstetrique & fertilite 20050101

• [Risking more freedom? Cyproterone acetate, sexual offenders and the German 'Law on voluntary castration and other methods of treatment', 1960-1975].

  Medizinhistorisches Journal 20050101

• Effects of metformin combined with cyproterone acetate on clinical features, endocrine and metabolism of non-obese women with polycystic ovarian syndrome.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

• Interleukin-6 and flow-mediated dilatation as markers of increased vascular inflammation in women receiving hormone therapy.

  Menopause (New York, N.Y.) 20050101

• Hormone treatment of the adult transsexual patient.

  Hormone research 20050101

• Atmospheric pressure photoionization applied to quantitation of cyproterone acetate in human plasma.

  Journal of chromatographic science 20050101

• A novel circulating hormone of testis origin in humans.

  The Journal of clinical endocrinology and metabolism 20041201

• Rhabdomyolysis in prostate cancer--caution in prescribing cyproterone acetate with statins.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20041201

• Polycystic ovary syndrome.

  Clinical evidence 20041201

• Inherent growth advantage of (pre)malignant hepatocytes associated with nuclear translocation of pro-transforming growth factor alpha.

  British journal of cancer 20041129

• Specific oral contraceptive use and venous thromboembolism resulting in hospital admission.

  The New Zealand medical journal 20041126

• Fully automated method for the liquid chromatographic-tandem mass spectrometric determination of cyproterone acetate in human plasma using restricted access material for on-line sample clean-up.

  Journal of chromatography. A 20041112

• Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor.

  Molecular endocrinology (Baltimore, Md.) 20041101

• Prothrombotic changes in users of combined oral contraceptives containing drospirenone and cyproterone acetate.

  Journal of thrombosis and haemostasis : JTH 20041101

• 11beta-alkyl-Delta9-19-nortestosterone derivatives: high-affinity ligands and potent partial agonists of the androgen receptor.

  Journal of medicinal chemistry 20041007

• [Confluent and reticulated papillomatosis. Gougerot-Carteaud disease].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20041001

• Finasteride versus cyproterone acetate-estrogen regimens in the treatment of hirsutism.

  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20041001

• Development and validation of a high-performance liquid chromatographic method for the determination of cyproterone acetate in human skin.

  Journal of pharmaceutical and biomedical analysis 20040921

• Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study.

  Human reproduction (Oxford, England) 20040901

• Early versus delayed endocrine treatment of pN1-3 M0 prostate cancer without local treatment of the primary tumor: results of European Organisation for the Research and Treatment of Cancer 30846--a phase III study.

  The Journal of urology 20040901

• Monotherapy in advanced prostate cancer: an overview.

  Experimental oncology 20040901

• Ethinylestradiol/cyproterone acetate in polycystic ovary syndrome: lipid and carbohydrate changes.

  The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20040901

• Effects of androgen manipulation on alpha1-adrenoceptor subtypes in the rat seminal vesicle.

  Life sciences 20040806

• Partial agonist/antagonist properties of androstenedione and 4-androsten-3beta,17beta-diol.

  The Journal of steroid biochemistry and molecular biology 20040801

• Venous thromboembolism associated with cyproterone acetate in combination with ethinyloestradiol (Dianette): observational studies using the UK General Practice Research Database.

  Pharmacoepidemiology and drug safety 20040701

• The effect of cyproterone acetate on the antler cycle in red deer (Cervus elaphus L.).

  Reproductive biology 20040701

• Cyproterone acetate with ethinylestradiol as a risk factor for venous thromboembolism: an epidemiological evaluation.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20040701

• Rapid, hierarchical modulation of vocal patterning by steroid hormones.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040630

• No-effect level in the mutagenic activity of the drug cyproterone acetate in rat liver. Part I. Single dose treatment.

  Mutation research 20040604

• No-effect level in the mutagenic activity of the drug cyproterone acetate in rat liver. Part II. Multiple dose treatment.

  Mutation research 20040604

• The characterization and hormonal regulation of kidney androgen-regulated protein (Kap)-luciferase transgenic mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20040601

• Study on anti-androgenic effects of bisphenol a diglycidyl ether (BADGE), bisphenol F diglycidyl ether (BFDGE) and their derivatives using cells stably transfected with human androgen receptor, AR-EcoScreen.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040601

• Cyproterone acetate with ethinylestradiol as a risk factor for venous thromboembolism: an epidemiological evaluation.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20040601

• Differential modulation of androgen receptor transcriptional activity by the nuclear receptor co-repressor (N-CoR).

  The Biochemical journal 20040501

• Valuable scientific contributions of Brambilla and Martelli.

  Mutation research 20040501

• Quality of life compared during pharmacological treatments and clinical monitoring for non-localized prostate cancer: a randomized controlled trial.

  BJU international 20040501

• Medical treatment regimens of hirsutism.

  Reproductive biomedicine online 20040501

• Cyproterone acetate with ethinylestradiol as a risk factor for venous thromboembolism: an epidemiological evaluation.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20040501

• [Hormonal factors in etiology of common acne].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20040501

• Effects of a model androgen (methyl testosterone) and a model anti-androgen (cyproterone acetate) on reproductive endocrine endpoints in a short-term adult mummichog (Fundulus heteroclitus) bioassay.

  Aquatic toxicology (Amsterdam, Netherlands) 20040428

• Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative.

  Journal of medicinal chemistry 20040422

• Metastatic prostate cancer treated by flutamide versus cyproterone acetate. Final analysis of the 'European Organization for Research and Treatment of Cancer' (EORTC) Protocol 30892.

  European urology 20040401

• Toxic hepatitis after sequential administration of flutamide and cyproterone acetate.

  Digestive diseases and sciences 20040301

• Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals.

  Toxicology 20040215

• Spironolactone inhibits production of proinflammatory cytokines by human mononuclear cells.

  Immunology letters 20040215

• Effects of steroids on oxytocin secretion by the human prostate in vitro.

  International journal of andrology 20040201

• Metabolic and endocrine effects of treatment with peroral or transdermal oestrogens in conjunction with peroral cyproterone acetate in women with polycystic ovary syndrome.

  European journal of endocrinology 20040201

• [The abnormalities of pubertal development: a review of treatment for them].

  Nihon rinsho. Japanese journal of clinical medicine 20040201

• The treatment of polycystic ovary syndrome.

  Minerva ginecologica 20040201

• Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women: the effect of cyproterone acetate-ethinyl estradiol treatment.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20040201

• Screening of some anti-androgenic endocrine disruptors using a recombinant cell-based in vitro bioassay.

  The Journal of steroid biochemistry and molecular biology 20040201

• Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth.

  Biochemical pharmacology 20040101

• Immunohistochemical detection of activated caspases in apoptotic hepatocytes in rat liver.

  Toxicologic pathology 20040101

• Relationship between serum gonadotropins and spermatogenic suppression in men undergoing steroidal contraceptive treatment.

  The Journal of clinical endocrinology and metabolism 20040101

• Antiandrogen monotherapy: recommendations for the treatment of prostate cancer.

  Urologia internationalis 20040101

• Neoadjuvant hormone treatment with leuprolide acetate depot 3.75 mg and cyproterone acetate, before radical prostatectomy: a randomized study.

  Urologia internationalis 20040101

• [Combined use of metformin and Diane35 in polycystic ovary syndrome].

  Akusherstvo i ginekologiia 20040101

• Apoptosis-related gene expression affected by a GnRH analogue without induction of programmed cell death in LNCaP cells.

  Anticancer research 20040101

• The Menopause Rating Scale (MRS) as outcome measure for hormone treatment? A validation study.

  Health and quality of life outcomes 20040101

• Hormonal therapy of acne.

  Journal of cutaneous medicine and surgery 20040101

• Hormonal approach to the treatment of acne a Canadian perspective.

  Journal of cutaneous medicine and surgery 20040101

• Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor.

  Molecular and cellular endocrinology 20031231

• Cyproterone acetate with ethinylestradiol as a risk factor for venous thromboembolism: an epidemiological evaluation.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20031201

• Venous thrombosis and changes of hemostatic variables during cross-sex hormone treatment in transsexual people.

  The Journal of clinical endocrinology and metabolism 20031201

• Testosterone undecanoate maintains spermatogenic suppression induced by cyproterone acetate plus testosterone undecanoate in normal men.

  The Journal of clinical endocrinology and metabolism 20031201

• [Endocrine and metabolic effects of metformin in combination with compound cyproterone acetate in women with polycystic ovarian syndrome].

  Zhonghua fu chan ke za zhi 20031201

• Modulation by progestogens of the effects of oestrogen on hepatic endocrine function in postmenopausal women.

  Clinical endocrinology 20031201

• Urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women with polycystic ovary syndrome: the effect of ethinyl estradiol-cyproterone acetate treatment.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20031201

• Antiandrogen-associated hepatotoxicity in the management of advanced prostate cancer.

  Journal of the Chinese Medical Association : JCMA 20031201

• Effects of estradiol alone or in combination with cyproterone acetate on carotid artery pulsatility index in postmenopausal women.

  Maturitas 20031120

• Effect of cyproterone acetate on alpha1-adrenoceptor subtypes in rat vas deferens.

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20031101

• Sibutramine has a positive effect on clinical and metabolic parameters in obese patients with polycystic ovary syndrome.

  Fertility and sterility 20031101

• Use of progestins in male contraception.

  Steroids 20031101

• Metformin reduces serum C-reactive protein levels in women with polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20031001

• Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

  Chemical research in toxicology 20031001

• Fully automated method for the liquid chromatographic determination of cyproterone acetate in plasma using restricted access material for sample pre-treatment.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030925

• Long-term followup of a randomized trial of 0 versus 3 months of neoadjuvant androgen ablation before radical prostatectomy.

  The Journal of urology 20030901

• Metformin or antiandrogen in the treatment of hirsutism in polycystic ovary syndrome.

  The Journal of clinical endocrinology and metabolism 20030901

• A direct beta-catenin-independent interaction between androgen receptor and T cell factor 4.

  The Journal of biological chemistry 20030815

• [Hirsutism].

  MMW Fortschritte der Medizin 20030807

• Leptin levels in patients with polycystic ovary syndrome in response to two different oral contraceptive treatments.

  Acta obstetricia et gynecologica Scandinavica 20030801

• Testosterone stimulates intracellular calcium release and mitogen-activated protein kinases via a G protein-coupled receptor in skeletal muscle cells.

  Endocrinology 20030801

• Prostate specific antigen: a prognostic marker of survival in good prognosis metastatic prostate cancer? (EORTC 30892).

  European urology 20030801

• Glucose metabolism and insulin resistance in women with polycystic ovary syndrome during therapy with oral contraceptives containing cyproterone acetate or desogestrel.

  The Journal of clinical endocrinology and metabolism 20030801

• Pharmacotherapy of paraphilias with long-acting agonists of luteinizing hormone-releasing hormone: a systematic review.

  The Journal of clinical psychiatry 20030801

• Simultaneous spectrophotometric determination of cyproterone acetate and estradiol valerate in pharmaceutical preparations by ratio spectra derivative and chemometric methods.

  Journal of pharmaceutical and biomedical analysis 20030714

• Acne: comparing hormonal approaches to antibiotics and isotretinoin.

  Expert opinion on pharmacotherapy 20030701

• Absolute and attributable risk of venous thromboembolism in women on combined cyproterone acetate and ethinylestradiol.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20030701

• Osteoporosis associated with the treatment of paraphilias: a clinical review of seven case reports.

  Journal of forensic sciences 20030701

• Breast fibroadenoma in a male-to-female transsexual patient after hormonal treatment.

  The European journal of surgery. Supplement. : = Acta chirurgica. Supplement 20030701

• Vitellogenin synthesis via androgens in primary cultures of tilapia hepatocytes.

  General and comparative endocrinology 20030615

• Permeation of cyproterone acetate through pig skin from different vehicles with phospholipids.

  International journal of pharmaceutics 20030604

• Determination of cyproterone acetate in plasma samples by high-performance liquid chromatography.

  Bollettino chimico farmaceutico 20030601

• Low-dose cyproterone acetate treatment of sexual acting out in men with dementia.

  International psychogeriatrics 20030601

• Effects of estradiol, cyproterone acetate, tibolone and raloxifene on uterus and aorta atherosclerosis in oophorectomized cholesterol-fed rabbits.

  Maturitas 20030530

• First-use risks.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20030527

• Glucocorticoid receptor antagonism by cyproterone acetate and RU486.

  Molecular pharmacology 20030501

• Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals.

  Atherosclerosis 20030501

• Bioassay of steroid hormone agonist and antagonist activities of anti-androgens on mammary gland, seminal vesicles and spleen of male mice.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030501

• Mutation of the androgen receptor at amino acid 708 (Gly-->Ala) abolishes partial agonist activity of steroidal antiandrogens.

  Molecular pharmacology 20030401

• Too much disclosure of product risks? CBC television, SOGC, and Diane-35.

  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC 20030401

• Use of cyproterone acetate, finasteride, and spironolactone to treat idiopathic hirsutism.

  Fertility and sterility 20030401

• Comparison of the efficiency of anti-androgenic regimens consisting of spironolactone, Diane 35, and cyproterone acetate in hirsutism.

  Acta medica Okayama 20030401

• Cluster-like headache time-locked to the menstrual cycle.

  Neurology 20030325

• Exogenous oestrogen as an alternative to food allergy in the aetiology of angioneurotic oedema.

  Toxicology 20030314

• Differences in the use of combined oral contraceptives amongst women with and without acne.

  Human reproduction (Oxford, England) 20030301

• The risk of venous thromboembolism in women prescribed cyproterone acetate in combination with ethinyl estradiol: a nested cohort analysis and case-control study.

  Human reproduction (Oxford, England) 20030301

• Differential expression of c-fos and c-myc protooncogenes by estrogens, xenobiotics and other growth-stimulatory agents in primary rat hepatocytes.

  Archives of toxicology 20030301

• Diane-35 (cyproterone acetate): safety concerns.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20030218

• Relation of androgen receptor gene polymorphism to bone mineral density and fracture risk in early postmenopausal women during a 5-year randomized hormone replacement therapy trial.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20030201

• Different effectiveness of cyproterone acetate doses in treatment of acne.

  Clinical endocrinology 20030201

• Antiandrogens in hormonal contraception limit muscle strength gain in strength training: comparison study.

  Croatian medical journal 20030201

• Metformin versus ethinyl estradiol-cyproterone acetate in the treatment of nonobese women with polycystic ovary syndrome: a randomized study.

  The Journal of clinical endocrinology and metabolism 20030101

• Treatment of hyperandrogenic alopecia in women.

  Fertility and sterility 20030101

• Progestogens with antiandrogenic properties.

  Drugs 20030101

• [Hormonal treatments of acne].

  Annales de dermatologie et de venereologie 20030101

• Effect of two modes of antiandrogen treatment on insulin sensitivity and serum leptin in women with PCOS.

  Gynecologic and obstetric investigation 20030101

• [Assessment of efficacy of Diane-35 in androgenetic feminine alopecia].

  Wiadomosci lekarskie (Warsaw, Poland : 1960) 20030101

• [Evaluation of efficacy of cyproterone acetate monotherapy in prostatic cancer].

  Urologiia (Moscow, Russia : 1999) 20030101

• The risk of liver disorders in women prescribed cyproterone acetate in combination with ethinyloestradiol (Dianette): a nested case-control study using the GPRD.

  Pharmacoepidemiology and drug safety 20030101

• Cyproterone acetate for hirsutism.

  The Cochrane database of systematic reviews 20030101

• [Cyproterone acetate improves beta-cell function in postmenopausal women with diabetes mellitus type 2].

  Akusherstvo i ginekologiia 20030101

• Sex hormones, neurotransmitters, and psychopharmacological treatments in men with paraphilic disorders.

  Journal of child sexual abuse 20030101

• Evidence that chlormadinone acetate exhibits antiandrogenic activity in androgen-dependent cell line.

  Molecular and cellular endocrinology 20021230

• Receptor-dependent regulation of the CYP3A4 gene.

  Toxicology 20021227

• Effects of different progestin regimens in hormone replacement therapy on blood coagulation factor VII and tissue factor pathway inhibitor.

  Human reproduction (Oxford, England) 20021201

• Shortness of breath: an uncommon side-effect of cyproterone acetate in the treatment of androgenetic alopecia.

  International journal of dermatology 20021201

• Effect of different hormone replacement therapy regimens on circadian blood pressure profile and active renin in postmenopausal women.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20021201

• Ligand-dependent aggregation of polyglutamine-expanded androgen receptor in neuronal cells.

  Neuroreport 20021115

• Pathologic effects of neoadjuvant cyproterone acetate on nonneoplastic prostate, prostatic intraepithelial neoplasia, and adenocarcinoma: a detailed analysis of radical prostatectomy specimens from a randomized trial.

  The American journal of surgical pathology 20021101

• Protein expression analysis of drug-mediated hepatotoxicity in the Sprague-Dawley rat.

  Proteomics 20021101

• Important effects of cyproterone acetate on endometriosis?

  Fertility and sterility 20021001

• The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism.

  Endocrine reviews 20021001

• Altered cognitive function in men treated for prostate cancer with luteinizing hormone-releasing hormone analogues and cyproterone acetate: a randomized controlled trial.

  BJU international 20020901

• Nerve growth factor induces the re-expression of functional androgen receptors and p75(NGFR) in the androgen-insensitive prostate cancer cell line DU145.

  European journal of endocrinology 20020901

• Evaluation of a 15-day screening assay using intact male rats for identifying antiandrogens.

  Toxicological sciences : an official journal of the Society of Toxicology 20020901

• [Pharmacological agents for treatment of paraphilias and hypersexual disorders].

  Fortschritte der Neurologie-Psychiatrie 20020901

• Improved prostate cancer treatment.

  Health news (Waltham, Mass.) 20020901

• A comparison of the relative efficacy of antiandrogens for the treatment of acne in hyperandrogenic women.

  Clinical endocrinology 20020801

• Cyproterone acetate-ethinyl estradiol treatment alters urinary 6-sulfatoxymelatonin excretion in hyperandrogenic women.

  Neuro endocrinology letters 20020801

• Pure antiandrogens disrupt the recruitment of coactivator GRIP1 to colocalize with androgen receptor in nuclei.

  FEBS letters 20020717

• Estrogen and cyproterone acetate combination-induced autoimmune hepatitis.

  Journal of clinical gastroenterology 20020701

• Clinical, endocrine and metabolic effects of metformin added to ethinyl estradiol-cyproterone acetate in non-obese women with polycystic ovarian syndrome: a randomized controlled study.

  Human reproduction (Oxford, England) 20020701

• Testosterone stimulates proliferation and inhibits interleukin-6 production of normal and hereditary gingival fibromatosis fibroblasts.

  Oral microbiology and immunology 20020601

• Can changes in sex hormone binding globulin predict the risk of venous thromboembolism with combined oral contraceptive pills?

  Acta obstetricia et gynecologica Scandinavica 20020601

• Effects of minoxidil 2% vs. cyproterone acetate treatment on female androgenetic alopecia: a controlled, 12-month randomized trial.

  The British journal of dermatology 20020601

• Hormone replacement therapy with estradiol valerate and cyproterone acetate: effects on endothelium-dependent vasodilatation and arterial wall compliance.

  Maturitas 20020520

• Acute renal artery occlusion in a 15-year-old girl taking oral contraceptives.

  BJU international 20020501

• Twenty-one day administration of dienogest reversibly suppresses gonadotropins and testosterone in normal men.

  The Journal of clinical endocrinology and metabolism 20020501

• Androgen and lipid profiles in adolescents with polycystic ovary syndrome who were treated with two forms of combined oral contraceptives.

  Fertility and sterility 20020501

• Hormone replacement therapy: estrogen and progestin effects on plasma C-reactive protein concentrations.

  American journal of obstetrics and gynecology 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Risk of venous thromboembolism and oral contraceptives.

  Lancet (London, England) 20020413

• The amino terminus of the human AR is target for corepressor action and antihormone agonism.

  Molecular endocrinology (Baltimore, Md.) 20020401

• Antihormonal treatment of paraphilic patients in German forensic psychiatric clinics.

  European psychiatry : the journal of the Association of European Psychiatrists 20020401

• [On the dependency of larynx carcinoma on steroid sex hormones].

  Laryngo- rhino- otologie 20020401

• Pre-treatment nomogram for biochemical control after neoadjuvant androgen deprivation and radical radiotherapy for clinically localised prostate cancer.

  British journal of cancer 20020304

• Effect of antiandrogen cyproterone acetate on the development of the antler cycle in Southern pudu (Pudu puda).

  The Journal of experimental zoology 20020301

• Effects of finasteride and cyproterone acetate on hematuria associated with benign prostatic hyperplasia: a prospective, randomized, controlled study.

  Urology 20020301

• In vivo cell lineage analysis in cyproterone acetate-treated rat liver using genetic labeling of hepatocytes.

  Hepatology (Baltimore, Md.) 20020201

• [Clinical effects of hormone replacement therapy with estradiol valerate and cyproterone acetate in perimenopausal women].

  Minerva ginecologica 20020201

• Effect of hormone replacement therapy on insulin secretion and insulin sensitivity in postmenopausal diabetic women.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20020201

• [Cyproterone acetate].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20020201

• Role of cadmium in the regulation of AR gene expression and activity.

  Endocrinology 20020101

• Cyproterone acetate versus a continuous monophasic oral contraceptive in the treatment of recurrent pelvic pain after conservative surgery for symptomatic endometriosis.

  Fertility and sterility 20020101

• The effect of hormone replacement therapy on appendicular lean tissue mass in early postmenopausal women.

  Menopause (New York, N.Y.) 20020101

• Cyproterone acetate could counteract the benefits of estradiol valerate in oophorectomized cholesterol-fed rabbits.

  Menopause (New York, N.Y.) 20020101

• Higher testosterone dose impairs sperm suppression induced by a combined androgen-progestin regimen.

  Journal of andrology 20020101

• Coping and health-related quality of life in men with prostate cancer randomly assigned to hormonal medication or close monitoring.

  Psycho-oncology 20020101

• Cyproterone acetate in topical delivery system.

  Journal of cosmetic science 20020101

• Comparison of the clinical efficacy and safety of flutamide versus flutamide plus an oral contraceptive in the treatment of hirsutism.

  Gynecologic and obstetric investigation 20020101

• Clinical effectiveness and cost-consequences of selective serotonin reuptake inhibitors in the treatment of sex offenders.

  Health technology assessment (Winchester, England) 20020101

• Effect of estradiol valerate alone or in association with cyproterone acetate upon vascular function of postmenopausal women at increased risk for cardiovascular disease.

  Maturitas 20011214

• Effects of endocrine disruptors on prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part III: Cyproterone acetate and vinclozolin as antiandrogens.

  Ecotoxicology (London, England) 20011201

• [Brain metastasis of prostatic cancer: regression under hormonal treatment].

  Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 20011201

• Management of unwanted hair in females.

  Clinical and experimental dermatology 20011101

• Efficient retroviral gene transfer to the liver in vivo using nonpolypeptidic mitogens.

  Biochemical and biophysical research communications 20010907

• Mammographic density changes during different postmenopausal hormone replacement therapies.

  Fertility and sterility 20010901

• Acute hepatitis induced by cyproterone acetate.

  The Annals of pharmacotherapy 20010901

• Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy.

  Maturitas 20010825

• Cyproterone acetate induces a cellular tolerance to cadmium in rat liver epithelial cells involving reduced cadmium accumulation.

  Toxicology 20010813

• Androgen-induced up-regulation of tubulin isoforms in neuroblastoma cells.

  Journal of neurochemistry 20010801

• Deletion hybrid genes, due to unequal crossing over between CYP11B1 (11beta-hydroxylase) and CYP11B2(aldosterone synthase) cause steroid 11beta-hydroxylase deficiency and congenital adrenal hyperplasia.

  The Journal of clinical endocrinology and metabolism 20010701

• Why phase III trials of maximal androgen blockade versus castration in M1 prostate cancer rarely show statistically significant differences.

  The Prostate 20010615

• Different methods for the determination of gestodene, and cyproterone acetate in raw material and dosage forms.

  Journal of pharmaceutical and biomedical analysis 20010601

• Endothelin-1 in human prostatic carcinoma treated with androgen withdrawal: an immunohistochemical study.

  Cancer 20010515

• Sebocytes are the key regulators of androgen homeostasis in human skin.

  The Journal of investigative dermatology 20010501

• Diane 35 and spironolactone combination in the treatment of hirsutism.

  Clinical endocrinology 20010501

• Cyproterone acetate: a genotoxic carcinogen?

  Pharmacology & toxicology 20010501

• Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism.

  Fertility and sterility 20010301

• [Comparison of 2 therapeutic strategies in severe endometriosis, in young women consulting for sterility or pain. II. In the case of infertility, value of ovarian stimulation with intrauterine insemination after surgery].

  Gynecologie, obstetrique & fertilite 20010301

• Comparison of the effect on acne with a combiphasic desogestrel-containing oral contraceptive and a preparation containing cyproterone acetate.

  The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception 20010301

• [Two case reports of long-term treatment of endometriosis with cyproterone acetate].

  Zentralblatt fur Gynakologie 20010301

• Evidence that cyproterone acetate improves psychological symptoms and enhances the activity of the dopaminergic system in postmenopause.

  The Journal of clinical endocrinology and metabolism 20010201

• Effects of androgen deprivation on prostatic morphology and vascular permeability evaluated with mr imaging.

  Radiology 20010201

• Oral contraceptives in the treatment of acne.

  Skin therapy letter 20010201

• [Comparison of 2 therapeutic strategies for severe endometriosis, in young women counsulting for sterility or pain. Results in cases of chronic pelvic pain].

  Gynecologie, obstetrique & fertilite 20010201

• Efficacy of the combination ethinyl oestradiol and cyproterone acetate on endocrine, clinical and ultrasonographic profile in polycystic ovarian syndrome.

  Human reproduction (Oxford, England) 20010101

• Insulin action and insulin secretion in polycystic ovary syndrome treated with ethinyl oestradiol/cyproterone acetate.

  QJM : monthly journal of the Association of Physicians 20010101

• Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.

  Clinical oncology (Royal College of Radiologists (Great Britain)) 20010101

• Castration-induced hyperactivity of seminal vesicle in the catfish Clarias batrachus: a case of paradox and blockade by antiandrogen (cyproterone acetate) treatment.

  Acta biologica Hungarica 20010101

• Comparison of transdermal and oral estrogen-progestin replacement therapy: effects on cardiovascular risk factors.

  Menopause (New York, N.Y.) 20010101

• [Hormonal correction of the resident microflora of the vagina and uterus cervix in women with chronic cervicitis].

  Zhurnal mikrobiologii, epidemiologii, i immunobiologii 20010101

• Dose dependent induction of DNA adducts, gene mutations, and cell proliferation by the antiandrogenic drug cyproterone acetate in rat liver.

  Advances in experimental medicine and biology 20010101

• [Hormone replacement therapy and uterine leiomyomas].

  Akusherstvo i ginekologiia 20010101

• Hormonal and clinical effects of GnRH agonist alone, or in combination with a combined oral contraceptive or flutamide in women with severe hirsutism.

  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20001201

• The role of estrogen receptor, androgen receptor and growth factors in diethylstilbestrol-induced programming of prostate differentiation.

  Urological research 20000801

• In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humans.

  The Journal of clinical endocrinology and metabolism 20000401

• Dramatic suppression of plasma and urinary prostate specific antigen and human glandular kallikrein by antiandrogens in male-to-female transsexuals.

  The Journal of urology 20000301

• Prostate cancer treated by anti-androgens: is sexual function preserved? EORTC Genitourinary Group. European Organization for Research and Treatment of Cancer.

  British journal of cancer 20000101

• [Central retinal vein occlusion in a patient treated with antiandrogenic drug].

  Journal francais d'ophtalmologie 20000101

• [Long-term side-effects following cyproterone acetate containing therapy in gynecology].

  Zentralblatt fur Gynakologie 20000101

• Fatal fulminant hepatic failure due to cyproterone acetate.

  Digestive diseases and sciences 19990701

• Cirrhosis in a child with hypothalamic syndrome and central precocious puberty treated with cyproterone acetate.

  European journal of pediatrics 19990501

• Cleavage of poly(ADP-ribose) transferase during p53-independent apoptosis in rat liver after treatment with N-nitrosomorpholine and cyproterone acetate.

  Molecular carcinogenesis 19990401

• Rapid and sensitive reporter gene assays for detection of antiandrogenic and estrogenic effects of environmental chemicals.

  Toxicology and applied pharmacology 19990301

• Environmental xenobiotics and the antihormones cyproterone acetate and spironolactone use the nuclear hormone pregnenolone X receptor to activate the CYP3A23 hormone response element.

  Molecular pharmacology 19981201

• Synthesis and biological activity of a novel series of nonsteroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-g]quinolines.

  Journal of medicinal chemistry 19980212

• Follow-up study of children with precocious puberty treated with cyproterone acetate. Ad hoc Committee for CPA.

  Journal of epidemiology 19970901

• Skin ulcers in a young woman on low-dose estrogen-combination pill.

  International journal of dermatology 19970401

• Activation of androgen receptor in epidermal growth factor modulation of fetal mouse sexual differentiation.

  Molecular and cellular endocrinology 19961014

• Severe hepatitis and liver failure induced by cyproterone acetate.

  Australian and New Zealand journal of medicine 19961001

• Lactotroph hyperplasia in an estrogen treated male-to-female transsexual patient.

  The Journal of clinical endocrinology and metabolism 19960901

• Carcinogenicity of cyproterone acetate in the mouse.

  Carcinogenesis 19960701

• Cyproterone acetate in the treatment of advanced prostatic cancer: retrospective analysis of liver toxicity in the long-term follow-up of 89 patients.

  European urology 19960101

• [Fatal sub-fulminant hepatitis caused by cyproterone acetate. A new case].

  Gastroenterologie clinique et biologique 19960101

• Hepatocellular carcinoma after treatment with cyproterone acetate combined with ethinyloestradiol.

  Lancet (London, England) 19950218

• Hepatocellular carcinoma during hormonotherapy for prostatic cancer.

  American journal of clinical oncology 19941001

• Fatal fulminant hepatitis from cyproterone acetate.

  Israel journal of medical sciences 19940301

• Effect of 4-acetylaminofluorene and other tumour promoters on hepatocellular growth and binucleation.

  Carcinogenesis 19940201

• [Fatal hepatitis caused by cyproterone acetate].

  Therapie 19940101

• Double-blind placebo crossover study of cyproterone acetate in the treatment of the paraphilias.

  Archives of sexual behavior 19931001

• Cyproterone acetate generates DNA adducts in rat liver and in primary rat hepatocyte cultures.

  Carcinogenesis 19930301

• Systemic sclerosis following anti-androgenic treatment for prostatic adenocarcinoma.

  Clinical rheumatology 19930301

• [Cyproterone acetate: cardiovascular tolerance].

  Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie 19920401

• Cyproterone acetate induces DNA damage in cultured rat hepatocytes and preferentially stimulates DNA synthesis in gamma-glutamyltranspeptidase-positive cells.

  Carcinogenesis 19920301

• Hepatitis due to cyproterone acetate.

  European journal of cancer (Oxford, England : 1990) 19920101

• [Fatal subfulminant hepatitis caused by cyproterone acetate].

  Gastroenterologie clinique et biologique 19910101

• Severe hepatitis caused by cyproterone acetate.

  Gut 19900501

• Effects of hypolipidemic drugs nafenopin and clofibrate on phenotypic expression and cell death (apoptosis) in altered foci of rat liver.

  Carcinogenesis 19900401

• Characterization of adenocarcinomas of the dorsolateral prostate induced in Wistar rats by N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl, following sequential treatment with cyproterone acetate and testosterone propionate.

  Cancer research 19900201

• Induction of dorsolateral prostate adenocarcinomas and other accessory sex gland lesions in male Wistar rats by a single administration of N-methyl-N-nitrosourea, 7,12-dimethylbenz(a)anthracene, and 3,2'-dimethyl-4-aminobiphenyl after sequential treatment with cyproterone acetate and testosterone propionate.

  Cancer research 19900201

• [Hepatitis after treatment with cyproterone acetate. Apropos of a case].

  Journal d'urologie 19900101

• Fulminant hepatitis due to cyproterone acetate.

  Lancet (London, England) 19890128

• Pulmonary embolism after short-term treatment of acne vulgaris with ovulation suppressor agents.

  The Medical journal of Australia 19861006

• Comparison of diethylstilbestrol, cyproterone acetate and medroxyprogesterone acetate in the treatment of advanced prostatic cancer: final analysis of a randomized phase III trial of the European Organization for Research on Treatment of Cancer Urological Group.

  The Journal of urology 19860901

• Cardiovascular side effects of diethylstilbestrol, cyproterone acetate, medroxyprogesterone acetate and estramustine phosphate used for the treatment of advanced prostatic cancer: results from European Organization for Research on Treatment of Cancer trials 30761 and 30762.

  The Journal of urology 19860201

• The effect of cyproterone and gonadotrophins on the adrenal gland of juvenile and adult rats. A morphological and morphometrical study.

  Pathology, research and practice 19850301

• Follow-up of prolactin levels in long-term oestrogen-treated male-to-female transsexuals with regard to prolactinoma induction.

  Clinical endocrinology 19850201

• Androgen antagonists in androgen target tissues.

  Pharmacology & therapeutics 19840101

• Effects of cyproterone acetate on adrenal steroidogenesis in vitro.

  Hormone research 19840101

• Effect of cyproterone acetate on glucocorticoid secretion in patients treated for hirsutism.

  Acta endocrinologica 19831001

• Teratogenic effects of cyproterone acetate and medroxyprogesterone treatment during the pre- and postimplantation period of mouse embryos. I.

  Teratology 19820201

• [Prevention of testosterone-vasopressin induced necrosis of the kidney cortex by cyproterone acetate].

  Morphologiai es igazsagugyi orvosi szemle 19790701

• Cyproterone acetate-promoted prevention of renal cortical necrosis following testosterone and vasopressin administration.

  British journal of experimental pathology 19790201

• Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate.

  The Biochemical journal 19730301