42924-53-8 | Nabumetone

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$25.00	$18.00
1g	98%	in stock	$42.00	$29.00
5g	98%	in stock	$134.00	$94.00
10g	98%	in stock	$182.00	$127.00
25g	98%	in stock	$324.00	$227.00

Description

• Catalog Number: AD27454
• Chemical Name: Nabumetone
• CAS Number: 42924-53-8
• Molecular Formula: C15H16O2
• Molecular Weight: 228.2863
• MDL Number: MFCD00079518
• SMILES: COc1ccc2c(c1)ccc(c2)CCC(=O)C
• NSC Number: 758623

Computed Properties

• Complexity: 262
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• XLogP3: 3.1

Literature

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• Management of nonsteroidal anti-inflammatory drug-related peptic ulcer bleeding.

  The American journal of medicine 20010108

• Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs.

  Alimentary pharmacology & therapeutics 20010101

• The use of particle beam mass spectrometry for the measurement of impurities in a nabumetone drug substance, not easily amenable to atmospheric pressure ionisation techniques.

  Rapid communications in mass spectrometry : RCM 20010101

• Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.

  BMC clinical pharmacology 20010101

• Inclusion complexes of nabumetone with beta-cyclodextrins: thermodynamics and molecular modelling studies. Influence of sodium perchlorate.

  Luminescence : the journal of biological and chemical luminescence 20010101

• Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis.

  Drugs 20010101

• The ever-emerging anti-inflammatories. Have there been any real advances?

  Journal of physiology, Paris 20010101

• [Evaluation of early biomarkers of cartilage degeneration in the diagnosis and clinico-therapeutic monitoring of primary osteoarthrosis].

  La Clinica terapeutica 20010101

• Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.

  Experimental nephrology 20010101

• The effects of nabumetone, a cyclooxygenase-2 inhibitor, on cisplatin-induced 5-hydroxytryptamine release from the isolated rat ileum.

  Research communications in molecular pathology and pharmacology 20010101

• Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.

  Cytokine 19990501

• Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon.

  Biochimica et biophysica acta 19980824

• Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis.

  British journal of cancer 19980201

• Differential effects of nonsteroidal anti-inflammatory drugs on constitutive and inducible prostaglandin G/H synthase in cultured bone cells.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19970801

• Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs.

  JAMA 19960814

• Nabumetone-associated interstitial nephritis.

  Pharmacotherapy 19950101

• Nabumetone, a new non-steroidal anti-inflammatory drug: a comparison with naproxen.

  The New Zealand medical journal 19831214