4449-51-8 | Cyclopamine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$22.00	$16.00
5mg	98%	in stock	$48.00	$34.00
10mg	98%	in stock	$73.00	$52.00
50mg	98%	in stock	$196.00	$137.00

Description

• Catalog Number: AG16720
• Chemical Name: Cyclopamine
• CAS Number: 4449-51-8
• Molecular Formula: C27H41NO2
• Molecular Weight: 411.6199
• MDL Number: MFCD09878269
• SMILES: O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC2=C(C)[C@]4(CC[C@@H]32)O[C@H]2[C@H]([C@H]4C)NC[C@H](C2)C)C1)C
• NSC Number: 734950

Computed Properties

• Complexity: 801
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Heavy Atom Count: 30
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• XLogP3: 3.5

Literature

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  Genome medicine 20110101

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• Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer.

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• Aberrant Hedgehog ligands induce progressive pancreatic fibrosis by paracrine activation of myofibroblasts and ductular cells in transgenic zebrafish.

  PloS one 20110101

• Development of posterior hypothalamic neurons enlightens a switch in the prosencephalic basic plan.

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  Clinical cancer research : an official journal of the American Association for Cancer Research 20101215

• Activation of the sonic hedgehog signaling controls human pulmonary arterial smooth muscle cell proliferation in response to hypoxia.

  Biochimica et biophysica acta 20101201

• Hedgehog signaling regulates E-cadherin expression for the maintenance of the actin cytoskeleton and tight junctions.

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  Pharmaceutical research 20101101

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  Cancer biology & therapy 20101101

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  Saudi medical journal 20101101

• Targeting metabolic remodeling in glioblastoma multiforme.

  Oncotarget 20101101

• {Alpha}2B-adrenoceptor deficiency leads to postnatal respiratory failure in mice.

  The Journal of biological chemistry 20101029

• Sonic Hedgehog improves in vitro development of porcine parthenotes and handmade cloned embryos.

  Theriogenology 20101015

• CD133+ cells from medulloblastoma and PNET cell lines are more resistant to cyclopamine inhibition of the sonic hedgehog signaling pathway than CD133- cells.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20101001

• Erythropoietin and sonic hedgehog mediate the neuroprotective effects of brain-derived neurotrophic factor against mitochondrial inhibition.

  Neurobiology of disease 20101001

• Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.

  Molecular pharmacology 20101001

• Mouse models and mouse supermodels.

  EMBO molecular medicine 20101001

• Blockade of the sonic hedgehog signalling pathway inhibits choroidal neovascularization in a laser-induced rat model.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20101001

• Modulators of the hedgehog signaling pathway.

  Bioorganic & medicinal chemistry 20100915

• Hedgehog antagonist cyclopamine isomerizes to less potent forms when acidified.

  Journal of pharmaceutical and biomedical analysis 20100905

• Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program.

  The Journal of biological chemistry 20100903

• Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

  Oncogene 20100902

• Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling.

  The international journal of biochemistry & cell biology 20100901

• Sonic hedgehog signaling induces vascular smooth muscle cell proliferation via induction of the G1 cyclin-retinoblastoma axis.

  Arteriosclerosis, thrombosis, and vascular biology 20100901

• Recent advances and prospects in the differentiation of pancreatic cells from human embryonic stem cells.

  Diabetes 20100901

• Molecular therapy targeting Sonic hedgehog and hepatocyte growth factor signaling in a mouse model of medulloblastoma.

  Molecular cancer therapeutics 20100901

• Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway.

  Genes & cancer 20100901

• Sonic Hedgehog influences the balance of osteogenesis and adipogenesis in mouse adipose-derived stromal cells.

  Tissue engineering. Part A 20100801

• Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.

  Toxicology in vitro : an international journal published in association with BIBRA 20100801

• Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.

  Journal of cellular biochemistry 20100801

• A biomimetic approach to C-nor-D-homo-steroids.

  Journal of the American Chemical Society 20100728

• Hedgehog signaling regulates segment formation in the annelid Platynereis.

  Science (New York, N.Y.) 20100716

• Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines.

  Journal of neuro-oncology 20100701

• Gli2 expression and human bladder transitional carcinoma cell invasiveness.

  The Journal of urology 20100701

• Assessing the efficacy of the hedgehog pathway inhibitor vitamin D3 in a murine xenograft model for pancreatic cancer.

  Cancer biology & therapy 20100701

• Expression of sonic hedgehog signaling components in hepatocellular carcinoma and cyclopamine-induced apoptosis through Bcl-2 downregulation in vitro.

  Archives of medical research 20100701

• Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.

  British journal of cancer 20100629

• Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum.

  Phytotherapy research : PTR 20100601

• Neuroprotective effect of upregulated sonic Hedgehog in retinal ganglion cells following chronic ocular hypertension.

  Investigative ophthalmology & visual science 20100601

• Stability study of the human G-protein coupled receptor, Smoothened.

  Biochimica et biophysica acta 20100601

• Early development of medaka Oryzias latipes muscles as revealed by transgenic approaches using embryonic and larval types of myosin heavy chain genes.

  Developmental dynamics : an official publication of the American Association of Anatomists 20100601

• Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog.

  PLoS biology 20100601

• Activation of Sonic hedgehog signaling pathway in S-type neuroblastoma cell lines.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100601

• Nonsurgical innovations in the treatment of nonmelanoma skin cancer.

  The Journal of clinical and aesthetic dermatology 20100601

• Terpenoids and a flavonoid glycoside from Acacia pennata leaves as hedgehog/GLI-mediated transcriptional inhibitors.

  Journal of natural products 20100528

• Cyclopamine and hedgehog signaling: chemistry, biology, medical perspectives.

  Angewandte Chemie (International ed. in English) 20100503

• Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function.

  Diabetes 20100501

• Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice.

  Hepatology (Baltimore, Md.) 20100501

• [Mechanism of combined use of cyclopamine and hydroxycamptothecin in inducing the apoptosis of human oral squamous cell carcinoma cell line].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100501

• Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer.

  Cancer research 20100415

• Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.

  Cancer cell 20100413

• Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100401

• Sonic hedgehog promotes angiogenesis and osteogenesis in a coculture system consisting of primary osteoblasts and outgrowth endothelial cells.

  Tissue engineering. Part A 20100401

• Novel xenograft and cell line derived from an invasive intraductal papillary mucinous neoplasm of the pancreas give new insights into molecular mechanisms.

  Pancreas 20100401

• Study of a cyclopamine glucuronide prodrug for the selective chemotherapy of glioblastoma.

  European journal of medicinal chemistry 20100401

• Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications.

  Birth defects research. Part A, Clinical and molecular teratology 20100401

• The Hedgehog morphogen in myocardial ischemia-reperfusion injury.

  Experimental biology and medicine (Maywood, N.J.) 20100401

• Hedgehog signaling regulates proliferation of prostate cancer cells via stathmin1.

  Clinical and experimental medicine 20100301

• Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells.

  Molecular carcinogenesis 20100301

• Hedgehog signaling and laminin play unique and synergistic roles in muscle development.

  Developmental dynamics : an official publication of the American Association of Anatomists 20100301

• Cytotoxic effects induced by docetaxel, gefitinib, and cyclopamine on side population and nonside population cell fractions from human invasive prostate cancer cells.

  Molecular cancer therapeutics 20100301

• Activation of Hedgehog signaling by the environmental toxicant arsenic may contribute to the etiology of arsenic-induced tumors.

  Cancer research 20100301

• [Effects of cyclopamine on the proliferation and cycle of prostate cancer cell line DU145].

  Zhonghua nan ke xue = National journal of andrology 20100301

• Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer.

  British journal of cancer 20100216

• Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.

  The Journal of biological chemistry 20100212

• Corticosteroid-induced kidney dysmorphogenesis is associated with deregulated expression of known cystogenic molecules, as well as Indian hedgehog.

  American journal of physiology. Renal physiology 20100201

• Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage.

  Developmental dynamics : an official publication of the American Association of Anatomists 20100201

• Controlling destiny through chemistry: small-molecule regulators of cell fate.

  ACS chemical biology 20100115

• Late reactivation of sonic hedgehog by Helicobacter pylori results in population of gastric epithelial cells that are resistant to apoptosis: implication for gastric carcinogenesis.

  Cancer letters 20100101

• Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis.

  Basic research in cardiology 20100101

• Stage-specific role for shh in dopaminergic differentiation of human embryonic stem cells induced by stromal cells.

  Stem cells and development 20100101

• Autocrine and paracrine Shh signaling are necessary for tooth morphogenesis, but not tooth replacement in snakes and lizards (Squamata).

  Developmental biology 20100101

• Hedgehog pathway activity is required for the lethality and intestinal phenotypes of mice with hyperactive Wnt signaling.

  Mechanisms of development 20100101

• Small-molecule modulators of the Sonic Hedgehog signaling pathway.

  Molecular bioSystems 20100101

• Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway.

  PloS one 20100101

• Regulation of Emx2 expression by antisense transcripts in murine cortico-cerebral precursors.

  PloS one 20100101

• Smoothened as a new therapeutic target for human osteosarcoma.

  Molecular cancer 20100101

• A current review of targeted therapeutics for ovarian cancer.

  Journal of oncology 20100101

• Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells.

  PloS one 20100101

• BMP-2 functions independently of SHH signaling and triggers cell condensation and apoptosis in regenerating axolotl limbs.

  BMC developmental biology 20100101

• Hedgehog/Gli supports androgen signaling in androgen deprived and androgen independent prostate cancer cells.

  Molecular cancer 20100101

• A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.

  PloS one 20100101

• Newly generated cells are increased in hippocampus of adult mice lacking a serine protease inhibitor.

  BMC neuroscience 20100101

• T cells enhance stem-like properties and conditional malignancy in gliomas.

  PloS one 20100101

• Cancerous stem cells: deviant stem cells with cancer-causing misbehavior.

  Stem cell research & therapy 20100101

• A systems approach to mapping transcriptional networks controlling surfactant homeostasis.

  BMC genomics 20100101

• The role of tumor initiating cells in drug resistance of breast cancer: Implications for future therapeutic approaches.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20100101

• Mtmr8 is essential for vasculature development in zebrafish embryos.

  BMC developmental biology 20100101

• Role of Wnt canonical pathway in hematological malignancies.

  Journal of hematology & oncology 20100101

• Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice.

  PloS one 20100101

• cDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.

  PloS one 20100101

• Hedgehog signaling is required at multiple stages of zebrafish tooth development.

  BMC developmental biology 20100101

• Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation.

  PloS one 20100101

• Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.

  PloS one 20100101

• Visualization of Gli activity in craniofacial tissues of hedgehog-pathway reporter transgenic zebrafish.

  PloS one 20100101

• Characterization of new otic enhancers of the pou3f4 gene reveal distinct signaling pathway regulation and spatio-temporal patterns.

  PloS one 20100101

• Synthesis of all diastereomers of the piperidine--alkaloid substructure of cyclopamine.

  Organic letters 20091203

• Sonic hedgehog is a polarized signal for motor neuron regeneration in adult zebrafish.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20091202

• Transgenic zebrafish line with over-expression of Hedgehog on the skin: a useful tool to screen Hedgehog-inhibiting compounds.

  Transgenic research 20091201

• Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis.

  American journal of physiology. Gastrointestinal and liver physiology 20091201

• Blocking hedgehog signaling after ablation of the dorsal neural tube allows regeneration of the cardiac neural crest and rescue of outflow tract septation.

  Developmental biology 20091115

• Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation.

  Stroke 20091101

• Cyclopamine and quercetin suppress the growth of leukemia and lymphoma cells.

  Anticancer research 20091101

• Blockade of hedgehog signaling pathway as a therapeutic strategy for pancreatic cancer.

  Cancer letters 20091008

• Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.

  Gastroenterology 20091001

• Cross talk between hedgehog and bone morphogenetic proteins occurs during cardiomyogenesis in P19 cells.

  In vitro cellular & developmental biology. Animal 20091001

• Targeted inhibition of the Hedgehog pathway in established malignant glioma xenografts enhances survival.

  Oncogene 20091001

• A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells.

  Cancer science 20091001

• From teratogens to potential therapeutics: natural inhibitors of the Hedgehog signaling network come of age.

  Planta medica 20091001

• Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.

  Experimental cell research 20090910

• Review of the hair follicle origin hypothesis for basal cell carcinoma.

  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20090901

• Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.

  Gastroenterology 20090901

• The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation.

  Journal of cell science 20090901

• Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion.

  EMBO molecular medicine 20090901

• Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090826

• The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontin.

  The Journal of biological chemistry 20090821

• Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090819

• BMP7 and SHH regulate Pax2 in mouse retinal astrocytes by relieving TLX repression.

  Developmental biology 20090815

• Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy.

  Expert opinion on therapeutic patents 20090801

• Sonic hedgehog improves delayed wound healing via enhancing cutaneous nitric oxide function in diabetes.

  American journal of physiology. Endocrinology and metabolism 20090801

• Sonic hedgehog expression and its role in form-deprivation myopia in mice.

  Current eye research 20090801

• Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926).

  Journal of medicinal chemistry 20090723

• Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription.

  Journal of medicinal chemistry 20090723

• Sonic hedgehog mediates BDNF-induced neuroprotection against mitochondrial inhibitor 3-nitropropionic acid.

  Biochemical and biophysical research communications 20090717

• Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers.

  Developmental biology 20090715

• Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

  Bioorganic & medicinal chemistry 20090715

• Design and synthesis of inhibitors of Hedgehog signaling based on the alkaloid cyclopamine.

  Organic letters 20090702

• Cyclopamine-induced synophthalmia in sheep: defining a critical window and toxicokinetic evaluation.

  Journal of applied toxicology : JAT 20090701

• Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A.

  Arteriosclerosis, thrombosis, and vascular biology 20090701

• Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.

  Developmental dynamics : an official publication of the American Association of Anatomists 20090701

• Hedgehog signaling regulates the survival of gastric cancer cells by regulating the expression of Bcl-2.

  International journal of molecular sciences 20090701

• Sonic hedgehog maintains proliferation in secondary heart field progenitors and is required for normal arterial pole formation.

  Developmental biology 20090615

• Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo).

  Breast cancer research and treatment 20090601

• Deciphering the role of Shh signaling in axial defects produced by ethanol exposure.

  Birth defects research. Part A, Clinical and molecular teratology 20090601

• Evidence for allosteric interactions of antagonist binding to the smoothened receptor.

  The Journal of pharmacology and experimental therapeutics 20090601

• Bone marrow stromal cells increase oligodendrogenesis after stroke.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090601

• [Hedgehog pathway is associated with the proliferation and differentiation of osteoblasts].

  Shanghai kou qiang yi xue = Shanghai journal of stomatology 20090601

• Inhibition of S6K by resveratrol: in search of the purpose.

  Aging 20090601

• Signaling hierarchy regulating human endothelial cell development.

  Arteriosclerosis, thrombosis, and vascular biology 20090501

• Drug resistance is dramatically restored by hedgehog inhibitors in CD34+ leukemic cells.

  Cancer science 20090501

• KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway.

  Neurobiology of disease 20090501

• Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent.

  Developmental biology 20090415

• Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia.

  Nature 20090409

• Human fetal radial glia cells generate oligodendrocytes in vitro.

  Glia 20090401

• Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors.

  Carcinogenesis 20090401

• Germ cell sex determination in mammals.

  Molecular human reproduction 20090401

• Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation.

  Virchows Archiv : an international journal of pathology 20090401

• Lack of evidence for activation of the hedgehog pathway in psoriasis.

  The Journal of investigative dermatology 20090301

• Sonic Hedgehog signaling in astrocytes is dependent on p38 mitogen-activated protein kinase and G-protein receptor kinase 2.

  Journal of neurochemistry 20090301

• The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer.

  Anticancer research 20090301

• Spatial and temporal pattern for the dentition in the Australian lungfish revealed with sonic hedgehog expression profile.

  Proceedings. Biological sciences 20090222

• Identification of Hedgehog signaling outcomes in mouse testis development using a hanging drop-culture system.

  Biology of reproduction 20090201

• A dynamic Gli code interprets Hh signals to regulate induction, patterning, and endocrine cell specification in the zebrafish pituitary.

  Developmental biology 20090201

• A direct pancreatic cancer xenograft model as a platform for cancer stem cell therapeutic development.

  Molecular cancer therapeutics 20090201

• Blocking the hedgehog pathway inhibits hepatoblastoma growth.

  Hepatology (Baltimore, Md.) 20090201

• Blocking Ihh signaling pathway inhibits the proliferation and promotes the apoptosis of PSCs.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090201

• Cross talk between hedgehog and epithelial-mesenchymal transition pathways in gastric pit cells and in diffuse-type gastric cancers.

  British journal of cancer 20090127

• Cathepsin B is a target of Hedgehog signaling in pancreatic cancer.

  Cancer letters 20090118

• N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

  Genes & development 20090115

• Antiandrogen exposure in utero disrupts expression of desert hedgehog and insulin-like factor 3 in the developing fetal rat testis.

  Endocrinology 20090101

• Human embryonic stem cell differentiation toward regional specific neural precursors.

  Stem cells (Dayton, Ohio) 20090101

• Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.

  Gastroenterology 20090101

• Hedgehog signalling is required for cloacal development in the zebrafish embryo.

  The International journal of developmental biology 20090101

• Androgenic regulation of hedgehog signaling pathway components in prostate cancer cells.

  Cell cycle (Georgetown, Tex.) 20090101

• [The effects of Hedgehog-Gli 1 signaling pathway on proliferation and apoptosis of hepatic stellate cells].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20090101

• Frame-shifts of digit identity in bird evolution and Cyclopamine-treated wings.

  Evolution & development 20090101

• Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation.

  Molecular cancer 20090101

• Mechanisms of KGF mediated signaling in pancreatic duct cell proliferation and differentiation.

  PloS one 20090101

• FGF4 and retinoic acid direct differentiation of hESCs into PDX1-expressing foregut endoderm in a time- and concentration-dependent manner.

  PloS one 20090101

• The role of hedgehog signaling during gastric regeneration.

  Journal of gastroenterology 20090101

• Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

  PloS one 20090101

• Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development.

  PloS one 20090101

• Choosing the right path: enhancement of biologically relevant sets of genes or proteins using pathway structure.

  Genome biology 20090101

• Sonic hedgehog: its expression in a healing cornea and its role in neovascularization.

  Molecular vision 20090101

• Oligodendrocyte development and the onset of myelination in the human fetal brain.

  Frontiers in neuroanatomy 20090101

• Immune regulatory neural stem/precursor cells protect from central nervous system autoimmunity by restraining dendritic cell function.

  PloS one 20090101

• Sonic hedgehog promotes porcine oocyte maturation and early embryo development.

  Reproduction, fertility, and development 20090101

• Inhibition of p70S6K2 down-regulates Hedgehog/GLI pathway in non-small cell lung cancer cell lines.

  Molecular cancer 20090101

• Synthesis of cyclopamine using a biomimetic and diastereoselective approach.

  Angewandte Chemie (International ed. in English) 20090101

• Highly efficient differentiation and enrichment of spinal motor neurons derived from human and monkey embryonic stem cells.

  PloS one 20090101

• Expression of the glioma-associated oncogene homolog (GLI) 1 in human breast cancer is associated with unfavourable overall survival.

  BMC cancer 20090101

• Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells.

  Journal of carcinogenesis 20090101

• Activation of sonic hedgehog signaling pathway in olfactory neuroblastoma.

  Oncology 20090101

• Sonic hedgehog is a chemoattractant for midbrain dopaminergic axons.

  PloS one 20090101

• Generation of cortical neurons from mouse embryonic stem cells.

  Nature protocols 20090101

• GLI3 repressor controls nephron number via regulation of Wnt11 and Ret in ureteric tip cells.

  PloS one 20090101

• Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells.

  BMC developmental biology 20090101

• GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors.

  PloS one 20090101

• Zebrafish con/disp1 reveals multiple spatiotemporal requirements for Hedgehog-signaling in craniofacial development.

  BMC developmental biology 20090101

• The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth.

  Molecular cancer 20090101

• Fishing for the signals that pattern the face.

  Journal of biology 20090101

• Hedgehog signalling in androgen independent prostate cancer.

  European urology 20081201

• Stemming cancer: functional genomics of cancer stem cells in solid tumors.

  Stem cell reviews 20081201

• Role of hedgehog signaling in ovarian cancer.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20081201

• The hedgehog inhibitor cyclopamine induces apoptosis in leukemic cells in vitro.

  Leukemia & lymphoma 20081201

• Hedgehog-induced survival of B-cell chronic lymphocytic leukemia cells in a stromal cell microenvironment: a potential new therapeutic target.

  Molecular cancer research : MCR 20081201

• Hedgehog signaling during expansion of human pancreatic islet-derived precursors.

  Annals of the New York Academy of Sciences 20081201

• Zebrafish dorsal root ganglia neural precursor cells adopt a glial fate in the absence of neurogenin1.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119

• Semisynthetic cyclopamine analogues as potent and orally bioavailable hedgehog pathway antagonists.

  Journal of medicinal chemistry 20081113

• Neuroprotective effect of sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury.

  Journal of neurochemistry 20081101

• Toward understanding the development of scleral ossicles in the chicken, Gallus gallus.

  Developmental dynamics : an official publication of the American Association of Anatomists 20081101

• Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.

  Pancreas 20081101

• MSX2 stimulates chondrocyte maturation by controlling Ihh expression.

  The Journal of biological chemistry 20081024

• Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer.

  Gut 20081001

• Oxysterol-induced osteogenic differentiation of marrow stromal cells is regulated by Dkk-1 inhibitable and PI3-kinase mediated signaling.

  Journal of cellular biochemistry 20081001

• Tri-phasic expression of posterior Hox genes during development of pectoral fins in zebrafish: implications for the evolution of vertebrate paired appendages.

  Developmental biology 20081001

• An intrinsic mechanism of corticogenesis from embryonic stem cells.

  Nature 20080918

• Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.

  Cancer cell 20080909

• An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

  Molecular cancer therapeutics 20080901

• Autonomous Hedgehog signalling is undetectable in PC-3 prostate cancer cells.

  Biochemical and biophysical research communications 20080815

• Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury.

  Experimental biology and medicine (Maywood, N.J.) 20080801

• Hedgehog signaling is required for effective regeneration of exocrine pancreas.

  Gastroenterology 20080801

• Antitumor activity of extracts and compounds from the rhizomes of Veratrum dahuricum.

  Phytotherapy research : PTR 20080801

• Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation.

  Cancer science 20080701

• Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse.

  Toxicological sciences : an official journal of the Society of Toxicology 20080701

• Initiation and patterning of the snake dentition are dependent on Sonic hedgehog signaling.

  Developmental biology 20080701

• Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye.

  Developmental biology 20080701

• Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice.

  The Journal of clinical investigation 20080701

• Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20080615

• Survival and function of human thymic dendritic cells are dependent on autocrine Hedgehog signaling.

  Journal of leukocyte biology 20080601

• Sonic hedgehog derived from human pancreatic cancer cells augments angiogenic function of endothelial progenitor cells.

  Cancer science 20080601

• Hh and Wnt signaling regulate formation of olig2+ neurons in the zebrafish cerebellum.

  Developmental biology 20080601

• Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.

  Development (Cambridge, England) 20080601

• Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish.

  Developmental biology 20080601

• Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy.

  British journal of cancer 20080520

• Vsx2/Chx10 ensures the correct timing and magnitude of Hedgehog signaling in the mouse retina.

  Developmental biology 20080515

• ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification.

  Cell stem cell 20080508

• Cyclopamine treatment of full-blown Hh/Ptch-associated RMS partially inhibits Hh/Ptch signaling, but not tumor growth.

  Molecular carcinogenesis 20080501

• Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin.

  Stem cells (Dayton, Ohio) 20080501

• Patched1 haploinsufficiency increases adult bone mass and modulates Gli3 repressor activity.

  Developmental cell 20080501

• Hypoxia-induced compensatory effect as related to Shh and HIF-1alpha in ischemia embryo rat heart.

  Molecular and cellular biochemistry 20080401

• Different effects of anti-sonic hedgehog antibodies and the hedgehog pathway inhibitor cyclopamine on generation of dopaminergic neurons from neurospheres of mesencephalic precursors.

  Developmental dynamics : an official publication of the American Association of Anatomists 20080401

• Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer.

  Bioorganic & medicinal chemistry 20080315

• A hedgehog homolog is involved in muscle formation and organization of Sepia officinalis (mollusca) mantle.

  Developmental dynamics : an official publication of the American Association of Anatomists 20080301

• Cancer metastasis as disrupted developmental phenotype.

  Current genomics 20080301

• Synthesis and anticancer activity studies of cyclopamine derivatives.

  Bioorganic & medicinal chemistry letters 20080215

• Smarcd3 regulates the timing of zebrafish myogenesis onset.

  The Journal of biological chemistry 20080208

• Cyclopamine inhibition of the sonic hedgehog pathway in the stomach requires concomitant acid inhibition.

  Regulatory peptides 20080207

• CNS-derived glia ensheath peripheral nerves and mediate motor root development.

  Nature neuroscience 20080201

• New developments in medulloblastoma treatment: the potential of a cyclopamine-lovastatin combination.

  Expert opinion on investigational drugs 20080201

• Commercially available recombinant sonic hedgehog up-regulates Ptc and modulates the cytokine and chemokine expression of human macrophages: an effect mediated by endotoxin contamination?

  Immunobiology 20080101

• The vitamin D receptor is a Wnt effector that controls hair follicle differentiation and specifies tumor type in adult epidermis.

  PloS one 20080101

• Muscarinic signaling influences the patterning and phenotype of cholinergic amacrine cells in the developing chick retina.

  BMC developmental biology 20080101

• Genetic analysis of the two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway.

  BMC developmental biology 20080101

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  Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20080101

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  Differentiation; research in biological diversity 20071201

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  Toxicological sciences : an official journal of the Society of Toxicology 20071201

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  Breast cancer research and treatment 20071001

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  Molecular cancer therapeutics 20070301

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  Current biology : CB 20070123

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  Aquatic toxicology (Amsterdam, Netherlands) 20060615

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