446-08-2 | 2-Amino-5-fluorobenzoic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$9.00	$6.00
10g	98%	in stock	$12.00	$8.00
25g	98%	in stock	$20.00	$14.00
100g	98%	in stock	$79.00	$55.00

Description

• Catalog Number: AB61115
• Chemical Name: 2-Amino-5-fluorobenzoic acid
• CAS Number: 446-08-2
• Molecular Formula: C7H6FNO2
• Molecular Weight: 155.12644319999998
• MDL Number: MFCD00055566
• SMILES: Fc1ccc(c(c1)C(=O)O)N
• NSC Number: 513308

Computed Properties

• Complexity: 163
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1

Upstream Synthesis Route

2-Amino-5-fluorobenzoic acid, also known as AFBA, is a versatile compound widely used in chemical synthesis as a valuable building block for various pharmaceuticals, agrochemicals, and materials. With its unique structural properties, 2-Amino-5-fluorobenzoic acid serves as a key intermediate in the synthesis of biologically active compounds and functionalized materials.In the field of pharmaceutical chemistry, 2-Amino-5-fluorobenzoic acid is employed in the development of pharmaceutical drugs due to its ability to modulate specific biological targets. It is utilized in the synthesis of potential drug candidates targeting various diseases such as cancer, inflammation, and neurological disorders. The functional groups present in AFBA can be manipulated to design molecules with enhanced pharmacological activity and improved drug-like properties.Furthermore, 2-Amino-5-fluorobenzoic acid finds application in agrochemical research for the production of crop protection agents and herbicides. By incorporating AFBA into the molecular structure of agrochemicals, researchers can create compounds with selective herbicidal activity and improved environmental safety profiles. The versatility of AFBA as a chemical building block enables the synthesis of novel agrochemicals with enhanced efficacy and reduced environmental impact.In addition to its role in pharmaceuticals and agrochemicals, 2-Amino-5-fluorobenzoic acid is utilized in materials science for the preparation of functional materials with tailored properties. By incorporating AFBA into polymer matrices, researchers can enhance the mechanical, thermal, and optical properties of the resulting materials. AFBA-derived polymers exhibit improved performance characteristics, making them suitable for a wide range of applications including coatings, adhesives, and electronic devices.Overall, the diverse applications of 2-Amino-5-fluorobenzoic acid in chemical synthesis highlight its significance as a key building block in the development of advanced pharmaceuticals, agrochemicals, and functional materials. Its unique structural features and reactivity make AFBA a valuable tool for researchers seeking to design and synthesize new compounds with targeted properties and applications.

Literature

• A TRP5/5-fluoroanthranilic acid counter-selection system for gene disruption in Candida guilliermondii.

  Current genetics 20120801

• The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis.

  PLoS genetics 20111101

• Mutator suppression and escape from replication error-induced extinction in yeast.

  PLoS genetics 20111001

• FT-IR, Raman and DFT study of 2-amino-5-fluorobenzoic acid and its biological activity with other halogen (Cl, Br) substitution.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110701

• New selectable host-marker systems for multiple genetic manipulations based on TRP1, MET2 and ADE2 in the methylotrophic yeast Hansenula polymorpha.

  Yeast (Chichester, England) 20090901

• Characterization of two cotton cDNAs encoding trans-2-enoyl-CoA reductase reveals a putative novel NADPH-binding motif.

  Journal of experimental botany 20090401

• Molecular cloning, expression profiling, and yeast complementation of 19 beta-tubulin cDNAs from developing cotton ovules.

  Journal of experimental botany 20080701

• Inhibitors of pathogen intercellular signals as selective anti-infective compounds.

  PLoS pathogens 20070901

• Synthesis and antifungal activity of novel s-substituted 6-fluoro-4-alkyl(aryl)thioquinazoline derivatives.

  Bioorganic & medicinal chemistry 20070601

• New tools for phenotypic analysis in Candida albicans: the WAR1 gene confers resistance to sorbate.

  Yeast (Chichester, England) 20060301

• Identification of anthranilate and benzoate metabolic operons of Pseudomonas fluorescens and functional characterization of their promoter regions.

  Microbial cell factories 20060101

• A network of multi-tasking proteins at the DNA replication fork preserves genome stability.

  PLoS genetics 20051201

• Isolation and characterization of the TRP1 gene from the yeast Yarrowia lipolytica and multiple gene disruption using a TRP blaster.

  Yeast (Chichester, England) 20030601