446859-33-2 | 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$10.00	$7.00
50mg	98%	in stock	$50.00	$35.00
100mg	98%	in stock	$86.00	$60.00
250mg	98%	in stock	$143.00	$100.00
1g	98%	in stock	$361.00	$253.00

Description

• Catalog Number: AG25056
• Chemical Name: 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
• CAS Number: 446859-33-2
• Molecular Formula: C17H13N5
• Molecular Weight: 287.31862
• MDL Number: MFCD09037561
• SMILES: Cc1cccc(n1)c1n[nH]cc1c1ccc2c(n1)cccn2

Computed Properties

• Complexity: 376
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 2.2

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Nephronectin expression is regulated by SMAD signaling in osteoblast-like MC3T3-E1 cells.

  Biochemical and biophysical research communications 20120824

• A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

  Cell stem cell 20091106

• Identification of 1,5-naphthyridine derivatives as a novel series of potent and selective TGF-beta type I receptor inhibitors.

  Journal of medicinal chemistry 20040826