452342-67-5 | Gw 788388

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$16.00	$11.00
5mg	95%	in stock	$26.00	$18.00
10mg	95%	in stock	$39.00	$27.00
25mg	95%	in stock	$95.00	$67.00
50mg	95%	in stock	$108.00	$75.00

Description

• Catalog Number: AB49084
• Chemical Name: Gw 788388
• CAS Number: 452342-67-5
• Molecular Formula: C25H23N5O2
• Molecular Weight: 425.4824
• MDL Number: MFCD20527321
• SMILES: O=C(c1ccc(cc1)c1nccc(c1)c1c[nH]nc1c1ccccn1)NC1CCOCC1

Computed Properties

• Complexity: 605
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 2.7

Literature

• Oral administration of GW788388, an inhibitor of transforming growth factor beta signaling, prevents heart fibrosis in Chagas disease.

  PLoS neglected tropical diseases 20120601

• 2-Phenyl and 2-heterocyclic-4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridines as inhibitors of TGF-β1 and activin A signalling.

  Bioorganic & medicinal chemistry letters 20110915

• Targeted inhibition of activin receptor-like kinase 5 signaling attenuates cardiac dysfunction following myocardial infarction.

  American journal of physiology. Heart and circulatory physiology 20100501

• Endothelin 1 contributes to the effect of transforming growth factor beta1 on wound repair and skin fibrosis.

  Arthritis and rheumatism 20100301

• The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis.

  Gastroenterology 20080601

• Oral administration of GW788388, an inhibitor of TGF-beta type I and II receptor kinases, decreases renal fibrosis.

  Kidney international 20080301

• Inhibition of ALK5 signaling induces physeal dysplasia in rats.

  Toxicologic pathology 20070201

• Discovery of 4-{4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridin-2-yl}-N-(tetrahydro-2H- pyran-4-yl)benzamide (GW788388): a potent, selective, and orally active transforming growth factor-beta type I receptor inhibitor.

  Journal of medicinal chemistry 20060406