456-48-4 | 3-Fluorobenzaldehyde

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$13.00	$9.00
25g	98%	in stock	$15.00	$10.00
100g	98%	in stock	$25.00	$17.00
500g	98%	in stock	$76.00	$53.00

Description

• Catalog Number: AB44573
• Chemical Name: 3-Fluorobenzaldehyde
• CAS Number: 456-48-4
• Molecular Formula: C7H5FO
• Molecular Weight: 124.1124
• MDL Number: MFCD00003348
• SMILES: O=Cc1cccc(c1)F
• NSC Number: 66830

Computed Properties

• Complexity: 103
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.8

Upstream Synthesis Route

3-Fluorobenzaldehyde is a key building block in chemical synthesis due to its versatile reactivity and wide range of applications. This compound is commonly utilized in the pharmaceutical industry as a precursor for the synthesis of various drugs and pharmaceutical intermediates. Its unique fluorine substitution makes it an important component in the creation of fluorinated organic compounds, which often exhibit enhanced bioactivity and metabolic stability.In organic synthesis, 3-Fluorobenzaldehyde serves as a valuable starting material for the preparation of diverse chemical compounds through a variety of synthetic routes. Its reactive aldehyde group enables the formation of carbon-carbon bonds, making it a useful reagent in the construction of complex molecular structures. Additionally, the fluorine atom on the benzene ring can participate in selective fluorination reactions, allowing for the introduction of fluorine atoms at specific positions within a molecule.Furthermore, 3-Fluorobenzaldehyde plays a crucial role in the development of agrochemicals, such as insecticides and herbicides, where its fluorinated moiety can impart desired properties such as increased potency and selectivity. Its application in material science also extends to the synthesis of functionalized organic molecules for the production of advanced materials with tailored properties.Overall, the prominence of 3-Fluorobenzaldehyde in chemical synthesis lies in its ability to serve as a foundational reactant for the creation of diverse organic compounds with enhanced properties and functionalities.

Literature

• (E)-N'-(3-Fluoro-benzyl-idene)-3-nitro-benzohydrazide.

  Acta crystallographica. Section E, Structure reports online 20120301

• 1,1-Dibenzyl-3-(4-fluoro-benzo-yl)thio-urea.

  Acta crystallographica. Section E, Structure reports online 20110801

• 4-(3-Fluoro-phen-yl)-6-hy-droxy-5-(thio-phen-2-ylcarbon-yl)-6-trifluoro-methyl-1,3-diazinan-2-one.

  Acta crystallographica. Section E, Structure reports online 20110401

• Total synthesis and analgesic activity of 6-fluoroindan-1-acetic acid and its 3-oxo derivative.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20090901

• Efficient hydrogenation of benzaldehydes over mesopolymer-entrapped Pt nanoparticles in water.

  Chemistry, an Asian journal 20090504

• Asymmetric Morita-Baylis-Hillman reaction of arylaldehydes with 2-cyclohexen-1-one catalyzed by chiral bis(thio)urea and DABCO.

  Organic letters 20080320

• Inhibitory effects of fluorobenzaldehydes on the activity of mushroom tyrosinase.

  Journal of enzyme inhibition and medicinal chemistry 20060801

• Stability analysis of the two rotational isomers of meta-fluorobenzaldehyde in the S0, S1, and S2 electronic states.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040601