462-88-4 | 3-Ureidopropionic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	10mM in DMSO	in stock	$97.00	$68.00
1g	10mM in DMSO	in stock	$193.00	$135.00
5g	98%	in stock	$853.00	$597.00

Description

• Catalog Number: AB65586
• Chemical Name: 3-Ureidopropionic acid
• CAS Number: 462-88-4
• Molecular Formula: C4H8N2O3
• Molecular Weight: 132.1179
• MDL Number: MFCD00043023
• SMILES: OC(=O)CCNC(=O)N
• NSC Number: 65768

Computed Properties

• Complexity: 123
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: -1.5

Literature

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• Chemometric analysis of biofluids from mice experimentally infected with Schistosoma mansoni.

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• The 3-ureidopropionase of Caenorhabditis elegans, an enzyme involved in pyrimidine degradation.

  The FEBS journal 20101001

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• Five cases of beta-ureidopropionase deficiency detected by GC/MS analysis of urine metabolome.

  Journal of mass spectrometry : JMS 20090201

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  Journal of molecular biology 20080411

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• Beta-ureidopropionase deficiency presenting with congenital anomalies of the urogenital and colorectal systems.

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  The Journal of biological chemistry 20071207

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  Wei sheng wu xue bao = Acta microbiologica Sinica 20060801

• Liquid chromatography-tandem mass spectrometric assay for the analysis of uracil, 5,6-dihydrouracil and beta-ureidopropionic acid in urine for the measurement of the activities of the pyrimidine catabolic enzymes.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060724

• The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity.

  The Journal of biological chemistry 20060512

• Physiologically based pharmacokinetic modelling of the three-step metabolism of pyrimidine using C-uracil as an in vivo probe.

  British journal of clinical pharmacology 20051201

• Purification and properties of beta-alanine synthase from calf liver.

  Protein and peptide letters 20050101

• Molecular cloning and biochemical characterization of L-N-carbamoylase from Sinorhizobium meliloti CECT4114.

  Journal of molecular microbiology and biotechnology 20050101

• Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry.

  Journal of inherited metabolic disease 20050101

• beta-Ureidopropionase deficiency: an inborn error of pyrimidine degradation associated with neurological abnormalities.

  Human molecular genetics 20041115

• Sensitive method for the quantification of urinary pyrimidine metabolites in healthy adults by gas chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

• Crystallization and preliminary X-ray diffraction analysis of thermophilic imidase from pig liver.

  Acta crystallographica. Section D, Biological crystallography 20030501

• Profiles of pyrimidine biosynthesis, salvage and degradation in disks of potato (Solanum tuberosum L.) tubers.

  Planta 20020901

• Screening and diagnosis of beta-ureidopropionase deficiency by gas chromatographic/mass spectrometric analysis of urine.

  Journal of mass spectrometry : JMS 20020901

• Development and characterization of a monoclonal antibody with cross-reactivity towards uracil and thymine, and its potential use in screening patients treated with 5-fluorouracil for possible risks.

  Clinica chimica acta; international journal of clinical chemistry 20020801

• Detection of beta-ureidopropionase deficiency with HPLC-electrospray tandem mass spectrometry and confirmation of the defect at the enzyme level.

  Journal of inherited metabolic disease 20011201

• 3-Ureidopropionate contributes to the neuropathology of 3-ureidopropionase deficiency and severe propionic aciduria: a hypothesis.

  Journal of neuroscience research 20011115

• beta-Ureidopropionase deficiency: a novel inborn error of metabolism discovered using NMR spectroscopy on urine.

  Magnetic resonance in medicine 20011101

• Eukaryotic beta-alanine synthases are functionally related but have a high degree of structural diversity.

  Genetics 20010701

• Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent.

  Journal of medicinal chemistry 20010412

• Expression and properties of human liver beta-ureidopropionase.

  Journal of nutritional science and vitaminology 20010401

• Characterization of plant beta-ureidopropionase and functional overexpression in Escherichia coli.

  Plant physiology 20010201