4696-76-8 | Bekanamycin

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$80.00	$56.00
250mg	95%	in stock	$174.00	$122.00
500mg	95%	in stock	$308.00	$216.00
1g	95%	in stock	$459.00	$322.00

Description

• Catalog Number: AI50752
• Chemical Name: Bekanamycin
• CAS Number: 4696-76-8
• Molecular Formula: C18H37N5O10
• Molecular Weight: 483.5139
• MDL Number: MFCD28390297
• SMILES: OC[C@H]1O[C@H](O[C@H]2[C@H](N)C[C@@H]([C@H]([C@@H]2O)O[C@H]2O[C@H](CN)[C@H]([C@@H]([C@H]2N)O)O)N)[C@@H]([C@H]([C@@H]1O)N)O

Computed Properties

• Complexity: 639
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 15
• Heavy Atom Count: 33
• Hydrogen Bond Acceptor Count: 15
• Hydrogen Bond Donor Count: 11
• Rotatable Bond Count: 6
• XLogP3: -7.2

Literature

• In vitro and in vivo activities of ruthenium(II) phosphine/diimine/picolinate complexes (SCAR) against Mycobacterium tuberculosis.

  PloS one 20130101

• Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of β-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors.

  Bioorganic & medicinal chemistry letters 20120715

• Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation.

  Nature chemical biology 20111009

• Synthesis, antibacterial activities and molecular docking studies of Schiff bases derived from N-(2/4-benzaldehyde-amino) phenyl-N'-phenyl-thiourea.

  Bioorganic & medicinal chemistry 20110915

• Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors.

  Bioorganic & medicinal chemistry 20110801

• Influence of charge and structure on the coordination chemistry of copper aminoglycosides.

  Dalton transactions (Cambridge, England : 2003) 20110227

• Construction of kanamycin B overproducing strain by genetic engineering of Streptomyces tenebrarius.

  Applied microbiology and biotechnology 20110201

• Rational design and synthesis of potent aminoglycoside antibiotics against resistant bacterial strains.

  Bioorganic & medicinal chemistry 20110101

• Antibacterial to antifungal conversion of neamine aminoglycosides through alkyl modification. Strategy for reviving old drugs into agrofungicides.

  The Journal of antibiotics 20101101

• Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: implications for drug design.

  Journal of the American Chemical Society 20100901

• Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors.

  Bioorganic & medicinal chemistry letters 20100801

• Thermodynamics and kinetics of association of antibiotics with the aminoglycoside acetyltransferase (3)-IIIb, a resistance-causing enzyme.

  Biochemistry 20100518

• Design and synthesis of novel deoxybenzoin derivatives as FabH inhibitors and anti-inflammatory agents.

  Bioorganic & medicinal chemistry letters 20100315

• Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors.

  Bioorganic & medicinal chemistry letters 20091201

• Synthesis, structure and structure-activity relationship analysis of 3-tert-butoxycarbonyl-2-arylthiazolidine-4-carboxylic acid derivatives as potential antibacterial agents.

  European journal of medicinal chemistry 20091001

• Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics.

  Bioorganic & medicinal chemistry 20090901

• Synthesis, characterization and structure-activity relationship analysis of novel depsides as potential antibacterials.

  European journal of medicinal chemistry 20090401

• Synthesis and biological evaluation of novel luteolin derivatives as antibacterial agents.

  European journal of medicinal chemistry 20090201

• Cleavage of RNA oligonucleotides by aminoglycosides.

  Organic & biomolecular chemistry 20090107

• Antiviral activity of geneticin against bovine viral diarrhoea virus.

  Antiviral chemistry & chemotherapy 20080101

• Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis.

  Journal of molecular biology 20070525

• Determination of tobramycin in human serum by capillary electrophoresis with contactless conductivity detection.

  Electrophoresis 20060501

• Determination of tobramycin and impurities using high-performance anion exchange chromatography with integrated pulsed amperometric detection.

  Journal of pharmaceutical and biomedical analysis 20060303

• Glycodiversification for the optimization of the kanamycin class aminoglycosides.

  Journal of medicinal chemistry 20051006

• Thermodynamics of aminoglycoside binding to aminoglycoside-3'-phosphotransferase IIIa studied by isothermal titration calorimetry.

  Biochemistry 20041123

• Identification and functional analysis of dTDP-glucose-4,6-dehydratase gene and its linked gene cluster in an aminoglycoside antibiotics producer of Streptomyces tenebrarius H6.

  Current microbiology 20040801

• Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues.

  Organic letters 20040219

• Targeting RNA with small molecules.

  Chembiochem : a European journal of chemical biology 20031006

• Antimycobacterial activity of phorbol esters from the fruits of Sapium indicum.

  Journal of natural products 20030401

• Development and validation of capillary electrophoresis method for tobramycin with precapillary derivatization and UV detection.

  Electrophoresis 20020601

• Aminoglycoside binding to human and bacterial A-Site rRNA decoding region constructs.

  Bioorganic & medicinal chemistry 20011001

• In vitro selection of RNA against kanamycin B.

  Molecules and cells 20010630

• Which aminoglycoside ring is most important for binding? A hydropathic analysis of gentamicin, paromomycin, and analogues.

  Bioorganic & medicinal chemistry letters 20010122

• Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production.

  Cell 19930924

• In vitro and in vivo susceptibility of atypical mycobacteria to various drugs.

  Reviews of infectious diseases 19810101

• [Experimental study on renal tolerability of aminoglycosides butirosin and bekanamycin (author's transl)].

  Arzneimittel-Forschung 19800101

• [Comparative studies on the problem of nephrotoxicity of the aminoglycosides: kanamycin, amikacin, butirosin and kanendomycin].

  Verhandlungen der Deutschen Gesellschaft fur Innere Medizin 19760101