470-17-7 | Isoalantolactone

Packsize	Purity	Availability	Price	Discounted Price
10mg	95%	in stock	$42.00	$29.00
20mg	95%	in stock	$76.00	$53.00
50mg	95%	in stock	$90.00	$63.00
250mg	95%	in stock	$146.00	$102.00

Description

• Catalog Number: AB53672
• Chemical Name: Isoalantolactone
• CAS Number: 470-17-7
• Molecular Formula: C15H20O2
• Molecular Weight: 232.3181
• MDL Number: MFCD08689940
• SMILES: O=C1O[C@H]2[C@@H](C1=C)C[C@@H]1[C@](C2)(C)CCCC1=C
• NSC Number: 241036

Computed Properties

• Complexity: 409
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 4
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 3.4

Literature

• Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells.

  Toxicology and applied pharmacology 20180801

• Antistaphylococcal activity of Inula helenium L. root essential oil: eudesmane sesquiterpene lactones induce cell membrane damage.

  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120601

• Chemical composition of essential oils from a multiple shoot culture of Telekia speciosa and different plant organs.

  Natural product communications 20120501

• Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells.

  International journal of biological sciences 20120101

• Ultrasound-assisted extraction of total flavonoids from Inula helenium.

  Pharmacognosy magazine 20120101

• Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20120101

• Isoalantolactone protects against Staphylococcus aureus pneumonia.

  FEMS microbiology letters 20111101

• Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by Inula racemosa.

  Toxicology in vitro : an international journal published in association with BIBRA 20100901

• Structure-activity relationship studies on derivatives of eudesmanolides from Inula helenium as toxicants against Aedes aegypti larvae and adults.

  Chemistry & biodiversity 20100701

• HPLC determination and NMR structural elucidation of sesquiterpene lactones in Inula helenium.

  Journal of pharmaceutical and biomedical analysis 20100311

• Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots.

  Pharmacognosy magazine 20100101

• Isoalantolactone from Inula helenium caused Nrf2-mediated induction of detoxifying enzymes.

  Journal of medicinal food 20091001

• Nrf2-mediated induction of detoxifying enzymes by alantolactone present in Inula helenium.

  Phytotherapy research : PTR 20081101

• Neural networks as valuable tools to differentiate between sesquiterpene lactones' inhibitory activity on serotonin release and on NF-kappaB.

  Journal of medicinal chemistry 20080313

• Induction of detoxifying enzyme by sesquiterpenes present in Inula helenium.

  Journal of medicinal food 20070901

• Simultaneous quantification of eudesmanolides and thymol derivatives from tissues of Inula helenium and I. royleana by reversed-phase high-performance liquid chromatography.

  Phytochemical analysis : PCA 20060101

• Separation and determination of two sesquiterpene lactones in Radix inulae and Liuwei Anxian San by microemulsion electrokinetic chromatography.

  Biomedical chromatography : BMC 20041201

• Constituents of two Flourensia species.

  Phytochemistry 20040701

• Antiproliferative sesquiterpene lactones from the roots of Inula helenium.

  Biological & pharmaceutical bulletin 20021001

• Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones.

  Planta medica 20020801

• Antimycobacterial plant terpenoids.

  Planta medica 20011101

• Cytotoxic Michael-type amine adducts of alpha-methylene lactones alantolactone and isoalantolactone.

  Bioorganic & medicinal chemistry letters 20010212

• Antimycobacterial eudesmanolides from Inula helenium and Rudbeckia subtomentosa.

  Planta medica 19990501

• A murine in vitro model of allergic contact dermatitis to sesquiterpene alpha-methylene-gamma-butyrolactones.

  Archives of dermatological research 19920101