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Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.
Chemical research in toxicology 20140421
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Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
Bioorganic & medicinal chemistry 20121115
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Synthesis and structure-activity relationships of lapacho analogues. 1. Suppression of human keratinocyte hyperproliferation by 2-substituted naphtho[2,3-b]furan-4,9-diones, activation by enzymatic one- and two-electron reduction, and intracellular generation of superoxide.
Journal of medicinal chemistry 20120823
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New oxirane derivatives of 1,4-naphthoquinones and their evaluation against T. cruzi epimastigote forms.
Bioorganic & medicinal chemistry 20120815
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β-Lapachone analogs with enhanced antiproliferative activity.
European journal of medicinal chemistry 20120701
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An NQO1 substrate with potent antitumor activity that selectively kills by PARP1-induced programmed necrosis.
Cancer research 20120615
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On the search for potential anti-Trypanosoma cruzi drugs: synthesis and biological evaluation of 2-hydroxy-3-methylamino and 1,2,3-triazolic naphthoquinoidal compounds obtained by click chemistry reactions.
European journal of medicinal chemistry 20120601
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Screening of anti-cancer agent using zebrafish: comparison with the MTT assay.
Biochemical and biophysical research communications 20120525
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NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones.
Biochemical pharmacology 20120415
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Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase.
Free radical biology & medicine 20120301
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Temperature-sensitive gels for intratumoral delivery of β-lapachone: effect of cyclodextrins and ethanol.
TheScientificWorldJournal 20120101
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No role of homologous recombination in dealing with β-lapachone cytotoxicity in yeast.
Chemical research in toxicology 20111219
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Preclinical genotoxicology of nor-β-lapachone in human cultured lymphocytes and Chinese hamster lung fibroblasts.
Chemical research in toxicology 20110919
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Corpus cavernosal smooth muscle relaxation effect of a novel AMPK activator, beta-lapachone.
The journal of sexual medicine 20110801
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Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Cardiovascular research 20110801
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Synthesis and anti-Trypanosoma cruzi activity of β-lapachone analogues.
European journal of medicinal chemistry 20110701
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β-lapachone accelerates the recovery of burn-wound skin.
Histology and histopathology 20110701
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Identification of nor-β-lapachone derivatives as potential antibacterial compounds against Enterococcus faecalis clinical strain.
Current microbiology 20110201
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β-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells.
Chemico-biological interactions 20110115
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Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 20110115
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Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.
Experimental parasitology 20110101
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Hyperthermia enhances the effect of β-lapachone to cause γH2AX formations and cell death in human osteosarcoma cells.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20110101
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Synthesis and evaluation of quinonoid compounds against tumor cell lines.
European journal of medicinal chemistry 20110101
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Synthesis of biologically active (-)-dehydroiso-β-lapachone and the determination of its absolute configuration.
Chemical & pharmaceutical bulletin 20110101
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Endoplasmic reticulum stress-induced JNK activation is a critical event leading to mitochondria-mediated cell death caused by β-lapachone treatment.
PloS one 20110101
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β-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos.
Journal of biomedical science 20110101
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β-lapachone significantly increases the effect of ionizing radiation to cause mitochondrial apoptosis via JNK activation in cancer cells.
PloS one 20110101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Prostate cancer radiosensitization through poly(ADP-Ribose) polymerase-1 hyperactivation.
Cancer research 20101015
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Activity of β-lapachone derivatives against rifampicin-susceptible and -resistant strains of Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland) 20100901
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Synthesis of naturally occurring naphthoquinone epoxides and application in the synthesis of beta-lapachone.
Organic & biomolecular chemistry 20100821
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Beta-lapachone suppresses radiation-induced activation of nuclear factor-kappaB.
Experimental & molecular medicine 20100531
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Beta-lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.
Cancer research 20100515
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A naphthoquinone derivative can induce anemia through phosphatidylserine exposure-mediated erythrophagocytosis.
The Journal of pharmacology and experimental therapeutics 20100501
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The evaluation of quinonoid compounds against Trypanosoma cruzi: synthesis of imidazolic anthraquinones, nor-beta-lapachone derivatives and beta-lapachone-based 1,2,3-triazoles.
Bioorganic & medicinal chemistry 20100501
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Antifungal activity of the naphthoquinone beta-lapachone against disseminated infection with Cryptococcus neoformans var. neoformans in dexamethasone-immunosuppressed Swiss mice.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20100401
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Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.
Bioorganic & medicinal chemistry 20100401
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Paclitaxel and beta-lapachone synergistically induce apoptosis in human retinoblastoma Y79 cells by downregulating the levels of phospho-Akt.
Journal of cellular physiology 20100201
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Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.
Bioorganic & medicinal chemistry letters 20091201
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The trypanocidal activity of naphthoquinones: a review.
Molecules (Basel, Switzerland) 20091110
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Cisplatin enhances the anticancer effect of beta-lapachone by upregulating NQO1.
Anti-cancer drugs 20091101
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Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
Nature chemical biology 20091001
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Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats.
Phytotherapy research : PTR 20090901
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Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.
Bioorganic & medicinal chemistry 20090901
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In vitro synergic effect of beta-lapachone and isoniazid on the growth of Mycobacterium fortuitum and Mycobacterium smegmatis.
Memorias do Instituto Oswaldo Cruz 20090701
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Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation.
Circulation research 20090410
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Restenosis revisited.
Circulation research 20090410
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Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.
Diabetes 20090401
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Ex vivo activities of beta-lapachone and alpha-lapachone on macrophages: a quantitative pharmacological analysis based on amperometric monitoring of oxidative bursts by single cells.
Chembiochem : a European journal of chemical biology 20090213
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Photosensitizing properties of triplet beta-lapachones in acetonitrile solution.
Photochemistry and photobiology 20090101
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In vitro metabolism of beta-lapachone (ARQ 501) in mammalian hepatocytes and cultured human cells.
Rapid communications in mass spectrometry : RCM 20090101
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Increased susceptibility of spinal muscular atrophy fibroblasts to camptothecin is p53-independent.
BMC cell biology 20090101
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Heat shock increases expression of NAD(P)H:quinone oxidoreductase (NQO1), mediator of beta-lapachone cytotoxicity, by increasing NQO1 gene activity and via Hsp70-mediated stabilisation of NQO1 protein.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20090101
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Modulatory effects of Tabebuia impetiginosa (Lamiales, Bignoniaceae) on doxorubicin-induced somatic mutation and recombination in Drosophila melanogaster.
Genetics and molecular biology 20090101
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Involvement of endoplasmic reticulum stress and activation of MAP kinases in beta-lapachone-induced human prostate cancer cell apoptosis.
Histology and histopathology 20081101
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Semisynthesis and antitumoral activity of 2-acetylfuranonaphthoquinone and other naphthoquinone derivatives from lapachol.
Bioorganic & medicinal chemistry letters 20081015
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Inner reorganization during the radical-biradical transition in a nor-beta-lapachone derivative possessing two redox centers.
Organic & biomolecular chemistry 20080921
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Development and validation of a liquid chromatography-tandem mass spectrometry method for the determination of ARQ 501 (beta-lapachone) in plasma and tumors from nu/nu mouse xenografts.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080901
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Inactivation of the SMN complex by oxidative stress.
Molecular cell 20080725
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Identification of the in vitro metabolites of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (ARQ 501; beta-lapachone) in whole blood.
Drug metabolism and disposition: the biological fate of chemicals 20080401
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Identification of a novel glucosylsulfate conjugate as a metabolite of 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione (ARQ 501, beta-lapachone) in mammals.
Drug metabolism and disposition: the biological fate of chemicals 20080401
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Laser flash photolysis study of the triplet reactivity of beta-lapachones.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080401
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Beta-lapachone inhibits proliferation and induces apoptosis in retinoblastoma cell lines.
Eye (London, England) 20080301
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Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock.
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20080301
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Topoisomerase inhibitors as anti-arthritic agents.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20080301
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Trypanosoma cruzi: activities of lapachol and alpha- and beta-lapachone derivatives against epimastigote and trypomastigote forms.
Bioorganic & medicinal chemistry 20080115
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Compatibility of the antitumoral beta-lapachone with different solid dosage forms excipients.
Journal of pharmaceutical and biomedical analysis 20071130
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Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells.
Journal of controlled release : official journal of the Controlled Release Society 20071008
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Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of beta-lapachone in human hepatocarcinoma cells.
Bioscience, biotechnology, and biochemistry 20070901
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Upregulation of NAD(P)H:quinone oxidoreductase by radiation potentiates the effect of bioreductive beta-lapachone on cancer cells.
Neoplasia (New York, N.Y.) 20070801
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Nonhomologous end joining is essential for cellular resistance to the novel antitumor agent, beta-lapachone.
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Applications of counter-current chromatography in organic synthesis purification of heterocyclic derivatives of lapachol.
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Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.
Journal of cellular physiology 20070501
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Anti-inflammatory effects of beta-lapachone in lipopolysaccharide-stimulated BV2 microglia.
International immunopharmacology 20070401
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Synthesis and pharmacophore modeling of naphthoquinone derivatives with cytotoxic activity in human promyelocytic leukemia HL-60 cell line.
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Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair.
The Journal of biological chemistry 20061103
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Beta-lapachone activates a Mre11p-Tel1p G1/S checkpoint in budding yeast.
Cell cycle (Georgetown, Tex.) 20061101
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Modulating beta-lapachone release from polymer millirods through cyclodextrin complexation.
Journal of pharmaceutical sciences 20061001
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Oxyrane derivative of alpha-lapachone is potent growth inhibitor of Trypanosoma cruzi epimastigote forms.
Parasitology research 20060901
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Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro.
Radiation research 20060501
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Preparation of alpha-diazocarbonyl compounds from beta-lapachone derivatives and other 1,2-naphthoquinones: use of the 2D NMR 1H,15N and 1H,13C HMBC techniques in assigning regiochemistry.
Magnetic resonance in chemistry : MRC 20060401
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beta-lapachone induces growth inhibition and apoptosis in bladder cancer cells by modulation of Bcl-2 family and activation of caspases.
Experimental oncology 20060301
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Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase.
Journal of medicinal food 20060101
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Heat-induced up-regulation of NAD(P)H:quinone oxidoreductase potentiates anticancer effects of beta-lapachone.
Clinical cancer research : an official journal of the American Association for Cancer Research 20051215
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Effect of a beta-lapachone-derived naphthoimidazole on Trypanosoma cruzi: identification of target organelles.
The Journal of antimicrobial chemotherapy 20051201
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Development of beta-lapachone prodrugs for therapy against human cancer cells with elevated NAD(P)H:quinone oxidoreductase 1 levels.
Clinical cancer research : an official journal of the American Association for Cancer Research 20050415
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Growth inhibition of A549 human lung carcinoma cells by beta-lapachone through induction of apoptosis and inhibition of telomerase activity.
International journal of oncology 20050401
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Antiplasmodial activity of naphthoquinones related to lapachol and beta-lapachone.
Chemistry & biodiversity 20050201
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Susceptibility of cancer cells to beta-lapachone is enhanced by ionizing radiation.
International journal of radiation oncology, biology, physics 20050101
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Efficacy of beta-lapachone in pancreatic cancer treatment: exploiting the novel, therapeutic target NQO1.
Cancer biology & therapy 20050101
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2-Phenyl-beta-lapachone can affect mitochondrial function by redox cycling mediated oxidation.
Archives of biochemistry and biophysics 20041215
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Alkaline-earth cations enhance ortho-quinone-catalyzed ascorbate oxidation.
Free radical biology & medicine 20041115
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Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor kappaB inhibition.
Biochemical pharmacology 20040915
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Studies on the trypanocidal activity of semi-synthetic pyran[b-4,3]naphtho[1,2-d]imidazoles from beta-lapachone.
European journal of medicinal chemistry 20040701
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Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation.
The Journal of biological chemistry 20040604
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Antimalarial activity of phenazines from lapachol, beta-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo.
Bioorganic & medicinal chemistry letters 20040308
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beta-Lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-kappaB in human colon cancer HCT-116 cells.
Anti-cancer drugs 20031101
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Enhancement of solubility and bioavailability of beta-lapachone using cyclodextrin inclusion complexes.
Pharmaceutical research 20031001
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beta-Lapachone reduces endotoxin-induced macrophage activation and lung edema and mortality.
American journal of respiratory and critical care medicine 20030701
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Inhibitory effects of lapachol derivatives on epstein-barr virus activation.
Bioorganic & medicinal chemistry 20030220
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Mu-calpain activation in beta-lapachone-mediated apoptosis.
Cancer biology & therapy 20030101
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Calpains can do it alone: implications for cancer therapy.
Cancer biology & therapy 20030101
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Toxic potential of dietary genistein isoflavone and beta-lapachone on capacitation and acrosome reaction of epididymal spermatozoa.
Journal of medicinal food 20030101
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Cancer therapy with beta-lapachone.
Current cancer drug targets 20020901
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Studies on fertilization in the teleost IV. Effects of aphidicolin and camptothecin on chromosome formation in fertilized medaka eggs.
Development, growth & differentiation 20020801
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Effect of the lipophilic o-naphthoquinone CG 10-248 on rat liver mitochondria structure and function.
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20020801
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Inhibition of poly(ADP-ribose) polymerase activation attenuates beta-lapachone-induced necrotic cell death in human osteosarcoma cells.
Toxicology and applied pharmacology 20020715
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beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Experimental hematology 20020701
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Reduction of lapachones and their reaction with L-cysteine and mercaptoethanol on glassy carbon electrodes.
Bioelectrochemistry (Amsterdam, Netherlands) 20020515
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Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
The Journal of biological chemistry 20020419
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Chemosensitivity of human prostate cancer cells PC3 and LNCaP to genistein isoflavone and beta-lapachone.
Biology of the cell 20020201
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Preparation and cytotoxicity toward cancer cells of mono(arylimino) derivatives of beta-lapachone.
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beta-Lapachone-induced apoptosis in human prostate cancer cells: involvement of NQO1/xip3.
Experimental cell research 20010701
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Characterization of poly(ADP-ribose)polymerase from Crithidia fasciculata: enzyme inhibition by beta-lapachone.
Molecular and biochemical parasitology 20010701
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Calcium is a key signaling molecule in beta-lapachone-mediated cell death.
The Journal of biological chemistry 20010601
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Induction of CDK inhibitors (p21(WAF1) and p27(Kip1)) and Bak in the beta-lapachone-induced apoptosis of human prostate cancer cells.
Molecular pharmacology 20010401
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Effect of dyskinetoplastic agents on ultrastructure and oxidative phosphorylation in Crithidia fasciculata.
Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al 20010401
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Novel mechanism of cellular DNA topoisomerase II inhibition by the pyranonaphthoquinone derivatives alpha-lapachone and beta-lapachone.
Cancer chemotherapy and pharmacology 20010301
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p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.
Experimental cell research 20010115
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Medicina 20010101
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Comparison of antibacterial and antifungal activities of lapachol and beta-lapachone.
Planta medica 19940801
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Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.
Proceedings of the National Academy of Sciences of the United States of America 19930301