471-53-4 | Glycyrrhetinic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$16.00	$11.00
5g	97%	in stock	$30.00	$21.00
25g	97%	in stock	$105.00	$74.00
100g	97%	in stock	$249.00	$175.00
500g	97%	in stock	$945.00	$661.00

Description

• Catalog Number: AI50771
• Chemical Name: Glycyrrhetinic acid
• CAS Number: 471-53-4
• Molecular Formula: C30H46O4
• Molecular Weight: 470.6838
• MDL Number: MFCD00003706
• SMILES: O=C1C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@]2([C@]2([C@H]1[C@@]1(C)CC[C@@H](C(C1CC2)(C)C)O)C)C)C(=O)O

Computed Properties

• Complexity: 965
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 9
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 6.4

Literature

• Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption.

  Toxicology 20170701

• Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid.

  Chemico-biological interactions 20170525

• Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M.

  Toxicology and applied pharmacology 20170401

• Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.

  Chemico-biological interactions 20150605

• 18β-Glycyrrhetinic acid suppresses TNF-α induced matrix metalloproteinase-9 and vascular endothelial growth factor by suppressing the Akt-dependent NF-κB pathway.

  Toxicology in vitro : an international journal published in association with BIBRA 20140801

• Uralsaponins M-Y, antiviral triterpenoid saponins from the roots of Glycyrrhiza uralensis.

  Journal of natural products 20140725

• Inhibitory effects of herbal constituents on P-glycoprotein in vitro and in vivo: herb-drug interactions mediated via P-gp.

  Toxicology and applied pharmacology 20140301

• Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.

  Microbiology and immunology 20140301

• Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.

  Journal of medicinal chemistry 20130613

• Discovery of a potential anti-inflammatory agent: 3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile.

  Journal of medicinal chemistry 20130314

• Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.

  Journal of ethnopharmacology 20130109

• The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2.

  PloS one 20130101

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.

  Molecular and cellular biochemistry 20121101

• LC-MS/MS as a tool for identification of bioactive compounds in marine sponge Spongosorites halichondriodes (Dendy 1905).

  Toxicon : official journal of the International Society on Toxinology 20121101

• QRS widening and QT prolongation under bupropion: a unique cardiac electrophysiological profile.

  Fundamental & clinical pharmacology 20121001

• The blood-brain barrier permeability of 18β-glycyrrhetinic acid, a major metabolite of glycyrrhizin in Glycyrrhiza root, a constituent of the traditional Japanese medicine yokukansan.

  Cellular and molecular neurobiology 20121001

• Optimization on condition of glycyrrhetinic acid liposome by RSM and the research of its immunological activity.

  International journal of biological macromolecules 20121001

• The effect of water loading on the urinary ratio of cortisone to cortisol in healthy subjects and a new approach to the evaluation of the ratio as an index for in vivo human 11β-hydroxysteroid dehydrogenase 2 activity.

  Steroids 20121001

• In-vitro metabolism of glycyrrhetinic acid by human and rat liver microsomes and its interactions with six CYP substrates.

  The Journal of pharmacy and pharmacology 20121001

• Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis.

  European journal of pharmacology 20120915

• Myoendothelial coupling is unidirectional in guinea pig spiral modiolar arteries.

  Microvascular research 20120901

• [Effect of glycyrrhetinic acid on the expression of inflammatory factors in fibroblast-like synovial cells from collagen induced arthritis rats].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120901

• Visual input modulates audiomotor function via hypothalamic dopaminergic neurons through a cooperative mechanism.

  Neuron 20120823

• Self-assembly and liver targeting of sulfated chitosan nanoparticles functionalized with glycyrrhetinic acid.

  Nanomedicine : nanotechnology, biology, and medicine 20120801

• Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption.

  Journal of cellular and molecular medicine 20120801

• Induction of apoptosis with mitochondrial membrane depolarization by a glycyrrhetinic acid derivative in human leukemia K562 cells.

  Cytotechnology 20120801

• 3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11β-hydroxysteroid dehydrogenase 2.

  The Journal of pharmacology and experimental therapeutics 20120801

• Chromolithic method development, validation and system suitability analysis of ultra-sound assisted extraction of glycyrrhizic acid and glycyrrhetinic acid from Glycyrrhiza glabra.

  Natural product communications 20120801

• Laminin-111 stimulates proliferation of mouse embryonic stem cells through a reduction of gap junctional intercellular communication via RhoA-mediated Cx43 phosphorylation and dissociation of Cx43/ZO-1/drebrin complex.

  Stem cells and development 20120720

• Enhanced transdermal delivery of 18β-glycyrrhetic acid via elastic vesicles: in vitro and in vivo evaluation.

  Drug development and industrial pharmacy 20120701

• UPLC-MS/MS determination of paeoniflorin, naringin, naringenin and glycyrrhetinic acid in rat plasma and its application to a pharmacokinetic study after oral administration of Si-Ni-San decoction.

  Journal of pharmaceutical and biomedical analysis 20120701

• In vitro evaluation of polymeric micelles based on hydrophobically-modified sulfated chitosan as a carrier of doxorubicin.

  Journal of materials science. Materials in medicine 20120701

• Loss of responsiveness of circular smooth muscle cells from the guinea pig ileum is associated with changes in gap junction coupling.

  American journal of physiology. Gastrointestinal and liver physiology 20120615

• TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity.

  American journal of physiology. Cell physiology 20120615

• The anti-ulcer agent, irsogladine, increases insulin secretion by MIN6 cells.

  European journal of pharmacology 20120615

• Study on the interaction of glycyrrhizin and glycyrrhetinic acid with RNA.

  Journal of photochemistry and photobiology. B, Biology 20120604

• HPLC assay and pharmacokinetics and tissue distribution study of glycyrrhetinic acid liposomes modified with galactosylated lipid.

  Journal of liposome research 20120601

• Utilization of [11C]phosgene for radiosynthesis of N-(2-{3-[3,5-bis(trifluoromethyl)]phenyl[11C]ureido}ethyl)glycyrrhetinamide, an inhibitory agent for proteasome and kinase in tumors.

  Bioorganic & medicinal chemistry letters 20120601

• The anti-tumor performance of docetaxel liposomes surface-modified with glycyrrhetinic acid.

  Journal of drug targeting 20120601

• 18β-Glycyrrhetinic acid preferentially blocks late Na current generated by ΔKPQ Nav1.5 channels.

  Acta pharmacologica Sinica 20120601

• Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents.

  Bioorganic & medicinal chemistry letters 20120515

• 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells.

  Journal of cellular physiology 20120501

• Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives.

  British journal of pharmacology 20120501

• Saponins can perturb biologic membranes and reduce the surface tension of aqueous solutions: a correlation?

  Bioorganic & medicinal chemistry 20120501

• Gap junctions propagate opposite effects in normal and tumor testicular cells in response to cisplatin.

  Cancer letters 20120428

• Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

  Journal of natural products 20120427

• 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis.

  Biochemical and biophysical research communications 20120420

• Study on the noncovalent interactions of saikosaponins and cytochrome c by electrospray ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20120415

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  Ugeskrift for laeger 20120409

• ERK acts in parallel to PKCδ to mediate the connexin43-dependent potentiation of Runx2 activity by FGF2 in MC3T3 osteoblasts.

  American journal of physiology. Cell physiology 20120401

• Facile synthesis of triterpenoid saponins bearing β-Glu/Gal-(1→3)-β-GluA methyl ester and their cytotoxic activities.

  Bioorganic & medicinal chemistry letters 20120401

• (3β,18β,20β)-N-Eth-oxy-carbonyl-methyl-3-nitrato-11-oxoolean-12-ene-29-carboxamide methanol monosolvate.

  Acta crystallographica. Section E, Structure reports online 20120401

• GlialCAM, a protein defective in a leukodystrophy, serves as a ClC-2 Cl(-) channel auxiliary subunit.

  Neuron 20120308

• Inhibition of gap junction channel attenuates the migration of breast cancer cells.

  Molecular biology reports 20120301

• Conversions at C-30 of glycyrrhetinic acid and their impact on antitumor activity.

  Archiv der Pharmazie 20120301

• Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy.

  Biomaterials 20120301

• Effects of 18β-Glycyrrhetinic acid in hTNFtg mice - a model of rheumatoid arthritis.

  Wiener klinische Wochenschrift 20120301

• Antimycobacterial and synergistic effects of 18β-glycyrrhetinic acid or glycyrrhetinic acid-30-piperazine in combination with isoniazid, rifampicin or streptomycin against Mycobacterium bovis.

  Phytotherapy research : PTR 20120201

• Design and synthesis of dual-ligand modified chitosan as a liver targeting vector.

  Journal of materials science. Materials in medicine 20120201

• [Effect of oral administration of glycyrrhetinic acid on six metal elements in rat serum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

• Glycyrrhizin and glycyrrhetinic acid directly modulate rat cardiac performance.

  The Journal of nutritional biochemistry 20120101

• Inhibitory effects of glycyrrhetinic Acid on DNA polymerase and inflammatory activities.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Characterization of a novel oral glucocorticoid system and its possible role in disease.

  Journal of dental research 20120101

• 11β-Hydroxysteroid dehydrogenase type 1, but not type 2, deficiency worsens acute inflammation and experimental arthritis in mice.

  Endocrinology 20120101

• Interaction of glycyrrhizin and glycyrrhetinic acid with DNA.

  DNA and cell biology 20120101

• Does one keto group matter? Structure-activity relationships of glycyrrhetinic acid derivatives modified at position C-11.

  Archiv der Pharmazie 20120101

• Glycyrrhetinic acid protects mice from Staphylococcus aureus pneumonia.

  Fitoterapia 20120101

• Effects of a non-conservative sequence on the properties of β-glucuronidase from Aspergillus terreus Li-20.

  PloS one 20120101

• Ursolic acid inhibits the initiation, progression of prostate cancer and prolongs the survival of TRAMP mice by modulating pro-inflammatory pathways.

  PloS one 20120101

• Endothelium-derived relaxing factor-mediated vasodilation in mouse mesenteric vascular beds.

  Journal of pharmacological sciences 20120101

• Potent Antifungal Activity of Pure Compounds from Traditional Chinese Medicine Extracts against Six Oral Candida Species and the Synergy with Fluconazole against Azole-Resistant Candida albicans.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Ethnopharmacology of medicinal plants of the pantanal region (mato grosso, Brazil).

  Evidence-based complementary and alternative medicine : eCAM 20120101

• [Simultaneous determination of five main index components and specific chromatograms analysis in Xiaochaihu granules].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120101

• Pharmacokinetic analysis of alpha and beta epimers of glycyrrhetinic acid in rat plasma: differences in singly and combined administrations.

  Yao xue xue bao = Acta pharmaceutica Sinica 20120101

• Application of Monoclonal Antibodies against Bioactive Natural Products: Eastern Blotting and Preparation of Knockout Extract.

  International journal of analytical chemistry 20120101

• Safety and Efficacy of Tien-Hsien Liquid Practical in Patients with Refractory Metastatic Breast Cancer: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase IIa Trial.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• An overview of the evidence and mechanisms of herb-drug interactions.

  Frontiers in pharmacology 20120101

• Suppression of the Nrf2-dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells.

  PloS one 20120101

• The biphasic role of microglia in Alzheimer's disease.

  International journal of Alzheimer's disease 20120101

• Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of Oldenlandia diffusa extract in rats.

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• [Effect of decoction of turtle shell for anti-fibrosis combined with stronger neo-minophagen C on indices of hepatic fibrosis in chronic hepatitis B].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101

• 18α-glycyrrhetinic acid down-regulates expression of type I and III collagen via TGF-Β1/Smad signaling pathway in human and rat hepatic stellate cells.

  International journal of medical sciences 20120101

• A novel transdermal fomulation of 18β-glycyrrhetic acid with lysine for improving bioavailability and efficacy.

  Skin pharmacology and physiology 20120101

• Synthesis and antiviral activities of spacer-linked 1-thioglucuronide analogues of glycyrrhizin.

  Beilstein journal of organic chemistry 20120101

• Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts.

  PloS one 20120101

• Immunological adjuvant efficacy of glycyrrhetinic acid liposome against Newcastle disease vaccine.

  Vaccine 20111206

• [The old man and the syrup].

  Pathologie-biologie 20111201

• Identification and quantification of oleanolic acid and ursolic acid in Chinese herbs by liquid chromatography-ion trap mass spectrometry.

  Biomedical chromatography : BMC 20111201

• DU-145 prostate carcinoma cells that selectively transmigrate narrow obstacles express elevated levels of Cx43.

  Cellular & molecular biology letters 20111201

• The use of Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, in robust neuroprotection in the postischemic brain.

  Anatomy & cell biology 20111201

• Antitumor activity of drug loaded glycyrrhetinic acid modified alginate nanoparticles on mice bearing orthotopic liver tumor.

  Journal of controlled release : official journal of the Controlled Release Society 20111130

• Understanding the role of the C3-hydroxyl group in glycyrrhetinic acid on liver targeting.

  Journal of controlled release : official journal of the Controlled Release Society 20111130

• Gap junctions contribute to astrocytic resistance against zinc toxicity.

  Brain research bulletin 20111125

• Glycyrrhetinic acid prevents cutaneous scratching behavior in mice elicited by substance P or PAR-2 agonist.

  European journal of pharmacology 20111116

• Synthesis and antitumor activity of ring A modified glycyrrhetinic acid derivatives.

  European journal of medicinal chemistry 20111101

• Triterpene functional genomics in licorice for identification of CYP72A154 involved in the biosynthesis of glycyrrhizin.

  The Plant cell 20111101

• Propargylaminyl 3α-hy-droxy-11-oxo-18β-olean-12-en-29-oate.

  Acta crystallographica. Section E, Structure reports online 20111101

• [Identification of the metabolites of Sinisan extract in rat plasma, urine, feces and bile after intragastric administration].

  Yao xue xue bao = Acta pharmaceutica Sinica 20111101

• [Research progress of anticancer mechanism of glycyrrhetinic acid].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111101

• Ligand-receptor interaction between triterpenoids and the 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) enzyme predicts their toxic effects against tumorigenic r/m HM-SFME-1 cells.

  The Journal of biological chemistry 20111021

• N-(2-{3-[3,5-bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): a novel anticancer glycyrrhetinic acid derivative that targets the proteasome and displays anti-kinase activity.

  Journal of medicinal chemistry 20111013

• Determination of corosolic acid, a natural potential anti-diabetes compound, in rat plasma by high-performance liquid chromatography-mass spectrometry and its application to pharmacokinetic and bioavailability studies.

  Planta medica 20111001

• Glycyrrhetinic acid extracted from Glycyrrhiza uralensis Fisch. induces the expression of Toll-like receptor 4 in Ana-1 murine macrophages.

  Journal of Asian natural products research 20111001

• Disruption of gap junctions reduces biomarkers of decidualization and angiogenesis and increases inflammatory mediators in human endometrial stromal cell cultures.

  Molecular and cellular endocrinology 20110915

• Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins.

  Molecular carcinogenesis 20110901

• Preparation and characterization of galactose-modified liposomes by a nonaqueous enzymatic reaction.

  Journal of liposome research 20110901

• 18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.

  International journal of oncology 20110901

• Gap junctions favor normal rat kidney epithelial cell adaptation to chronic hypertonicity.

  American journal of physiology. Cell physiology 20110901

• Structure-activity relationship analyses of glycyrrhetinic acid derivatives as anticancer agents.

  Mini reviews in medicinal chemistry 20110901

• Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase.

  European journal of medicinal chemistry 20110901

• 11β-hydroxysteroid dehydrogenases and the brain: from zero to hero, a decade of progress.

  Frontiers in neuroendocrinology 20110801

• Current and future drug targets in weight management.

  Pharmaceutical research 20110801

• Comparison of ethanolamine/ethylenediamine-functionalized poly(glycidyl methacrylate) for efficient gene delivery.

  Acta biomaterialia 20110801

• Improvement of the cytotoxicity and tumor selectivity of glycyrrhetinic acid by derivatization with bifunctional amino acids.

  Archiv der Pharmazie 20110801

• Therapeutic effects of connexin inhibitors on detrusor overactivity induced by bladder outlet obstruction in rats.

  Urology 20110801

• Inhibition of osteoblastic differentiation by warfarin and 18-α-glycyrrhetinic acid.

  Archives of pharmacal research 20110801

• Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.

  Journal of agricultural and food chemistry 20110727

• 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells.

  Bioorganic & medicinal chemistry 20110715

• Cellular radioprotecting potential of glyzyrrhizic acid, silver nanoparticle and their complex.

  Mutation research 20110714

• Selective toxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells is potentially attributed to downregulation of glutathione.

  Biochimie 20110701

• A new dual-responsive organogel based on uracil-appended glycyrrhetinic acid.

  Organic letters 20110701

• 18β-glycyrrhetic acid inhibits immune activation triggered by HMGB1, a pro-inflammatory protein found in the tear fluid during conjunctivitis and blepharitis.

  Ocular immunology and inflammation 20110601

• [Glycyrrhetinic acid induces apoptosis and alters survivin gene expression in human myeloma cell line U266].

  Zhongguo shi yan xue ye xue za zhi 20110601

• 18beta-glycyrrhetinic acid and glabridin prevent oxidative DNA fragmentation in UVB-irradiated human keratinocyte cultures.

  Anticancer research 20110601

• Chemopreventive potential of 18beta-glycyrrhetinic acid: an active constituent of liquorice, in 7,12-dimethylbenz(a)anthracene induced hamster buccal pouch carcinogenesis.

  Pakistan journal of biological sciences : PJBS 20110601

• Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.

  Journal of natural products 20110527

• Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11β-hydroxysteroid dehydrogenase type 2.

  The Journal of steroid biochemistry and molecular biology 20110501

• An over-the-counter moisturizer is as clinically effective as, and more cost-effective than, prescription barrier creams in the treatment of children with mild-to-moderate atopic dermatitis: a randomized, controlled trial.

  Journal of drugs in dermatology : JDD 20110501

• Effects of brucine combined with glycyrrhetinic acid or liquiritin on rat hepatic cytochrome P450 activities in vivo.

  Yao xue xue bao = Acta pharmaceutica Sinica 20110501

• [Alternative therapies for hepatitis C: UDCA and SNMC].

  Nihon rinsho. Japanese journal of clinical medicine 20110501

• Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity.

  Molecular and cellular endocrinology 20110410

• Effects of connexin-mimetic peptides on perfusion pressure in response to phenylephrine in isolated, perfused rat kidneys.

  Clinical and experimental nephrology 20110401

• Glycyrrhetinic acid-functionalized degradable micelles as liver-targeted drug carrier.

  Journal of materials science. Materials in medicine 20110401

• A glycyrrhizin-containing preparation reduces hepatic steatosis induced by hepatitis C virus protein and iron in mice.

  Liver international : official journal of the International Association for the Study of the Liver 20110401

• Synthesis and pro-apoptotic activity of novel glycyrrhetinic acid derivatives.

  Chembiochem : a European journal of chemical biology 20110321

• Synthesis of new glycyrrhetinic acid derived ring A azepanone, 29-urea and 29-hydroxamic acid derivatives as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.

  Bioorganic & medicinal chemistry 20110315

• Design, synthesis, and sustained-release property of 1,3-cyclic propanyl phosphate ester of 18β-glycyrrhetinic acid.

  Chemical biology & drug design 20110301

• Development of a liquid chromatography-mass spectrometry method for the determination of ursolic acid in rat plasma and tissue: application to the pharmacokinetic and tissue distribution study.

  Analytical and bioanalytical chemistry 20110301

• Allergic contact dermatitis caused by glycyrrhetinic acid and castor oil.

  Contact dermatitis 20110301

• [Expression of 11β-hydroxysteroid dehydrogenase type 2 in lymphoblastic cells and its relationship with glucocorticoid sensitivity].

  Zhongguo shi yan xue ye xue za zhi 20110201

• Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115

• Shp2 protein tyrosine phosphatase inhibitor activity of estramustine phosphate and its triterpenoid analogs.

  Bioorganic & medicinal chemistry letters 20110115

• Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) Root Extract Combinations Increase Hepatocarcinoma Cell (Hep-G2) Viability.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Herbal Medicine Containing Licorice May Be Contraindicated for a Patient with an HSD11B2 Mutation.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• A laboratory evaluation of the antibacterial and cytotoxic effect of Liquorice when used as root canal medicament.

  International endodontic journal 20110101

• Roles of phytochemicals in amino acid nutrition.

  Frontiers in bioscience (Scholar edition) 20110101

• Diet-induced obesity impairs endothelium-derived hyperpolarization via altered potassium channel signaling mechanisms.

  PloS one 20110101

• In vitro metabolism of glycyrrhetic acid by human cytochrome P450.

  Yao xue xue bao = Acta pharmaceutica Sinica 20110101

• Antioxidant status and immune activity of glycyrrhizin in allergic rhinitis mice.

  International journal of molecular sciences 20110101

• C-kit binding properties of hesperidin (a major component of KMP6) as a potential anti-allergic agent.

  PloS one 20110101

• Blockade of gap junction hemichannel suppresses disease progression in mouse models of amyotrophic lateral sclerosis and Alzheimer's disease.

  PloS one 20110101

• Glycyrrhizin as antiviral agent against Hepatitis C Virus.

  Journal of translational medicine 20110101

• Diacylglycerol signaling underlies astrocytic ATP release.

  Neural plasticity 20110101

• Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits.

  Molecular vision 20110101

• Intercellular communication amplifies stressful effects in high-charge, high-energy (HZE) particle-irradiated human cells.

  Journal of radiation research 20110101

• High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.

  PloS one 20110101

• A new approach in the first-line treatment of bacterial and mycotic vulvovaginitis with topical lipohydroperoxides and glycyrrhetic acid: a comparative study.

  Clinical and experimental obstetrics & gynecology 20110101

• Thalamic Gap Junctions Control Local Neuronal Synchrony and Influence Macroscopic Oscillation Amplitude during EEG Alpha Rhythms.

  Frontiers in psychology 20110101

• Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.

  Journal of pharmacological sciences 20110101

• Hepatoprotective and antioxidant effects of licorice extract against CCl₄-induced oxidative damage in rats.

  International journal of molecular sciences 20110101

• Mouse 11β-hydroxysteroid dehydrogenase type 2 for human application: homology modeling, structural analysis and ligand-receptor interaction.

  Cancer informatics 20110101

• Curative effect of 18β-glycyrrhetinic acid in experimental visceral leishmaniasis depends on phosphatase-dependent modulation of cellular MAP kinases.

  PloS one 20110101

• Quality control of modified xiaoyao san through the determination of 22 active components by ultra-performance liquid chromatography.

  Journal of AOAC International 20110101

• [Estimation of efficacy of Hexalyse used for the treatment of acute pharyngitis].

  Vestnik otorinolaringologii 20110101

• Separation and determination of four ganoderic acids from dried fermentation mycelia powder of Ganoderma lucidum by capillary zone electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20101215

• 18β-Glycyrrhetinic acid potentiates apoptotic effect of trichostatin A on human epithelial ovarian carcinoma cell lines.

  European journal of pharmacology 20101215

• Specific brainstem neurons switch each other into pacemaker mode to drive movement by activating NMDA receptors.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20101208

• 18β-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-κB inactivation in interleukin-10-deficient mice.

  Journal of periodontal research 20101201

• Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland.

  British journal of pharmacology 20101201

• Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid.

  European journal of medicinal chemistry 20101201

• Insight into glycyrrhetinic acid: the role of the hydroxyl group on liver targeting.

  International journal of pharmaceutics 20101115

• Synthesis and biological evaluation of furoxan-based nitric oxide-releasing derivatives of glycyrrhetinic acid as anti-hepatocellular carcinoma agents.

  Bioorganic & medicinal chemistry letters 20101115

• Synthesis of novel 3-amino and 29-hydroxamic acid derivatives of glycyrrhetinic acid as selective 11β-hydroxysteroid dehydrogenase 2 inhibitors.

  Bioorganic & medicinal chemistry 20101101

• Synthesis and antitumour activity of glycyrrhetinic acid derivatives.

  Bioorganic & medicinal chemistry 20101101

• An automated method of on-line extraction coupled with flow injection and capillary electrophoresis for phytochemical analysis.

  Journal of chromatographic science 20101101

• Effect and mechanism of penetration enhancement of organic base and alcohol on glycyrrhetinic acid in vitro.

  International journal of pharmaceutics 20101031

• Glycyrrhetinic acid-modified poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) micelles for liver targeting therapy.

  Acta biomaterialia 20101001

• Methyl 2-cyano-3,11-dioxo-18-olean-1,12-dien-30-oate (CDODA-Me), a derivative of glycyrrhetinic acid, functions as a potent angiogenesis inhibitor.

  The Journal of pharmacology and experimental therapeutics 20101001

• Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility.

  Developmental biology 20101001

• In vitro and in vivo pharmacokinetics of two novel 1,3-cyclic propanyl phosphate ester prodrugs of 18β-glycyrrhetic acid in rats.

  Journal of Asian natural products research 20101001

• (+)-Methyl 3β-acet-oxy-13-carb-oxy-19-hy-droxy-11-oxo-C-norolean-18-en-30-oate γ-lactone.

  Acta crystallographica. Section E, Structure reports online 20101001

• Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

  Toxins 20101001

• Development of glycyrrhetinic acid-modified stealth cationic liposomes for gene delivery.

  International journal of pharmaceutics 20100915

• Cytoplasm and organelle transfer between mesenchymal multipotent stromal cells and renal tubular cells in co-culture.

  Experimental cell research 20100910

• Evidence both L-type and non-L-type voltage-dependent calcium channels contribute to cerebral artery vasospasm following loss of NO in the rat.

  Vascular pharmacology 20100901

• [Dermatopharmacokinetic studies of liangfu cream in mice skin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100901

• Glycyrrhizic acid and 18beta-glycyrrhetinic acid inhibit inflammation via PI3K/Akt/GSK3beta signaling and glucocorticoid receptor activation.

  Journal of agricultural and food chemistry 20100811

• Glycyrrhetinic acid attenuates vascular smooth muscle vasodilatory function in healthy humans.

  Clinical science (London, England : 1979) 20100805

• Synthesis and binding ability of 1,2,3-triazole-based triterpenoid receptors for recognition of Hg(2+) ion.

  Bioorganic & medicinal chemistry letters 20100801

• Selection and optimization of MCF-7 cell line for screening selective inhibitors of 11beta-hydroxysteroid dehydrogenase 2.

  Cell biochemistry and function 20100801

• Disruption of gap junctions attenuates aminoglycoside-elicited renal tubular cell injury.

  British journal of pharmacology 20100801

• Efficacy and safety of intravenous stronger neo-minophagen C and S-adenosyl-L-methionine in treatment of pregnant woman with chronic hepatitis B: a pilot study.

  Medical science monitor : international medical journal of experimental and clinical research 20100801

• Synthesis of procyanidin B3 and its anti-inflammatory activity. the effect of 4-alkoxy group of catechin electrophile in the Yb(OTf)(3)-catalyzed condensation with catechin nucleophile.

  The Journal of organic chemistry 20100716

• Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity.

  European journal of medicinal chemistry 20100701

• Connexin 43 hemichannel regulates H9c2 cell proliferation by modulating intracellular ATP and [Ca2+].

  Acta biochimica et biophysica Sinica 20100701

• Plant Natural compounds with antibacterial activity towards common pathogens of pond-cultured channel catfish (Ictalurus punctatus).

  Toxins 20100701

• The synthesis of glycyrrhetinic acid derivatives containing a nitrogen heterocycle and their antiproliferative effects in human leukemia cells.

  Molecules (Basel, Switzerland) 20100621

• Glycyrrhetinic acid-modified chitosan/poly(ethylene glycol) nanoparticles for liver-targeted delivery.

  Biomaterials 20100601

• A practical approach to genetic hypokalemia.

  Electrolyte & blood pressure : E & BP 20100601

• Overcoming multidrug resistance in human cancer cells by natural compounds.

  Toxins 20100601

• Regulation of renin release by connexin 43 in As 4.1 cell line.

  Peptides 20100501

• Glycyrrhetinic acid inhibits ICAM-1 expression via blocking JNK and NF-kappaB pathways in TNF-alpha-activated endothelial cells.

  Acta pharmacologica Sinica 20100501

• Final report of the safety assessment of allantoin and its related complexes.

  International journal of toxicology 20100501

• Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality.

  Forensic science international 20100415

• Enhanced distribution and extended elimination of glycyrrhetinic acid in mice liver by mPEG-PLA modified (mPEGylated) liposome.

  Journal of pharmaceutical and biomedical analysis 20100406

• Nanoemulsions as vehicles for topical administration of glycyrrhetic acid: characterization and in vitro and in vivo evaluation.

  Drug delivery 20100401

• [Anti-inflammatory effect of enoxolone in an ex-vivo human gingival mucosa model].

  Revue de stomatologie et de chirurgie maxillo-faciale 20100401

• Inhibition of human renin activity by saponins.

  Biomedical research (Tokyo, Japan) 20100401

• Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.

  The Journal of biological chemistry 20100312

• Selective cytotoxicity of glycyrrhetinic acid against tumorigenic r/m HM-SFME-1 cells: potential involvement of H-Ras downregulation.

  Toxicology letters 20100215

• Gap junctions and memory: an investigation using a single trial discrimination avoidance task for the neonate chick.

  Neurobiology of learning and memory 20100201

• Bioactive microbial metabolites from glycyrrhetinic acid.

  Phytochemistry 20100201

• Structural determination of two new triterpenoids biotransformed from glycyrrhetinic acid by Mucor polymorphosporus.

  Magnetic resonance in chemistry : MRC 20100201

• Glycyrrhizin and its metabolite 18 beta-glycyrrhetinic acid in glycyrrhiza, a constituent herb of yokukansan, ameliorate thiamine deficiency-induced dysfunction of glutamate transport in cultured rat cortical astrocytes.

  European journal of pharmacology 20100125

• 18Beta-glycyrrhetinic acid ameliorates acute Propionibacterium acnes-induced liver injury through inhibition of macrophage inflammatory protein-1alpha.

  The Journal of biological chemistry 20100108

• Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases.

  Bioorganic & medicinal chemistry 20100101

• Downregulation of c-FLIP, XIAP and Mcl-1 protein as well as depletion of reduced glutathione contribute to the apoptosis induction of glycyrrhetinic acid derivatives in leukemia cells.

  Cancer biology & therapy 20100101

• N-acetylcysteine, reactive oxygen species and beyond.

  Cancer biology & therapy 20100101

• GnRH-Induced [Ca2+]i-signalling patterns in mouse gonadotrophs recorded from acute pituitary slices in vitro.

  Neuroendocrinology 20100101

• Glycyrrhetinic acid induces anoikis-like death and cytoskeletal disruption in the central nervous system tumorigenic cells.

  Biological & pharmaceutical bulletin 20100101

• Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice.

  Journal of biomedicine & biotechnology 20100101

• Stanniocalcin-1 regulates extracellular ATP-induced calcium waves in human epithelial cancer cells by stimulating ATP release from bystander cells.

  PloS one 20100101

• EST analysis reveals putative genes involved in glycyrrhizin biosynthesis.

  BMC genomics 20100101

• Selective inhibition of the tumor marker AKR1B10 by antiinflammatory N-phenylanthranilic acids and glycyrrhetic acid.

  Biological & pharmaceutical bulletin 20100101

• Aldose reductase inhibitory compounds from Glycyrrhiza uralensis.

  Biological & pharmaceutical bulletin 20100101

• Gemcitabine intercellular diffusion mediated by gap junctions: new implications for cancer therapy.

  Molecular cancer 20100101

• How neurons generate behavior in a hatchling amphibian tadpole: an outline.

  Frontiers in behavioral neuroscience 20100101

• Mechanism underlying endothelium-dependent relaxation by 2-methylthio-ADP in monkey cerebral artery.

  Journal of pharmacological sciences 20100101

• Bioconversion of glycyrrhizinic acid in liquorice into 18-beta-glycyrrhetinic acid by Aspergillus parasiticus speare BGB.

  Prikladnaia biokhimiia i mikrobiologiia 20100101

• Astroglial Wiring is Adding Complexity to Neuroglial Networking.

  Frontiers in neuroenergetics 20100101

• Connexin modulators and their potential targets under the magnifying glass.

  Current medicinal chemistry 20100101

• 4-oxo-N-(4-hydroxyphenyl)retinamide: two independent ways to kill cancer cells.

  PloS one 20100101

• In vitro and in vivo inhibitory effects of glycyrrhetinic acid on cytochrome P450 3A activity.

  Pharmacology 20100101

• [Anti-inflammatory and repair activity of two toothpastes in an ex-vivo human gingival mucosa model].

  Revue de stomatologie et de chirurgie maxillo-faciale 20100101

• c-Jun NH2-terminal kinase-dependent upregulation of DR5 mediates cooperative induction of apoptosis by perifosine and TRAIL.

  Molecular cancer 20100101

• Panax notoginseng saponins potentiate osteogenesis of bone marrow stromal cells by modulating gap junction intercellular communication activities.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• The traditional Japanese formula keishibukuryogan inhibits the production of inflammatory cytokines by dermal endothelial cells.

  Mediators of inflammation 20100101

• Update on the management of chronic eczema: new approaches and emerging treatment options.

  Clinical, cosmetic and investigational dermatology 20100101

• Formulation and evaluation of floating tablets of liquorice extract.

  Pharmacognosy research 20100101

• Critical analysis of herbs acting on Mutravaha srotas.

  Ayu 20100101

• A simple and rapid method for simultaneous estimation of glycyrrhetinic Acid and piperine by hptlc in a herbomineral formulation.

  Journal of advanced pharmaceutical technology & research 20100101

• Comparative pharmacognostical investigation on four ethanobotanicals traditionally used as Shankhpushpi in India.

  Journal of advanced pharmaceutical technology & research 20100101

• Spectroscopic studies on the interaction between erlotinib hydrochloride and bovine serum albumin.

  Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20100101

• Role of connexin-43 hemichannels in the pathogenesis of Yersinia enterocolitica.

  Veterinary journal (London, England : 1997) 20091201

• Hepatic 11 beta-hydroxysteroid dehydrogenase 1 involvement in alterations of glucose metabolism produced by acidotic stress in rat.

  Journal of physiology and biochemistry 20091201

• At the bottom of the differential diagnosis list: unusual causes of pediatric hypertension.

  Pediatric nephrology (Berlin, Germany) 20091101

• 11beta-hydroxysteroid dehydrogenase type 1 regulates glucocorticoid-induced insulin resistance in skeletal muscle.

  Diabetes 20091101

• Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18beta-olean-1,12-dien-30-oate in colon cancer cells.

  International journal of cancer 20091015

• Glycyrrhetinic acid food supplementation lowers serum potassium concentration in chronic hemodialysis patients.

  Kidney international 20091001

• Licorice: a sweet alternative to prevent hyperkalemia in dialysis patients?

  Kidney international 20091001

• Tramadol and flurbiprofen depress the cytotoxicity of cisplatin via their effects on gap junctions.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20090915

• Glycyrretinic acid blocks cardiac sodium channels expressed in Xenopus oocytes.

  Journal of ethnopharmacology 20090907

• Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative.

  Molecular carcinogenesis 20090801

• Glycyrrhizin prevents 7-ketocholesterol toxicity against differentiated PC12 cells by suppressing mitochondrial membrane permeability change.

  Neurochemical research 20090801

• Direct formation of proteo-liposomes by in vitro synthesis and cellular cytosolic delivery with connexin-expressing liposomes.

  Biomaterials 20090801

• A heterotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer.

  Molecular cancer therapeutics 20090801

• Novel 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1) and 3beta-methoxyserrat-14-en-21beta-ol (PJ-2)-curcumin, kojic acid, quercetin, and baicalein conjugates as HIV agents.

  Bioorganic & medicinal chemistry 20090715

• Infusion of gliotoxins or a gap junction blocker in the prelimbic cortex increases alcohol preference in Wistar rats.

  Journal of psychopharmacology (Oxford, England) 20090701

• [Effects of penetration enhancers on in vitro percutaneous absorption and amount retained in skin of paeonol, dictamnine, fraxinellone and glycyrrhetinic acid in Liangfu cream].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

• 1,2,5-Oxadiazolo[3,4-b]glycyrrhetinic acid.

  Acta crystallographica. Section E, Structure reports online 20090701

• Prejunctional and postjunctional actions of heptanol and 18 beta-glycyrretinic acid in the rodent vas deferens.

  Autonomic neuroscience : basic & clinical 20090615

• Efficient synthesis of glycyrrhetinic acid glycoside/glucuronide derivatives using silver zeolite as promoter.

  Carbohydrate research 20090612

• Hypolipidemic activity of 18beta-glycyrrhetinic acid on streptozotocin-induced diabetic rats.

  European journal of pharmacology 20090610

• Effect of gap junction blocker beta-glycyrrhetinic acid on taste disk cells in frog.

  Cellular and molecular neurobiology 20090601

• Treatment of pruritus in mild-to-moderate atopic dermatitis with a topical non-steroidal agent.

  Journal of drugs in dermatology : JDD 20090601

• Atopiclair.

  Expert opinion on pharmacotherapy 20090501

• In vitro effects of glycyrrhetinic acid on the growth of clinical isolates of Candida albicans.

  Phytotherapy research : PTR 20090401

• Locomotor rhythm maintenance: electrical coupling among premotor excitatory interneurons in the brainstem and spinal cord of young Xenopus tadpoles.

  The Journal of physiology 20090401

• Synthesis, anti-inflammatory, and antioxidant activities of 18beta-glycyrrhetinic acid derivatives as chemical mediators and xanthine oxidase inhibitors.

  Bioorganic & medicinal chemistry 20090401

• Synthesis of (-)-epicatechin 3-(3-O-methylgallate) and (+)-catechin 3-(3-O-methylgallate), and their anti-inflammatory activity.

  Chemistry & biodiversity 20090401

• The effect of carbenoxolone on hippocampal formation theta rhythm in rats: in vitro and in vivo approaches.

  Brain research bulletin 20090330

• Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies.

  Progress in neuro-psychopharmacology & biological psychiatry 20090317

• Antihyperglycemic effect of 18 beta-glycyrrhetinic acid, aglycone of glycyrrhizin, on streptozotocin-diabetic rats.

  European journal of pharmacology 20090315

• Glycyrrhizin and licorice significantly affect the pharmacokinetics of methotrexate in rats.

  Journal of agricultural and food chemistry 20090311

• Possible participation of chloride ion channels in ATP release from cancer cells in suspension.

  Clinical and experimental pharmacology & physiology 20090301

• High glucose-induced downregulation of connexin 43 expression promotes apoptosis in microvascular endothelial cells.

  Investigative ophthalmology & visual science 20090301

• ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide.

  European journal of pharmacology 20090301

• Pharmacological 'cross-inhibition' of connexin hemichannels and swelling activated anion channels.

  Glia 20090201

• Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins.

  European journal of cell biology 20090201

• Selective inhibition of 11beta-hydroxysteroid dehydrogenase 1 by 18alpha-glycyrrhetinic acid but not 18beta-glycyrrhetinic acid.

  The Journal of steroid biochemistry and molecular biology 20090201

• 4-Hydroxy-phenyl 4-fluoro-benzoate.

  Acta crystallographica. Section E, Structure reports online 20090201

• Evidence against a role of gap junctions in vestibular compensation.

  Neuroscience letters 20090130

• Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway.

  Journal of agricultural and food chemistry 20090128

• The role of gap junctions in megakaryocyte-mediated osteoblast proliferation and differentiation.

  Bone 20090101

• Simultaneous determination of 18alpha- and 18beta-glycyrrhetic acid in human plasma by LC-ESI-MS and its application to pharmacokinetics.

  Biomedical chromatography : BMC 20090101

• Regulatory effects of myoendothelial gap junction on vascular reactivity after hemorrhagic shock in rats.

  Shock (Augusta, Ga.) 20090101

• ATP-dependent infra-slow (<0.1 Hz) oscillations in thalamic networks.

  PloS one 20090101

• Microbial transformation of 18beta-glycyrrhetinic acid by Cunninghamella elegans and Fusarium lini, and lipoxygenase inhibitory activity of transformed products.

  Natural product research 20090101

• Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats.

  Lipids in health and disease 20090101

• PAR6, a potential marker for the germ cells selected to form primordial follicles in mouse ovary.

  PloS one 20090101

• Inhibitory effects of Kampo medicine on human UGT2B7 activity.

  Drug metabolism and pharmacokinetics 20090101

• Identification of human UDP-glucuronosyltransferase isoforms responsible for the glucuronidation of glycyrrhetinic acid.

  Drug metabolism and pharmacokinetics 20090101

• Inactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase enzymes increases during the meiotic maturation of porcine oocytes.

  Reproduction (Cambridge, England) 20081201

• Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.

  Journal of Korean medical science 20081201

• Use of calcium imaging for analysis of neuronal gap junction coupling.

  Neuroscience letters 20081107

• A double-blind, randomized, vehicle-controlled clinical study to evaluate the efficacy and safety of MAS063DP (ATOPICLAIR) in the management of atopic dermatitis in paediatric patients.

  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology 20081101

• Effect of glycyrrhetinic acid on membrane band 3 in human erythrocytes.

  Archives of biochemistry and biophysics 20081101

• Effects of 18-glycyrrhetinic acid on serine 368 phosphorylation of connexin43 in rat neonatal cardiomyocytes.

  Cell biology international 20081101

• Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis.

  Life sciences 20081010

• Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals.

  Cancer chemotherapy and pharmacology 20081001

• Mechanistic investigation of the noncytochrome P450-mediated metabolism of triadimefon to triadimenol in hepatic microsomes.

  Chemical research in toxicology 20081001

• [Effect of glycyrrhetinic acid on invasive capacity of leukemic cells and activity of gelatinase].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20081001

• [Preparation of coated tablets of glycyrrhetic acid-HP-beta-cyclodextrin tablets for colon-specific release].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081001

• 18beta-Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti-cancer drug toxicity.

  Life sciences 20080926

• Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.

  Bioorganic & medicinal chemistry 20080915

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• The disposition of diammonium glycyrrhizinate and glycyrrhetinic acid in the isolated perfused rat intestine and liver.

  Planta medica 20080901

• Blockade of glucocorticoid excess at the tissue level: inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 as a therapy for type 2 diabetes.

  Journal of medicinal chemistry 20080828

• Enhanced spontaneous Ca2+ events in endothelial cells reflect signalling through myoendothelial gap junctions in pressurized mesenteric arteries.

  Cell calcium 20080801

• [Expression, characterization and application of thermostable beta-glucuronidase from Thermotoga maritima].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20080801

• Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

  Journal of medicinal chemistry 20080724

• Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.

  Bioorganic & medicinal chemistry 20080715

• Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury.

  Drug metabolism and disposition: the biological fate of chemicals 20080701

• Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport.

  Drug metabolism and disposition: the biological fate of chemicals 20080701

• [Synthesis and in vitro antioxidant activity of homo- and heterocyclic diene derivatives of glycyrrhetol].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080701

• Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

  Journal of medicinal chemistry 20080626

• Connexin 40 and ATP-dependent intercellular calcium wave in renal glomerular endothelial cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080601

• Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds.

  Phytotherapy research : PTR 20080601

• Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.

  Hepatology (Baltimore, Md.) 20080601

• Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics.

  Journal of clinical pharmacy and therapeutics 20080601

• MAS063DP is effective monotherapy for mild to moderate atopic dermatitis in infants and children: a multicenter, randomized, vehicle-controlled study.

  The Journal of pediatrics 20080601

• [Study on pharmacokinetics of glycyrrhetic acid in rats by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

• N-(3,4-Difluoro-phen-yl)-3,4-dimethoxy-benzene-sulfonamide.

  Acta crystallographica. Section E, Structure reports online 20080601

• In vitro and in vivo evaluation of mPEG-PLA modified liposomes loaded glycyrrhetinic acid.

  International journal of pharmaceutics 20080522

• Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells.

  The Journal of pharmacy and pharmacology 20080501

• Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives.

  Bioorganic & medicinal chemistry letters 20080415

• A time course analysis of systemic administration of aqueous licorice extract on spatial memory retention in rats.

  Planta medica 20080401

• Targeting connexin 43 prevents platelet-derived growth factor-BB-induced phenotypic change in porcine coronary artery smooth muscle cells.

  Circulation research 20080328

• Interaction of glycyrrhetinic acid, furosemide and hydrochlorothiazide with bovine serum albumin and their displacement interactions: capillary electrophoresis and fluorescence quenching study.

  Biomedical chromatography : BMC 20080301

• Antiviral effects of Glycyrrhiza species.

  Phytotherapy research : PTR 20080201

• Role of gap junctions and protein kinase A during the development of oocyte maturational competence in Ayu (Plecoglossus altivelis).

  General and comparative endocrinology 20080201

• Methyl 2-cyano-3,11-dioxo-18 beta-olean-1,12-dien-30-oate is a peroxisome proliferator-activated receptor-gamma agonist that induces receptor-independent apoptosis in LNCaP prostate cancer cells.

  Molecular pharmacology 20080201

• Endothelium-derived hyperpolarizing factor in preeclampsia: heterogeneous contribution, mechanisms, and morphological prerequisites.

  American journal of physiology. Regulatory, integrative and comparative physiology 20080201

• Connexin expression and functional analysis of gap junctional communication in mouse embryonic stem cells.

  Stem cells (Dayton, Ohio) 20080201

• Ligand supplementation as a method to increase soluble heterologous protein production.

  Expert review of proteomics 20080201

• Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors.

  Bulletin of experimental biology and medicine 20080201

• [General therapy of type C chronic hepatitis: efficacy and limitation of hepatoprotective agents].

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20080110

• Glycyrrhetinic acid as inhibitor or amplifier of permeability transition in rat heart mitochondria.

  Biochimica et biophysica acta 20080101

• A novel approach for screening of new anti-Helicobacter pylori substances.

  Biological & pharmaceutical bulletin 20080101

• Inhibition of 11beta-hydroxysteroid dehydrogenase enzymatic activities by glycyrrhetinic acid in vivo supports direct glucocorticoid-mediated suppression of steroidogenesis in Leydig cells.

  Journal of andrology 20080101

• [Effect of phospholipid on absorption of diammonium glycyrrhizinate].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080101

• A double-blind, randomised, vehicle-controlled clinical study to evaluate the efficacy of MAS065D in limiting the effects of radiation on the skin: interim analysis.

  European journal of dermatology : EJD 20080101

• Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity.

  AIDS research and therapy 20080101

• Glucuronide-sulfate diconjugate as a novel metabolite of glycyrrhetic acid in rat bile.

  Drug metabolism and pharmacokinetics 20080101

• Patient-reported outcomes from a multicenter, randomized, vehicle-controlled clinical study of MAS063DP (Atopiclair) in the management of mild-to-moderate atopic dermatitis in adults.

  The Journal of dermatological treatment 20080101

• Association between umbilical cord glucocorticoids and blood pressure at age 3 years.

  BMC medicine 20080101

• PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents.

  PPAR research 20080101

• [Severe hypokalemia after holidays return].

  Revue medicale de Bruxelles 20080101

• [Hypertension due to liquorice and liquorice tea consumption].

  Nederlands tijdschrift voor geneeskunde 20071222

• Induction of growth hormone release by glycyrrhizae radix on rat.

  Journal of biochemistry and molecular biology 20071130

• New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

  Journal of medicinal chemistry 20071129

• Gap junction mediated transport of shRNA between human embryonic stem cells.

  Biochemical and biophysical research communications 20071123

• Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.

  Carbohydrate research 20071105

• Role of gap junctions in spontaneous activity of the rat bladder.

  American journal of physiology. Renal physiology 20071001

• Anti-tumor agents 255: novel glycyrrhetinic acid-dehydrozingerone conjugates as cytotoxic agents.

  Bioorganic & medicinal chemistry 20070915

• Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis.

  The Journal of physiology 20070915

• [Study on adscription of plasma effective constituents of rat after administrated with Paeonia lacliflora and Glycyrrhiza uralensis compound].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

• Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

  Journal of medicinal chemistry 20070823

• The synthesis of 18beta-glycyrrhetinic acid derivatives which have increased antiproliferative and apoptotic effects in leukemia cells.

  Bioorganic & medicinal chemistry 20070815

• Enhancing effect of connexin 32 gene on vinorelbine-induced cytotoxicity in A549 lung adenocarcinoma cells.

  Cancer chemotherapy and pharmacology 20070801

• Blockade of gap junction coupling by glycyrrhetinic acids in guinea pig cochlear artery: a whole-cell voltage- and current-clamp study.

  British journal of pharmacology 20070801

• Stronger Neo-Minophagen C, a glycyrrhizin-containing preparation, protects liver against carbon tetrachloride-induced oxidative stress in transgenic mice expressing the hepatitis C virus polyprotein.

  Liver international : official journal of the International Association for the Study of the Liver 20070801

• Corticosteroids, 11beta-hydroxysteroid dehydrogenase isozymes and the rabbit choroid plexus.

  Journal of neuroendocrinology 20070801

• Effect of immunosuppressive and other drugs on the cortisol-cortisone shuttle in human kidney and liver.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20070801

• Preparation, characterization and uptake by primary cultured rat hepatocytes of liposomes surface-modified with glycyrrhetinic acid.

  Die Pharmazie 20070801

• Physicochemical and biological properties of 6(1),6(3),6(5)-tri-O-alpha-maltosyl-cyclomaltoheptaose (6(1),6(3),6(5)-tri-O-alpha-maltosyl-beta-cyclodextrin).

  Carbohydrate research 20070723

• Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions.

  Experimental eye research 20070701

• Liquorice and soy sauce, a life-saving concoction in a patient with Addison's disease.

  Annals of clinical biochemistry 20070701

• Novel eye cream containing a mixture of human growth factors and cytokines for periorbital skin rejuvenation.

  Journal of drugs in dermatology : JDD 20070701

• [A 87-year-old woman with mineralocorticoid excess due to 11 beta-HSD2 deficiency].

  Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20070701

• Inhibition of release of vasoactive and inflammatory mediators in airway and vascular tissues and macrophages by a chinese herbal medicine formula for allergic rhinitis.

  Evidence-based complementary and alternative medicine : eCAM 20070601

• Effects of 11beta-hydroxysteroid dehydrogenase inhibitor on body weight and glucose tolerance in Sprague-Dawley rats fed with a high-fat diet.

  Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20070601

• Changes in components, glycyrrhizin and glycyrrhetinic acid, in raw Glycyrrhiza uralensis Fisch, modify insulin sensitizing and insulinotropic actions.

  Bioscience, biotechnology, and biochemistry 20070601

• [Separation and refine of Xiaoyao Pill by macroporous adsorption resin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070601

• Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents.

  Bioorganic & medicinal chemistry letters 20070515

• Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model.

  Liver international : official journal of the International Association for the Study of the Liver 20070501

• Endogenous inhibitors (GALFs) of 11beta-hydroxysteroid dehydrogenase isoforms 1 and 2: derivatives of adrenally produced corticosterone and cortisol.

  The Journal of steroid biochemistry and molecular biology 20070501

• Inhibition of human and rat 11beta-hydroxysteroid dehydrogenase type 1 by 18beta-glycyrrhetinic acid derivatives.

  The Journal of steroid biochemistry and molecular biology 20070501

• Structure-dependent activity of glycyrrhetinic acid derivatives as peroxisome proliferator-activated receptor {gamma} agonists in colon cancer cells.

  Molecular cancer therapeutics 20070501

• [Protective effects of triterpenoids on primarily cultured rat hepatocytes injured by D-galactosamine and carbon tetrachloride].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20070501

• A possible involvement of 3-monoglucuronyl-glycyrrhetinic acid, a metabolite of glycyrrhizin (GL), in GL-induced pseudoaldosteronism.

  Life sciences 20070403

• Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts.

  Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 20070401

• [From gene to disease; 'apparent mineralocorticoid excess' syndrome, a syndrome with an apparent excess of mineral corticoids].

  Nederlands tijdschrift voor geneeskunde 20070324

• Do gap junctions play a role in nerve transmissions as well as pacing in mouse intestine?

  American journal of physiology. Gastrointestinal and liver physiology 20070301

• Herpes simplex virus-type 2 infectivity and agents that block gap junctional intercellular communication.

  Virus research 20070301

• Gap-junctional communication is required for mitotic clonal expansion during adipogenesis.

  Obesity (Silver Spring, Md.) 20070301

• 18beta-glycyrrhetinic acid promotes src interaction with connexin43 in rat cardiomyocytes.

  Journal of cellular biochemistry 20070215

• Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats.

  Planta medica 20070201

• Re-evaluation of tacrine hepatotoxicity using gel entrapped hepatocytes.

  Toxicology letters 20070130

• Protective effect and mechanism of stronger neo-minophagen C against fulminant hepatic failure.

  World journal of gastroenterology 20070121

• Cardiac mitochondrial connexin 43 regulates apoptosis.

  Biochemical and biophysical research communications 20070105

• A hyperparathyroid state in a patient with glycyrrhetinic acid-induced pseudoaldosteronism.

  Internal medicine (Tokyo, Japan) 20070101

• [Effects of glycyrrihizic acid and prednisone on pathological and ultrastructural changes of kidney in rats with chronic aristolochic acid nephropathy].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20070101

• Inhibition of release of inflammatory mediators in primary and cultured cells by a Chinese herbal medicine formula for allergic rhinitis.

  Chinese medicine 20070101

• Effect of oestradiol and progesterone on the instant and directional velocity of microsphere movements in the rat oviduct: gap junctions mediate the kinetic effect of oestradiol.

  Reproduction, fertility, and development 20070101

• Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate.

  International journal of toxicology 20070101

• A novel role for connexin hemichannel in oxidative stress and smoking-induced cell injury.

  PloS one 20070101

• Screening of gap junction antagonists on dye coupling in the rabbit retina.

  Visual neuroscience 20070101

• 18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20070101

• [Effect of nitrogen-containing derivatives of the plant triterpenes betulin and glycyrrhetic acid on the growth of MT-4, MOLT-4, CEM, and Hep G2 tumor cells].

  Bioorganicheskaia khimiia 20070101

• Inhibition of P-glycoprotein-mediated transport by terpenoids contained in herbal medicines and natural products.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20061201

• Why are mineralocorticoid receptor antagonists cardioprotective?

  Naunyn-Schmiedeberg's archives of pharmacology 20061201

• The function of connexin 43 on the differentiation of rat bone marrow cells in culture.

  Biomedical research (Tokyo, Japan) 20061201

• [High-performance liquid chromatography for quantification of 5 major components in Wenshenpingchuan tablet by together].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20061201

• Free radical scavenging action of the natural polyamine spermine in rat liver mitochondria.

  Free radical biology & medicine 20061015

• A gap junction blocker inhibits isolated whole bladder activity in normal rats and rats with partial bladder outlet obstruction.

  Biomedical research (Tokyo, Japan) 20061001

• Cortisol metabolism in hypertension.

  Best practice & research. Clinical endocrinology & metabolism 20060901

• Cancer treatment-induced mucositis pain: strategies for assessment and management.

  Therapeutics and clinical risk management 20060901

• Neuroprotective effects of roasted licorice, not raw form, on neuronal injury in gerbil hippocampus after transient forebrain ischemia.

  Acta pharmacologica Sinica 20060801

• [Role of gap junction in ischemic preconditioning].

  Zhonghua xin xue guan bing za zhi 20060801

• Both endothelium and afferent nerve endings play a role in acetylcholine-induced renal vasodilation.

  Life sciences 20060724

• Possible involvement of gap junctions in the barrier function of tight junctions of brain and lung endothelial cells.

  Journal of cellular physiology 20060701

• 'Let there be bile'--understanding hepatic injury in cholestasis.

  Journal of pediatric gastroenterology and nutrition 20060701

• Comparison between conventional indirect competitive enzyme-linked immunosorbent assay (icELISA) and simplified icELISA for small molecules.

  Analytica chimica acta 20060630

• The effect of liquorice extract-containing starch gel on the amount and microbial composition of plaque.

  Clinical oral investigations 20060601

• Inhibitory effects of triterpenes and flavonoids on the enzymatic activity of hyaluronic acid-splitting enzymes.

  Archiv der Pharmazie 20060601

• Allergic contact dermatitis mimicking atopic dermatitis due to enoxolone in a topical medicament.

  Contact dermatitis 20060601

• Gap junctions modulate apoptosis and colony growth of human embryonic stem cells maintained in a serum-free system.

  Biochemical and biophysical research communications 20060526

• Antioxidant and redox properties of supramolecular complexes of carotenoids with beta-glycyrrhizic acid.

  Free radical biology & medicine 20060515

• Binding analysis of glycyrrhetinic acid to human serum albumin: fluorescence spectroscopy, FTIR, and molecular modeling.

  Bioorganic & medicinal chemistry 20060501

• Effect of licorice on PTH levels in healthy women.

  Steroids 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The role of connexins in the differentiation of NT2 cells in Sertoli-NT2 cell tissue constructs grown in the rotating wall bioreactor.

  Experimental brain research 20060401

• The role of tyrosine 177 in human 11beta-hydroxysteroid dehydrogenase type 1 in substrate and inhibitor binding: an unlikely hydrogen bond donor for the substrate.

  Biochimica et biophysica acta 20060401

• Generation of reactive oxygen species and induction of apoptosis of HL60 cells by ingredients of traditional herbal medicine, Sho-saiko-to.

  Basic & clinical pharmacology & toxicology 20060401

• 11beta-Hydroxysteroid dehydrogenase type 1-driven cortisone reactivation regulates plasminogen activator inhibitor type 1 in adipose tissue of obese women.

  Journal of thrombosis and haemostasis : JTH 20060301

• In-vitro and in-vivo evaluation of oligoethylene esters as dermal prodrugs of 18beta-glycyrrhetic acid.

  The Journal of pharmacy and pharmacology 20060301

• A multicenter, randomized, vehicle-controlled clinical study to examine the efficacy and safety of MAS063DP (Atopiclair) in the management of mild to moderate atopic dermatitis in adults.

  Journal of drugs in dermatology : JDD 20060301

• Determination of glycyrrhetic acid in human plasma by LC-ESI-MS.

  Journal of pharmaceutical and biomedical analysis 20060224

• Isolated primary osteocytes express functional gap junctions in vitro.

  Cell and tissue research 20060201

• Protective effect of gap junction uncouplers given during hypoxia against reoxygenation injury in isolated rat hearts.

  American journal of physiology. Heart and circulatory physiology 20060201

• Glycyrrhetic acid (a metabolic substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic leukemia and stomach cancer cells.

  International journal of molecular medicine 20060201

• Microbial transformation of glycyrrhetinic acid by Mucor polymorphosporus.

  Planta medica 20060201

• Determination of oleanolic acid in human plasma and study of its pharmacokinetics in Chinese healthy male volunteers by HPLC tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20060123

• Preparation, characterization, and drug release in vitro of chitosan-glycyrrhetic acid nanoparticles.

  Journal of pharmaceutical sciences 20060101

• Pharmaceutical quality control of acid and neutral drugs based on competitive self-assembly in amphiphilic systems.

  The Analyst 20060101

• Role of gap junctional coupling in astrocytic networks in the determination of global ischaemia-induced oxidative stress and hippocampal damage.

  The European journal of neuroscience 20060101

• Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products.

  Phytochemical analysis : PCA 20060101

• Liquorice in moderate doses does not affect sex steroid hormones of biological importance although the effect differs between the genders.

  Hormone research 20060101

• [Mechanisms of action of the stimulators of granulocytopoiesis under cytostatic myelosuppression conditions].

  Eksperimental'naia i klinicheskaia farmakologiia 20060101

• Differential expression, function and response to inflammatory stimuli of 11beta-hydroxysteroid dehydrogenase type 1 in human fibroblasts: a mechanism for tissue-specific regulation of inflammation.

  Arthritis research & therapy 20060101

• Clostridium glycyrrhizinilyticum sp. nov., a glycyrrhizin-hydrolysing bacterium isolated from human faeces.

  Microbiology and immunology 20060101

• The liquorice effect on the RAAS differs between the genders.

  Blood pressure 20060101

• Natural products that reduce rotavirus infectivity identified by a cell-based moderate-throughput screening assay.

  Virology journal 20060101

• A double-blind, vehicle-controlled clinical study to evaluate the efficacy of MAS065D (XClair), a hyaluronic acid-based formulation, in the management of radiation-induced dermatitis.

  Cutaneous and ocular toxicology 20060101

• Altered intercellular communication in lung fibroblast cultures from patients with idiopathic pulmonary fibrosis.

  Respiratory research 20060101

• Potential adverse and allergic reactions from complementary and alternative medicine and dietary supplements.

  Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 20060101

• Validation of the plasma half-life of 11alpha-deuterium cortisol as a sensitive index for the analysis of human 11beta-HSD2 activity in vivo.

  Steroids 20051101

• Organotins disrupt the 11beta-hydroxysteroid dehydrogenase type 2-dependent local inactivation of glucocorticoids.

  Environmental health perspectives 20051101

• Identification of novel functional inhibitors of 17beta-hydroxysteroid dehydrogenase type III (17beta-HSD3).

  The Prostate 20051001

• Role of gap junctions in synchronized neuronal oscillations in the inferior olive.

  Journal of neurophysiology 20051001

• Staphylococcus aureus-derived peptidoglycan induces Cx43 expression and functional gap junction intercellular communication in microglia.

  Journal of neurochemistry 20051001

• The influence of the sennosides on absorption of glycyrrhetic acid in rats.

  Biological & pharmaceutical bulletin 20051001

• Bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang in laxative-treated rats.

  The Journal of pharmacy and pharmacology 20051001

• Antiabsence effects of carbenoxolone in two genetic animal models of absence epilepsy (WAG/Rij rats and lh/lh mice).

  Neuropharmacology 20050901

• Single-cell microinjection of cytochrome c can result in gap junction-mediated apoptotic cell death of bystander cells in head and neck cancer.

  Head & neck 20050901

• 11beta-hydroxysteroid dehydrogenase in the testis of Bufo arenarum: changes in its seasonal activity.

  General and comparative endocrinology 20050901

• Anti-herpes virus type 1 activity of oleanane-type triterpenoids.

  Biological & pharmaceutical bulletin 20050901

• Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts.

  Chemical & pharmaceutical bulletin 20050901

• Sensitive liquid chromatographic assay for the simultaneous determination of ibuprofen and its prodrug, ibuprofen eugenol ester, in rat plasma.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050901

• [Targeting glycyrrhetinic acid to hepatic stellate cells in treating rat liver fibrosis].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20050901

• Electrical coupling in sustentacular cells of the mouse olfactory epithelium.

  Journal of neurophysiology 20050801

• Analysis and comparison of Radix Glycyrrhizae (licorice) from Europe and China by capillary-zone electrophoresis (CZE).

  Journal of pharmaceutical and biomedical analysis 20050715

• 18 Beta-glycyrrhetinic acid triggers curative Th1 response and nitric oxide up-regulation in experimental visceral leishmaniasis associated with the activation of NF-kappa B.

  Journal of immunology (Baltimore, Md. : 1950) 20050715

• Separation and analysis of glycyrrhizin, 18beta-glycyrrhetic acid and 18alpha-glycyrrhetic acid in liquorice roots by means of capillary zone electrophoresis.

  Journal of chromatography. A 20050715

• Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application.

  Steroids 20050701

• Genetic characterization of the beta-glucuronidase enzyme from a human intestinal bacterium, Ruminococcus gnavus.

  Microbiology (Reading, England) 20050701

• Inhibition of interleukin-8 production in the human colonic epithelial cell line HT-29 by 18 beta-glycyrrhetinic acid.

  International journal of molecular medicine 20050601

• Cx31 is assembled and trafficked to cell surface by ER-Golgi pathway and degraded by proteasomal or lysosomal pathways.

  Cell research 20050601

• Use of nano-liquid chromatography for the analysis of glycyrrhizin and glycyrrhetic acid in licorice roots and candies.

  Journal of separation science 20050601

• Carbenoxolone induces oxidative stress in liver mitochondria, which is responsible for transition pore opening.

  Endocrinology 20050501

• A central role for ceramide in the age-related acceleration of apoptosis in the female germline.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050501

• Rhythmic expression of clock-controlled genes in retinal photoreceptors is sensitive to 18-beta-glycyrrhetnic acid and 18-alpha-glycyrrhetnic acid-3-hemisuccinate.

  Brain research. Molecular brain research 20050427

• Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells.

  American journal of physiology. Gastrointestinal and liver physiology 20050401

• Liquorice and hypertension.

  The Netherlands journal of medicine 20050401

• Severe hypokalaemic paralysis and rhabdomyolysis due to ingestion of liquorice.

  The Netherlands journal of medicine 20050401

• The old lady who liked liquorice: hypertension due to chronic intoxication in a memory-impaired patient.

  The Netherlands journal of medicine 20050401

• Connexin26 is responsible for anionic molecule permeability in the cochlea for intercellular signalling and metabolic communications.

  The European journal of neuroscience 20050401

• Seasonal changes in the activity of 11 beta-hydroxysteroid dehydrogenase in toad testes.

  Annals of the New York Academy of Sciences 20050401

• Licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes.

  The Journal of biological chemistry 20050318

• Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes.

  Journal of neurochemistry 20050301

• Use of 11alpha-deuterium labeled cortisol as a tracer for assessing reduced 11beta-HSD2 activity in vivo following glycyrrhetinic acid ingestion in a human subject.

  Steroids 20050201

• Effects of glucose, fructose and 5-hydroxymethyl-2-furaldehyde on the presystemic metabolism and absorption of glycyrrhizin in rabbits.

  The Journal of pharmacy and pharmacology 20050201

• Simultaneous determination of glycyrrhizin, a marker component in radix Glycyrrhizae, and its major metabolite glycyrrhetic acid in human plasma by LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050125

• Profound difference of metabolic pharmacokinetics between pure glycyrrhizin and glycyrrhizin in licorice decoction.

  Life sciences 20050121

• Secretion of ATP from Schwann cells in response to uridine triphosphate.

  The European journal of neuroscience 20050101

• A randomised, double-blind, vehicle-controlled study to evaluate the efficacy and safety of MAS063D (Atopiclair) in the treatment of mild to moderate atopic dermatitis.

  European journal of dermatology : EJD 20050101

• [Studies on the shade-endurance capacity of Glycyrrhiza uralensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050101

• Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas.

  BMC cell biology 20050101

• Effects of glycyrrhizin on UVB-irradiated melanoma cells.

  In vivo (Athens, Greece) 20050101

• Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model.

  Anticancer research 20050101

• Connexin 43 mediated gap junctional communication enhances breast tumor cell diapedesis in culture.

  Breast cancer research : BCR 20050101

• Inhibitory effect of 18beta-glycyrrhetinic acid on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in mice.

  Redox report : communications in free radical research 20050101

• Glycyrrhetinic acid and related compounds induce G1 arrest and apoptosis in human hepatocellular carcinoma HepG2.

  Anticancer research 20050101

• Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line.

  International immunopharmacology 20041215

• Anticonvulsant effects of carbenoxolone in genetically epilepsy prone rats (GEPRs).

  Neuropharmacology 20041201

• Global organization of dynamics in cultured cardiac monolayers.

  Chaos (Woodbury, N.Y.) 20041201

• Synthesis and in vitro antioxidant activity of glycyrrhetinic acid derivatives tested with the cytochrome P450/NADPH system.

  Chemical & pharmaceutical bulletin 20041201

• HDACi phenylbutyrate increases bystander killing of HSV-tk transfected glioma cells.

  Biochemical and biophysical research communications 20041105

• On the mechanism of mitochondrial permeability transition induction by glycyrrhetinic acid.

  Biochimica et biophysica acta 20041004

• Metabolic activities of ginsenoside Rb1, baicalin, glycyrrhizin and geniposide to their bioactive compounds by human intestinal microflora.

  Biological & pharmaceutical bulletin 20041001

• Chemical analysis of raw, dry-roasted, and honey-roasted licorice by capillary electrophoresis.

  Electrophoresis 20041001

• Enantioselectivity of carbonyl reduction of 4-methylnitrosamino-1-(3-pyridyl)-1-butanone by tissue fractions from human and rat and by enzymes isolated from human liver.

  Drug metabolism and disposition: the biological fate of chemicals 20040901

• Novel 18beta-glycyrrhetinic acid analogues as potent and selective inhibitors of 11beta-hydroxysteroid dehydrogenases.

  Bioorganic & medicinal chemistry 20040815

• [Targeted glycyrrhetinic acid to receptors of hepatic stellate cells for the treatment of rat liver fibrosis: a pilot study].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20040801

• Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection.

  Journal of separation science 20040801

• Adenoviral delivery of human connexin37 induces endothelial cell death through apoptosis.

  Biochemical and biophysical research communications 20040709

• Mechanical regulation of HB-GAM expression in bone cells.

  Biochemical and biophysical research communications 20040702

• Functional characterization of Cx43 based gap junctions during spermatogenesis.

  Journal of cellular physiology 20040701

• In vitro anti-Helicobacter pylori activity of Extractum liquiritiae, glycyrrhizin and its metabolites.

  The Journal of antimicrobial chemotherapy 20040701

• Junctional and nonjunctional effects of heptanol and glycyrrhetinic acid derivates in rat mesenteric small arteries.

  British journal of pharmacology 20040701

• A novel 18 beta-glycyrrhetinic acid analogue as a potent and selective inhibitor of 11 beta-hydroxysteroid dehydrogenase 2.

  Bioorganic & medicinal chemistry letters 20040621

• The obligatory link: role of gap junctional communication in endothelium-dependent smooth muscle hyperpolarization.

  Pharmacological research 20040601

• Prostaglandin F2alpha amplifies tumor necrosis factor-alpha promoter activity by the FPB prostanoid receptor.

  Biochemical and biophysical research communications 20040514

• Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040501

• Significance of reductases in the detoxification of the tobacco-specific carcinogen NNK.

  Trends in pharmacological sciences 20040501

• Different responsiveness in body weight and hepatic 11beta-hydroxysteroid dehydrogenase (11beta-HSD) type 1 mrna to 11beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean zucker rats.

  Metabolism: clinical and experimental 20040501

• Pharmaceutical evaluation of liquorice before and after roasting in mice.

  The Journal of pharmacy and pharmacology 20040501

• Gap junction communication dynamics and bystander effects from ultrasoft X-rays.

  British journal of cancer 20040405

• Cytotoxicity evaluation of enzyme inhibitors and absorption enhancers in Caco-2 cells for oral delivery of salmon calcitonin.

  Journal of pharmaceutical sciences 20040401

• Global, synchronous oscillations in cytosolic calcium and adherence in bradykinin-stimulated Madin-Darby canine kidney cells.

  Acta physiologica Scandinavica 20040401

• Effect of aldosterone and glycyrrhetinic acid on the protein expression of PAI-1 and p22(phox) in human mononuclear leukocytes.

  The Journal of clinical endocrinology and metabolism 20040401

• Glycyrrhetic acid-loaded microparticles: liver-specific delivery and therapeutic potential against carbon tetrachloride-induced hepatitis.

  The Journal of pharmacy and pharmacology 20040401

• [Licorice of 'shakuyaku kanzou tou' induced pseudoaldosteronism].

  Hinyokika kiyo. Acta urologica Japonica 20040301

• Comparative pharmacokinetic behavior of glycyrrhetic acid after oral administration of glycyrrhizic acid and Gancao-Fuzi-Tang.

  Biological & pharmaceutical bulletin 20040201

• Influence of carbenoxolone on the anticonvulsant efficacy of conventional antiepileptic drugs against audiogenic seizures in DBA/2 mice.

  European journal of pharmacology 20040119

• Cytogenetic detection of a trans-species bystander effect: induction of sister chromatid exchanges in murine 3T3 cells by ganciclovir metabolized in HSV thymidine kinase gene-transfected Chinese hamster ovary cells.

  Mutagenesis 20040101

• Anti-allergic activity of 18beta-glycyrrhetinic acid-3-O-beta-D-glucuronide.

  Archives of pharmacal research 20040101

• [Cellular immunity state assessed in bronchial and alveolar lavage for experimental animals exposed to the rubber dust].

  Meditsina truda i promyshlennaia ekologiia 20040101

• Human primary endothelial cells stimulate human osteoprogenitor cell differentiation.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

• Model for transition from waves to synchrony in the olfactory lobe of Limax.

  Journal of computational neuroscience 20040101

• Retinaldehyde, a potent inhibitor of gap junctional intercellular communication.

  Cell communication & adhesion 20040101

• [Involvement of gap junctions in stimulation of in vitro maturation of the common frog oocytes by low progesterone concentrations].

  Ontogenez 20040101

• Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria.

  Biochemical pharmacology 20031215

• 11beta-hydroxysteroid dehydrogenase type 1 as a novel therapeutic target in metabolic and neurodegenerative disease.

  Expert opinion on therapeutic targets 20031201

• Synthesis of new glycyrrhetinic acid (GA) derivatives and their effects on tyrosinase activity.

  Bioorganic & medicinal chemistry 20031201

• The gap junction-independent tumor-suppressing effect of connexin 43.

  The Journal of biological chemistry 20031107

• Pharmacological sensitivity of ATP release triggered by photoliberation of inositol-1,4,5-trisphosphate and zero extracellular calcium in brain endothelial cells.

  Journal of cellular physiology 20031101

• Repetitive administration of Shaoyao-Gancao-tang to rats restores the bioavailability of glycyrrhizin reduced by antibiotic treatment.

  The Journal of pharmacy and pharmacology 20031101

• Proton permeation through the myocardial gap junction.

  Circulation research 20031017

• ECM-induced gap junctional communication enhances mammary epithelial cell differentiation.

  Journal of cell science 20030901

• Angiotensin II regulates 11beta-hydroxysteroid dehydrogenase type 2 via AT2 receptors.

  Kidney international 20030901

• Effects of 18beta-glycyrrhetinic acid on the junctional complex and steroidogenesis in rat adrenocortical cells.

  Journal of cellular biochemistry 20030901

• Licorice consumption and serum testosterone in healthy man.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20030901

• In vitro antibacterial effects of glycyrrhetinic acid on periodontopathogenic and capnophilic bacteria isolated from adult periodontitis.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20030901

• Anti-inflammatory lanostane-type triterpene acids from Piptoporus betulinus.

  Journal of natural products 20030801

• Phenolic constituents from Dalbergia cochinchinensis.

  Journal of natural products 20030801

• Intercellular calcium waves mediate preferential cell growth toward the wound edge in polarized hepatic cells.

  Experimental cell research 20030715

• Pharmacokinetic study on the multi-constituents of Huangqin-Tang decoction in rats.

  Biological & pharmaceutical bulletin 20030701

• Effect of licorice on the reduction of body fat mass in healthy subjects.

  Journal of endocrinological investigation 20030701

• Effects of glycyrrhetinic acid derivatives on hepatic and renal 11beta-hydroxysteroid dehydrogenase activities in rats.

  The Journal of pharmacy and pharmacology 20030601

• Pseudohyperaldosteronism: pathogenetic mechanisms.

  Critical reviews in clinical laboratory sciences 20030601

• Functional hemichannels in astrocytes: a novel mechanism of glutamate release.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030501

• Simultaneous determination of glycyrrhizin metabolites formed by the incubation of glycyrrhizin with rat feces by semi-micro high-performance liquid chromatography.

  Biological & pharmaceutical bulletin 20030501

• Expression of connexin 43 mRNA in microisolated murine osteoclasts and regulation of bone resorption in vitro by gap junction inhibitors.

  Biochemical and biophysical research communications 20030418

• Gap junction-mediated bystander effect in primary cultures of human malignant gliomas with recombinant expression of the HSVtk gene.

  Experimental cell research 20030401

• [Preparation of liposomes surface-modified with glycyrrhetinic acid targeting to hepatocytes].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20030401

• Abnormal expression of 11 beta-hydroxysteroid dehydrogenase type 2 in human pituitary adenomas: a prereceptor determinant of pituitary cell proliferation.

  Oncogene 20030320

• Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice.

  Journal of human hypertension 20030201

• Hypokalaemia and paralysis.

  QJM : monthly journal of the Association of Physicians 20030201

• Purification, characterization and NNK carbonyl reductase activities of 11beta-hydroxysteroid dehydrogenase type 1 from human liver: enzyme cooperativity and significance in the detoxification of a tobacco-derived carcinogen.

  Chemico-biological interactions 20030201

• Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone.

  Chemico-biological interactions 20030201

• Polyprenylated benzophenones from Garcinia assigu and their potential cancer chemopreventive activities.

  Journal of natural products 20030201

• Characterization of complement C3 as a glycyrrhizin (GL)-binding protein and the phosphorylation of C3alpha by CK-2, which is potently inhibited by GL and glycyrrhetinic acid in vitro.

  Journal of biochemistry 20030201

• Blockade of brain stem gap junctions increases phrenic burst frequency and reduces phrenic burst synchronization in adult rat.

  Journal of neurophysiology 20030101

• Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26.

  Cell calcium 20030101

• Biological activities of synthetic saponins and cardiac glycosides.

  Phytotherapy research : PTR 20030101

• [Effect of cocktails of different gaseous composition containing preparations of licorice root on hemopoiesis and immunity of animals].

  Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20030101

• Anticonvulsant, sedative and muscle relaxant effects of carbenoxolone in mice.

  BMC pharmacology 20030101

• [A simple method for preparation of 18alpha-glycyrretinic acid ant its derivatives].

  Bioorganicheskaia khimiia 20030101

• [Intermolecular interactions of dipeptide triterpene derivatives and natural quinones with alpha-tocopherol].

  Biomeditsinskaia khimiia 20030101

• The gap junction blockers carbenoxolone and 18beta-glycyrrhetinic acid antagonize cone-driven light responses in the mouse retina.

  Visual neuroscience 20030101

• Selectivity of action of glycyrrhizin derivatives on the growth of MCF-7 and HEP-2 cells.

  Anticancer research 20030101

• Hemichannels formed by connexin 43 play an important role in the release of prostaglandin E(2) by osteocytes in response to mechanical strain.

  Cell communication & adhesion 20030101

• Presence and importance of connexin43 during myogenesis.

  Cell communication & adhesion 20030101

• Smooth muscle membrane potential modulates endothelium-dependent relaxation of rat basilar artery via myo-endothelial gap junctions.

  The Journal of physiology 20021215

• Inhibitors of gap junctions attenuate myogenic tone in cerebral arteries.

  American journal of physiology. Heart and circulatory physiology 20021201

• Expression of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue is not increased in human obesity.

  The Journal of clinical endocrinology and metabolism 20021201

• Short-term cortisol infusion in the brachial artery, with and without inhibiting 11 beta-hydroxysteroid dehydrogenase, does not alter forearm vascular resistance in normotensive and hypertensive subjects.

  European journal of clinical investigation 20021201

• Bone morphogenetic protein-2 modulation of chondrogenic differentiation in vitro involves gap junction-mediated intercellular communication.

  Journal of cellular physiology 20021101

• Acute intrarenal administration of cortisol has no effect on renal blood flow in hypertensive individuals.

  Journal of hypertension 20021101

• Modulation of renal calcium handling by 11 beta-hydroxysteroid dehydrogenase type 2.

  Journal of the American Society of Nephrology : JASN 20021001

• 11beta-hydroxysteroid dehydrogenase type 1: a new regulator of fetal lung maturation.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20021001

• Foetal lung maturation in 11beta-hydroxysteroid dehydrogenase type 1 knockout mice.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20021001

• Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression.

  Pharmacological research 20020901

• Inhibition of 3 alpha/beta,20 beta-hydroxysteroid dehydrogenase by dexamethasone, glycyrrhetinic acid and spironolactone is attenuated by deletion of 12 carboxyl-terminal residues.

  Biological & pharmaceutical bulletin 20020901

• [Rhabdomyolysis due to licorice ingestion].

  Recenti progressi in medicina 20020901

• Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells.

  Journal of cell science 20020815

• Coordination of mesangial cell contraction by gap junction--mediated intercellular Ca(2+) wave.

  Journal of the American Society of Nephrology : JASN 20020801

• The role of gap junctions in mediating endothelium-dependent responses to bradykinin in myometrial small arteries isolated from pregnant women.

  British journal of pharmacology 20020801

• UDP-glucuronic acid:soyasapogenol glucuronosyltransferase involved in saponin biosynthesis in germinating soybean seeds.

  Planta 20020801

• A puzzling cause of hypokalaemia.

  Lancet (London, England) 20020720

• Critical role of gap junctions in endothelium-dependent hyperpolarization in rat mesenteric arteries.

  Clinical and experimental pharmacology & physiology 20020701

• Synthesis of a targeting drug for antifibrosis of liver; a conjugate for delivering glycyrrhetin to hepatic stellate cells.

  Glycoconjugate journal 20020701

• IL-1beta-induced production of metalloproteinases by synovial cells depends on gap junction conductance.

  American journal of physiology. Cell physiology 20020601

• Annexin 1 (lipocortin 1) mimics inhibitory effects of glucocorticoids on testosterone secretion and enhances effects of interleukin-1beta.

  Endocrine 20020601

• Metabolism of constituents in Huangqin-Tang, a prescription in traditional Chinese medicine, by human intestinal flora.

  Biological & pharmaceutical bulletin 20020501

• Endothelin 1 type a receptor antagonism prevents vascular dysfunction and hypertension induced by 11beta-hydroxysteroid dehydrogenase inhibition: role of nitric oxide.

  Circulation 20020430

• Kinetics and mechanism of intercellular ice propagation in a micropatterned tissue construct.

  Biophysical journal 20020401

• Retinoids inhibit squamous cell carcinoma growth and intercellular communication.

  The Journal of surgical research 20020401

• Glycyrrhizic acid suppresses type 2 11 beta-hydroxysteroid dehydrogenase expression in vivo.

  The Journal of steroid biochemistry and molecular biology 20020401

• Molecular pharmacophore determination of lipid lowering drugs with the receptor mapping method.

  Mini reviews in medicinal chemistry 20020401

• Gap junction intercellular communication propagates cell death in cancerous cells.

  Oncogene 20020327

• [Licorice--not just candy].

  Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020320

• [Effects of glycyrrhetic acid on transmitter secretion].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20020301

• Induction of inducible nitric oxide synthase expression by 18beta-glycyrrhetinic acid in macrophages.

  FEBS letters 20020227

• 11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase.

  Biochemistry 20020219

• Effect of glycyrrhetinic acid on 11 beta-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects.

  Clinical science (London, England : 1979) 20020201

• Blocked gap junctional coupling increases glutamate-induced neurotoxicity in neuron-astrocyte co-cultures.

  Journal of neuropathology and experimental neurology 20020201

• [Effects of glycyrrhetinic acid and IFN-alpha on HSCs collagen metabolism in rat fibrotic liver of varying stages].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20020201

• Primary afferent fibers establish dye-coupled connections in the frog central nervous system.

  Brain research bulletin 20020201

• Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries.

  Biochemical and biophysical research communications 20020125

• Glycyrrhetinic derivatives inhibit hyperpolarization in endothelial cells of guinea pig and rat arteries.

  American journal of physiology. Heart and circulatory physiology 20020101

• Glycyrrhetinic acid decreases plasma potassium concentrations in patients with anuria.

  Journal of the American Society of Nephrology : JASN 20020101

• Stimulation of the BK(Ca) channel in cultured smooth muscle cells of human trachea by magnolol.

  Thorax 20020101

• Influence of honey on the gastrointestinal metabolism and disposition of glycyrrhizin and glycyrrhetic acid in rabbits.

  Biological & pharmaceutical bulletin 20020101

• The isolated rat spinal cord as an in vitro model to study the pharmacologic control of myoclonic-like activity.

  Advances in neurology 20020101

• [Rhabdomyolysis and arterial hypertension caused by apparent excess of mineralocorticoids: a case report].

  Annali italiani di medicina interna : organo ufficiale della Societa italiana di medicina interna 20020101

• An unexpected case of primary pulmonary hypertension of the neonate (PPHN). Potential role of topical administration of enoxolone.

  Journal of perinatal medicine 20020101

• [Quantitative determinations of glycyrrhizic acid, glycyrrhetinic acid, morphine and sodium benzoate in compound liquorice tablets by capillary zone electrophoresis].

  Se pu = Chinese journal of chromatography 20020101

• Enzyme-linked immunosorbent assay for glycyrrhizin using anti-glycyrrhizin monoclonal antibody and an eastern blotting technique for glucuronides of glycyrrhetic acid.

  Analytical chemistry 20011215

• In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice.

  Hypertension (Dallas, Tex. : 1979) 20011201

• Potentiation of L-type calcium channels reveals nonsynaptic mechanisms that correlate spontaneous activity in the developing mammalian retina.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20011101

• Modulation of 11 beta-hydroxysteroid dehydrogenase type 2 activity in Ishikawa cells is associated with changes in cellular proliferation.

  Molecular and cellular endocrinology 20011025

• Therapeutic effect of glycyrrhetinic acid in MRL lpr/lpr mice: implications of alteration of corticosteroid metabolism.

  Life sciences 20011005

• Bimodal inhibition of connexin 43 gap junctions decreases ACTH-induced steroidogenesis and increases bovine adrenal cell population growth.

  The Journal of endocrinology 20011001

• LAF1, a MYB transcription activator for phytochrome A signaling.

  Genes & development 20011001

• Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.

  British journal of pharmacology 20011001

• An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide.

  Hypertension (Dallas, Tex. : 1979) 20011001

• Effect of pH on metabolism of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid monoglucuronide by collected human intestinal flora.

  Biological & pharmaceutical bulletin 20011001

• Simultaneous determination of glycyrrhizin, glycyrrhetic acid and glycyrrhetic acid mono-glucuronide in Shakuyaku-kanzo-to incubated with rat feces by semi-micro high-performance liquid chromatography.

  Biological & pharmaceutical bulletin 20011001

• [Prevention of development of hepatocellular carcinoma from HCV-associated liver cirrhosis by multi-agents therapy including stronger-neo-minophagen C].

  Nihon rinsho. Japanese journal of clinical medicine 20011001

• Stimulation of melanogenesis by glycyrrhizin in B16 melanoma cells.

  Experimental & molecular medicine 20010930

• Characterization of secretory type IIA phospholipase A2 (sPLA2-IIA) as a glycyrrhizin (GL)-binding protein and the GL-induced inhibition of the CK-II-mediated stimulation of sPLA2-IIA activity in vitro.

  Biological & pharmaceutical bulletin 20010901

• [Licorice-induced pseudoaldosteronism in a patient with a non-functioning adrenal tumor].

  Hinyokika kiyo. Acta urologica Japonica 20010901

• Evidence of a role for cyclic ADP-ribose in calcium signalling and neurotransmitter release in cultured astrocytes.

  Journal of neurochemistry 20010801

• Liquorice-induced rise in blood pressure: a linear dose-response relationship.

  Journal of human hypertension 20010801

• Dual mechanism of intercellular communication in HOBIT osteoblastic cells: a role for gap-junctional hemichannels.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010801

• Inhibitory effect of glycyrrhizin on the phosphorylation and DNA-binding abilities of high mobility group proteins 1 and 2 in vitro.

  Biological & pharmaceutical bulletin 20010801

• 18-beta-Glycyrrhetinic acid (BGA) as an electrical uncoupler for intracellular recordings in confluent monolayer cultures.

  Pflugers Archiv : European journal of physiology 20010801

• The enhancement of glucose uptake caused by the collapse of gap junction communication is due to an increase in astrocyte proliferation.

  Journal of neurochemistry 20010801

• Do gap junctions couple interstitial cells of Cajal pacing and neurotransmission to gastrointestinal smooth muscle?

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20010801

• The intracellular localization of the mineralocorticoid receptor is regulated by 11beta-hydroxysteroid dehydrogenase type 2.

  The Journal of biological chemistry 20010727

• Toward prevention of hepatocellular carcinoma developing in chronic hepatitis C.

  Journal of gastroenterology and hepatology 20010701

• 'Pseudo-aldosteronism' induced by intravenous glycyrrhizin treatment of chronic hepatitis C patients.

  Journal of gastroenterology and hepatology 20010701

• Persistence of gap junction communication during myocardial ischemia.

  American journal of physiology. Heart and circulatory physiology 20010601

• Determination of 14 chemical constituents in the traditional Chinese medicinal preparation Huangqin-Tang by high performance liquid chromatography.

  Biological & pharmaceutical bulletin 20010601

• Antibacterial compounds of licorice against upper airway respiratory tract pathogens.

  Journal of nutritional science and vitaminology 20010601

• Characterization of bovine angiogenin-1 and lactogenin-like protein as glycyrrhizin-binding proteins and their in vitro phosphorylation by C-kinase.

  Biological & pharmaceutical bulletin 20010501

• The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling.

  Drug metabolism reviews 20010501

• Inhibition of gap-junctional communication induces the trans-differentiation of osteoblasts to an adipocytic phenotype in vitro.

  The Journal of biological chemistry 20010427

• The effect of absorption enhancers on the initial degradation kinetics of insulin by alpha-chymotrypsin.

  International journal of pharmaceutics 20010417

• Endothelium-dependent vasorelaxation independent of nitric oxide and K(+) release in isolated renal arteries of rats.

  British journal of pharmacology 20010401

• Gap-junctional communication is required for the maturation process of osteoblastic cells in culture.

  Bone 20010401

• Allergic contact dermatitis from enoxolone.

  Contact dermatitis 20010301

• K+ currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels.

  The Journal of physiology 20010301

• Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301

• Effects of glycyrrhetinic acid on collagen metabolism of hepatic stellate cells at different stages of liver fibrosis in rats.

  World journal of gastroenterology 20010215

• Magnolol from Magnolia officinalis inhibits 11beta-hydroxysteroid dehydrogenase without increases of corticosterone and thymocyte apoptosis in mice.

  Planta medica 20010201

• A gap-junction-mediated signal, rather than an external paracrine factor, predominates during meiotic induction in isolated mouse oocytes.

  Zygote (Cambridge, England) 20010201

• Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5.

  Molecular and cellular endocrinology 20010122

• Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder.

  The Journal of physiology 20010115

• A population physiologically based pharmacokinetic/pharmacodynamic model for the inhibition of 11-beta-hydroxysteroid dehydrogenase activity by glycyrrhetic acid.

  Toxicology and applied pharmacology 20010101

• Blockade of chloride channels reveals relaxations of rat small mesenteric arteries to raised potassium.

  British journal of pharmacology 20010101

• Spreading depolarization waves triggered by vagal stimulation in the embryonic chick brain: optical evidence for intercellular communication in the developing central nervous system.

  Neuroscience 20010101

• Glycyrrhetinic acid induced apoptosis in murine splenocytes.

  Biological & pharmaceutical bulletin 20010101

• How to close a gap junction channel. Efficacies and potencies of uncoupling agents.

  Methods in molecular biology (Clifton, N.J.) 20010101

• Expression of the 11beta-hydroxysteroid dehydrogenase type II enzyme in breast tumors and modulation of activity and cell growth in PMC42 cells.

  The Journal of steroid biochemistry and molecular biology 20010101

• [Experimental study of anti-inflammatory and wound healing properties of 1% ointments of 18-dehydroglycyrrhetic acid sodium salt].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• [Immunoenzyme test-system for detection of glycyrrhizic acid].

  Eksperimental'naia i klinicheskaia farmakologiia 20010101

• [The assessment of safety of enoxaparin administration during percutaneous transluminal coronary angioplasty after ticlopidine pretreatment. Application of low molecular weigh heparins in prevention of coronary micro-embolization].

  Przeglad lekarski 20010101

• [Simultaneous measurements of electrical coupling and action potential transfer in pairs of ventricular cardiomyocytes].

  Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma 20010101

• Regulation of the action of hydrocortisone in airway epithelial cells by 11beta-hydroxysteroid dehydrogenase.

  American journal of respiratory cell and molecular biology 19990901

• The role of 11 beta-hydroxysteroid dehydrogenase in the pathogenesis of hypertension.

  Cardiovascular research 19980401

• Glycyrrhizin, an active component of licorice roots, reduces morbidity and mortality of mice infected with lethal doses of influenza virus.

  Antimicrobial agents and chemotherapy 19970301

• [Effect of human serum albumin on transport of drugs through human erythrocyte membranes].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 19960801

• A case of drug-induced ductopenia resulting in fatal biliary cirrhosis.

  Liver 19930801

• Inhibitors of 11 beta-hydroxysteroid dehydrogenase and 5 beta-steroid reductase in urine from patients with congestive heart failure.

  Annals of clinical and laboratory science 19930101

• [Effect of sodium 18 beta-glycyrrhetate on experimental arrhythmia].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 19920301

• [The anti-HIV activity of beta-glycyrrhizic acid].

  Voprosy virusologii 19920101

• Antiviral activities of glycyrrhizin and its modified compounds against human immunodeficiency virus type 1 (HIV-1) and herpes simplex virus type 1 (HSV-1) in vitro.

  Chemical & pharmaceutical bulletin 19910101

• Drug-induced acute pulmonary edema--sequential changes in CT images.

  Radiation medicine 19910101

• Antiviral agents with activity against human retroviruses.

  Journal of acquired immune deficiency syndromes 19890101

• [Pharmacological study of the anti-inflammatory agent glyderinine].

  Farmakologiia i toksikologiia 19880101

• Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV (HTLV-III/LAV)].

  Antiviral research 19870301

• Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro.

  Antiviral research 19870201

• [Etiological studies of secondary hypertension. e. Drug-induced hypertension].

  Nihon rinsho. Japanese journal of clinical medicine 19840201