472-15-1 | Betulinic acid

Packsize	Purity	Availability	Price	Discounted Price
1g	98%(HPLC)	in stock	$45.00	$32.00
5g	≥ 98% (HPLC)	in stock	$140.00	$98.00
25g	≥ 98% (HPLC)	in stock	$498.00	$348.00
100g	≥ 98% (HPLC)	in stock	$1,398.00	$978.00

Description

• Catalog Number: AB71109
• Chemical Name: Betulinic acid
• CAS Number: 472-15-1
• Molecular Formula: C30H48O3
• Molecular Weight: 456.7003
• MDL Number: MFCD00009619
• SMILES: CC(=C)[C@@H]1CC[C@]2([C@H]1[C@H]1CC[C@H]3[C@@]([C@]1(C)CC2)(C)CC[C@@H]1[C@]3(C)CC[C@@H](C1(C)C)O)C(=O)O
• NSC Number: 677578

Computed Properties

• Complexity: 861
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Heavy Atom Count: 33
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 8.2

Literature

• Synthesis and biological investigation of new carbonic anhydrase IX (CAIX) inhibitors.

  Chemico-biological interactions 20180325

• Intrinsic capabilities of Leptospermum javanicum in inducing apoptosis and suppressing the metastatic potential of human lung carcinoma cells.

  Chemico-biological interactions 20170801

• Biological evaluation of a halogenated triterpenoid, 2α-bromo-dihydrobelulonic acid as inhibitor of human topoisomerase IIα and HeLa cell proliferation.

  Chemico-biological interactions 20170425

• In vitro anticancer activity of Betulinic acid and derivatives thereof on equine melanoma cell lines from grey horses and in vivo safety assessment of the compound NVX-207 in two horses.

  Chemico-biological interactions 20160225

• Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.

  Bioorganic & medicinal chemistry letters 20160101

• Betulinyl Sulfamates as Anticancer Agents and Radiosensitizers in Human Breast Cancer Cells.

  International journal of molecular sciences 20151101

• Ionic derivatives of betulinic acid exhibit antiviral activity against herpes simplex virus type-2 (HSV-2), but not HIV-1 reverse transcriptase.

  Bioorganic & medicinal chemistry letters 20150815

• Combined effect of microRNA, nutraceuticals and drug on pancreatic cancer cell lines.

  Chemico-biological interactions 20150525

• Synthesis and anti-HCV entry activity studies of β-cyclodextrin-pentacyclic triterpene conjugates.

  ChemMedChem 20140501

• Betulinic acid, a bioactive pentacyclic triterpenoid, inhibits skeletal-related events induced by breast cancer bone metastases and treatment.

  Toxicology and applied pharmacology 20140301

• Hypericum hircinum L. components as new single-molecule inhibitors of both HIV-1 reverse transcriptase-associated DNA polymerase and ribonuclease H activities.

  Pathogens and disease 20130801

• Development of oleanane-type triterpenes as a new class of HCV entry inhibitors.

  Journal of medicinal chemistry 20130613

• Synthesis and biological evaluation of a new derivative of bevirimat that targets the Gag CA-SP1 cleavage site.

  European journal of medicinal chemistry 20130401

• Quantitative purity-activity relationships of natural products: the case of anti-tuberculosis active triterpenes from Oplopanax horridus.

  Journal of natural products 20130322

• GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.

  Cancer letters 20130201

• A simple GC-MS method for the screening of betulinic, corosolic, maslinic, oleanolic and ursolic acid contents in commercial botanicals used as food supplement ingredients.

  Food chemistry 20130115

• Antidepressant-like effects of fractions, essential oil, carnosol and betulinic acid isolated from Rosmarinus officinalis L.

  Food chemistry 20130115

• A novel one-step microbial transformation of betulin to betulinic acid catalysed by Cunninghamella blakesleeana.

  Food chemistry 20130101

• Phytochemical profile of Rosmarinus officinalis and Salvia officinalis extracts and correlation to their antioxidant and anti-proliferative activity.

  Food chemistry 20130101

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Molecular characterization of the pentacyclic triterpenoid biosynthetic pathway in Catharanthus roseus.

  Planta 20121101

• Antimycobacterial assessment of Salicylanilide benzoates including multidrug-resistant tuberculosis strains.

  Molecules (Basel, Switzerland) 20121031

• Bioactive oleanane, lupane and ursane triterpene acid derivatives.

  Molecules (Basel, Switzerland) 20121017

• Zizimauritic acids A-C, three novel nortriterpenes from Ziziphus mauritiana.

  Bioorganic & medicinal chemistry letters 20121015

• Synthesis and antiplasmodial activity of betulinic acid and ursolic acid analogues.

  Molecules (Basel, Switzerland) 20121012

• Ionic derivatives of betulinic acid as novel HIV-1 protease inhibitors.

  Journal of enzyme inhibition and medicinal chemistry 20121001

• A novel triterpene extract from mistletoe induces rapid apoptosis in murine B16.F10 melanoma cells.

  Phytotherapy research : PTR 20121001

• Dipeptidyl peptidase IV inhibition potentiates amino acid- and bile acid-induced bicarbonate secretion in rat duodenum.

  American journal of physiology. Gastrointestinal and liver physiology 20121001

• Poly (lactide-co-glycolide) encapsulated extract of Phytolacca decandra demonstrates better intervention against induced lung adenocarcinoma in mice and on A549 cells.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120929

• Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.

  Journal of medicinal chemistry 20120927

• Mesua beccariana (Clusiaceae), a source of potential anti-cancer lead compounds in drug discovery.

  Molecules (Basel, Switzerland) 20120910

• Investigation of the interactions of lupane type pentacyclic triterpenes with outer leaflet membrane phospholipids--Langmuir monolayer and synchrotron X-ray scattering study.

  Journal of colloid and interface science 20120901

• Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid.

  Journal of ethnopharmacology 20120830

• Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.

  Bioorganic & medicinal chemistry letters 20120815

• Triterpene acids from rose hip powder inhibit self-antigen- and LPS-induced cytokine production and CD4⁺ T-cell proliferation in human mononuclear cell cultures.

  Phytotherapy research : PTR 20120801

• Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.

  Cell death and differentiation 20120801

• Betulinic acid exerts immunoregulation and anti-tumor effect on cervical carcinoma (U14) tumor-bearing mice.

  Die Pharmazie 20120801

• Betulin as an antitumor agent tested in vitro on A431, HeLa and MCF7, and as an angiogenic inhibitor in vivo in the CAM assay.

  Natural product communications 20120801

• Exploration of the antiplatelet activity profile of betulinic acid on human platelets.

  Journal of agricultural and food chemistry 20120718

• Synthesis and cytotoxicity of lupane-type triterpenoid glyceryl esters.

  Bioorganic & medicinal chemistry letters 20120715

• Antiparasitic compounds from Cornus florida L. with activities against Plasmodium falciparum and Leishmania tarentolae.

  Journal of ethnopharmacology 20120713

• Betulinic acid has an inhibitory effect on pancreatic lipase and induces adipocyte lipolysis.

  Phytotherapy research : PTR 20120701

• Betulinic acid targets YY1 and ErbB2 through cannabinoid receptor-dependent disruption of microRNA-27a:ZBTB10 in breast cancer.

  Molecular cancer therapeutics 20120701

• [Chemical constituents contained in Macropanax rosthornii].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120701

• Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

  Bioorganic & medicinal chemistry letters 20120615

• Molecular dynamics simulation studies of betulinic acid with human serum albumin.

  Journal of molecular modeling 20120601

• Effect on tumor necrosis factor-α production and antioxidant ability of black alder, as factors related to its anti-inflammatory properties.

  Journal of medicinal food 20120601

• Orthoquinone and naphthalenone derivatives from Berrya ammonilla and their anti-inflammatory activity.

  Planta medica 20120601

• Cytotoxic heterocyclic triterpenoids derived from betulin and betulinic acid.

  Bioorganic & medicinal chemistry 20120601

• NOXA as critical mediator for drug combinations in polychemotherapy.

  Cell death & disease 20120601

• Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells.

  Molecules and cells 20120531

• Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in rats.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20120512

• Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7.

  Chest 20120501

• [Chemical constituents of Dolomiaea souliei].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120501

• Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

  Journal of natural products 20120427

• Flacourtosides A-F, phenolic glycosides isolated from Flacourtia ramontchi.

  Journal of natural products 20120427

• Synthesis and biological evaluation of heterocyclic ring-fused betulinic acid derivatives as novel inhibitors of osteoclast differentiation and bone resorption.

  Journal of medicinal chemistry 20120412

• Preliminary study of the anticancer applications of mesoporous materials functionalized with the natural product betulinic acid.

  ChemMedChem 20120401

• Rapid separation and determination of betulinic acid from a complex matrix using combination of TLC and RP-HPLC.

  Pakistan journal of pharmaceutical sciences 20120401

• Arsenite-induced apoptosis of human neuroblastoma cells requires p53 but occurs independently of c-Jun.

  Neuroscience 20120329

• Lupane-type pentacyclic triterpenes in Langmuir monolayers: a synchrotron radiation scattering study.

  Langmuir : the ACS journal of surfaces and colloids 20120320

• alpha-Mangostin enhances betulinic acid cytotoxicity and inhibits cisplatin cytotoxicity on HCT 116 colorectal carcinoma cells.

  Molecules (Basel, Switzerland) 20120308

• A comparison investigation on the solubilization of betulin and betulinic acid in cyclodextrin derivatives.

  Natural product communications 20120301

• New ionic derivatives of betulinic acid as highly potent anti-cancer agents.

  Bioorganic & medicinal chemistry letters 20120215

• The anti-fibrotic effect of betulinic acid is mediated through the inhibition of NF-κB nuclear protein translocation.

  Chemico-biological interactions 20120205

• Does NAD(P)H oxidase-derived H2O2 participate in hypotonicity-induced insulin release by activating VRAC in β-cells?

  Pflugers Archiv : European journal of physiology 20120201

• [Study on absorption kinetics of betulic acid in rat's intestines].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120201

• The natural product betulinic acid inhibits C/EBP family transcription factors.

  Chembiochem : a European journal of chemical biology 20120123

• Physico-chemical comparison of betulinic acid, betulin and birch bark extract and in vitro investigation of their cytotoxic effects towards skin epidermoid carcinoma (A431), breast carcinoma (MCF7) and cervix adenocarcinoma (HeLa) cell lines.

  Natural product research 20120101

• Bioguided isolation of pentacyclic triterpenes from the leaves of Alstonia scholaris (Linn.) R. Br. growing in Egypt.

  Natural product research 20120101

• A new triterpene from Barringtonia asiatica.

  Natural product research 20120101

• A new fatty aldol ester from the aerial part of Mimosa invisa (Mimosaceae).

  Natural product research 20120101

• Synthesis of bioactive 28-hydroxy-3-oxolup-20(29)-en-30-al with antileukemic activity.

  Journal of Asian natural products research 20120101

• Bioactivity Evaluation of Plant Extracts Used in Indigenous Medicine against the Snail, Biomphalaria glabrata, and the Larvae of Aedes aegypti.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Antiviral activity of recombinant ankyrin targeted to the capsid domain of HIV-1 Gag polyprotein.

  Retrovirology 20120101

• Antiproliferative property of n-hexane and chloroform extracts of Anisomeles malabarica (L). R. Br. in HPV16-positive human cervical cancer cells.

  Journal of pharmacology & pharmacotherapeutics 20120101

• New galloyl derivative from winged sumac (Rhus copallinum) fruit.

  Natural product communications 20120101

• Triterpenes from Callicarpa integerrima Champ.

  Yao xue xue bao = Acta pharmaceutica Sinica 20120101

• Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Growth inhibition of human gynecologic and colon cancer cells by Phyllanthus watsonii through apoptosis induction.

  PloS one 20120101

• Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

  PloS one 20120101

• Notch, wnt, and hedgehog pathways in rhabdomyosarcoma: from single pathways to an integrated network.

  Sarcoma 20120101

• Mitochondria: redox metabolism and dysfunction.

  Biochemistry research international 20120101

• Antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants: a mini review.

  Advances in pharmacological sciences 20120101

• Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo.

  PloS one 20120101

• Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Radiation, inflammation, and immune responses in cancer.

  Frontiers in oncology 20120101

• Antimicrobial Constituents of Artemisia afra Jacq. ex Willd. against Periodontal Pathogens.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Influence of betulinic acid on lymphocyte subsets and humoral immune response in mice.

  Polish journal of veterinary sciences 20120101

• Lignans and triterpenes from the root of Pseuderanthemum carruthersii var. atropurpureum.

  Chemical & pharmaceutical bulletin 20120101

• Betulinic Acid inhibits growth of cultured vascular smooth muscle cells in vitro by inducing g(1) arrest and apoptosis.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Betulinic acid inhibits superoxide anion-mediated impairment of endothelium-dependent relaxation in rat aortas.

  Indian journal of pharmacology 20120101

• A new biphenyl and antimicrobial activity of extracts and compounds from Clusia burlemarxii.

  Fitoterapia 20111201

• Low molecular weight heparin downregulates tissue factor expression and activity by modulating growth factor receptor-mediated induction of nuclear factor-κB.

  Biochimica et biophysica acta 20111201

• CYP716A subfamily members are multifunctional oxidases in triterpenoid biosynthesis.

  Plant & cell physiology 20111201

• Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography.

  Chemistry & biodiversity 20111201

• First self-assembly study of betulinic acid, a renewable nano-sized, 6-6-6-6-5 pentacyclic monohydroxy triterpenic acid.

  Nanoscale 20111101

• Triterpenoid constituents from the roots of Paeonia rockii ssp. rockii.

  Journal of natural products 20111028

• Two new xanthones from Calophyllum nodusum (Guttiferae).

  Molecules (Basel, Switzerland) 20111025

• Efficient synthesis of lupane-type saponins via gold(I)-catalyzed glycosylation with glycosyl ortho-alkynylbenzoates as donors.

  Organic letters 20111021

• Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20111009

• Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release.

  Molecular carcinogenesis 20111001

• New betulinic acid derivatives as potent proteasome inhibitors.

  Bioorganic & medicinal chemistry letters 20111001

• A new furanoxanthone from the stem bark of Calophyllum inophyllum.

  Journal of Asian natural products research 20111001

• In vitro effect of combined hybrid molecules from vitamin E analogues and betulinic acid on macrophage activity.

  Bulletin of experimental biology and medicine 20111001

• Simultaneous qualitative and quantitative analysis of triterpenic acids, saponins and flavonoids in the leaves of two Ziziphus species by HPLC-PDA-MS/ELSD.

  Journal of pharmaceutical and biomedical analysis 20110910

• An amphiphilic conjugate approach toward the design and synthesis of betulinic acid-polyphenol conjugates as inhibitors of the HIV-1 gp41 fusion core formation.

  ChemMedChem 20110905

• Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling.

  British journal of pharmacology 20110901

• Targeting Sp1 transcription factors in prostate cancer therapy.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20110901

• Identification and determination of carboxylic acids in food samples using 2-(2-(anthracen-10-yl)-1H-phenanthro[9,10-d]imidazol-1-yl)ethyl 4-methylbenzenesulfonate (APIETS) as labeling reagent by HPLC with FLD and APCI/MS.

  Talanta 20110815

• Sp1 inhibition-mediated upregulation of VEGF 165 b induced by rh-endostatin enhances antiangiogenic and anticancer effect of rh-endostatin in A549.

  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20110801

• Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.

  Cancer research 20110801

• Improvement of the cytotoxicity and tumor selectivity of glycyrrhetinic acid by derivatization with bifunctional amino acids.

  Archiv der Pharmazie 20110801

• Up-regulation of cyclooxygenase-2-derived prostaglandin E(2) in colon cancer cells resistant to 5-fluorouracil.

  Journal of the Korean Surgical Society 20110801

• [Study on the chemical constituents of Leptopus chineseis].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110801

• Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.

  Molecules (Basel, Switzerland) 20110719

• Birch bark extract as therapy for chronic hepatitis C--a pilot study.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20110715

• Understanding the structure-activity relationship of betulinic acid derivatives as anti-HIV-1 agents by using 3D-QSAR and docking.

  Journal of molecular modeling 20110701

• A single polymorphism in HIV-1 subtype C SP1 is sufficient to confer natural resistance to the maturation inhibitor bevirimat.

  Antimicrobial agents and chemotherapy 20110701

• Novel 3-oxo- and 3,24-dinor-2,4-secooleanane-type triterpenes from Terminalia ivorensis A. Chev.

  Chemistry & biodiversity 20110701

• Constituents of the root of Anemone tomentosa.

  Archives of pharmacal research 20110701

• New betulinic acid derivatives induce potent and selective antiproliferative activity through cell cycle arrest at the S phase and caspase dependent apoptosis in human cancer cells.

  Biochimie 20110601

• Selective inhibition of the tumor marker aldo-keto reductase family member 1B10 by oleanolic acid.

  Journal of natural products 20110527

• Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress.

  Nitric oxide : biology and chemistry 20110430

• Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

  Bioorganic & medicinal chemistry letters 20110415

• Development of a new HPLC method with precolumn fluorescent derivatization for rapid, selective and sensitive detection of triterpenic acids in fruits.

  Journal of agricultural and food chemistry 20110413

• Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells.

  Investigational new drugs 20110401

• Betulinic acid prevention of d-galactosamine/lipopolysaccharide liver toxicity is triggered by activation of Bcl-2 and antioxidant mechanisms.

  The Journal of pharmacy and pharmacology 20110401

• Antileukemic activity of the leaf extract of Bischofia javanica blume on human leukemic cell lines.

  Indian journal of pharmacology 20110401

• Anti-angiogenic effects of betulinic acid administered in nanoemulsion formulation using chorioallantoic membrane assay.

  Journal of biomedical nanotechnology 20110401

• Betulinic acid inhibits endotoxin-stimulated phosphorylation cascade and pro-inflammatory prostaglandin E(2) production in human peripheral blood mononuclear cells.

  British journal of pharmacology 20110301

• Betulinic acid delivered in liposomes reduces growth of human lung and colon cancers in mice without causing systemic toxicity.

  Anti-cancer drugs 20110301

• Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health.

  Oncotarget 20110301

• Betulin and betulinic acid attenuate ethanol-induced liver stellate cell activation by inhibiting reactive oxygen species (ROS), cytokine (TNF-α, TGF-β) production and by influencing intracellular signaling.

  Toxicology 20110227

• Isolation of immunomodulatory triterpene acids from a standardized rose hip powder (Rosa canina L.).

  Phytotherapy research : PTR 20110201

• Anxiolytic activity of a supercritical carbon dioxide extract of Souroubea sympetala (Marcgraviaceae).

  Phytotherapy research : PTR 20110201

• In vitro hepatoprotective and antioxidant activities of crude extract and isolated compounds from Ficus gnaphalocarpa.

  Inflammopharmacology 20110201

• Effect of culture conditions on synthesis of triterpenoids in suspension cultures of Lantana camara L.

  Bioprocess and biosystems engineering 20110101

• Biotransformation optimization of betulin into betulinic acid production catalysed by cultured Armillaria luteo-virens Sacc ZJUQH100-6 cells.

  Journal of applied microbiology 20110101

• Monolayer behavior of binary systems of betulinic acid and cardiolipin: thermodynamic analyses of Langmuir monolayers and AFM study of Langmuir-Blodgett monolayers.

  Journal of colloid and interface science 20110101

• Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Anticancer Potential of Aqueous Ethanol Seed Extract of Ziziphus mauritiana against Cancer Cell Lines and Ehrlich Ascites Carcinoma.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Two oxidosqualene cyclases responsible for biosynthesis of tomato fruit cuticular triterpenoids.

  Plant physiology 20110101

• Unexpected applications of secondary metabolites.

  Biotechnology advances 20110101

• Synthesis, encapsulation and antitumor activity of new betulin derivatives.

  Archiv der Pharmazie 20110101

• Antiapoptotic and Antioxidant Properties of Orthosiphon stamineus Benth (Cat's Whiskers): Intervention in the Bcl-2-Mediated Apoptotic Pathway.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Phenylpropanoids from the stem bark of Jacaranda mimosaefolia.

  Natural product research 20110101

• Antimicrobial activities of the methanol extract, fractions and compounds from Ficus polita Vahl. (Moraceae).

  BMC complementary and alternative medicine 20110101

• 3-O-(E)-p-coumaroyl tormentic acid from Eriobotrya japonica leaves induces caspase-dependent apoptotic cell death in human leukemia cell line.

  Chemical & pharmaceutical bulletin 20110101

• Docking study of HIV-1 reverse transcriptase with phytochemicals.

  Bioinformation 20110101

• Anti-inflammatory effects of seeds of the tropical fruit camu-camu (Myrciaria dubia).

  Journal of nutritional science and vitaminology 20110101

• The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism.

  BMC cancer 20110101

• Preparation of herbal tea as infusion or by maceration at room temperature using mistletoe tea as an example.

  Scientia pharmaceutica 20110101

• Cell entry and trafficking of human adenovirus bound to blood factor X is determined by the fiber serotype and not hexon:heparan sulfate interaction.

  PloS one 20110101

• Synergistic antimicrobial activity between pentacyclic triterpenoids and antibiotics against Staphylococcus aureus strains.

  Annals of clinical microbiology and antimicrobials 20110101

• Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark.

  Malaria journal 20110101

• Anticancer activity of 2α, 3α, 19β, 23β-Tetrahydroxyurs-12-en-28-oic acid (THA), a novel triterpenoid isolated from Sinojackia sarcocarpa.

  PloS one 20110101

• Chemical analysis of Greek pollen - Antioxidant, antimicrobial and proteasome activation properties.

  Chemistry Central journal 20110101

• Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells.

  PloS one 20110101

• A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.

  BMC cancer 20110101

• Safety of higher dosages of Viscum album L. in animals and humans--systematic review of immune changes and safety parameters.

  BMC complementary and alternative medicine 20110101

• Anti-inflammatory effects of Scoparia dulcis L. and betulinic acid.

  The American journal of Chinese medicine 20110101

• Increased betulinic acid induced cytotoxicity and radiosensitivity in glioma cells under hypoxic conditions.

  Radiation oncology (London, England) 20110101

• Transgenic Plasmodium parasites stably expressing Plasmodium vivax dihydrofolate reductase-thymidylate synthase as in vitro and in vivo models for antifolate screening.

  Malaria journal 20110101

• Characterization of a novel type of HIV-1 particle assembly inhibitor using a quantitative luciferase-Vpr packaging-based assay.

  PloS one 20110101

• Inhibitory effect of aqueous Dandelion extract on HIV-1 replication and reverse transcriptase activity.

  BMC complementary and alternative medicine 20110101

• Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.

  International journal of nanomedicine 20110101

• The prototype HIV-1 maturation inhibitor, bevirimat, binds to the CA-SP1 cleavage site in immature Gag particles.

  Retrovirology 20110101

• Morphogenesis of the Infectious HIV-1 Virion.

  Frontiers in microbiology 20110101

• Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves.

  Journal of parasitology research 20110101

• Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stellate cells.

  Pharmacological reports : PR 20110101

• Prostate cancer cell lines under hypoxia exhibit greater stem-like properties.

  PloS one 20110101

• Biological activities and medicinal properties of Cajanus cajan (L) Millsp.

  Journal of advanced pharmaceutical technology & research 20110101

• Effects of newcastle disease virus strains AF2240 and V4-UPM on cytolysis and apoptosis of leukemia cell lines.

  International journal of molecular sciences 20110101

• Bioactive constituents and medicinal importance of genus Alnus.

  Pharmacognosy reviews 20110101

• The prospective role of plant products in radiotherapy of cancer: a current overview.

  Frontiers in pharmacology 20110101

• Triterpenoids from Schleichera oleosa of Darjeeling Foothills and Their Antimicrobial Activity.

  Indian journal of pharmaceutical sciences 20110101

• Triterpenoid contents and anti-inflammatory properties of the methanol extracts of ligustrum species leaves.

  Molecules (Basel, Switzerland) 20101223

• Betulinic acid inhibits high glucose-induced vascular smooth muscle cells proliferation and migration.

  Journal of cellular biochemistry 20101215

• Redefining the TGR5 triterpenoid binding pocket at the C-3 position.

  ChemMedChem 20101203

• Immunomodulatory effects of betulinic acid from the bark of white birch on mice.

  Journal of veterinary science 20101201

• Antiurolithiatic and antioxidant activity of Mimusops elengi on ethylene glycol-induced urolithiasis in rats.

  Indian journal of pharmacology 20101201

• Zfra is a small wizard in the mitochondrial apoptosis.

  Aging 20101201

• Extended longevity of Drosophila melanogaster by water and ethanol extracts of Stachys lavandulifolia.

  Pharmaceutical biology 20101101

• Inhibition of insulin and T3-induced fatty acid synthase by hexanoate.

  Lipids 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• [Influence of betulinic acid on proliferation, migration, cell cycle and apoptosis of pancreatic cancer cells].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20101101

• [Advances in the study of structural modifications and biological activities of betulinic acids].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101101

• 3β-Acet-oxy-lup-20(29)-en-28-yl 1H-1,2,4-tri-azole-1-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20101101

• Synthesis, cytotoxicity and liposome preparation of 28-acetylenic betulin derivatives.

  Bioorganic & medicinal chemistry 20101015

• New coumarin glycosides from the leaves of Diospyros crassiflora (Hiern).

  Fitoterapia 20101001

• Antimicrobial and antioxidant effects of phenolic constituents from Klainedoxa gabonensis.

  Pharmaceutical biology 20101001

• Antiinflammatory properties of Morus nigra leaves.

  Phytotherapy research : PTR 20101001

• Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

  Toxins 20101001

• Synthesis, proapoptotic screening, and structure-activity relationships of novel aza-lupane triterpenoids.

  Bioorganic & medicinal chemistry letters 20100915

• Two new flavones from Tridax procumbens Linn.

  Molecules (Basel, Switzerland) 20100909

• Exploring the potential of Nelumbo nucifera rhizome on membrane stabilization, mast cell protection, nitric oxide synthesis, and expression of costimulatory molecules.

  Immunopharmacology and immunotoxicology 20100901

• Conjugates of betulin derivatives with AZT as potent anti-HIV agents.

  Bioorganic & medicinal chemistry 20100901

• [Betulinic acid ameliorates impairment of endothelium-dependent relaxation induced by oxidative stress in rat aorta].

  Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20100901

• Betulinic acid isolated from Bacopa monniera (L.) Wettst suppresses lipopolysaccharide stimulated interleukin-6 production through modulation of nuclear factor-kappaB in peripheral blood mononuclear cells.

  International immunopharmacology 20100801

• Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties.

  European journal of medicinal chemistry 20100801

• Modulation of apoptosis by natural products for cancer therapy.

  Planta medica 20100801

• Antitumor effect of betulinic acid on human acute leukemia K562 cells in vitro.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100801

• Synthesis and anticancer activity of novel betulinic acid and betulin derivatives.

  Archiv der Pharmazie 20100801

• Last stop before exit - hepatitis C assembly and release as antiviral drug targets.

  Viruses 20100801

• Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells.

  International journal of cancer 20100715

• Betulinic acid inhibits the expression of hypoxia-inducible factor 1alpha and vascular endothelial growth factor in human endometrial adenocarcinoma cells.

  Molecular and cellular biochemistry 20100701

• Antidiabetic medicinal plants as a source of alpha glucosidase inhibitors.

  Current diabetes reviews 20100701

• A new steroidal glycoside and fatty acid esters from the stem bark of Tectona grandis Linn.

  Natural product research 20100701

• Betulin induces mitochondrial cytochrome c release associated apoptosis in human cancer cells.

  Molecular carcinogenesis 20100701

• 3β-Hy-droxy-lup-20(29)-en-28-yl 1H-imidazole-1-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20100701

• Betulinic acid induces apoptosis and inhibits hedgehog signalling in rhabdomyosarcoma.

  British journal of cancer 20100629

• Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid.

  Bioorganic & medicinal chemistry 20100615

• Betulinic acid stimulates the differentiation and mineralization of osteoblastic MC3T3-E1 cells: involvement of BMP/Runx2 and beta-catenin signals.

  Journal of agricultural and food chemistry 20100609

• Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites.

  DNA repair 20100604

• Anti-angiogenic and cytotoxicity studies of some medicinal plants.

  Planta medica 20100601

• Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.

  Pharmacological research 20100601

• Secondary plant substances in various extracts of the leaves, fruits, stem and bark of Caraipa densifolia Mart.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

• Carbamate derivatives of betulinic acid and betulin with selective cytotoxic activity.

  Bioorganic & medicinal chemistry letters 20100601

• Acylated manoyl oxide diterpenes of Stemodia trifoliata.

  Magnetic resonance in chemistry : MRC 20100601

• Nonsurgical innovations in the treatment of nonmelanoma skin cancer.

  The Journal of clinical and aesthetic dermatology 20100601

• [Studies on the chemical constituents of Callicarpa kochiana].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

• [Studies on the triterpenoids of Vitex trifolia].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100601

• Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.

  Journal of natural products 20100528

• Anti-leukemic activity of Dillenia indica L. fruit extract and quantification of betulinic acid by HPLC.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100501

• Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells.

  Molecular cancer research : MCR 20100501

• In vitro anticancer studies of alpha- and beta-D-glucopyranose betulin anomers.

  Chemico-biological interactions 20100429

• Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.

  Journal of medicinal chemistry 20100422

• Antiprotozoal activity of betulinic acid derivatives.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100401

• Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities.

  Planta medica 20100401

• Synthesis and biological evaluation of antitumor-active gamma-butyrolactone substituted betulin derivatives.

  Bioorganic & medicinal chemistry 20100401

• A pentacyclic triterpene from Litchi chinensis.

  Natural product communications 20100401

• Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach.

  Journal of natural products 20100326

• Bioactivity-guided isolation of cytotoxic triterpenoids from the trunk of Berberis koreana.

  Bioorganic & medicinal chemistry letters 20100315

• Betulinic acid protects against ischemia/reperfusion-induced renal damage and inhibits leukocyte apoptosis.

  Phytotherapy research : PTR 20100301

• Anti-HIV-1 and anti-inflammatory lupanes from the leaves, twigs, and resin of Garcinia hanburyi.

  Planta medica 20100301

• Betulinic acid, a natural compound with potent anticancer effects.

  Anti-cancer drugs 20100301

• Anti-leishmanial activity of betulin derivatives.

  The Journal of antibiotics 20100301

• Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines.

  Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] 20100301

• Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7.

  Pharmaceutical biology 20100301

• Antiproliferative cardenolides from Pentopetia androsaemifolia Decne. from the Madagascar rain forest.

  Indian journal of experimental biology 20100301

• Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives.

  Bioorganic & medicinal chemistry 20100215

• Effects of triterpene derivatives from Maytenus rigida on VEGF-induced Kaposi's sarcoma cell proliferation.

  Chemico-biological interactions 20100212

• Augmentation of expression of immunocytes' functions by seed extract of Ziziphus mauritiana (Lamk.).

  Journal of ethnopharmacology 20100203

• Synthesis and biological evaluation of antitumour-active betulin derivatives.

  Bioorganic & medicinal chemistry 20100201

• Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.

  Journal of medicinal chemistry 20100114

• Synthesis of a molecularly imprinted polymer for the solid-phase extraction of betulin and betulinic acid from plane bark.

  Phytochemical analysis : PCA 20100101

• Protective role of betulinic acid on TNF-alpha-induced cell adhesion molecules in vascular endothelial cells.

  Biochemical and biophysical research communications 20100101

• Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells.

  Acta pharmacologica Sinica 20100101

• Molecular interaction studies of trimethoxy flavone with human serum albumin.

  PloS one 20100101

• Indigenous use and bio-efficacy of medicinal plants in the Rasuwa District, Central Nepal.

  Journal of ethnobiology and ethnomedicine 20100101

• Effects of hydroxy pentacyclic triterpene acids from Forsythia viridissima on asthmatic responses to ovalbumin challenge in conscious guinea pigs.

  Biological & pharmaceutical bulletin 20100101

• Polymorphisms in Gag spacer peptide 1 confer varying levels of resistance to the HIV- 1 maturation inhibitor bevirimat.

  Retrovirology 20100101

• Anticancer activity of 3-O-acylated betulinic acid derivatives obtained by enzymatic synthesis.

  Bioscience, biotechnology, and biochemistry 20100101

• Possible fungistatic implications of betulin presence in betulaceae plants and their hymenochaetaceae parasitic fungi.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101

• Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells.

  The American journal of Chinese medicine 20100101

• NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.

  Molecular cancer 20100101

• Rapid validated HPTLC method for estimation of betulinic acid in Nelumbo nucifera (Nymphaeaceae) rhizome extract.

  Phytochemical analysis : PCA 20100101

• Peroxynitrite mediates diabetes-induced endothelial dysfunction: possible role of Rho kinase activation.

  Experimental diabetes research 20100101

• Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death.

  Parasites & vectors 20100101

• Baculovirus display of single chain antibody (scFv) using a novel signal peptide.

  BMC biotechnology 20100101

• Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.

  PloS one 20100101

• 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induce autophagic cell death in estrogen receptor negative breast cancer.

  BMC cancer 20100101

• Traditional herbal medicine in far-west Nepal: a pharmacological appraisal.

  Journal of ethnobiology and ethnomedicine 20100101

• Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel.

  Journal of inflammation (London, England) 20100101

• Triterpenoids from Psidium guajava with Biocidal Activity.

  Indian journal of pharmaceutical sciences 20100101

• Bioactivity of Syzygium jambos methanolic extracts: Antibacterial activity and toxicity.

  Pharmacognosy research 20100101

• Diuretic and natriuretic activity of two mistletoe species in rats.

  Pharmacognosy research 20100101

• Cameroonian medicinal plants: pharmacology and derived natural products.

  Frontiers in pharmacology 20100101

• Ethnopharmacology and integrative medicine - Let the history tell the future.

  Journal of Ayurveda and integrative medicine 20100101

• Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.

  Journal of medicinal chemistry 20091210

• Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.

  Planta medica 20091201

• Bioactive constituents of the stem bark of Beilschmiedia zenkeri.

  Journal of natural products 20091201

• Pharmacotherapy of actinic keratosis.

  Expert opinion on pharmacotherapy 20091201

• The hunt for natural skin whitening agents.

  International journal of molecular sciences 20091201

• Phytotoxic activity of Salvia x jamensis.

  Natural product communications 20091201

• Triterpenoids as new promising anticancer drugs.

  Anti-cancer drugs 20091101

• Cellular fingerprints: a novel approach using large-scale cancer cell line data for the identification of potential anticancer agents.

  Chemical biology & drug design 20091101

• Betulin-derived compounds as inhibitors of alphavirus replication.

  Journal of natural products 20091101

• A lichen substance as an antiproliferative compound against HL-60 human leukemia cells: 16-O-acetyl-leucotylic acid isolated from Myelochroa aurulenta.

  Bioscience, biotechnology, and biochemistry 20091101

• Anticancer agents derived from natural products.

  Mini reviews in medicinal chemistry 20091101

• [Studies on the chemical constituents from the seed of Forsythia suspense].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20091101

• Betulinic acid, a natural pentacyclic triterpenoid, prevents abdominal fat accumulation in mice fed a high-fat diet.

  Journal of agricultural and food chemistry 20091014

• Palbinone and triterpenes from Moutan Cortex (Paeonia suffruticosa, Paeoniaceae) stimulate glucose uptake and glycogen synthesis via activation of AMPK in insulin-resistant human HepG2 Cells.

  Bioorganic & medicinal chemistry letters 20091001

• Betulinic acid treatment promotes apoptosis in hepatoblastoma cells.

  International journal of oncology 20091001

• [Effect of betulinic acid on inducing apoptosis of human multiple myeloma cell line RPMI-8226].

  Zhongguo shi yan xue ye xue za zhi 20091001

• Recent developments in anti-inflammatory natural products.

  Medicinal research reviews 20090901

• Phytochemical and antifungal studies on Terminalia mollis and Terminalia brachystemma.

  Fitoterapia 20090901

• Mitochondrial membrane potential disruption pattern in human sperm.

  Human reproduction (Oxford, England) 20090901

• Targeting mitochondrial apoptosis by betulinic acid in human cancers.

  Drug discovery today 20090901

• Novel semisynthetic derivatives of betulin and betulinic acid with cytotoxic activity.

  Bioorganic & medicinal chemistry 20090901

• Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors.

  Journal of natural products 20090901

• Study on determination of pentacyclic triterpenoids in Chaenomeles by HPLC-ELSD.

  Journal of chromatographic science 20090901

• Antifungal activity of Eugenia umbelliflora against dermatophytes.

  Natural product communications 20090901

• [Chemical constituents from fruits of Ailanthus altissima].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090901

• [Studies on the chemical constituents of Coleus forskohlii].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090901

• Triterpenes augment the inhibitory effects of anticancer drugs on growth of human esophageal carcinoma cells in vitro and suppress experimental metastasis in vivo.

  International journal of cancer 20090815

• Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells.

  Bioorganic & medicinal chemistry letters 20090815

• Antimicrobial activity of the crude extract, fractions and compounds from stem bark of Ficus ovata (Moraceae).

  Journal of ethnopharmacology 20090730

• High-performance liquid chromatography--two wavelength detection of triterpenoid acids from the fruits of Ziziphus jujuba containing various cultivars in different regions and classification using chemometric analysis.

  Journal of pharmaceutical and biomedical analysis 20090712

• Antimalarial activity of betulinic acid and derivatives in vitro against Plasmodium falciparum and in vivo in P. berghei-infected mice.

  Parasitology research 20090701

• Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents.

  Bioorganic & medicinal chemistry letters 20090701

• Phytochemical analyses and gastroprotective effects of Eugenia umbelliflora (Myrtaceae) on experimental gastric ulcers.

  Natural product communications 20090701

• A new lipid and other constituents from the rhizomes of Nelumbo nucifera.

  Journal of Asian natural products research 20090701

• Triterpenoids from the roots of Pterospermum heterophyllum Hance.

  Journal of Asian natural products research 20090701

• Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts.

  Molecules (Basel, Switzerland) 20090604

• Bioactive triterpenoids from Callistemon lanceolatus.

  Archives of pharmacal research 20090601

• Curtisia dentata (Cornaceae) leaf extracts and isolated compounds inhibit motility of parasitic and free-living nematodes.

  The Onderstepoort journal of veterinary research 20090601

• 2'-Methyl-pyrazolo[4',3':16,17]androst-5-en-3β-ol.

  Acta crystallographica. Section E, Structure reports online 20090601

• Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.

  Journal of medicinal chemistry 20090528

• Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound.

  European journal of clinical investigation 20090501

• Betulinic acid-mediated inhibitory effect on hepatitis B virus by suppression of manganese superoxide dismutase expression.

  The FEBS journal 20090501

• Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines.

  Molecules (Basel, Switzerland) 20090424

• Synthesis, cytotoxicity, and haemolytic activity of chacotrioside lupane-type neosaponins and their germanicane-type rearrangement products.

  Bioorganic & medicinal chemistry letters 20090415

• Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones.

  Bioorganic & medicinal chemistry letters 20090415

• Haemolytic activity, cytotoxicity and membrane cell permeabilization of semi-synthetic and natural lupane- and oleanane-type saponins.

  Bioorganic & medicinal chemistry 20090301

• Efficacy and mechanism of action of KHBJ-9B, a new herbal medicine, and its major compound triterpenoids in human cartilage culture and in a rabbit model of collagenase-induced osteoarthritis.

  International immunopharmacology 20090201

• Acasiane A and B and farnesirane A and B, diterpene derivatives from the roots of Acacia farnesiana.

  Planta medica 20090201

• Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion.

  Apoptosis : an international journal on programmed cell death 20090201

• Anti-oxidative and anti-inflammatory activities of some isolated constituents from the stem bark of Allanblackia monticola Staner L.C (Guttiferae).

  Inflammopharmacology 20090201

• Peltophorum africanum, a traditional South African medicinal plant, contains an anti HIV-1 constituent, betulinic acid.

  The Tohoku journal of experimental medicine 20090201

• Identification and isolation of pharmacologically active triterpenes in Betuale cortex, Betula pendula Roth., Betulaceae.

  Bosnian journal of basic medical sciences 20090201

• Antioxidative action of methanolic extract and buthanolic fraction of Vochysia tucanorum Mart. in the gastroprotection.

  Journal of ethnopharmacology 20090130

• Enhancing the divergent activities of betulinic acid via neoglycosylation.

  Organic letters 20090115

• Betulinic acid binding to human serum albumin: a study of protein conformation and binding affinity.

  Journal of photochemistry and photobiology. B, Biology 20090109

• Isolation of betulinic acid, its methyl ester and guaiane sesquiterpenoids with protein tyrosine phosphatase 1B inhibitory activity from the roots of Saussurea lappa C.B.Clarke.

  Molecules (Basel, Switzerland) 20090108

• Uapaca genus (Euphorbiaceae), a good source of betulinic acid.

  Fitoterapia 20090101

• Analysis of pentacyclic triterpenes by LC-MS. A comparative study between APCI and APPI.

  Journal of mass spectrometry : JMS 20090101

• Betulinic acid: a natural product with anticancer activity.

  Molecular nutrition & food research 20090101

• Synthesis and cytotoxicity of bidesmosidic betulin and betulinic acid saponins.

  Journal of natural products 20090101

• Drugs targeting the mitochondrial pore act as cytotoxic and cytostatic agents in temozolomide-resistant glioma cells.

  Journal of translational medicine 20090101

• Dual role of Sp3 transcription factor as an inducer of apoptosis and a marker of tumour aggressiveness.

  PloS one 20090101

• [Drug discovery based on classic natural products].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090101

• Betulin is a potent anti-tumor agent that is enhanced by cholesterol.

  PloS one 20090101

• Mechanism of betulinic acid inhibition of collagen biosynthesis in human endometrial adenocarcinoma cells.

  Neoplasma 20090101

• Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research.

  Journal of experimental & clinical cancer research : CR 20090101

• Antimalarial compounds from the stem bark of Vismia laurentii.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation.

  PloS one 20090101

• Chemical composition of the stem bark and leaves of Ficus pandurata Hance.

  Natural product research 20090101

• Prevention of atherosclerosis by interference with the vascular nitric oxide system.

  Current pharmaceutical design 20090101

• Antimicrobial activity of pentacyclic triterpenes isolated from Acacia mellifera.

  African journal of traditional, complementary, and alternative medicines : AJTCAM 20090101

• Betulinic acid does not modulate the activity of P-gp/ABCB1 or MRP1/ABCC1 in a non-tumoral renal cell line: Possible utility in multidrug resistance cancer chemotherapy.

  Molecular medicine reports 20090101

• Betulinic acid exhibits stronger cytotoxic activity on the normal melanocyte NHEM-neo cell line than on drug-resistant and drug-sensitive MeWo melanoma cell lines.

  Molecular medicine reports 20090101

• Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection.

  Journal of pharmaceutical and biomedical analysis 20081215

• Triterpene based compounds with potent anti-maturation activity against HIV-1.

  Bioorganic & medicinal chemistry letters 20081215

• Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers.

  Journal of chromatography. A 20081212

• Betulinic acid suppresses constitutive and TNFalpha-induced NF-kappaB activation and induces apoptosis in human prostate carcinoma PC-3 cells.

  Molecular carcinogenesis 20081201

• Effect of hydrogen peroxide on secretory response, calcium mobilisation and caspase-3 activity in the isolated rat parotid gland.

  Molecular and cellular biochemistry 20081201

• Effects of betulinic acid on proliferation and apoptosis in Jurkat cells and its in vitro mechanism.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20081201

• Screening of Chinese medicinal plants for inhibition against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).

  Journal of ethnopharmacology 20081120

• Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes.

  Journal of ethnopharmacology 20081120

• Two novel triterpenoids with antiproliferative and apoptotic activities in human leukemia cells isolated from the resin of Garcinia hanburyi.

  Planta medica 20081101

• Hedgehog/GLI-mediated transcriptional inhibitors from Zizyphus cambodiana.

  Bioorganic & medicinal chemistry 20081101

• Study of antimalarial activity of chemical constituents from Diospyros quaesita.

  Chemistry & biodiversity 20081101

• Determination of betulinic acid from Orthosiphon stamineus leaf extract in rat plasma.

  Die Pharmazie 20081101

• Betulin binds to gamma-aminobutyric acid receptors and exerts anticonvulsant action in mice.

  Pharmacology, biochemistry, and behavior 20081001

• Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20081001

• Purity-activity relationships of natural products: the case of anti-TB active ursolic acid.

  Journal of natural products 20081001

• Four pentacyclic triterpenoids with antifungal and antibacterial activity from Curtisia dentata (Burm.f) C.A. Sm. leaves.

  Journal of ethnopharmacology 20080926

• Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid.

  The Journal of organic chemistry 20080919

• Synthesis and cytotoxic activity of heterocyclic ring-substituted betulinic acid derivatives.

  Bioorganic & medicinal chemistry letters 20080915

• Conventional and dense gas techniques for the production of liposomes: a review.

  AAPS PharmSciTech 20080901

• Cancer is a preventable disease that requires major lifestyle changes.

  Pharmaceutical research 20080901

• Comparison with various parts of Broussonetia papyrifera as to the antinociceptive and anti-inflammatory activities in rodents.

  Bioscience, biotechnology, and biochemistry 20080901

• Identification of alpha amylase inhibitors from Syzygium cumini Linn seeds.

  Indian journal of experimental biology 20080901

• Lupane-type triterpenoids from Microtropis fokienensis and Perrottetia arisanensis and the apoptotic effect of 28-hydroxy-3-oxo-lup-20(29)-en-30-al.

  Journal of natural products 20080801

• [Studies on chemical constituents from stem barks of Fraxinus paxiana].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

• [Studies on chemical constituents from roots of Pterospermum heterophyllum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080801

• [Effect of betulinic acid on proliferation and apoptosis in Jurkat cells and its mechanism].

  Zhonghua zhong liu za zhi [Chinese journal of oncology] 20080801

• In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.

  British journal of cancer 20080722

• Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria.

  Cellular signalling 20080701

• Nitric oxide induces caspase activity in boar spermatozoa.

  Theriogenology 20080701

• Antibacterial activity of labdane diterpenoids from Stemodia foliosa.

  Journal of natural products 20080701

• [Chemical constituents from herb of Gueldenstaedtia stenophylla].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701

• Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

  Journal of medicinal chemistry 20080626

• A new source of whitening agent from a Thai Mulberry plant and its betulinic acid quantitation.

  Natural product research 20080615

• Fas receptor is not present on ejaculated human sperm.

  Human reproduction (Oxford, England) 20080601

• Investigation of Indian diospyros species for antiplasmodial properties.

  Evidence-based complementary and alternative medicine : eCAM 20080601

• Betulinic Acid for cancer treatment and prevention.

  International journal of molecular sciences 20080601

• Synthesis of lupane-type saponins bearing mannosyl and 3,6-branched trimannosyl residues and their evaluation as anticancer agents.

  Carbohydrate research 20080505

• alpha-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus.

  Journal of natural products 20080501

• A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta.

  Archives of pharmacal research 20080501

• Inhibitors of DNA polymerase beta: activity and mechanism.

  Bioorganic & medicinal chemistry 20080415

• [RP-HPLC determination of betulinic acid in Callicarpa macrophylla].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080401

• Chemical constituents of radix Ranunculus ternati.

  Natural product research 20080215

• Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.

  Investigational new drugs 20080201

• Antimycobacterial activity of cinnamate-based esters of the triterpenes betulinic, oleanolic and ursolic acids.

  Chemical & pharmaceutical bulletin 20080201

• Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum.

  Chemical & pharmaceutical bulletin 20080201

• [Study on triterpenes from of Ligularia xanthotricha].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080201

• Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.

  Antimicrobial agents and chemotherapy 20080101

• Isolation of cytotoxic metabolites from targeted peruvian amazonian medicinal plants.

  Journal of natural products 20080101

• Silencing of GM3 synthase suppresses lung metastasis of murine breast cancer cells.

  Breast cancer research : BCR 20080101

• Pre-clinical development as microbicide of zinc tetra-ascorbo-camphorate, a novel terpenoid derivative: potent in vitro inhibitory activity against both R5- and X4-tropic HIV-1 strains without significant in vivo mucosal toxicity.

  AIDS research and therapy 20080101

• PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents.

  PPAR research 20080101

• HA14-1 is able to reconstitute the impaired mitochondrial pathway of apoptosis in renal cell carcinoma cell lines.

  Cellular oncology : the official journal of the International Society for Cellular Oncology 20080101

• The inhibition of assembly of HIV-1 virus-like particles by 3-O-(3',3'-dimethylsuccinyl) betulinic acid (DSB) is counteracted by Vif and requires its Zinc-binding domain.

  Virology journal 20080101

• Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells but does not affect the process of cell death.

  Cancer research 20071215

• Antielastase and free radical scavenging activities of compounds from the stems of Cornus kousa.

  Phytotherapy research : PTR 20071201

• Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives.

  Bioorganic & medicinal chemistry letters 20071201

• Tyrosinase inhibitory pentacyclic triterpenes and analgesic and spasmolytic activities of methanol extracts of Rhododendron collettianum.

  Phytotherapy research : PTR 20071101

• 2-cyano-lup-1-en-3-oxo-20-oic acid, a cyano derivative of betulinic acid, activates peroxisome proliferator-activated receptor gamma in colon and pancreatic cancer cells.

  Carcinogenesis 20071101

• Cimicifuga foetida extract inhibits proliferation of hepatocellular cells via induction of cell cycle arrest and apoptosis.

  Journal of ethnopharmacology 20071101

• Activation and inhibition of the proteasome by betulinic acid and its derivatives.

  FEBS letters 20071016

• Antimicrobial activity of the methanolic extract, fractions and compounds from the stem bark of Irvingia gabonensis (Ixonanthaceae).

  Journal of ethnopharmacology 20071008

• Effect of betulinic acid on anticancer drug-resistant colon cancer cells.

  Basic & clinical pharmacology & toxicology 20071001

• [Chemical constituents in the root of Cynanchum auriculatum].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20071001

• Synthesis and structure-activity relationship study of cytotoxic germanicane- and lupane-type 3beta-O-monodesmosidic saponins starting from betulin.

  Bioorganic & medicinal chemistry 20070915

• Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa.

  Journal of ethnopharmacology 20070905

• Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

  Evidence-based complementary and alternative medicine : eCAM 20070901

• In vitro anti-Candida Activity of Zataria multiflora Boiss.

  Evidence-based complementary and alternative medicine : eCAM 20070901

• Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

  Journal of medicinal chemistry 20070823

• Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells.

  The Journal of pharmacology and experimental therapeutics 20070801

• Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.

  Journal of natural products 20070801

• High-performance thin-layer chromatographic method for quantitative determination of 4alpha-methyl-24beta-ethyl-5alpha-cholesta-14,25-dien-3beta-ol, 24beta-ethylcholesta-5,9(11),22E-trien-3beta-ol, and betulinic acid in Clerodendrum inerme.

  Journal of separation science 20070801

• Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities.

  Molecular cancer therapeutics 20070701

• The constituents from the stems of Garcinia cowa Roxb. and their cytotoxic activities.

  Die Pharmazie 20070701

• Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types.

  Cancer letters 20070618

• Antimicrobial activity of oleanolic acid from Salvia officinalis and related compounds on vancomycin-resistant enterococci (VRE).

  Biological & pharmaceutical bulletin 20070601

• Antiviral triterpenoids from the medicinal plant Schefflera heptaphylla.

  Phytotherapy research : PTR 20070501

• In vitro evaluation of the cytotoxic and trypanocidal activities of Ampelozizyphus amazonicus (Rhamnaceae).

  Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20070501

• Triterpenoid pyrazines and benzopyrazines with cytotoxic activity.

  Journal of natural products 20070401

• Two new triterpenoids and a steroidal glycoside from the aerial parts of Ocimum basilicum.

  Chemical & pharmaceutical bulletin 20070401

• Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors.

  Cancer research 20070315

• Triterpenoids from Eugenia grandis: structure elucidation by NMR spectroscopy.

  Magnetic resonance in chemistry : MRC 20070301

• Biotransformation of betulinic and betulonic acids by fungi.

  Phytochemistry 20070301

• alpha-Glucosidase inhibitory pentacyclic triterpenes from the stem bark of Fagara tessmannii (Rutaceae).

  Phytochemistry 20070301

• Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives.

  Bioorganic & medicinal chemistry letters 20070301

• Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae).

  Chemical & pharmaceutical bulletin 20070301

• Two new flavanone glycosides of Jasminum lanceolarium and their anti-oxidant activities.

  Chemical & pharmaceutical bulletin 20070301

• [Studies on chemical constituents in fruits of Eucalyptus globulus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070301

• Simultaneous determination of betulin and betulinic acid in white birch bark using RP-HPLC.

  Journal of pharmaceutical and biomedical analysis 20070219

• A new multiparameter flow cytometric method for human semen analysis.

  Human reproduction (Oxford, England) 20070201

• Antidermatophytic triterpenoids from Syzygium jambos (L.) Alston (Myrtaceae).

  Phytotherapy research : PTR 20070201

• [Biological activity tests of chemical constituents from two Brazilian Labiatae plants].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070201

• Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L.

  Planta medica 20070201

• New developments in natural products-based anti-AIDS research.

  Medicinal research reviews 20070101

• Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine.

  Journal of ethnobiology and ethnomedicine 20070101

• Phytochemical investigation of Perovskia abrotanoides.

  Planta medica 20070101

• Betulin binds to melanocortin receptors and antagonizes alpha-melanocyte stimulating hormone induced cAMP generation in mouse melanoma cells.

  Cell biochemistry and function 20070101

• New flavonoids and other constituents from Lespedeza cuneata.

  Journal of Asian natural products research 20070101

• Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

  PloS one 20070101

• The oncoprotein H-RasV12 increases mitochondrial metabolism.

  Molecular cancer 20070101

• [Effect of nitrogen-containing derivatives of the plant triterpenes betulin and glycyrrhetic acid on the growth of MT-4, MOLT-4, CEM, and Hep G2 tumor cells].

  Bioorganicheskaia khimiia 20070101

• The 3-O-(3',3'-dimethylsuccinyl) derivative of betulinic acid (DSB) inhibits the assembly of virus-like particles in HIV-1 Gag precursor-expressing cells.

  Antiviral therapy 20070101

• Targeting human immunodeficiency virus type 1 assembly, maturation and budding.

  Drug target insights 20070101

• Design, synthesis, and anti-inflammatory activity both in vitro and in vivo of new betulinic acid analogues having an enone functionality in ring A.

  Bioorganic & medicinal chemistry letters 20061215

• Determinants of activity of the HIV-1 maturation inhibitor PA-457.

  Virology 20061201

• Physical, chemical and pharmacological characterization of a new oleogel-forming triterpene extract from the outer bark of birch (betulae cortex).

  Planta medica 20061201

• Anti-HIV-1 constituents from leaves and twigs of Cratoxylum arborescens.

  Planta medica 20061201

• Antihyperglycemic activity and chemical constituents of Eysenhardtia platycarpa.

  Journal of natural products 20061201

• Glycosidation of lupane-type triterpenoids as potent in vitro cytotoxic agents.

  Bioorganic & medicinal chemistry 20061001

• Betulinic acid decreases expression of bcl-2 and cyclin D1, inhibits proliferation, migration and induces apoptosis in cancer cells.

  Naunyn-Schmiedeberg's archives of pharmacology 20061001

• Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.

  Journal of medicinal chemistry 20060907

• Triterpenic and other lipophilic components from industrial cork byproducts.

  Journal of agricultural and food chemistry 20060906

• Pharmacological properties of the ubiquitous natural product betulin.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060901

• [Studies on triterpenoids from Potentilla chinensis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060901

• Topical anti-inflammatory activity of 2alpha-hydroxy pentacyclic triterpene acids from the leaves of Ugni molinae.

  Bioorganic & medicinal chemistry 20060815

• A new assault on HIV.

  Scientific American 20060601

• 3-O-(3',3'-dimethysuccinyl) betulinic acid inhibits maturation of the human immunodeficiency virus type 1 Gag precursor assembled in vitro.

  Journal of virology 20060601

• Loading of erythrocyte membrane with pentacyclic triterpenes inhibits Plasmodium falciparum invasion.

  Planta medica 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Betulinic acid derivatives as anticancer agents: structure activity relationship.

  Anti-cancer agents in medicinal chemistry 20060501

• Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.

  Bioorganic & medicinal chemistry 20060401

• Ceanothane- and lupane-type triterpenes with antiplasmodial and antimycobacterial activities from Ziziphus cambodiana.

  Chemical & pharmaceutical bulletin 20060401

• Two new 18-en-oleane derivatives from marine mangrove plant, Barringtonia racemosa.

  Die Pharmazie 20060401

• Signalling responses linked to betulinic acid-induced apoptosis are antagonized by MEK inhibitor U0126 in adherent or 3D spheroid melanoma irrespective of p53 status.

  International journal of cancer 20060301

• Cytotoxic constituents from the stem bark of Dichapetalum gelonioides collected in the Philippines.

  Journal of natural products 20060301

• Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia.

  Archives of pharmacal research 20060301

• Antiproliferative terpenoids from almond hulls (Prunus dulcis): identification and structure-activity relationships.

  Journal of agricultural and food chemistry 20060208

• Human ACAT-1 and ACAT-2 inhibitory activities of pentacyclic triterpenes from the leaves of Lycopus lucidus TURCZ.

  Biological & pharmaceutical bulletin 20060201

• [Treatment of actinic keratoses with birch bark extract: a pilot study].

  Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20060201

• Inhibition of diacylglycerol acyltransferase by betulinic acid from Alnus hirsuta.

  Planta medica 20060201

• [Studies on chemical constituents of hairy root of Cassia obtusifolia].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• Betulinic acid, a natural cytotoxic agent, fails to trigger apoptosis in human Burkitt's lymphoma-derived B-cell lines.

  International journal of cancer 20060101

• Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

  Medicinal research reviews 20060101

• [Antimitochondrial agents: a new class of anticancer agents].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20060101

• Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.

  BMC cell biology 20060101

• [Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives].

  Bioorganicheskaia khimiia 20060101

• Dereplication of pentacyclic triterpenoids in plants by GC-EI/MS.

  Phytochemical analysis : PCA 20060101

• Chemical study of triterpenoid resinous materials in archaeological findings by means of direct exposure electron ionisation mass spectrometry and gas chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20060101

• Is translational research compatible with preclinical publication strategies?

  Radiation oncology (London, England) 20060101

• Activation of apoptosis by derivatives of betulinic acid in human tumor cells in vitro.

  Doklady. Biochemistry and biophysics 20060101

• A disease epidemic on Zizyphus mucronata in the Kruger National Park caused by Coniodictyum chevalieri.

  Studies in mycology 20060101

• Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.

  The Journal of biological chemistry 20051223

• A new bisabolane sesquiterpenoid from Euphorbia chrysocoma.

  Journal of Asian natural products research 20051201

• Lupane-triterpenes from Bupleurum flavum.

  Natural product research 20051201

• [Studies on the chemical constituents in root of Coleus forskohlii].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051101

• Betulinic acid as new activator of NF-kappaB: molecular mechanisms and implications for cancer therapy.

  Oncogene 20051020

• Antibacterial triterpenes from Syzygium guineense (Myrtaceae).

  Journal of ethnopharmacology 20051003

• Betulinic acid induces apoptosis in skin cancer cells and differentiation in normal human keratinocytes.

  Experimental dermatology 20051001

• Phospholipid nanosomes.

  Current drug delivery 20051001

• [Chemical constituents from the mangrove plant Ceriops tagal].

  Yao xue xue bao = Acta pharmaceutica Sinica 20051001

• Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats.

  Journal of ethnopharmacology 20050914

• Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide.

  The Biochemical journal 20050901

• Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.

  International journal of oncology 20050901

• Combination of betulinic acid with cisplatin--different cytotoxic effects in two head and neck cancer cell lines.

  Oncology reports 20050901

• [Mitochondrial damage in human sperm caused by the antineoplastic agent betulinic acid].

  Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20050801

• Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy.

  The Journal of pharmacology and experimental therapeutics 20050801

• Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.

  Journal of natural products 20050801

• Antibacterial constituents from fruit bodies of ascomyce Bulgaria inquinans.

  Archives of pharmacal research 20050801

• [Chemical investingation of Chinese mangrove Sonneratia apetala II].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050801

• Lupane triterpenoids from Maytenus species.

  Journal of natural products 20050701

• The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV.

  Expert opinion on investigational drugs 20050601

• Chemical constituents and antioxidant activity of Mallotus roxburghianus leaves.

  Chemistry & biodiversity 20050601

• Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity.

  Bioorganic & medicinal chemistry 20050516

• Prenylated anthronoid antioxidants from the stem bark of Harungana madagascariensis.

  Phytochemistry 20050501

• Betulinic acid and its derivatives, potent DNA topoisomerase II inhibitors, from the bark of Bischofia javanica.

  Chemistry & biodiversity 20050501

• Caspase activation in human spermatozoa in response to physiological and pathological stimuli.

  Fertility and sterility 20050401

• Betulinic acid induces apoptosis in human chronic myelogenous leukemia (CML) cell line K-562 without altering the levels of Bcr-Abl.

  Toxicology letters 20050315

• Effect of water and temperature stress on the content of active constituents of Hypericum brasiliense Choisy.

  Plant physiology and biochemistry : PPB 20050301

• Three new triterpenes from Nerium oleander and biological activity of the isolated compounds.

  Journal of natural products 20050201

• Sensitization for anticancer drug-induced apoptosis by betulinic Acid.

  Neoplasia (New York, N.Y.) 20050201

• The chemical constituents of Rhododendron ovatum Planch.

  Yao xue xue bao = Acta pharmaceutica Sinica 20050201

• Four new prenylated isoflavonoids in Tadehagi triquetrum.

  Journal of agricultural and food chemistry 20050126

• Apoptosis inducing activity of viscin, a lipophilic extract from Viscum album L.

  The Journal of pharmacy and pharmacology 20050101

• Betulinic acid derivatives as HIV-1 antivirals.

  Trends in molecular medicine 20050101

• Betulinic acid and its derivatives: a review on their biological properties.

  Current medicinal chemistry 20050101

• Bioactive triterpenoids from Vochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4.

  Phytotherapy research : PTR 20050101

• Quantitative analysis of 23-hydroxybetulinic acid in mouse plasma using electrospray liquid chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• [Synthesis and antitumor activity of cyclopropane derivatives of betulinic and betulonic acids].

  Bioorganicheskaia khimiia 20050101

• Protective effects of betulin and betulinic acid against ethanol-induced cytotoxicity in HepG2 cells.

  Pharmacological reports : PR 20050101

• Quantitative structure-cytotoxicity relationship analysis of betulinic acid and its derivatives by semi-empirical molecular-orbital method.

  Anticancer research 20050101

• Purification of betulinic acid from Eugenia florida (Myrtaceae) by high-speed counter-current chromatography.

  Phytochemical analysis : PCA 20050101

• Chemosensitization and radiosensitization of tumors by plant polyphenols.

  Antioxidants & redox signaling 20050101

• 3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents.

  Bioorganic & medicinal chemistry letters 20041206

• A new flavone from Hypericum wightianum.

  Journal of Asian natural products research 20041201

• Protection of Ewing's sarcoma family tumor (ESFT) cell line SK-N-MC from betulinic acid induced apoptosis by alpha-DL-tocopherol.

  Toxicology letters 20041102

• Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba.

  Biological & pharmaceutical bulletin 20041101

• Apoptosis protease activator protein-1 expression is dispensable for response of human melanoma cells to distinct proapoptotic agents.

  Cancer research 20041015

• Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.

  Oncogene 20041007

• From chemoprevention to chemotherapy: common targets and common goals.

  Expert opinion on investigational drugs 20041001

• Cytotoxic saponins from Schefflera rotundifolia.

  Planta medica 20041001

• Immobilized betulinic acid column and its interactions with phospholipase A2 and snake venom proteins.

  Journal of separation science 20041001

• Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line.

  European journal of pharmacology 20040913

• Constituents of Senecio chionophilus with potential antitubercular activity.

  Journal of natural products 20040901

• Evaluation of bioactive saponins and triterpenoidal aglycons for their binding properties on human endothelin ETA and angiotensin AT1 receptors.

  Phytotherapy research : PTR 20040901

• Synthesis and cytotoxic activity of 3-O-acyl/3-hydrazine /2-bromo/20,29-dibromo betulinic acid derivatives.

  Bioorganic & medicinal chemistry letters 20040802

• Betulinic acid-induced apoptosis in leukemia cells.

  Leukemia 20040801

• [Inhibitory effects of some traditional medicines on proliferation of HIV-1 and its protease].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801

• Rapid analysis of triterpenic acids by liquid chromatography using porous graphitic carbon and evaporative light scattering detection.

  Journal of separation science 20040801

• Cell death induction by betulinic acid, ceramide and TRAIL in primary glioblastoma multiforme cells.

  Acta neurochirurgica 20040701

• Betulinic acid enhances 1alpha,25-dihydroxyvitamin D3-induced differentiation in human HL-60 promyelocytic leukemia cells.

  Anti-cancer drugs 20040701

• Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.

  Biological & pharmaceutical bulletin 20040701

• Synthesis of A-seco derivatives of betulinic acid with cytotoxic activity.

  Journal of natural products 20040701

• Synthesis of 3-O-acyl/3-benzylidene/3-hydrazone/3-hydrazine/17-carboxyacryloyl ester derivatives of betulinic acid as anti-angiogenic agents.

  Bioorganic & medicinal chemistry letters 20040621

• Quantitative analysis of anti-inflammatory and radical scavenging triterpenoid esters in evening primrose oil.

  Journal of agricultural and food chemistry 20040602

• Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala.

  Journal of natural products 20040601

• New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.

  Journal of natural products 20040601

• Antitubercular constituents of Valeriana laxiflora.

  Planta medica 20040601

• Betulinic acid and its derivatives as anti-angiogenic agents.

  Bioorganic & medicinal chemistry letters 20040503

• Betulinic acid augments the inhibitory effects of vincristine on growth and lung metastasis of B16F10 melanoma cells in mice.

  British journal of cancer 20040419

• Marmenol: a 7-geranyloxycoumarin from the leaves of Aegle marmelos Corr.

  Natural product research 20040401

• Betulinic acid: a promising anticancer candidate.

  IDrugs : the investigational drugs journal 20040401

• Cytotoxic lupane-type triterpenoids from Acacia mellifera.

  Phytochemistry 20040401

• Lipoxygenase inhibition by anadanthoflavone, a new flavonoid from the aerial parts of Anadenanthera colubrina.

  Planta medica 20040301

• Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.

  Antimicrobial agents and chemotherapy 20040201

• Apoptosis-modulating agents in combination with radiotherapy-current status and outlook.

  International journal of radiation oncology, biology, physics 20040201

• Phytotoxic and antimicrobial constituents of Bacopa monnieri and Holmskioldia sanguinea.

  Phytotherapy research : PTR 20040201

• Antiplasmodial constituents of Cajanus cajan.

  Phytotherapy research : PTR 20040201

• Phenolic compounds obtained from stems of Couepia ulei with the potential to induce quinone reductase.

  Archives of pharmacal research 20040201

• Erythrocyte membrane modifying agents and the inhibition of Plasmodium falciparum growth: structure-activity relationships for betulinic acid analogues.

  Bioorganic & medicinal chemistry 20040102

• Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection.

  Medicinal research reviews 20040101

• New prenylated isoflavanones and other constituents of Lespedeza bicolor.

  Fitoterapia 20040101

• Role of the ectodomain of the gp41 transmembrane envelope protein of human immunodeficiency virus type 1 in late steps of the membrane fusion process.

  Journal of virology 20040101

• Steroids and triterpenes from Eleocharis acutangula and E. sellowiana (Cyperaceae).

  Phytochemical analysis : PCA 20040101

• The sequence of the CA-SP1 junction accounts for the differential sensitivity of HIV-1 and SIV to the small molecule maturation inhibitor 3-O-{3',3'-dimethylsuccinyl}-betulinic acid.

  Retrovirology 20040101

• Apoptosis of human carcinoma cells in the presence of potential anti-cancer drugs: III. Treatment of Colo-205 and SKBR3 cells with: cis -platin, Tamoxifen, Melphalan, Betulinic acid, L-PDMP, L-PPMP, and GD3 ganglioside.

  Glycoconjugate journal 20040101

• Constituents of Quinchamalium majus with potential antitubercular activity.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• New lupane derived compounds with pro-apoptotic activity in cancer cells: synthesis and structure-activity relationships.

  Journal of medicinal chemistry 20031204

• Immunomodulatory activity of betulinic acid by producing pro-inflammatory cytokines and activation of macrophages.

  Archives of pharmacal research 20031201

• News from the bench.

  GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20031201

• [Studies on the constituents from the stems of Spatholobus suberectus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031201

• Antitumor-promoting constituents from Chaenomeles sinensis KOEHNE and their activities in JB6 mouse epidermal cells.

  Chemical & pharmaceutical bulletin 20031101

• A new acylated oleanane triterpenoid from Couepia polyandra that inhibits the lyase activity of DNA polymerase beta.

  Journal of natural products 20031101

• Cytotoxic triterpenoids from the fruits of Zizyphus jujuba.

  Planta medica 20031101

• Lupane triterpenes and derivatives with antiviral activity.

  Bioorganic & medicinal chemistry letters 20031020

• Synthesis and cytotoxic activity of A-ring modified betulinic acid derivatives.

  Bioorganic & medicinal chemistry letters 20031006

• Antiplasmodial triterpenes from twigs of Gardenia saxatilis.

  Journal of ethnopharmacology 20031001

• Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

  Journal of immunology (Baltimore, Md. : 1950) 20030915

• A review of natural and modified betulinic, ursolic and echinocystic acid derivatives as potential antitumor and anti-HIV agents.

  Mini reviews in medicinal chemistry 20030901

• Betulinic acid: a new cytotoxic compound against malignant head and neck cancer cells.

  Head & neck 20030901

• Constituents of the stem bark of Pongamia pinnata with the potential to induce quinone reductase.

  Journal of natural products 20030901

• Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.

  Fitoterapia 20030701

• Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation.

  Clinical cancer research : an official journal of the American Association for Cancer Research 20030701

• A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells.

  Molecular pharmacology 20030601

• Broncho-vasodilatory activity of fractions and pure constituents isolated from Bacopa monniera.

  Journal of ethnopharmacology 20030501

• A new acylglycosyl sterol from Quisqualis Fructus.

  Archives of pharmacal research 20030401

• New ursolic and betulinic derivatives as potential cytotoxic agents.

  Journal of enzyme inhibition and medicinal chemistry 20030401

• New cytotoxic lupane triterpenoids from the twigs of Coussarea paniculata.

  Journal of natural products 20030301

• Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L.

  Phytotherapy research : PTR 20030201

• Natural anti-HIV agents. Part IV. Anti-HIV constituents from Vatica cinerea.

  Journal of natural products 20030201

• Constituents of antibacterial extract of Caesalpinia paraguariensis Burk.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

• [Epimerization of hydroxyl group in the lupan series of triterpenes].

  Bioorganicheskaia khimiia 20030101

• Dihydrobetulinic acid induces apoptosis in Leishmania donovani by targeting DNA topoisomerase I and II: implications in antileishmanial therapy.

  Molecular medicine (Cambridge, Mass.) 20030101

• [Synthesis and antiviral activity of hydrazides and substituted benzalhydrazides of betulinic acid and its derivatives].

  Bioorganicheskaia khimiia 20030101

• Differential effect of betulin and betulinic acid on cytokine production in human whole blood cell cultures.

  Polish journal of pharmacology 20030101

• Quantitative analysis of betulinic acid in mouse, rat and dog plasma using electrospray liquid chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20030101

• [Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives].

  Bioorganicheskaia khimiia 20030101

• Activity-guided fractionation of the seeds of Ziziphus jujuba using a cyclooxygenase-2 inhibitory assay.

  Planta medica 20021201

• Isolation and structure elucidation of an isoflavone and a sesterterpenoic acid from Henriettella fascicularis.

  Journal of natural products 20021201

• Fatty acid synthase inhibitors from plants: isolation, structure elucidation, and SAR studies.

  Journal of natural products 20021201

• Structure and spasmolytic activity of eucalyptanoic acid from Eucalyptus camaldulensis var. obtusa and synthesis of its active derivative from oleanolic acid.

  Journal of natural products 20021201

• Betulinic acid-induced Mcl-1 expression in human melanoma--mode of action and functional significance.

  Molecular medicine (Cambridge, Mass.) 20021201

• 23-Hydroxybetulinic acid-mediated apoptosis is accompanied by decreases in bcl-2 expression and telomerase activity in HL-60 Cells.

  Life sciences 20021122

• Effect of three triterpenoids, lupeol, betulin, and betulinic acid on the stimulus-induced superoxide generation and tyrosyl phosphorylation of proteins in human neutrophils.

  Clinica chimica acta; international journal of clinical chemistry 20021101

• Ursolic acid as a trypanocidal constituent in rosemary.

  Biological & pharmaceutical bulletin 20021101

• Pentacyclic triterpenoids from Ilex macropoda.

  Archives of pharmacal research 20021001

• Constituents in evening primrose oil with radical scavenging, cyclooxygenase, and neutrophil elastase inhibitory activities.

  Journal of agricultural and food chemistry 20020925

• Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid.

  Journal of medicinal chemistry 20020912

• Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I.

  The Biochemical journal 20020901

• [Study on chemical constituents of rhizome of Anemone raddeana].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020901

• [Studies on chemical constituents in fruit of Eucalyptus globulus].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020801

• Betulinic acid, a potent inhibitor of eukaryotic topoisomerase I: identification of the inhibitory step, the major functional group responsible and development of more potent derivatives.

  Medical science monitor : international medical journal of experimental and clinical research 20020701

• Preparation of a 24-nor-1,4-dien-3-one triterpene derivative from betulin: a new route to 24-nortriterpene analogues.

  The Journal of organic chemistry 20020503

• Synthesis of combinatorial libraries based on terpenoid scaffolds.

  Combinatorial chemistry & high throughput screening 20020501

• Differentiation- and apoptosis-inducing activities by pentacyclic triterpenes on a mouse melanoma cell line.

  Journal of natural products 20020501

• Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.

  Japanese journal of cancer research : Gann 20020401

• [Studies on flavoniod constituents of Hedysarum multijugum].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020301

• Mitochondrial involvement in tracheary element programmed cell death.

  Cell death and differentiation 20020201

• Selective cytotoxicity of betulinic acid on tumor cell lines, but not on normal cells.

  Cancer letters 20020110

• Natural products inhibiting Candida albicans secreted aspartic proteases from Tovomita krukovii.

  Planta medica 20020101

• Betulinic acid sensitization of low pH adapted human melanoma cells to hyperthermia.

  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20020101

• Determination of the triterpenoid, betulinic acid, in Doliocarpus schottianus by HPLC.

  Phytochemical analysis : PCA 20020101

• [Are mitochondria targets of anticancer drugs responsible for apoptosis?].

  Annales de biologie clinique 20020101

• Review on phytochemical and medicinal aspects of jussiaea suferuticosa linn.

  Ancient science of life 20020101

• New developments in anti-HIV chemotherapy.

  Current medicinal chemistry 20011101

• Ethnopharmacology and bioinformatic combination for leads discovery: application to phospholipase A(2) inhibitors.

  Phytochemistry 20011101

• Antimycobacterial plant terpenoids.

  Planta medica 20011101

• Development of C-20 modified betulinic acid derivatives as antitumor agents.

  Bioorganic & medicinal chemistry letters 20010903

• A small-molecule antagonist of virion assembly.

  Expert opinion on investigational drugs 20010901

• The Bax/Bcl-2 ratio determines the susceptibility of human melanoma cells to CD95/Fas-mediated apoptosis.

  The Journal of investigative dermatology 20010801

• Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase.

  Lipids 20010501

• Anti-human immunodeficiency virus activity of YK-FH312 (a betulinic acid derivative), a novel compound blocking viral maturation.

  Antimicrobial agents and chemotherapy 20010401

• Betulinic acid reduces ultraviolet-C-induced DNA breakage in congenital melanocytic naeval cells: evidence for a potential role as a chemopreventive agent.

  Melanoma research 20010401

• Anthelmintic activity of the stem bark extracts of Berlina grandiflora and one of its active principles, Betulinic acid.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20010301

• p53-independent upregulation of KILLER/DR5 TRAIL receptor expression by glucocorticoids and interferon-gamma.

  Experimental cell research 20010115

• Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564.

  Antimicrobial agents and chemotherapy 20010101

• [Studies on chemical constituents from Buddleja lindleyana Fert].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20010101

• Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives.

  Journal of natural products 20001201

• Synthesis and anti-HIV activity of 3-alkylamido-3-deoxy-betulinic acid derivatives.

  Chemical & pharmaceutical bulletin 20000901

• Acetyl-boswellic acids are novel catalytic inhibitors of human topoisomerases I and IIalpha.

  Molecular pharmacology 20000701

• Inhibitory effects of constituents from Cynomorium songaricum and related triterpene derivatives on HIV-1 protease.

  Chemical & pharmaceutical bulletin 19990201

• Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.

  Journal of medicinal chemistry 19981105

• Anti-AIDS agents. 32. Synthesis and anti-HIV activity of betulin derivatives.

  Bioorganic & medicinal chemistry letters 19980519

• Anti-AIDS agents--XXVII. Synthesis and anti-HIV activity of betulinic acid and dihydrobetulinic acid derivatives.

  Bioorganic & medicinal chemistry 19971201

• Betulinic acid triggers CD95 (APO-1/Fas)- and p53-independent apoptosis via activation of caspases in neuroectodermal tumors.

  Cancer research 19971101

• Triterpenes as potential dimerization inhibitors of HIV-1 protease.

  Biochemical and biophysical research communications 19961014

• Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.

  Journal of medicinal chemistry 19960301

• Betulinic acid derivatives: a new class of human immunodeficiency virus type 1 specific inhibitors with a new mode of action.

  Journal of medicinal chemistry 19960301

• Betulinic acid derivatives: a new class of specific inhibitors of human immunodeficiency virus type 1 entry.

  Journal of medicinal chemistry 19960301

• Triterpene derivatives that block entry of human immunodeficiency virus type 1 into cells.

  Proceedings of the National Academy of Sciences of the United States of America 19940426

• Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids.

  Journal of natural products 19940201