475085-57-5 | MRE-269

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$16.00	$11.00
5mg	98%	in stock	$20.00	$14.00
10mg	98%	in stock	$25.00	$17.00
25mg	98%	in stock	$30.00	$21.00
50mg	98%	in stock	$38.00	$26.00
100mg	98%	in stock	$46.00	$32.00
250mg	98%	in stock	$82.00	$57.00
1g	98%	in stock	$202.00	$141.00
5g	98%	in stock	$703.00	$492.00

Description

• Catalog Number: AG19674
• Chemical Name: MRE-269
• CAS Number: 475085-57-5
• Molecular Formula: C25H29N3O3
• Molecular Weight: 419.5161
• MDL Number: MFCD11976884
• SMILES: OC(=O)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C

Computed Properties

• Complexity: 518
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 11
• XLogP3: 4.5

Literature

• Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20150101

• Prostacyclin: an inflammatory paradox.

  Frontiers in pharmacology 20110101

• Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.

  The Journal of pharmacology and experimental therapeutics 20101001

• A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery.

  The Journal of pharmacology and experimental therapeutics 20080901

• Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.

  Bioorganic & medicinal chemistry 20071215

• Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.

  Bioorganic & medicinal chemistry 20071101

• 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.

  The Journal of pharmacology and experimental therapeutics 20070901