475086-01-2 | Ns-304

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$22.00	$16.00
2mg	98%	in stock	$29.00	$20.00
5mg	98%	in stock	$33.00	$23.00
10mg	98%	in stock	$51.00	$36.00
25mg	98%	in stock	$114.00	$80.00
50mg	98%	in stock	$128.00	$90.00
100mg	98%	in stock	$218.00	$153.00
500mg	98%	in stock	$972.00	$680.00

Description

• Catalog Number: AG19680
• Chemical Name: Ns-304
• CAS Number: 475086-01-2
• Molecular Formula: C26H32N4O4S
• Molecular Weight: 496.6217
• MDL Number: MFCD10567093
• SMILES: O=C(NS(=O)(=O)C)COCCCCN(c1cnc(c(n1)c1ccccc1)c1ccccc1)C(C)C

Computed Properties

• Complexity: 730
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 35
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 12
• XLogP3: 3.8

Literature

• Selexipag for the treatment of pulmonary arterial hypertension.

  Expert review of respiratory medicine 20160101

• Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag.

  American journal of cardiovascular drugs : drugs, devices, and other interventions 20150101

• Pathways in pulmonary arterial hypertension: the future is here.

  European respiratory review : an official journal of the European Respiratory Society 20121201

• Selexipag: a selective prostacyclin receptor agonist that does not affect rat gastric function.

  The Journal of pharmacology and experimental therapeutics 20101001

• A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses of its active form, {4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}acetic acid (MRE-269), on rat pulmonary artery.

  The Journal of pharmacology and experimental therapeutics 20080901

• Synthesis and evaluation of N-acylsulfonamide and N-acylsulfonylurea prodrugs of a prostacyclin receptor agonist.

  Bioorganic & medicinal chemistry 20071215

• Structure-activity studies on diphenylpyrazine derivatives: a novel class of prostacyclin receptor agonists.

  Bioorganic & medicinal chemistry 20071101

• 2-[4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy]-N-(methylsulfonyl)acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug.

  The Journal of pharmacology and experimental therapeutics 20070901

• Prostanoid receptors and their biological actions.

  Progress in lipid research 19930101

• An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.

  Nature 19761021