480-40-0 | 5,7-dihydroxy-2-phenyl-4H-chromen-4-one

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$13.00	$9.00
10g	97%	in stock	$18.00	$13.00
25g	97%	in stock	$25.00	$18.00

Description

• Catalog Number: AB49877
• Chemical Name: 5,7-dihydroxy-2-phenyl-4H-chromen-4-one
• CAS Number: 480-40-0
• Molecular Formula: C15H10O4
• Molecular Weight: 254.23750000000004
• MDL Number: MFCD00006834
• SMILES: Oc1cc(O)c2c(c1)oc(cc2=O)c1ccccc1
• NSC Number: 407436

Computed Properties

• Complexity: 384
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 19
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 2.1

Upstream Synthesis Route

5,7-Dihydroxyflavone, a naturally occurring compound found in various plants, has gained attention in chemical synthesis due to its versatile applications. In the field of organic chemistry, this compound serves as a valuable intermediate for the synthesis of various flavonoid derivatives and other bioactive molecules. Its unique structure and reactivity make it a key building block for creating novel compounds with potential pharmaceutical and medicinal properties. Additionally, 5,7-Dihydroxyflavone has been utilized in the development of selective kinase inhibitors and neuroprotective agents, showcasing its significance in drug discovery and development. Furthermore, its antioxidant properties make it a promising candidate for applications in the food and cosmetic industries.

Literature

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  Chemico-biological interactions 20180825

• Chrysin, a natural and biologically active flavonoid suppresses tumor growth of mouse B16F10 melanoma cells: In vitro and In vivo study.

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  Chemico-biological interactions 20180105

• Incorporation of metabolic enzymes to improve predictivity of reporter gene assay results for estrogenic and anti-androgenic activity.

  Reproductive toxicology (Elmsford, N.Y.) 20180101

• Chrysin attenuates testosterone-induced benign prostate hyperplasia in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20180101

• Restorative effects of Chrysin pretreatment on oxidant-antioxidant status, inflammatory cytokine production, and apoptotic and autophagic markers in acute paracetamol-induced hepatotoxicity in rats: An experimental and biochemical study.

  Journal of biochemical and molecular toxicology 20171101

• Chrysin and silibinin sensitize human glioblastoma cells for arsenic trioxide.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20170701

• Chrysin, a PPAR-γ agonist improves myocardial injury in diabetic rats through inhibiting AGE-RAGE mediated oxidative stress and inflammation.

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  Chemico-biological interactions 20151205

• Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway.

  Chemico-biological interactions 20151005

• Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53.

  Chemico-biological interactions 20150505

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  Toxicology letters 20150304

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• Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes.

  Journal of biochemical and molecular toxicology 20141101

• Chrysin alleviates testicular dysfunction in adjuvant arthritic rats via suppression of inflammation and apoptosis: comparison with celecoxib.

  Toxicology and applied pharmacology 20140901

• Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II.

  Fitoterapia 20140401

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  Psychopharmacology 20140101

• Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway.

  Journal of applied toxicology : JAT 20140101

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  The American journal of Chinese medicine 20140101

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  Scientific reports 20140101

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  Biochemical pharmacology 20131215

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  Chemico-biological interactions 20131025

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  Journal of medicinal chemistry 20130523

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  Toxicology letters 20130204

• Protection by chrysin, apigenin, and luteolin against oxidative stress is mediated by the Nrf2-dependent up-regulation of heme oxygenase 1 and glutamate cysteine ligase in rat primary hepatocytes.

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• Rat α-Fetoprotein binding affinities of a large set of structurally diverse chemicals elucidated the relationships between structures and binding affinities.

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  Anti-cancer agents in medicinal chemistry 20121001

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  Geriatrics & gerontology international 20121001

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• AMP-activated protein kinase (AMPK) activation is involved in chrysin-induced growth inhibition and apoptosis in cultured A549 lung cancer cells.

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  Fitoterapia 20120701

• Chrysin attenuates allergic airway inflammation by modulating the transcription factors T-bet and GATA-3 in mice.

  Molecular medicine reports 20120701

• Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13.

  Bioorganic & medicinal chemistry letters 20120615

• Beneficial effects of chrysin on the reproductive system of adult male rats.

  Andrologia 20120601

• Chrysin restores PDGF-induced inhibition on protein tyrosine phosphatase and reduces PDGF signaling in cultured VSMCs.

  The Journal of nutritional biochemistry 20120601

• Discovery of flavonoid derivatives as anti-HCV agents via pharmacophore search combining molecular docking strategy.

  European journal of medicinal chemistry 20120601

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  The Journal of pharmacy and pharmacology 20120601

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  Journal of agricultural and food chemistry 20120509

• Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.

  Molecules (Basel, Switzerland) 20120507

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  European journal of pharmacology 20120405

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  The Journal of biological chemistry 20120102

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  Phytochemical analysis : PCA 20120101

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  Journal of applied microbiology 20111201

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  European journal of pharmacology 20111130

• Fast chromatographic separation for the quantitation of the main flavone dyes in Reseda luteola (weld).

  Journal of chromatography. A 20111125

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  Journal of cellular and molecular medicine 20111101

• Protective effect of chrysin on carbon tetrachloride (CCl4)-induced tissue injury in male Wistar rats.

  Toxicology and industrial health 20111101

• Hybrid flavan-chalcones, aromatase and lipoxygenase inhibitors, from Desmos cochinchinensis.

  Phytochemistry 20111101

• Investigations on membrane perturbation by chrysin and its copper complex using self-assembled lipid bilayers.

  Langmuir : the ACS journal of surfaces and colloids 20111101

• Ultra high performance liquid chromatography-time of flight mass spectrometry for analysis of avocado fruit metabolites: method evaluation and applicability to the analysis of ripening degrees.

  Journal of chromatography. A 20111021

• Potency of inhibition of human DNA topoisomerase I by flavones assessed through physicochemical parameters.

  Free radical biology & medicine 20111001

• Flavonoids in Scutellaria immaculata and S. ramosissima (Lamiaceae) and their biological activity.

  The Journal of pharmacy and pharmacology 20111001

• Protective effects of quercetin and chrysin against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress, body wasting and altered cytokine productions in rats.

  Immunopharmacology and immunotoxicology 20110901

• Antiproliferative effect of chrysin on anaplastic thyroid cancer.

  The Journal of surgical research 20110901

• A chrysin analog exhibited strong inhibitory activities against both PGE2 and NO production.

  European journal of medicinal chemistry 20110901

• Docking and 3D-QSAR (quantitative structure activity relationship) studies of flavones, the potent inhibitors of p-glycoprotein targeting the nucleotide binding domain.

  European journal of medicinal chemistry 20110901

• Potentiation of arsenic trioxide-induced apoptosis by 8-bromo-7-methoxychrysin in human leukemia cells involves depletion of intracellular reduced glutathione.

  Acta biochimica et biophysica Sinica 20110901

• Methylated chrysin induces co-ordinated attenuation of the canonical Wnt and NF-kB signaling pathway and upregulates apoptotic gene expression in the early hepatocarcinogenesis rat model.

  Chemico-biological interactions 20110815

• Chrysin protects epidermal keratinocytes from UVA- and UVB-induced damage.

  Journal of agricultural and food chemistry 20110810

• Inhibition of melanogenesis by 5,7-dihydroxyflavone (chrysin) via blocking adenylyl cyclase activity.

  Biochemical and biophysical research communications 20110722

• Chrysin suppresses mast cell-mediated allergic inflammation: involvement of calcium, caspase-1 and nuclear factor-κB.

  Toxicology and applied pharmacology 20110701

• Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

  Cell death & disease 20110701

• Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.

  Life sciences 20110606

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  Journal of ethnopharmacology 20110601

• Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3.

  Clinics (Sao Paulo, Brazil) 20110601

• Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids.

  Bioorganic & medicinal chemistry 20110501

• Intrinsic and extrinsic regulation of innate immune receptors.

  Yonsei medical journal 20110501

• Anti-asthmatic potential of chrysin on ovalbumin-induced bronchoalveolar hyperresponsiveness in rats.

  Pharmaceutical biology 20110501

• Quercetin-iron chelates are transported via glucose transporters.

  Free radical biology & medicine 20110415

• Screening of bacterial cytochrome P450s responsible for regiospecific hydroxylation of (iso)flavonoids.

  Enzyme and microbial technology 20110407

• Chrysin promotes tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced apoptosis in human cancer cell lines.

  Toxicology in vitro : an international journal published in association with BIBRA 20110401

• Can flavonoids from honey alter multidrug resistance?

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  Bioorganic & medicinal chemistry 20110315

• Ultrasonic-assisted synthesis of chrysin derivatives linked with 1,2,3-triazoles by 1,3-dipolar cycloaddition reaction.

  Ultrasonics sonochemistry 20110301

• Chrysin abrogates early hepatocarcinogenesis and induces apoptosis in N-nitrosodiethylamine-induced preneoplastic nodules in rats.

  Toxicology and applied pharmacology 20110215

• Furoxan nitric oxide donor coupled chrysin derivatives: synthesis and vasculoprotection.

  Bioorganic & medicinal chemistry letters 20110215

• Chrysin-induced apoptosis is mediated through p38 and Bax activation in B16-F1 and A375 melanoma cells.

  International journal of oncology 20110201

• Chemopreventive effect of dietary polyphenols in colorectal cancer cell lines.

  Nutrition research (New York, N.Y.) 20110201

• Anticonvulsant and neurotoxicity profile of the rhizome of Smilax china Linn. in mice.

  Indian journal of pharmacology 20110201

• Ethanolic Extract of Propolis Augments TRAIL-Induced Apoptotic Death in Prostate Cancer Cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Effects of methimazole on the elimination of irinotecan.

  Cancer chemotherapy and pharmacology 20110101

• Ethanol extract of chinese propolis facilitates functional recovery of locomotor activity after spinal cord injury.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Suppressive Effect on Lipopolysaccharide-Induced Proinflammatory Mediators by Citrus aurantium L. in Macrophage RAW 264.7 Cells via NF-κB Signal Pathway.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Methylated chrysin, a dimethoxy flavone, partially suppresses the development of liver preneoplastic lesions induced by N-nitrosodiethylamine in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110101

• Concentration-Dependent Protection by Ethanol Extract of Propolis against γ-Ray-Induced Chromosome Damage in Human Blood Lymphocytes.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Inhibitory effect of chinese propolis on phosphatidylcholine-specific phospholipase C activity in vascular endothelial cells.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Apigenin inhibits tumor necrosis factor alpha plus high glucose-induced LOX-1 expression in human endothelial cells.

  Microvascular research 20110101

• Synthesis, biological evaluation of chrysin derivatives as potential immunosuppressive agents.

  European journal of medicinal chemistry 20110101

• In vitro studies on the inhibition of colon cancer by butyrate and polyphenolic compounds.

  Nutrition and cancer 20110101

• The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

  International journal of molecular sciences 20110101

• Facile synthesis of chrysin-derivatives with promising activities as aromatase inhibitors.

  Natural product communications 20110101

• Honey induces apoptosis in renal cell carcinoma.

  Pharmacognosy magazine 20110101

• Chrysin modulates ethanol metabolism in Wistar rats: a promising role against organ toxicities.

  Alcohol and alcoholism (Oxford, Oxfordshire) 20110101

• Novel natural inhibitors of CYP1A2 identified by in silico and in vitro screening.

  International journal of molecular sciences 20110101

• Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Antiherpetic Efficacies.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells.

  PloS one 20110101

• Evaluation of antiaggregatory activity of flavonoid aglycone series.

  Nutrition journal 20110101

• Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin.

  Indian journal of nephrology 20110101

• Research strategies in the study of the pro-oxidant nature of polyphenol nutraceuticals.

  Journal of toxicology 20110101

• An integrated bioinformatics approach identifies elevated cyclin E2 expression and E2F activity as distinct features of tamoxifen resistant breast tumors.

  PloS one 20110101

• Development and validation of a UHPLC method for the determination of flavonoids in red wine.

  Journal of AOAC International 20110101

• 5-allyl-7-gen-difluoromethoxychrysin enhances TRAIL-induced apoptosis in human lung carcinoma A549 cells.

  BMC cancer 20110101

• Teucrium plant species as natural sources of novel anticancer compounds: antiproliferative, proapoptotic and antioxidant properties.

  International journal of molecular sciences 20110101

• Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells.

  Neoplasma 20110101

• Selection of herbal therapeutics against deltatoxin mediated Clostridial infections.

  Bioinformation 20110101

• Dietary α-eleostearic acid ameliorates experimental inflammatory bowel disease in mice by activating peroxisome proliferator-activated receptor-γ.

  PloS one 20110101

• Honey and renal cell carcinoma.

  Pharmacognosy magazine 20110101

• Antioxidant and potential anti-inflammatory activity of extracts and formulations of white tea, rose, and witch hazel on primary human dermal fibroblast cells.

  Journal of inflammation (London, England) 20110101

• Drug discovery for Duchenne muscular dystrophy via utrophin promoter activation screening.

  PloS one 20110101

• Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β.

  Journal of neuroinflammation 20110101

• Antimutagenic and free radical scavenger effects of leaf extracts from Accacia salicina.

  Annals of clinical microbiology and antimicrobials 20110101

• Protective effect of aqueous extract of Oroxylum indicum Linn. (root bark) against DNBS-induced colitis in rats.

  Indian journal of pharmacology 20110101

• Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays.

  PloS one 20110101

• Bioactive constituents and medicinal importance of genus Alnus.

  Pharmacognosy reviews 20110101

• A Review on the Taxonomy, Ethnobotany, Chemistry and Pharmacology of Oroxylum indicum Vent.

  Indian journal of pharmaceutical sciences 20110101

• Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.

  Chemical research in toxicology 20101220

• Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium.

  Chemico-biological interactions 20101205

• Gene expression profiles in human peripheral blood mononuclear cells as biomarkers for nutritional in vitro and in vivo investigations.

  Genes & nutrition 20101201

• Chrysin suppresses LPS-stimulated proinflammatory responses by blocking NF-κB and JNK activations in microglia cells.

  Neuroscience letters 20101126

• Flavonoids from Halostachys caspica and their antimicrobial and antioxidant activities.

  Molecules (Basel, Switzerland) 20101105

• Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.

  Acta tropica 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Induction of apoptosis by 5,7-dihydroxy-8-nitrochrysin in breast cancer cells: the role of reactive oxygen species and Akt.

  International journal of oncology 20101101

• Synthesis and biological evaluation of novel benzyl-substituted flavones as free radical (DPPH) scavengers and α-glucosidase inhibitors.

  Journal of Asian natural products research 20101101

• Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2. Kinetics analysis, molecular docking, and molecular dynamics simulations.

  Bioorganic & medicinal chemistry letters 20101015

• Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.

  European journal of medicinal chemistry 20101001

• Inhibition of CCAAT/enhancer binding protein δ expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effects.

  Journal of neurochemistry 20101001

• Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression.

  International journal of oncology 20101001

• Separation optimization of quercetin, hesperetin and chrysin in honey by micellar liquid chromatography and experimental design.

  Journal of separation science 20101001

• Seasonal variation, chemical composition and antioxidant activity of Brazilian propolis samples.

  Evidence-based complementary and alternative medicine : eCAM 20100901

• Flavonoid combinations cause synergistic inhibition of proinflammatory mediator secretion from lipopolysaccharide-induced RAW 264.7 cells.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100901

• Effects of propolis from different areas on mast cell degranulation and identification of the effective components in propolis.

  International immunopharmacology 20100901

• Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation.

  European journal of medicinal chemistry 20100901

• Selective inhibition of methoxyflavonoids on human CYP1B1 activity.

  Bioorganic & medicinal chemistry 20100901

• Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity.

  Nutrition research (New York, N.Y.) 20100901

• Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters.

  Biochemical pharmacology 20100815

• Role of oxidative stress in the antitumoral action of a new vanadyl(IV) complex with the flavonoid chrysin in two osteoblast cell lines: relationship with the radical scavenger activity.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100801

• Cucullamide, a new putrescine bisamide from Amoora cucullata.

  Chemical & pharmaceutical bulletin 20100801

• An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds.

  Journal of natural products 20100723

• 8-Bromo-7-methoxychrysin-induced apoptosis of hepatocellular carcinoma cells involves ROS and JNK.

  World journal of gastroenterology 20100721

• Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factor-kappaB.

  Cancer letters 20100701

• Structure-affinity relationship of flavones on binding to serum albumins: effect of hydroxyl groups on ring A.

  Molecular nutrition & food research 20100701

• Chrysin suppresses IL-6-induced angiogenesis via down-regulation of JAK1/STAT3 and VEGF: an in vitro and in ovo approach.

  Journal of agricultural and food chemistry 20100609

• Nitrofurantoin transport by placental choriocarcinoma JAr cells: involvement of BCRP, OATP2B1 and other MDR transporters.

  Archives of gynecology and obstetrics 20100601

• A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.

  European journal of medicinal chemistry 20100601

• Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner.

  International journal of biological macromolecules 20100601

• Influence of chrysin on hepatic marker enzymes and lipid profile against D-galactosamine-induced hepatotoxicity rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100601

• Effect of selected flavones on cancer and endothelial cells.

  General physiology and biophysics 20100601

• Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

  Bioorganic & medicinal chemistry letters 20100515

• Synthesis, characterization and vasculoprotective effects of nitric oxide-donating derivatives of chrysin.

  Bioorganic & medicinal chemistry 20100501

• Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells.

  Journal of natural products 20100423

• Effect of chrysin on hepatoprotective and antioxidant status in D-galactosamine-induced hepatitis in rats.

  European journal of pharmacology 20100410

• Antigenotoxic studies of different substances to reduce the DNA damage induced by aflatoxin B(1) and ochratoxin A.

  Toxins 20100401

• Spectrometric study of the interaction between alpinetin and bovine serum albumin using chemometrics approaches.

  Analytica chimica acta 20100324

• High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer.

  British journal of cancer 20100316

• Dietary flavonoids activate the constitutive androstane receptor (CAR).

  Journal of agricultural and food chemistry 20100224

• Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain.

  FEBS letters 20100219

• Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

  Bioorganic & medicinal chemistry 20100215

• Apigenin, chrysin, and luteolin selectively inhibit chymotrypsin-like and trypsin-like proteasome catalytic activities in tumor cells.

  Planta medica 20100201

• Design, synthesis and biological evaluation of chrysin long-chain derivatives as potential anticancer agents.

  Bioorganic & medicinal chemistry 20100201

• Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.

  Chemico-biological interactions 20100127

• Antiviral activity and mode of action of propolis extracts and selected compounds.

  Phytotherapy research : PTR 20100101

• In vitro anti-leukemic activity of the ethno-pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100101

• Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

  Bioorganic & medicinal chemistry 20100101

• Luteolin triggers global changes in the microglial transcriptome leading to a unique anti-inflammatory and neuroprotective phenotype.

  Journal of neuroinflammation 20100101

• Protection of burn-induced skin injuries by the flavonoid kaempferol.

  BMB reports 20100101

• Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20100101

• Potential effects of chrysin on MDA-MB-231 cells.

  International journal of molecular sciences 20100101

• Impact of dietary polyphenols on carbohydrate metabolism.

  International journal of molecular sciences 20100101

• Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells.

  BMC biochemistry 20100101

• Apoptotic effects of chrysin in human cancer cell lines.

  International journal of molecular sciences 20100101

• Reversal of multidrug resitance by natural substances from plants.

  Current topics in medicinal chemistry 20100101

• Differential mechanisms for the inhibition of human cytochrome P450 1A2 by apigenin and genistein.

  Journal of biochemical and molecular toxicology 20100101

• Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II.

  PloS one 20100101

• Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines.

  BMC complementary and alternative medicine 20100101

• Potent modification of inducible CYP1A1 expression by flavonoids.

  Biological & pharmaceutical bulletin 20100101

• Medicinal plants used in Northern Peru for reproductive problems and female health.

  Journal of ethnobiology and ethnomedicine 20100101

• Novel screening method for potential skin-whitening compounds by a luciferase reporter assay.

  Bioscience, biotechnology, and biochemistry 20100101

• Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism.

  Journal of neuroinflammation 20100101

• CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells.

  Toxicology letters 20091215

• Potent and selective steroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 7, an enzyme that catalyzes the reduction of the key hormones estrone and dihydrotestosterone.

  Journal of medicinal chemistry 20091210

• Mining biologically-active molecules for inhibitors of fatty acid amide hydrolase (FAAH): identification of phenmedipham and amperozide as FAAH inhibitors.

  Bioorganic & medicinal chemistry letters 20091201

• 7-Hydroxy-benzopyran-4-one derivatives: a novel pharmacophore of peroxisome proliferator-activated receptor alpha and -gamma (PPARalpha and gamma) dual agonists.

  Journal of medicinal chemistry 20091112

• Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.

  International journal of molecular sciences 20091101

• CYP1-mediated antiproliferative activity of dietary flavonoids in MDA-MB-468 breast cancer cells.

  Toxicology 20091029

• Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics.

  Bioorganic & medicinal chemistry 20090901

• Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

  Bioorganic & medicinal chemistry letters 20090815

• Evaluation of radioprotective effects of propolis and its flavonoid constituents: in vitro study on human white blood cells.

  Phytotherapy research : PTR 20090801

• Cytotoxicity of flavones and flavonols to a human esophageal squamous cell carcinoma cell line (KYSE-510) by induction of G2/M arrest and apoptosis.

  Toxicology in vitro : an international journal published in association with BIBRA 20090801

• In vitro kinetic properties of the Thr201Met variant of human aromatase gene CYP19A1: functional responses to substrate and product inhibition and enzyme inhibitors.

  The Journal of clinical endocrinology and metabolism 20090801

• Inhibitory effects of flavonoids isolated from Fragaria ananassa Duch on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3.

  Bioorganic & medicinal chemistry 20090801

• [Synthesis of biflavones and their interaction with DNA].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090801

• Development and validation of a high-performance liquid chromatographic method for determination of pinocembrin in rat plasma: application to pharmacokinetic study.

  Journal of pharmaceutical and biomedical analysis 20090712

• Antifeedant activity of ethanolic extract from Flourensia oolepis and isolation of pinocembrin as its active principle compound.

  Bioresource technology 20090701

• Antiinflammatory and antinociceptive activities of gossypin and procumbentin--cyclooxygenase-2 (COX-2) inhibition studies.

  Phytotherapy research : PTR 20090601

• Breast cancer resistance protein interacts with various compounds in vitro, but plays a minor role in substrate efflux at the blood-brain barrier.

  Drug metabolism and disposition: the biological fate of chemicals 20090601

• Hepatoprotective effect of chrysin on prooxidant-antioxidant status during ethanol-induced toxicity in female albino rats.

  The Journal of pharmacy and pharmacology 20090601

• Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora.

  Journal of natural products 20090601

• Simultaneous quantification of eight major bioactive phenolic compounds in Chinese propolis by high-performance liquid chromatography.

  Natural product communications 20090601

• Inhibitory effects of flavonoids on TNF-alpha-induced IL-8 gene expression in HEK 293 cells.

  BMB reports 20090531

• Correlation between antiangiogenic activity and antioxidant activity of various components from propolis.

  Molecular nutrition & food research 20090501

• Simultaneous determination of 11 active components in two well-known traditional Chinese medicines by HPLC coupled with diode array detection for quality control.

  Journal of pharmaceutical and biomedical analysis 20090501

• Chrysin, a natural flavone, improves murine inflammatory bowel diseases.

  Biochemical and biophysical research communications 20090417

• Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin.

  Biochemical pharmacology 20090415

• Main flavonoids, DPPH activity, and metal content allow determination of the geographical origin of propolis from the Province of San Juan (Argentina).

  Journal of agricultural and food chemistry 20090408

• Cytotoxic constituents of chinese propolis.

  Journal of natural products 20090401

• Food flavonoid aryl hydrocarbon receptor-mediated agonistic/antagonistic/synergic activities in human and rat reporter gene assays.

  Analytica chimica acta 20090401

• Comparison of intraperitoneal honey and sodium hyaluronate-carboxymethylcellulose (Seprafilm) for the prevention of postoperative intra-abdominal adhesions.

  Clinics (Sao Paulo, Brazil) 20090401

• Trihydroxynaphthalene reductase of Curvularia lunata--a target for flavonoid action?

  Chemico-biological interactions 20090316

• Mechanism of CYP2C9 inhibition by flavones and flavonols.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090301

• Quantum-SAR extension of the spectral-SAR algorithm: application to polyphenolic anticancer bioactivity.

  International journal of molecular sciences 20090301

• 5,7-Dimeth-oxy-2-phenyl-4H-chromen-4-one.

  Acta crystallographica. Section E, Structure reports online 20090301

• 6,8-Dibromo-5-hydr-oxy-4-oxo-2-phenyl-4H-chromen-7-yl acetate.

  Acta crystallographica. Section E, Structure reports online 20090301

• 2-Bromo-5,7-dimeth-oxy-4-phenyl-quinoline.

  Acta crystallographica. Section E, Structure reports online 20090301

• Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors.

  Bioorganic & medicinal chemistry letters 20090215

• Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography.

  Analytica chimica acta 20090202

• MS/MS spectral tag-based annotation of non-targeted profile of plant secondary metabolites.

  The Plant journal : for cell and molecular biology 20090201

• Dimethyl 2,2'-[(4-oxo-2-phenyl-4H-chromene-5,7-diyl)dioxy]diacetate: a more densely packed polymorph.

  Acta crystallographica. Section E, Structure reports online 20090201

• Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone.

  Bioorganic & medicinal chemistry 20090115

• In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids.

  Planta medica 20090101

• Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

  BMC medical genomics 20090101

• Bear bile: dilemma of traditional medicinal use and animal protection.

  Journal of ethnobiology and ethnomedicine 20090101

• Structure-activity relationship of 7 flavonoids on recombinant human protein kinase CK2 holoenzyme.

  Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090101

• Simple and reliable methods for the determination of sixteen marker components for quality control of Daochi pill by HPLC coupled with diode array detection.

  Phytochemical analysis : PCA 20090101

• From functional food to medicinal product: systematic approach in analysis of polyphenolics from propolis and wine.

  Nutrition journal 20090101

• Antiproliferative effects of honey and of its polyphenols: a review.

  Journal of biomedicine & biotechnology 20090101

• Differential effects of chrysin on nitrofurantoin pharmacokinetics mediated by intestinal breast cancer resistance protein in rats and mice.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20090101

• Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin.

  Bioinorganic chemistry and applications 20090101

• Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cells.

  BMC complementary and alternative medicine 20090101

• Cofactor-activated phosphorylation is required for inhibition of cortical neuron differentiation by Groucho/TLE1.

  PloS one 20090101

• Prevention of selenite-induced cataractogenesis by rutin in Wistar rats.

  Molecular vision 20090101

• [Comparative effects of flavonoids on cell cycle passage and apoptosis induction in human acute lymphoblastic leukemia MT-4 cells].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101

• 2-Phenyl-5,7-bis-(prop-2-en-1-yl-oxy)-4H-chromen-4-one.

  Acta crystallographica. Section E, Structure reports online 20090101

• Analysis of flavonoids in propolis and Ginkgo biloba by micellar electrokinetic capillary chromatography.

  Journal of agricultural and food chemistry 20081224

• Flow-injection chemiluminescence determination of chrysin and baicalein assisted by theoretical prediction of chemiluminescence behavior of chrysin and baicalein.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20081201

• Antioxidant and antimicrobial effects of phenolic compounds extracts of Northeast Portugal honey.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

• Negative ion 'chip-based' nanospray tandem mass spectrometry for the analysis of flavonoids in glandular trichomes of Lychnophora ericoides Mart. (Asteraceae).

  Rapid communications in mass spectrometry : RCM 20081201

• [Cytotoxicity of polyphenolic/flavonoid compounds in a leukaemia cell culture].

  Arhiv za higijenu rada i toksikologiju 20081201

• Authors' correction: chrysin is a Passiflora coerulea extract.

  AANA journal 20081201

• Hexaaqua-(5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonato)calcium(II) 5,7-dihydr-oxy-4-oxo-2-phenyl-4H-chromene-8-sulfonate trihydrate.

  Acta crystallographica. Section E, Structure reports online 20081201

• 5,7-Bis(benz-yloxy)-2-phenyl-4H-chromen-4-one.

  Acta crystallographica. Section E, Structure reports online 20081201

• Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein.

  Neuroscience letters 20081031

• Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SH-SY5Y cells.

  Journal of agricultural and food chemistry 20081008

• Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways.

  Steroids 20081001

• Relationship between the methylation status of dietary flavonoids and their growth-inhibitory and apoptosis-inducing activities in human cancer cells.

  Journal of cellular biochemistry 20081001

• Modulation of signalling nuclear factor-kappaB activation pathway by polyphenols in human intestinal Caco-2 cells.

  The British journal of nutrition 20080901

• A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells.

  Biochimica et biophysica acta 20080901

• Enhanced detection and structural characterization of flavonoids by complexation with N,O-bis(trimethysilyl)trifluoroacetamide using electrospray ionization mass spectrometry.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20080901

• Chemical composition and botanical origin of red propolis, a new type of brazilian propolis.

  Evidence-based complementary and alternative medicine : eCAM 20080901

• [Studies on ethyl acetate soluble constituents of Huanglian Jiedutang].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

• Effect of flavonoids on rat splenocytes, a structure-activity relationship study.

  Biochemical pharmacology 20080815

• QSAR modeling of the interaction of flavonoids with GABA(A) receptor.

  European journal of medicinal chemistry 20080801

• Modulation of glucose uptake in a human choriocarcinoma cell line (BeWo) by dietary bioactive compounds and drugs of abuse.

  Journal of biochemistry 20080801

• Chrysin induces hyperalgesia via the GABAA receptor in mice.

  Planta medica 20080801

• Protein engineering on biphenyl dioxygenase for conferring activity to convert 7-hydroxyflavone and 5,7-dihydroxyflavone (chrysin).

  Journal of bioscience and bioengineering 20080801

• Discovery of nonsteroidal 17beta-hydroxysteroid dehydrogenase 1 inhibitors by pharmacophore-based screening of virtual compound libraries.

  Journal of medicinal chemistry 20080724

• Galangin increases the cytotoxic activity of imatinib mesylate in imatinib-sensitive and imatinib-resistant Bcr-Abl expressing leukemia cells.

  Cancer letters 20080708

• Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle.

  Journal of experimental botany 20080701

• [Linear scale-up of the separation of active components from Oroxylum indicum using high-speed counter-current chromatography].

  Se pu = Chinese journal of chromatography 20080701

• Role of Bax in quercetin-induced apoptosis in human prostate cancer cells.

  Biochemical pharmacology 20080615

• Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

  Journal of medicinal chemistry 20080612

• Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20080601

• Investigations on the fluorescence quenching of 2,3-diazabicyclo[2.2.2]oct-2-ene by certain flavonoids.

  Journal of photochemistry and photobiology. B, Biology 20080529

• Assessment of luteolin (3',4',5,7-tetrahydroxyflavone) neuropharmacological activity.

  Behavioural brain research 20080516

• Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines.

  Biochemical pharmacology 20080515

• Aromatase inhibition by synthetic lactones and flavonoids in human placental microsomes and breast fibroblasts--a comparative study.

  Toxicology and applied pharmacology 20080501

• Chrysin, a natural flavonoid enhances steroidogenesis and steroidogenic acute regulatory protein gene expression in mouse Leydig cells.

  The Journal of endocrinology 20080501

• Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron.

  Journal of cellular biochemistry 20080415

• Signal molecules in the peanut-bradyrhizobia interaction.

  Archives of microbiology 20080401

• Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones.

  Chemical & pharmaceutical bulletin 20080401

• Phytoestrogens and breast cancer prevention: possible mechanisms of action.

  Environmental health perspectives 20080401

• The effects of chrysin, a Passiflora incarnata extract, on natural killer cell activity in male Sprague-Dawley rats undergoing abdominal surgery.

  AANA journal 20080401

• Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes.

  Biochemical pharmacology 20080315

• Pharmacological studies on hypotensive, diuretic and vasodilator activities of chrysin glucoside from Calycotome villosa in rats.

  Phytotherapy research : PTR 20080301

• Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as alpha-glucosidase inhibitors.

  Bioorganic & medicinal chemistry letters 20080301

• Effects of Food Natural Products on the Biotransformation of PCBs.

  Environmental toxicology and pharmacology 20080301

• Complexation of flavonoids with iron: structure and optical signatures.

  The journal of physical chemistry. B 20080214

• Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line.

  Chemico-biological interactions 20080110

• Behavioral effects of 6-bromoflavanone and 5-methoxy-6,8-dibromoflavanone as anxiolytic compounds.

  Progress in neuro-psychopharmacology & biological psychiatry 20080101

• Evaluation of the radioprotective effects of propolis and flavonoids in gamma-irradiated mice: the alkaline comet assay study.

  Biological & pharmaceutical bulletin 20080101

• Reversal of multidrug resistance by synthetic and natural compounds in drug-resistant MCF-7 cell lines.

  Chemotherapy 20080101

• Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells.

  PPAR research 20080101

• Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite.

  BMC research notes 20080101

• Jaceosidin induces apoptosis in human ovary cancer cells through mitochondrial pathway.

  Journal of biomedicine & biotechnology 20080101

• PPARgamma: The Portrait of a Target Ally to Cancer Chemopreventive Agents.

  PPAR research 20080101

• Synthesis and enantiomeric resolution of (+/-)-pinocembrin.

  Journal of Asian natural products research 20080101

• Inflammaging as a prodrome to Alzheimer's disease.

  Journal of neuroinflammation 20080101

• Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression.

  BMC genomics 20080101

• Influence of some bioflavonoids on the transport of nitrendipine.

  Drug metabolism and drug interactions 20080101

• Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin.

  Nutrition research and practice 20080101

• [Effects of flavonoids with different structures on proliferation of leukemia cell line HL-60].

  Ai zheng = Aizheng = Chinese journal of cancer 20071201

• Iron-binding properties of plant phenolics and cranberry's bio-effects.

  Dalton transactions (Cambridge, England : 2003) 20071121

• Enzymatic acylation of flavonoids: effect of the nature of the substrate, origin of lipase, and operating conditions on conversion yield and regioselectivity.

  Journal of agricultural and food chemistry 20071114

• Analysis of the polyphenolic fraction of propolis from different sources by liquid chromatography-tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20071105

• Sonoran propolis: chemical composition and antiproliferative activity on cancer cell lines.

  Planta medica 20071101

• Effect of 7-O-beta-D-glucopyranosylchrysin and its aglycone chrysin isolated from Podocytisus caramanicus on estrogen receptor alpha transcriptional activity.

  Planta medica 20071101

• Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal.

  Archives of biochemistry and biophysics 20071015

• Flavonoids induce germination of basidiospores of the ectomycorrhizal fungus Suillus bovinus.

  Mycorrhiza 20071001

• Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase.

  Bioorganic & medicinal chemistry 20071001

• Determination of flavonoid aglycones in several food samples by mixed micellar electrokinetic chromatography.

  Journal of separation science 20071001

• Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat.

  AANA journal 20071001

• 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.

  Bioorganic & medicinal chemistry 20070915

• Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice.

  European journal of nutrition 20070801

• Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages.

  International immunopharmacology 20070801

• Induction of apoptosis of human gastric carcinoma SGC-7901 cell line by 5, 7-dihydroxy-8-nitrochrysin in vitro.

  World journal of gastroenterology 20070728

• Chrysin inhibited stem cell factor (SCF)/c-Kit complex-induced cell proliferation in human myeloid leukemia cells.

  Biochemical pharmacology 20070715

• Computational studies of the binding mechanism of calmodulin with chrysin.

  Biochemical and biophysical research communications 20070713

• Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion.

  International journal of oncology 20070701

• Effect of chrysin and natural coumarins on UGT1A1 and 1A6 activities in rat and human hepatocytes in primary culture.

  Planta medica 20070701

• (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture.

  Toxicology and applied pharmacology 20070615

• Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects.

  International journal of biological macromolecules 20070601

• The effect of flavones and flavonols on colonization of tomato plants by arbuscular mycorrhizal fungi of the genera Gigaspora and Glomus.

  Canadian journal of microbiology 20070601

• Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones.

  Biochemical pharmacology 20070501

• Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin.

  International journal of cancer 20070501

• Variable sulfation of dietary polyphenols by recombinant human sulfotransferase (SULT) 1A1 genetic variants and SULT1E1.

  Drug metabolism and disposition: the biological fate of chemicals 20070501

• An antifungal compound involved in symbiotic germination of Cypripedium macranthos var. rebunense (Orchidaceae).

  Phytochemistry 20070501

• Assessment by survival analysis of the radioprotective properties of propolis and its polyphenolic compounds.

  Biological & pharmaceutical bulletin 20070501

• [Synthesis of chrysin derivatives and their interaction with DNA].

  Yao xue xue bao = Acta pharmaceutica Sinica 20070501

• Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.

  Toxicological sciences : an official journal of the Society of Toxicology 20070401

• Rational design of novel, potent small molecule pan-selectin antagonists.

  Journal of medicinal chemistry 20070322

• Identification of kaempferol as an inhibitor of cigarette smoke-induced activation of the aryl hydrocarbon receptor and cell transformation.

  Carcinogenesis 20070301

• Structure activity relationship of antioxidative property of flavonoids and inhibitory effect on matrix metalloproteinase activity in UVA-irradiated human dermal fibroblast.

  Archives of pharmacal research 20070301

• Antioxidant compounds of propolis determined by capillary electrophoresis-mass spectrometry.

  Journal of separation science 20070301

• Effects of the flavonoid chrysin on nitrofurantoin pharmacokinetics in rats: potential involvement of ABCG2.

  Drug metabolism and disposition: the biological fate of chemicals 20070201

• Flavonoids modulate monocarboxylate transporter-1-mediated transport of gamma-hydroxybutyrate in vitro and in vivo.

  Drug metabolism and disposition: the biological fate of chemicals 20070201

• The role of chrysin and the ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice.

  Hepatology (Baltimore, Md.) 20070201

• Structure-proteasome-inhibitory activity relationships of dietary flavonoids in human cancer cells.

  Frontiers in bioscience : a journal and virtual library 20070101

• Chrysin inhibits expression of hypoxia-inducible factor-1alpha through reducing hypoxia-inducible factor-1alpha stability and inhibiting its protein synthesis.

  Molecular cancer therapeutics 20070101

• In vitro antimicrobial activity of propolis samples from different geographical origins against certain oral pathogens.

  Anaerobe 20070101

• [Studies on chemical components of Cirsium segestum].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070101

• [The estimation of biological value and quality of propolis and propolis based food products and food dietary supplements].

  Voprosy pitaniia 20070101

• The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules.

  PloS one 20070101

• Evaluation of propolis polyphenols absorption in humans by liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• Peroxisome proliferator-activated receptors in lung cancer.

  PPAR research 20070101

• Estrogenic activity of the chlorinated derivatives of estrogens and flavonoids using a GFP expression system.

  Environmental toxicology and pharmacology 20070101

• Dietary flavonoids attenuate tumor necrosis factor alpha-induced adhesion molecule expression in human aortic endothelial cells. Structure-function relationships and activity after first pass metabolism.

  The Journal of biological chemistry 20061201

• Accumulation and metabolism of the anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish.

  Chemico-biological interactions 20061201

• Toxicological aspects of flavonoid interaction with biomacromolecules.

  Neuro endocrinology letters 20061201

• Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells.

  Biochemical pharmacology 20061115

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Oxidant/antioxidant properties of Croatian native propolis.

  Journal of agricultural and food chemistry 20061018

• Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship.

  Biochemical pharmacology 20061016

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20061001

• Analysis of flavonoids from propolis by on-line HPLC-electrospray mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20060926

• Aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha in MCF-7 breast cancer cells.

  Biological chemistry 20060901

• Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells.

  Archives of pharmacal research 20060801

• Retention behavior of silica-bonded and novel polymeric reversed-phase sorbents in studies on flavones as chemotaxonomic markers of Scutellaria L. genus.

  Journal of chromatography. A 20060707

• Flavonoid-induced glutathione depletion: potential implications for cancer treatment.

  Free radical biology & medicine 20060701

• Combinatorial biosynthesis of flavones and flavonols in Escherichia coli.

  Applied microbiology and biotechnology 20060601

• Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

  Journal of medicinal chemistry 20060601

• Chrysin inhibits lipopolysaccharide-induced angiogenesis via down-regulation of VEGF/VEGFR-2(KDR) and IL-6/IL-6R pathways.

  Planta medica 20060601

• Modulation of aromatase activity by diet polyphenolic compounds.

  Journal of agricultural and food chemistry 20060517

• Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines.

  Bioorganic & medicinal chemistry 20060501

• Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats.

  Oncology reports 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Dietary flavonoids: effects on xenobiotic and carcinogen metabolism.

  Toxicology in vitro : an international journal published in association with BIBRA 20060301

• Cyanobacterial chemotaxis to extracts of host and nonhost plants.

  FEMS microbiology ecology 20060301

• Effect of different flavonoids on collagen synthesis in human fibroblasts.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20060301

• A pilot study on the safety of combining chrysin, a non-absorbable inducer of UGT1A1, and irinotecan (CPT-11) to treat metastatic colorectal cancer.

  Cancer chemotherapy and pharmacology 20060201

• Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents.

  Bioorganic & medicinal chemistry letters 20060101

• Use of the pig caecum model to mimic the human intestinal metabolism of hispidulin and related compounds.

  Molecular nutrition & food research 20060101

• Biosynthesis of isoprenoids, polyunsaturated fatty acids and flavonoids in Saccharomyces cerevisiae.

  Microbial cell factories 20060101

• Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 Cells.

  The Journal of pharmacology and experimental therapeutics 20051201

• Bcl-2 attenuates anticancer agents-induced apoptosis by sustained activation of Akt/protein kinase B in U937 cells.

  Apoptosis : an international journal on programmed cell death 20051201

• Biflavonoids from Lonicera japonica.

  Phytochemistry 20051201

• Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase.

  Journal of medicinal chemistry 20051201

• Determination of the overlapping pK(a) values of chrysin using UV-vis spectroscopy and ab initio methods.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

• Antiherpetic activities of flavonoids against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro.

  Archives of pharmacal research 20051101

• Water-soluble derivative of propolis and its polyphenolic compounds enhance tumoricidal activity of macrophages.

  Journal of ethnopharmacology 20051031

• Molecular targets of dietary polyphenols with anti-inflammatory properties.

  Yonsei medical journal 20051031

• Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations.

  Toxicology letters 20051015

• Effects of hydroxyl group numbers on the B-ring of 5,7-dihydroxyflavones on the differential inhibition of human CYP 1A and CYP1B1 enzymes.

  Archives of pharmacal research 20051001

• Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

  Steroids 20050901

• Synthesis and inhibition of PGE2 production of 6,8-disubstituted chrysin derivatives.

  European journal of medicinal chemistry 20050901

• Endothelial nitric oxide production stimulated by the bioflavonoid chrysin in rat isolated aorta.

  Planta medica 20050901

• Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

  Steroids 20050801

• Structure and antiinflammatory activity relationships of wogonin derivatives.

  Archives of pharmacal research 20050801

• Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells.

  Free radical biology & medicine 20050715

• Flavonoids exhibit fungal species and genus specific effects on the presymbiotic growth of Gigaspora and Glomus.

  Mycological research 20050701

• Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression: involvement of p38 mitogen-activated protein kinase.

  Biochemical pharmacology 20050615

• Biotransformation of chrysin and apigenin by Cunninghamella elegans.

  Chemical & pharmaceutical bulletin 20050601

• Synthesis and iNOS inhibitory activities of thioflavones.

  Archives of pharmacal research 20050601

• Human gut microbial degradation of flavonoids: structure-function relationships.

  Journal of agricultural and food chemistry 20050518

• Production of cytokine and NO by RAW 264.7 macrophages and PBMC in vitro incubation with flavonoids.

  Archives of pharmacal research 20050501

• Effects of flavonoids on cell proliferation and caspase activation in a human colonic cell line HT29: an SAR study.

  Journal of medicinal chemistry 20050421

• Stability of ferric complexes with 3-hydroxyflavone (flavonol), 5,7-dihydroxyflavone (chrysin), and 3',4'-dihydroxyflavone.

  Journal of agricultural and food chemistry 20050420

• A sensitive method for determination of COL-3, a chemically modified tetracycline, in human plasma using high-performance liquid chromatography and ultraviolet detection.

  Journal of pharmaceutical and biomedical analysis 20050401

• Synergistic antitumor effect of polyphenolic components of water soluble derivative of propolis against Ehrlich ascites tumour.

  Biological & pharmaceutical bulletin 20050401

• [Isolation and structure identification of chemical constituents from Viscum liquidambaricolum].

  Yao xue xue bao = Acta pharmaceutica Sinica 20050401

• Flavonoids from the leaves of Litsea japonica and their anti-complement activity.

  Phytotherapy research : PTR 20050401

• Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray.

  FEBS letters 20050314

• Kinetic study of the quenching reaction of singlet oxygen by flavonoids in ethanol solution.

  The journal of physical chemistry. B 20050310

• Flavones suppress the expression of the high-affinity IgE receptor FcepsilonRI in human basophilic KU812 cells.

  Journal of agricultural and food chemistry 20050309

• Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.

  Drug metabolism and disposition: the biological fate of chemicals 20050301

• Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes.

  Toxicology in vitro : an international journal published in association with BIBRA 20050301

• [Xanthine oxidase inhibitory activity and hypouricemia effect of propolis in rats].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050301

• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.

  Journal of medicinal chemistry 20050210

• [Studies on chemical constituents from Elsholtzia bodinieri Vaniot].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050201

• Chrysin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity.

  FEBS letters 20050131

• Comparison of high-speed counter-current chromatography instruments for the separation of the extracts of the seeds of Oroxylum indicum.

  Journal of chromatography. A 20050121

• Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages.

  Biochemical pharmacology 20050115

• Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures.

  Biochemical pharmacology 20050115

• Analysis of substrate specificities and tissue expression of rat UDP-glucuronosyltransferases UGT1A7 and UGT1A8.

  Drug metabolism and disposition: the biological fate of chemicals 20050101

• Baicalein protects rat cardiomyocytes from hypoxia/reoxygenation damage via a prooxidant mechanism.

  Cardiovascular research 20050101

• In vitro digestion and lactase treatment influence uptake of quercetin and quercetin glucoside by the Caco-2 cell monolayer.

  Nutrition journal 20050101

• Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard.

  Journal of AOAC International 20050101

• Comparative effects of fibrates on drug metabolizing enzymes in human hepatocytes.

  Pharmaceutical research 20050101

• In vitro search for synergy between flavonoids and epirubicin on multidrug-resistant cancer cells.

  In vivo (Athens, Greece) 20050101

• Chemical compositions and antimicrobial activities of four different Anatolian propolis samples.

  Microbiological research 20050101

• The effects of dietary phytoestrogens on aromatase activity in human endometrial stromal cells.

  Reproduction, nutrition, development 20050101

• Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells.

  Biochemical and biophysical research communications 20041224

• Evaluation of the first-pass glucuronidation of selected flavones in gut by Caco-2 monolayer model.

  Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20041220

• A photoaffinity probe designed for host-specific signal flavonoid receptors in phytopathogenic Peronosporomycete zoospores of Aphanomyces cochlioides.

  Archives of biochemistry and biophysics 20041215

• Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells.

  Bioorganic & medicinal chemistry 20041201

• Induction and inhibition of aromatase (CYP19) activity by natural and synthetic flavonoid compounds in H295R human adrenocortical carcinoma cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20041101

• A UV resonance Raman (UVRR) spectroscopic study on the extractable compounds in Scots pine (Pinus sylvestris) wood. Part II. Hydrophilic compounds.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20041101

• Vascular and anti-oxidant actions of flavonols and flavones.

  Clinical and experimental pharmacology & physiology 20041101

• Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage.

  Toxicological sciences : an official journal of the Society of Toxicology 20041001

• Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

  Naunyn-Schmiedeberg's archives of pharmacology 20041001

• Dietary polyphenols (-)-epicatechin and chrysin inhibit intestinal glucuronidation metabolism to increase drug absorption.

  Journal of pharmaceutical sciences 20040901

• Flavonoids inhibit tumor necrosis factor-alpha-induced up-regulation of intercellular adhesion molecule-1 (ICAM-1) in respiratory epithelial cells through activator protein-1 and nuclear factor-kappaB: structure-activity relationships.

  Molecular pharmacology 20040901

• Inhibitory effect of flavonoids on N-acetylation of 5-aminosalicylic acid in cultured rat hepatocytes.

  Biological & pharmaceutical bulletin 20040901

• The pig caecum model: a suitable tool to study the intestinal metabolism of flavonoids.

  Molecular nutrition & food research 20040901

• Synthesis and biological evaluation of flavonoids as vasorelaxant agents.

  Bioorganic & medicinal chemistry letters 20040802

• Structural and spectroscopic study of 5,7-dihydroxy-flavone and its complex with aluminum.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20040801

• Electrospray ionization mass spectrometry fingerprinting of propolis.

  The Analyst 20040801

• Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.

  Journal of medicinal chemistry 20040729

• Effect of flavonoids and vitamin E on cyclooxygenase-2 (COX-2) transcription.

  Mutation research 20040713

• Combined effects of multiple flavonoids on breast cancer resistance protein (ABCG2)-mediated transport.

  Pharmaceutical research 20040701

• Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance.

  Cancer research 20040615

• Determination of SU5416, a novel angiogenesis inhibitor, in human plasma by liquid chromatography.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040605

• Separation of flavonoids and phenolic acids from propolis by capillary zone electrophoresis.

  Electrophoresis 20040601

• Investigation of the membrane localization and distribution of flavonoids by high-resolution magic angle spinning NMR spectroscopy.

  Biochimica et biophysica acta 20040527

• Identification of metabolites in plasma and urine of Uruguayan propolis-treated rats.

  Journal of agricultural and food chemistry 20040519

• Neuroprotective effects of flavones on hydrogen peroxide-induced apoptosis in SH-SY5Y neuroblostoma cells.

  Bioorganic & medicinal chemistry letters 20040503

• Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport.

  Molecular pharmacology 20040501

• Inhibitory effect of flavonoids on sulfo- and glucurono-conjugation of acetaminophen in rat cultured hepatocytes and liver subcellular preparations.

  Biological & pharmaceutical bulletin 20040501

• Antioxidative bioavailability of artepillin C in Brazilian propolis.

  Archives of biochemistry and biophysics 20040415

• Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives.

  Bioorganic & medicinal chemistry letters 20040308

• Effects of ethanol extract of propolis (EEP) and its flavones on inducible gene expression in J774A.1 macrophages.

  Journal of ethnopharmacology 20040301

• Synthesis and biological activities of 8-arylflavones.

  Archives of pharmacal research 20040301

• The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics.

  Biochemical pharmacology 20040301

• Quantitative high-performance liquid chromatography analyses of flavonoids in Australian Eucalyptus honeys.

  Journal of agricultural and food chemistry 20040128

• Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake.

  The Journal of biological chemistry 20040109

• Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-alpha2b.

  Bioorganic & medicinal chemistry letters 20040105

• Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives.

  Pharmacological research 20040101

• Antioxidant capacity of reaction products limits the applicability of the Trolox Equivalent Antioxidant Capacity (TEAC) assay.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101

• The nature of phosphorylated chrysin-protein interactions involved in noncovalent complex formation by electrospray ionization mass spectroscopy.

  Analytical chemistry 20040101

• A hydroxyl group of flavonoids affects oral anti-inflammatory activity and inhibition of systemic tumor necrosis factor-alpha production.

  Bioscience, biotechnology, and biochemistry 20040101

• Individual and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma cell lines.

  Nutrition and cancer 20040101

• Effects of the dietary flavonoid chrysin in isolated rat mesenteric vascular bed.

  Journal of vascular research 20040101

• Flavonoids induce apoptosis in human leukemia U937 cells through caspase- and caspase-calpain-dependent pathways.

  Nutrition and cancer 20040101

• Constituents of Quinchamalium majus with potential antitubercular activity.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101

• Effects of flavonoids on vascular smooth muscle of the isolated rat thoracic aorta.

  Life sciences 20031219

• P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1.

  Proceedings of the National Academy of Sciences of the United States of America 20031209

• Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context.

  Environmental health perspectives 20031201

• Screening of the inhibitory effect of vegetable constituents on the aryl hydrocarbon receptor-mediated activity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  Biological & pharmaceutical bulletin 20031201

• Drug/substance reversal effects of a novel tri-substituted benzoflavone moiety (BZF) isolated from Passiflora incarnata Linn.--a brief perspective.

  Addiction biology 20031201

• Analysis of propolis from the continental and Adriatic regions of Croatia.

  Acta pharmaceutica (Zagreb, Croatia) 20031201

• Synthesis, characterization and DNA-binding properties of La(III) complex of chrysin.

  Journal of inorganic biochemistry 20031101

• Ingestion of a dietary supplement containing dehydroepiandrosterone (DHEA) and androstenedione has minimal effect on immune function in middle-aged men.

  Journal of the American College of Nutrition 20031001

• Tricin from a malagasy connaraceous plant with potent antihistaminic activity.

  Journal of natural products 20030901

• Quantification of 6-deoxy-6-demethyl-4-dedimethylaminotetracycline (COL-3) in human plasma using liquid chromatography coupled with electrospray ionization tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030825

• Effect of chrysin, a flavonoid compound, on the mutagenic activity of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP) and benzo(a)pyrene (B(a)P) in bacterial and human hepatoma (HepG2) cells.

  Archives of toxicology 20030801

• Antiprotozoal activity of the constituents of Teloxys graveolens.

  Phytotherapy research : PTR 20030801

• Synthesis and PGE2 inhibitory activity of vinylated and allylated chrysin analogues.

  Archives of pharmacal research 20030801

• Flavonoids from Calicotome villosa.

  Fitoterapia 20030601

• Synthesis and PGE2 inhibitory activity of 5,7-dihydroxyflavones and their O-methylated flavone analogs.

  Archives of pharmacal research 20030501

• Inhibitory effects of some flavonoids on the activity of mushroom tyrosinase.

  Biochemistry. Biokhimiia 20030401

• Synthesis and anticancer effect of chrysin derivatives.

  Bioorganic & medicinal chemistry letters 20030310

• Role of NAD(P)H:quinone oxidoreductase in the progression of neuronal cell death in vitro and following cerebral ischaemia in vivo.

  Journal of neurochemistry 20030301

• Isolation and identification of four flavonoid constituents from the seeds of Oroxylum indicum by high-speed counter-current chromatography.

  Journal of chromatography. A 20030221

• Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors.

  European journal of pharmacology 20030214

• Effect of flavonoids on MRP1-mediated transport in Panc-1 cells.

  Journal of pharmaceutical sciences 20030201

• Effect of flavone derivatives on interleukin-1beta (IL-1beta) mRNA expression and IL-1beta protein synthesis in stimulated RAW 264.7 macrophages.

  Scandinavian journal of immunology 20030201

• Insect antifeedant activity of flavones and chromones against Spodoptera litura.

  Journal of agricultural and food chemistry 20030115

• Effects of flavonoids on cisplatin-induced apoptosis of HL-60 and L1210 leukemia cells.

  Leukemia research 20030101

• Trypanocidal activity of Lychnophora staavioides Mart. (Vernonieae, Asteraceae).

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20030101

• Cis-2', 3'-dihydrodiol production on flavone B-ring by biphenyl dioxygenase from Pseudomonas pseudoalcaligenes KF707 expressed in Escherichia coli.

  Antonie van Leeuwenhoek 20030101

• Effects of chrysin on urinary testosterone levels in human males.

  Journal of medicinal food 20030101

• Antioxidant and prooxidant effects of phenolics on pancreatic beta-cells in vitro.

  Journal of agricultural and food chemistry 20021204

• Pinostrobin from honey and Thai ginger (Boesenbergia pandurata): a potent flavonoid inducer of mammalian phase 2 chemoprotective and antioxidant enzymes.

  Journal of agricultural and food chemistry 20021204

• Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex.

  Planta medica 20021201

• Screening of ubiquitous plant constituents for COX-2 inhibition with a scintillation proximity based assay.

  Journal of natural products 20021101

• High-performance liquid chromatographic analysis of chrysin derivatives on a Nova-Pak C18 column.

  Archives of pharmacal research 20021001

• Effects of chronic chrysin treatment in spontaneously hypertensive rats.

  Planta medica 20020901

• GABA(A)-receptor ligands of flavonoid structure.

  Current topics in medicinal chemistry 20020801

• Antiproliferative constituents in plants 10. Flavones from the leaves of Lantana montevidensis Briq. and consideration of structure-activity relationship.

  Biological & pharmaceutical bulletin 20020701

• Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids.

  Bioscience, biotechnology, and biochemistry 20020701

• Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.

  Drug metabolism and disposition: the biological fate of chemicals 20020501

• Constituents of Chinese propolis and their antiproliferative activities.

  Journal of natural products 20020501

• Luteolin, a flavone, does not suppress postprandial glucose absorption through an inhibition of alpha-glucosidase action.

  Bioscience, biotechnology, and biochemistry 20020301

• Oxidation of the flavonoids galangin and kaempferide by human liver microsomes and CYP1A1, CYP1A2, and CYP2C9.

  Drug metabolism and disposition: the biological fate of chemicals 20020201

• Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1.

  Mutagenesis 20020101

• Chemical composition of European propolis: expected and unexpected results.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

• Beneficial effects of chrysin and benzoflavone on virility in 2-year-old male rats.

  Journal of medicinal food 20020101

• Flavonoids with epidermal growth factor-receptor tyrosine kinase inhibitory activity stimulate PEPT1-mediated cefixime uptake into human intestinal epithelial cells.

  The Journal of pharmacology and experimental therapeutics 20011001

• No evidence for the in vivo activity of aromatase-inhibiting flavonoids.

  The Journal of steroid biochemistry and molecular biology 20010901

• Effects of androstenedione-herbal supplementation on serum sex hormone concentrations in 30- to 59-year-old men.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20010901

• Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes.

  General and comparative endocrinology 20010801

• Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta.

  Planta medica 20010801

• 3D-QSAR model of flavonoids binding at benzodiazepine site in GABAA receptors.

  Journal of medicinal chemistry 20010607

• Common phytochemicals are ecdysteroid agonists and antagonists: a possible evolutionary link between vertebrate and invertebrate steroid hormones.

  The Journal of steroid biochemistry and molecular biology 20010601

• Suppression of inducible cyclooxygenase and nitric oxide synthase through activation of peroxisome proliferator-activated receptor-gamma by flavonoids in mouse macrophages.

  FEBS letters 20010504

• Structure-activity relationships for a large diverse set of natural, synthetic, and environmental estrogens.

  Chemical research in toxicology 20010301

• C-Isoprenylation of flavonoids enhances binding affinity toward P-glycoprotein and modulation of cancer cell chemoresistance.

  Journal of medicinal chemistry 20010301

• Chemoprotective potentials of homoisoflavonoids and chalcones of Dracaena cinnabari: modulations of drug-metabolizing enzymes and antioxidant activity.

  Phytotherapy research : PTR 20010301

• Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in Caco-2 cells--potential role in carcinogen bioinactivation.

  Pharmaceutical research 20010301

• Flavonoids as peroxynitrite scavengers: the role of the hydroxyl groups.

  Toxicology in vitro : an international journal published in association with BIBRA 20010201

• Disposition and metabolism of the flavonoid chrysin in normal volunteers.

  British journal of clinical pharmacology 20010201

• Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships.

  Journal of medicinal chemistry 20010118

• Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2.

  Drug metabolism and disposition: the biological fate of chemicals 20000901

• Cytotoxic activity of low molecular weight polyphenols against human oral tumor cell lines.

  Anticancer research 20000101

• Differential effects of dietary flavonoids on drug metabolizing and antioxidant enzymes in female rat.

  Xenobiotica; the fate of foreign compounds in biological systems 19991201

• Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.

  Journal of medicinal chemistry 19991021

• Inhibition of aromatase activity by flavonoids.

  Archives of pharmacal research 19990601

• Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta.

  Endocrinology 19981001

• Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

  Environmental health perspectives 19980201

• Antitumor agents. 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones.

  Journal of medicinal chemistry 19960510

• Inhibition of HIV activation in latently infected cells by flavonoid compounds.

  AIDS research and human retroviruses 19960101

• Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates.

  Drug metabolism and disposition: the biological fate of chemicals 19940101

• Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids.

  Journal of natural products 19940101

• Inhibition of HIV infection by flavanoids.

  Antiviral research 19931001

• Flavones are inhibitors of HIV-1 proteinase.

  Biochemical and biophysical research communications 19921030

• Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

  European journal of biochemistry 19900705

• Effects of propolis flavonoids on virus infectivity and replication.

  Microbiologica 19900701