480-96-6 | Benzofuroxan

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$15.00	$10.00
1g	95%	in stock	$16.00	$11.00
5g	95%	in stock	$19.00	$13.00
25g	95%	in stock	$27.00	$19.00
100g	95%	in stock	$63.00	$45.00
500g	95%	in stock	$231.00	$162.00

Description

• Catalog Number: AB45598
• Chemical Name: Benzofuroxan
• CAS Number: 480-96-6
• Molecular Formula: C6H4N2O2
• Molecular Weight: 136.1082
• MDL Number: MFCD00005807
• SMILES: [O-][n+]1onc2c1cccc2
• NSC Number: 19930

Computed Properties

• Complexity: 131
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 3
• XLogP3: 1.4

Literature

• Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites.

  PloS one 20120101

• Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics.

  PloS one 20120101

• Novel benzofuroxan derivatives against multidrug-resistant Staphylococcus aureus strains: design using Topliss' decision tree, synthesis and biological assay.

  Bioorganic & medicinal chemistry 20110815

• Synthesis of quinoxaline 1,4-di-N-oxide analogues and crystal structure of 2-carbomethoxy-3-hydroxyquinoxaline-di-N-oxide.

  Molecules (Basel, Switzerland) 20110812

• The stepwise Diels-Alder reaction of 4-nitrobenzodifuroxan with Danishefsky's diene.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20110627

• A small-molecule inhibitor of MDMX activates p53 and induces apoptosis.

  Molecular cancer therapeutics 20110101

• Structural relationships in the solid state of the anti-chagas agent (E)-phenylethenylbenzofuroxan.

  Molecular diversity 20101101

• o-Benzoquinone dioxime.

  Acta crystallographica. Section E, Structure reports online 20101101

• Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved?

  Biochemical pharmacology 20100615

• Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety.

  European journal of medicinal chemistry 20100601

• Synthesis and anticonvulsant activity of a new series of 1,4-dihydropyridine derivatives.

  Indian journal of pharmaceutical sciences 20100101

• Anti-trypanosomatid benzofuroxans and deoxygenated analogues: synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies.

  European journal of medicinal chemistry 20091201

• Cytotoxic, mutagenic and genotoxic effects of new anti-T. cruzi 5-phenylethenylbenzofuroxans. Contribution of phase I metabolites on the mutagenicity induction.

  Toxicology letters 20091028

• Design, synthesis, antimicrobial activity and molecular modeling studies of novel benzofuroxan derivatives against Staphylococcus aureus.

  Bioorganic & medicinal chemistry 20090415

• In vivo studies of 5-arylethenylbenzofuroxans in acute murine models of Chagas' disease.

  European journal of medicinal chemistry 20081001

• New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle.

  Bioorganic & medicinal chemistry 20080715

• Development of a HPLC method for the determination of antichagasic phenylethenylbenzofuroxans and its major synthetic secondary products in the chemical production processes.

  Journal of pharmaceutical and biomedical analysis 20080512

• Substitutions of fluorine atoms and phenoxy groups in the synthesis of quinoxaline 1,4-di-N-oxide derivatives.

  Molecules (Basel, Switzerland) 20080118

• In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.

  Journal of medicinal chemistry 20071129

• Synthesis of neutral spin-delocalized electron acceptors for multifunctional materials.

  Organic letters 20071108

• Evidence for the intermediacy of Wheland-Meisenheimer complexes in SEAr reactions of aminothiazoles with 4,6-dinitrobenzofuroxan.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20070101

• New potent 5-substituted benzofuroxans as inhibitors of Trypanosoma cruzi growth: quantitative structure-activity relationship studies.

  Bioorganic & medicinal chemistry 20051201

• Pharmacological properties of furoxans and benzofuroxans: recent developments.

  Mini reviews in medicinal chemistry 20050101

• Identification of 2,3-diaminophenazine and of o-benzoquinone dioxime as the major in vitro metabolites of benzofuroxan.

  Xenobiotica; the fate of foreign compounds in biological systems 20040401

• Nonselective inhibition of monoamine oxidases A and B by activators of soluble guanylate cyclase.

  Biochemistry. Biokhimiia 20030901

• Sigma-complex formation and oxidative nucleophilic aromatic substitution in 4-nitro-2,1,3-benzoxadiazoles.

  Organic & biomolecular chemistry 20030621

• Nitroanilines are the reduction products of benzofuroxan system by oxyhemoglobin (HbO2 2+).

  Farmaco (Societa chimica italiana : 1989) 20011001

• Toward an understanding of the furoxan-dinitrosoethylene equilibrium.

  Journal of the American Chemical Society 20010801

• [Formations and reactions of aromatic furazan compounds].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010601