483367-10-8 | Purmorphamine

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$21.00	$15.00
5mg	98%	in stock	$51.00	$36.00
10mg	98%	in stock	$82.00	$57.00
50mg	95%	in stock	$306.00	$214.00
100mg	98%	in stock	$370.00	$259.00
250mg	98%	in stock	$632.00	$443.00

Description

• Catalog Number: AD22423
• Chemical Name: Purmorphamine
• CAS Number: 483367-10-8
• Molecular Formula: C31H32N6O2
• Molecular Weight: 520.6248
• MDL Number: MFCD09037557
• SMILES: C1CCC(CC1)n1cnc2c1nc(nc2Nc1ccc(cc1)N1CCOCC1)Oc1cccc2c1cccc2
• NSC Number: 747596

Computed Properties

• Complexity: 768
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 6.5

Literature

• Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells.

  Biochemical and biophysical research communications 20121019

• Sonic hedgehog signaling regulates Bcr-Abl expression in human chronic myeloid leukemia cells.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120701

• Pharmacological modulation of the Hedgehog pathway differentially affects dorsal/ventral patterning in mouse and human embryonic stem cell models of telencephalic development.

  Stem cells and development 20120501

• Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells.

  Angewandte Chemie (International ed. in English) 20111118

• Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.

  Stem cells and development 20111101

• Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen.

  Nature protocols 20110728

• Modulators of the hedgehog signaling pathway.

  Bioorganic & medicinal chemistry 20100915

• Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Differentiation of embryonic stem cells into oligodendrocyte precursors.

  Journal of visualized experiments : JoVE 20100101

• Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

  BMC cancer 20100101

• Evidence for allosteric interactions of antagonist binding to the smoothened receptor.

  The Journal of pharmacology and experimental therapeutics 20090601

• Identification of osteogenic purmorphamine derivatives.

  Molecules and cells 20081031

• Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells.

  Stem cells (Dayton, Ohio) 20080401

• Agonizing hedgehog.

  Nature chemical biology 20060101

• Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

  Nature chemical biology 20060101

• Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.

  Chemistry & biology 20040901