484-12-8 | Osthole

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$31.00	$22.00
5g	98%	in stock	$65.00	$45.00
10g	98%	in stock	$113.00	$79.00
25g	98%	in stock	$161.00	$113.00
100g	98%	in stock	$448.00	$314.00

Description

• Catalog Number: AI50991
• Chemical Name: Osthole
• CAS Number: 484-12-8
• Molecular Formula: C15H16O3
• Molecular Weight: 244.2857
• MDL Number: MFCD00076049
• SMILES: COc1ccc2c(c1CC=C(C)C)oc(=O)cc2
• NSC Number: 31868

Computed Properties

• Complexity: 366
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 3.8

Literature

• Osthole induces human nasopharyngeal cancer cells apoptosis through Fas-Fas ligand and mitochondrial pathway.

  Environmental toxicology 20180401

• Resveratrol inhibits invasion and metastasis of colorectal cancer cells via MALAT1 mediated Wnt/β-catenin signal pathway.

  PloS one 20130101

• Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

  Bioorganic & medicinal chemistry 20121115

• Isolation and identification of metabolites of osthole in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20121101

• Osthole suppresses migration and invasion of A549 human lung cancer cells through inhibition of matrix metalloproteinase-2 and matrix metallopeptidase-9 in vitro.

  Molecular medicine reports 20121101

• Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers.

  Phytochemistry 20121001

• Reduction of rat cardiac hypertrophy by osthol is related to regulation of cardiac oxidative stress and lipid metabolism.

  Lipids 20121001

• Synthesis and anthelmintic activity of osthol analogs against Dactylogyrus intermedius in goldfish.

  European journal of medicinal chemistry 20120801

• Larvicidal activity of Cnidium monnieri fruit coumarins and structurally related compounds against insecticide-susceptible and insecticide-resistant Culex pipiens pallens and Aedes aegypti.

  Pest management science 20120701

• Osthole inhibits the invasive ability of human lung adenocarcinoma cells via suppression of NF-κB-mediated matrix metalloproteinase-9 expression.

  Toxicology and applied pharmacology 20120515

• Acute and subchronic toxicological evaluation of Echinophora platyloba DC (Apiaceae) total extract in Wistar rats.

  Clinics (Sao Paulo, Brazil) 20120501

• Analysis of herbal dietary supplements for sexual performance enhancement: first characterization of propoxyphenyl-thiohydroxyhomosildenafil and identification of sildenafil, thiosildenafil, phentolamine and tetrahydropalmatine as adulterants.

  Journal of pharmaceutical and biomedical analysis 20120407

• Mechanism of osthole inhibition of vascular Ca(v)1.2 current.

  European journal of pharmacology 20120405

• Involvement of the cGMP pathway in the osthole-facilitated glutamate release in rat hippocampal nerve endings.

  Synapse (New York, N.Y.) 20120301

• [Effect of osthol on apoptosis and bone resorption of osteoclasts cultured in vitro].

  Yao xue xue bao = Acta pharmaceutica Sinica 20120201

• Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats.

  Brain research 20120118

• Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

  Bioorganic & medicinal chemistry 20120115

• Main constituents from the seeds of Vietnamese Cnidium monnieri and cytotoxic activity.

  Natural product research 20120101

• [Effects of platycodin D in combination with different active ingredients of Chinese herbs on proliferation and invasion of 4T1 and MDA-MB-231 breast cancer cell lines].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20120101

• Angelicae Dahuricae Radix Inhibits Dust Mite Extract-Induced Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Modified huo-luo-xiao-ling dan suppresses adjuvant arthritis by inhibiting chemokines and matrix-degrading enzymes.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Osthole, a herbal compound, alleviates nucleus pulposus-evoked nociceptive responses through the suppression of overexpression of acid-sensing ion channel 3 (ASIC3) in rat dorsal root ganglion.

  Medical science monitor : international medical journal of experimental and clinical research 20120101

• Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma.

  PloS one 20120101

• Selected Extracts of Chinese Herbal Medicines: Their Effect on NF-κB, PPARα and PPARγ and the Respective Bioactive Compounds.

  Evidence-based complementary and alternative medicine : eCAM 20120101

• Osthole attenuates focal inflammatory reaction following permanent middle cerebral artery occlusion in rats.

  Biological & pharmaceutical bulletin 20120101

• Pharmacokinetics and tissue distribution study of Praeruptorin D from Radix peucedani in rats by high-performance liquid chromatography (HPLC).

  International journal of molecular sciences 20120101

• Osthole enhances glucose uptake through activation of AMP-activated protein kinase in skeletal muscle cells.

  Journal of agricultural and food chemistry 20111228

• Simultaneous quantification of 17 constituents from Yuanhu Zhitong tablet using rapid resolution liquid chromatography coupled with a triple quadrupole electrospray tandem mass spectrometry.

  Journal of pharmaceutical and biomedical analysis 20111101

• Reduction of isoprenaline-induced myocardial TGF-β1 expression and fibrosis in osthole-treated mice.

  Toxicology and applied pharmacology 20111015

• Insights into structure-activity relationship of GABAA receptor modulating coumarins and furanocoumarins.

  European journal of pharmacology 20111001

• [Inhibitory effects of osthole, psoralen and aconitine on invasive activities of breast cancer MDA-MB-231BO cell line and the mechanisms].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111001

• Osthole suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition via repression of the c-Met/Akt/mTOR pathway in human breast cancer cells.

  Journal of agricultural and food chemistry 20110914

• Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol regulatory element-binding protein-1c/2-mediated target gene expression.

  European journal of pharmacology 20110901

• Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.

  European journal of medicinal chemistry 20110901

• N-[4-(7-Meth-oxy-2-oxo-2H-chromen-8-yl)-2-methyl-butan-2-yl]propionamide.

  Acta crystallographica. Section E, Structure reports online 20110901

• Application of hollow fiber liquid phase microextraction coupled with high-performance liquid chromatography for the study of the osthole pharmacokinetics in cerebral ischemia hypoperfusion rat plasma.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110801

• Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

  Journal of natural products 20110624

• Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.

  European journal of pharmacology 20110611

• Neuroprotective effect of osthole against oxygen and glucose deprivation in rat cortical neurons: involvement of mitogen-activated protein kinase pathway.

  Neuroscience 20110602

• Identification and quantification of coumarins in Peucedanum ostruthium (L.) Koch by HPLC-DAD and HPLC-DAD-MS.

  Journal of agricultural and food chemistry 20110511

• Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative stress.

  Phytotherapy research : PTR 20110501

• [Inhibitory acting mechanism of psoralen-osthole on bone metastasis of breast cancer--an expatiation viewing from OPG/RANKL/RANK system].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110501

• [Effects and mechanisms of osthole on sciatica induced by lumber disc herniation].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

• Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats.

  Brain research 20110418

• Antifibrotic activity of coumarins from Cnidium monnieri fruits in HSC-T6 hepatic stellate cells.

  Journal of natural medicines 20110401

• HPLC-based activity profiling of Angelica pubescens roots for new positive GABAA receptor modulators in Xenopus oocytes.

  Fitoterapia 20110401

• Osthole ameliorates insulin resistance by increment of adiponectin release in high-fat and high-sucrose-induced fatty liver rats.

  Planta medica 20110201

• Anthelmintic activity of the crude extracts, fractions, and osthole from Radix angelicae pubescentis against Dactylogyrus intermedius in goldfish (Carassius auratus) in vivo.

  Parasitology research 20110101

• Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway.

  Journal of experimental & clinical cancer research : CR 20110101

• Anti-influenza activity of marchantins, macrocyclic bisbibenzyls contained in liverworts.

  PloS one 20110101

• Osthol, a coumarin isolated from common cnidium fruit, enhances the differentiation and maturation of osteoblasts in vitro.

  Pharmacology 20110101

• Protective Role of Black Tea Extract against Nonalcoholic Steatohepatitis-Induced Skeletal Dysfunction.

  Journal of osteoporosis 20110101

• Stimulation of Airway and Intestinal Mucosal Secretion by Natural Coumarin CFTR Activators.

  Frontiers in pharmacology 20110101

• Discovery of novel osthole derivatives as potential anti-breast cancer treatment.

  Bioorganic & medicinal chemistry letters 20101215

• Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats.

  Brain research 20101202

• [Effect of water-soluble polymers on the inhibition of osthole crystallization].

  Yao xue xue bao = Acta pharmaceutica Sinica 20101201

• Osthole regulates inflammatory mediator expression through modulating NF-κB, mitogen-activated protein kinases, protein kinase C, and reactive oxygen species.

  Journal of agricultural and food chemistry 20101013

• Neuroprotective effect of osthole on MPP+-induced cytotoxicity in PC12 cells via inhibition of mitochondrial dysfunction and ROS production.

  Neurochemistry international 20101001

• [Effect of Osthol on the proliferation and differentiate of osteoblasts in vitro].

  Zhongguo gu shang = China journal of orthopaedics and traumatology 20100901

• Antifungal activity of the osthol derivative JS-B against Phytophthora capsici.

  Journal of Asian natural products research 20100801

• Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20100701

• Osthole improves chronic cerebral hypoperfusion induced cognitive deficits and neuronal damage in hippocampus.

  European journal of pharmacology 20100625

• Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus.

  Bioorganic & medicinal chemistry letters 20100615

• On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of coumarins from traditional Chinese medicine and human serum.

  Biomedical chromatography : BMC 20100601

• Osthole stimulates osteoblast differentiation and bone formation by activation of beta-catenin-BMP signaling.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100601

• Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.

  Synapse (New York, N.Y.) 20100501

• [Optimization of extraction process for compund kaliziran gel with orthogonal design].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100501

• Osthole suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway.

  Journal of agricultural and food chemistry 20100428

• Synthesis of N-hydroxycinnamides capped with a naturally occurring moiety as inhibitors of histone deacetylase.

  ChemMedChem 20100406

• Fast separation and determination of coumarins in Fructus cnidii extracts by CEC using poly(butyl methacrylate-co-ethylene dimethacrylate-co-[2-(methacryloyloxy)ethyl] trimethylammonium chloride) monolithic columns.

  Journal of separation science 20100401

• Attenuation of experimental autoimmune encephalomyelitis in C57 BL/6 mice by osthole, a natural coumarin.

  European journal of pharmacology 20100310

• The effect of the major components of Fructus Cnidii on osteoblasts in vitro.

  Journal of acupuncture and meridian studies 20100301

• Dammarane-type glycosides from Gynostemma pentaphyllum and their effects on IL-4-induced eotaxin expression in human bronchial epithelial cells.

  Journal of natural products 20100226

• Osthol is a use-dependent blocker of voltage-gated Na+ channels in mouse neuroblastoma N2A cells.

  Planta medica 20100101

• Effects of osthole on migration and invasion in breast cancer cells.

  Bioscience, biotechnology, and biochemistry 20100101

• In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives.

  BMC neuroscience 20100101

• Separation and determination of coumarins in Fructus cnidii extracts by pressurized capillary electrochromatography using a packed column with a monolithic outlet frit.

  Journal of pharmaceutical and biomedical analysis 20091205

• Osthole, a potential antidiabetic agent, alleviates hyperglycemia in db/db mice.

  Chemico-biological interactions 20091030

• A vascular smooth muscle/cell membrane chromatography-offline-gas chromatography/mass spectrometry method for recognition, separation and identification of active components from traditional Chinese medicines.

  Journal of chromatography. A 20091016

• [Metabolism of osthol in isolated hepatocytes of rat].

  Yao xue xue bao = Acta pharmaceutica Sinica 20091001

• Efficacy of osthol, a potent coumarin compound, in controlling powdery mildew caused by Sphaerotheca fuliginea.

  Journal of Asian natural products research 20090901

• Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study.

  Epilepsy research 20090801

• Determination of osthol and its metabolites in a phase I reaction system and the Caco-2 cell model by HPLC-UV and LC-MS/MS.

  Journal of pharmaceutical and biomedical analysis 20090712

• Effects of osthole on apoptosis and TGF-beta1 of hypertrophic scar fibroblasts.

  Journal of Asian natural products research 20090701

• Osthole suppresses seizures in the mouse maximal electroshock seizure model.

  European journal of pharmacology 20090401

• Inhibitory effect of osthole on alcohol-induced fatty liver in mice.

  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20090201

• Osthole: a promising lead compound for drug discovery from a traditional Chinese medicine (TCM).

  Natural product communications 20090201

• Inhibitory effect of oxycoumarins isolated from the Thai medicinal plant Clausena guillauminii on the inflammation mediators, iNOS, TNF-alpha, and COX-2 expression in mouse macrophage RAW 264.7.

  Journal of natural medicines 20090101

• Identification and quantification of the volatile constituents in Cnidium monnieri using supercritical fluid extraction followed by GC-MS.

  Journal of separation science 20090101

• Anti-inflammatory and antinociceptive activity of coumarins from Seseli gummiferum subsp. corymbosum (Apiaceae).

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.

  BMC complementary and alternative medicine 20090101

• Immunomodulatory and anti-inflammatory activity of selected osthole derivatives.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Osthole and imperatorin, the active constituents of Cnidium monnieri (L.) Cusson, facilitate glutamate release from rat hippocampal nerve terminals.

  Neurochemistry international 20081201

• Osthol and isopimpinellin from Fructus cnidii for the control of Dactylogyrus intermedius in Carassius auratus.

  Veterinary parasitology 20081125

• [Purification technology of Rhizoma et Radix Notopterygii and Radix Angelicae Pubescentis in Fufang Xuelian dropping pills by macroporous resin].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081101

• Identification of natural coumarin compounds that rescue defective DeltaF508-CFTR chloride channel gating.

  Clinical and experimental pharmacology & physiology 20080801

• Attempts to bridge the gap between scientific mechanism-based medicine and Chinese herbal extract treatment for asthma.

  Pediatrics and neonatology 20080801

• Effect of the Chinese herb extract osthol on IL-4-induced eotaxin expression in BEAS-2B cells.

  Pediatrics and neonatology 20080801

• Micelle-mediated extraction and cloud-point preconcentration of osthole and imperatorin from Cnidium monnieri with analysis by high performance liquid chromatography.

  Journal of chromatography. A 20080725

• Isolation and identification of insecticidal components from Citrus aurantium fruit peel extract.

  Journal of agricultural and food chemistry 20080723

• Petroleum ether extract of Cnidium monnieri ameliorated scopolamine-induced amnesia through adrenal gland-mediated mechanism in male rats.

  Journal of ethnopharmacology 20080522

• Determination and pharmacokinetic study of indirubin in rat plasma by high-performance liquid chromatography.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20080401

• [Absorption and transport of 6 coumarins isolated from the roots of Angelica pubescens f. biserrata in human Caco-2 cell monolayer model].

  Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20080401

• Fusarium graminearum growth inhibition due to glucose starvation caused by osthol.

  International journal of molecular sciences 20080301

• Determination of osthole in rat plasma by high-performance liquid chromatograph using cloud-point extraction.

  Analytica chimica acta 20080211

• Chemical and antibacterial constituents of Skimmia anquetelia.

  Planta medica 20080201

• [In situ rats single pass perfusion intestinal absorption of the effectivein components in Radix Angelicae Pubescentis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20080101

• Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats.

  Journal of Asian natural products research 20080101

• Simultaneous determination of icariin, icariside II and osthole in rat plasma after oral administration of the extract of Gushudan (a Chinese compound formulation) by LC-MS/MS.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071201

• Fluorimetric and mass spectrometric study of the interaction of beta-cyclodextrin and osthole.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101

• [Simultaneous determination of 5 active components in Fructus Cnidii by HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901

• Constituents, biological activities and quality control parameters of the crude extract and essential oil from Arracacia tolucensis var. multifida.

  Journal of ethnopharmacology 20070815

• Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression.

  Planta medica 20070701

• Effects of osthol on blood pressure and lipid metabolism in stroke-prone spontaneously hypertensive rats.

  Journal of ethnopharmacology 20070530

• Antitumor effects of Osthol from Cnidium monnieri: an in vitro and in vivo study.

  Phytotherapy research : PTR 20070301

• Therapeutic effect of osthole on hyperlipidemic fatty liver in rats.

  Acta pharmacologica Sinica 20070301

• Antibacterial and anticoagulant activities of coumarins isolated from the flowers of Magydaris tomentosa.

  Planta medica 20070201

• Synthetic derivatives of osthole for the prevention of hepatitis.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20070101

• Coumarins from Cnidium monnieri and their antiosteoporotic activity.

  Planta medica 20070101

• A survey of Chinese herbal ingredients with liver protection activities.

  Chinese medicine 20070101

• Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.

  Natural product research 20060801

• Experimental study of osthole on treatment of hyperlipidemic and alcoholic fatty liver in animals.

  World journal of gastroenterology 20060721

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• [Studies on chemical constituents in roots of Heracleum rapula].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060201

• Chemical constituents of Selinum cryptotaenium.

  Journal of Asian natural products research 20060101

• Anti-inflammatory effect and mechanism of osthole in rats.

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051101

• Osthole-mediated cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells.

  The Journal of pharmacology and experimental therapeutics 20050901

• HPLC determination and pharmacokinetics of osthole in rat plasma after oral administration of Fructus Cnidii extract.

  Journal of chromatographic science 20050901

• [Progress in study of chemical constituents and anti-tumor activities of Cnidium monnieri].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

• [Study on extraction of coumarins in Cnidium monieri by supercritical CO2 and separation of compositions analysis].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050701

• [Coumarins from root of Zanthoxylum dimorphophyllum var. spinifolium].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050601

• [Determination of osthol in Shefengshi liqueur by HPLC].

  Se pu = Chinese journal of chromatography 20050501

• Chemical aspects of coumarin compounds for the prevention of hepatocellular carcinomas.

  Current medicinal chemistry. Anti-cancer agents 20050101

• Toxic epidermal necrolysis associated with high intake of sildenafil and its response to infliximab.

  Acta dermato-venereologica 20050101

• Genetic variation in primary metabolites of Pastinaca sativa; can herbivores act as selective agents?

  Journal of chemical ecology 20041001

• [Determination of isoimperatorin and osthol in ganmao yixiaoshi capsule by RP-HPLC].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20041001

• Coumarins from Cnidium monnieri (L.) and their proliferation stimulating activity on osteoblast-like UMR106 cells.

  Die Pharmazie 20040801

• [Effects of osthol on androgen level and nitric oxide synthase activity in castrate rats].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040701

• Structure-activity relationships of novel inhibitors of glyceraldehyde-3-phosphate dehydrogenase.

  Bioorganic & medicinal chemistry letters 20040503

• [Advances in study on the pharmacological effects of active components of Chinese herbs on Alzheimer's disease].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20040501

• Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb) using stepwise elution by high-speed counter-current chromatography.

  Journal of chromatography. A 20040416

• Osthole improves aspects of spatial performance in ovariectomized rats.

  The American journal of Chinese medicine 20040101

• Cytotoxic activity of coumarins from the fruits of Cnidium monnieri on leukemia cell lines.

  Planta medica 20031201

• Effect of enhancers on percutaneous absorption of osthol across the excised full thickness rat skin.

  Die Pharmazie 20030901

• Platelet anti-aggregatory effects of coumarins from the roots of Angelica genuflexa and A. gigas.

  Archives of pharmacal research 20030901

• [Pharmacokinetics of osthole in rabbits].

  Yao xue xue bao = Acta pharmaceutica Sinica 20030801

• Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway.

  Biochemical pharmacology 20030215

• [Advances in the study of chemical constituents and pharmacological actions of Cnidium monnieri (L.) Cusson].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030201

• 8-(2-bromo-3-methoxy-3-methylbutyl)-7-methoxycoumarin.

  Acta crystallographica. Section C, Crystal structure communications 20030101

• Effects of osthole on postmenopausal osteoporosis using ovariectomized rats; comparison to the effects of estradiol.

  Biological & pharmaceutical bulletin 20020601

• Anti-allergic effects of cnidii monnieri fructus (dried fruits of Cnidium monnieri) and its major component, osthol.

  Biological & pharmaceutical bulletin 20020601

• [Effect of osthol on memory impairment of mice in AlCl3-induced acute senile model].

  Yao xue xue bao = Acta pharmaceutica Sinica 20020301

• Antipruritic effect of Cnidii Monnieri Fructus (fruits of Cnidium monnieri CUSSON).

  Biological & pharmaceutical bulletin 20020201

• Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells.

  Biochemical pharmacology 20020115

• Inhibition of itch-scratch response by fruits of Cnidium monnieri in mice.

  Biological & pharmaceutical bulletin 20010901

• Quinoline alkaloids and other constituents of Melicope semecarpifolia with antiplatelet aggregation activity.

  Journal of natural products 20010901

• The coumarin osthol attenuates the binding of thyrotropin-releasing hormone in rat pituitary GH4C1 cells.

  Planta medica 20010401

• Vasorelaxing effect of coumarins from Cnidium monnieri on rabbit corpus cavernosum.

  Planta medica 20010401

• Inhibition of concanavalin A-induced mice hepatitis by coumarin derivatives.

  Japanese journal of pharmacology 20010101

• Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.

  Anticancer research 20010101

• Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.

  Phytochemistry 20000301