486-60-2 | Bergaptol

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$39.00	$27.00
100mg	95%	in stock	$104.00	$73.00
250mg	95%	in stock	$126.00	$88.00
1g	95%	in stock	$336.00	$236.00
5g	95%	in stock	$1,175.00	$822.00

Description

• Catalog Number: AB67660
• Chemical Name: Bergaptol
• CAS Number: 486-60-2
• Molecular Formula: C11H6O4
• Molecular Weight: 202.1629
• MDL Number: MFCD00210479
• SMILES: O=c1ccc2c(o1)cc1c(c2O)cco1
• NSC Number: 341958

Computed Properties

• Complexity: 312
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• XLogP3: 2

Literature

• Biotransformations of 6',7'-dihydroxybergamottin and 6',7'-epoxybergamottin by the citrus-pathogenic fungi diminish cytochrome P450 3A4 inhibitory activity.

  Bioorganic & medicinal chemistry letters 20120315

• Major furocoumarins in grapefruit juice II: phototoxicity, photogenotoxicity, and inhibitory potency vs. cytochrome P450 3A4 activity.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120301

• Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.

  Bioorganic & medicinal chemistry 20120115

• Characterization of coumarin-specific prenyltransferase activities in Citrus limon peel.

  Bioscience, biotechnology, and biochemistry 20120101

• Major furocoumarins in grapefruit juice I: levels and urinary metabolite(s).

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111201

• Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice.

  Die Pharmazie 20110701

• Identification of ostruthin from Peucedanum ostruthium rhizomes as an inhibitor of vascular smooth muscle cell proliferation.

  Journal of natural products 20110624

• Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice.

  Journal of food science 20110501

• Bergamot (Citrus bergamia Risso) fruit extracts and identified components alter expression of interleukin 8 gene in cystic fibrosis bronchial epithelial cell lines.

  BMC biochemistry 20110101

• Phytophotodermatitis due to chinese herbal medicine decoction.

  Indian journal of dermatology 20110101

• Sulfur fumigation processing of traditional chinese medicinal herbs: beneficial or detrimental?

  Frontiers in pharmacology 20110101

• Coumarins from Seseli hartvigii.

  Natural product communications 20100701

• Differentiation of four pairs of furocoumarin isomers by electrospray ionization tandem mass spectrometry.

  European journal of mass spectrometry (Chichester, England) 20100101

• Notopterygium forbesii Boiss extract and its active constituent phenethyl ferulate attenuate pro-inflammatory responses to lipopolysaccharide in RAW 264.7 macrophages. A 'protective' role for oxidative stress?

  Chemical research in toxicology 20090801

• Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures.

  Plant cell reports 20090201

• Identification and physiological evaluation of the components from citrus fruits as potential drugs for anti-corpulence and anticancer.

  Bioorganic & medicinal chemistry 20090101

• [Studies on chemical constituents in roots and rhizomes of Notopterygium incisum].

  Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20081201

• Notopterygium forbesii boiss extract and its active constituents increase reactive species and heme oxygenase-1 in human fetal hepatocytes: mechanisms of action.

  Chemical research in toxicology 20081201

• White and colored grapefruit juice produce similar pharmacokinetic interactions.

  Die Pharmazie 20080801

• [Contents of furanocoumarins in grapefruit juice and health foods].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20080801

• Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4.

  Applied microbiology and biotechnology 20080201

• Potent inhibition of human cytochrome P450 3A4, 2D6, and 2C9 isoenzymes by grapefruit juice and its furocoumarins.

  Journal of food science 20071001

• [A new coumarin glycoside from Glehnia littoralis].

  Yao xue xue bao = Acta pharmaceutica Sinica 20071001

• Antimicrobial activity of the methanolic extracts and compounds from Treculia obovoidea (Moraceae).

  Journal of ethnopharmacology 20070725

• Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit.

  Bioorganic & medicinal chemistry 20070601

• The use of heat treatment to eliminate drug interactions due to grapefruit juice.

  Biological & pharmaceutical bulletin 20061101

• Metabolism of bergamottin by cytochromes P450 2B6 and 3A5.

  The Journal of pharmacology and experimental therapeutics 20060901

• UV-irradiated grapefruit juice loses pharmacokinetic interaction with nifedipine in rats.

  Biological & pharmaceutical bulletin 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• [Comprehensive determination of furanocoumarin derivatives in citrus juice by high performance liquid chromatography].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051101

• Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

  Current drug metabolism 20051001

• Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.

  European journal of biochemistry 20040301

• Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats.

  Pharmaceutical research 20010201