490-83-5 | (5R)-5-[(1S)-1,2-dihydroxyethyl]oxolane-2,3,4-trione

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$57.00	$40.00
250mg	95%	in stock	$80.00	$56.00
1g	95%	in stock	$249.00	$175.00
5g	95%	in stock	$1,022.00	$716.00

Description

• Catalog Number: AG25366
• Chemical Name: (5R)-5-[(1S)-1,2-dihydroxyethyl]oxolane-2,3,4-trione
• CAS Number: 490-83-5
• Molecular Formula: C6H6O6
• Molecular Weight: 174.1082
• MDL Number: MFCD00066467
• SMILES: OC[C@@H]([C@H]1OC(=O)C(=O)C1=O)O

Computed Properties

• Complexity: 244
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: -1

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• Simultaneous nitric oxide and dehydroascorbic acid imaging by combining diaminofluoresceins and diaminorhodamines.

  Journal of neuroscience methods 20080315

• Oxidation of iron-nitrosyl-hemoglobin by dehydroascorbic acid releases nitric oxide to form nitrite in human erythrocytes.

  Biochemistry 20080304

• Anti-oxidant effect of ascorbic and dehydroascorbic acids in hippocampal slice culture.

  Biochemical and biophysical research communications 20080201

• Lead induced changes in the growth and antioxidant metabolism of the lead accumulating and non-accumulating ecotypes of Sedum alfredii.

  Journal of integrative plant biology 20080201

• Influence of postharvest hot water treatment on nutritional and functional properties of kumquat (Fortunella japonica Lour. Swingle Cv. Ovale) fruit.

  Journal of agricultural and food chemistry 20080123

• Altered stomatal dynamics in ascorbate oxidase over-expressing tobacco plants suggest a role for dehydroascorbate signalling.

  Journal of experimental botany 20080101

• Homocysteine toxicity in connective tissue: theories, old and new.

  Connective tissue research 20080101

• Dietary antioxidants as potential pharmacological agents for ischemic stroke.

  Current medicinal chemistry 20080101

• Lipoperoxidation and protein oxidative damage exhibit different kinetics during septic shock.

  Mediators of inflammation 20080101

• Anti-angiogenic effect of high doses of ascorbic acid.

  Journal of translational medicine 20080101

• Fatty acid profile of human milk of Portuguese lactating women: prospective study from the 1st to the 16th week of lactation.

  Annals of nutrition & metabolism 20080101

• A central role of abscisic acid in stress-regulated carbohydrate metabolism.

  PloS one 20080101

• Quantification of mesophyll resistance and apoplastic ascorbic acid as an antioxidant for tropospheric ozone in durum wheat (Triticum durum Desf. cv. Camacho).

  TheScientificWorldJournal 20080101

• No acute effects of grape juice on appetite, implicit memory and mood.

  Food & nutrition research 20080101

• Ascorbic Acid determination in commercial fruit juice samples by cyclic voltammetry.

  Journal of automated methods & management in chemistry 20080101

• Transplasma membrane electron transport comes in two flavors.

  BioFactors (Oxford, England) 20080101

• A comparative study of oxidative stress and interrelationship of important antioxidants in haloperidol and olanzapine treated patients suffering from schizophrenia.

  Indian journal of psychiatry 20080101

• Spinacia oleracea Modulates Radiation-Induced Biochemical Changes in Mice Testis.

  Indian journal of pharmaceutical sciences 20080101

• Polymorphism of glutathione S-transferase P1 gene affects human vitamin C metabolism.

  Biochemical and biophysical research communications 20071221

• Leaf extracellular ascorbate in relation to O(3) tolerance of two soybean cultivars.

  Environmental pollution (Barking, Essex : 1987) 20071201

• Osteoblast protects osteoclast devoid of sodium-dependent vitamin C transporters from oxidative cytotoxicity of ascorbic acid.

  European journal of pharmacology 20071201

• Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20071101

• Mercaptopropionaldehyde from homocysteine: implications for Alzheimer's disease.

  Journal of Alzheimer's disease : JAD 20071101

• Ascorbic acid, carotenoids, and visual quality of baby spinach as affected by shade netting and postharvest storage.

  Journal of agricultural and food chemistry 20071017

• Mechanism of the antioxidant to pro-oxidant switch in the behavior of dehydroascorbate during LDL oxidation by copper(II) ions.

  Archives of biochemistry and biophysics 20070915

• Cadmium-induced oxidative stress and response of the ascorbate-glutathione cycle in Bechmeria nivea (L.) Gaud.

  Chemosphere 20070801

• Reduction of dehydroascorbic acid at low pH.

  Journal of biochemical and biophysical methods 20070801

• Isolation, purification and characterization of histidino-threosidine, a novel Maillard reaction protein crosslink from threose, lysine and histidine.

  Archives of biochemistry and biophysics 20070701

• In vitro effects of calcium fructoborate on fMLP-stimulated human neutrophil granulocytes.

  Biological trace element research 20070701

• Development of a quantitative method for the analysis of total L-ascorbic acid in foods by high-performance liquid chromatography.

  Journal of chromatography. A 20070622

• A simple and sensitive assay for ascorbate using a plate reader.

  Analytical biochemistry 20070601

• Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

  PLoS medicine 20070601

• Spectrophotometric determination of ascorbic acid by the modified CUPRAC method with extractive separation of flavonoids-La(III) complexes.

  Analytica chimica acta 20070404

• Mechanistic studies on oxidation of L-ascorbic acid by an oxo-bridged diiron complex in aqueous acidic media.

  Dalton transactions (Cambridge, England : 2003) 20070328

• Identification of the products of oxidation of quercetin by air oxygen at ambient temperature.

  Molecules (Basel, Switzerland) 20070327

• Differential expression of the ascorbate oxidase multigene family during fruit development and in response to stress.

  Planta 20070301

• Antioxidant in mango (Mangifera indica L.) pulp.

  Plant foods for human nutrition (Dordrecht, Netherlands) 20070301

• Vitamin C transport and SVCT1 transporter expression in chick renal proximal tubule cells in culture.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20070301

• Measurements of oxidative stress status and antioxidant activity in chronic leukaemia patients.

  The Journal of pharmacy and pharmacology 20070301

• Reversible reduction of nitroxides to hydroxylamines: roles for ascorbate and glutathione.

  Free radical biology & medicine 20070201

• The contribution of ascorbic acid and dehydroascorbic acid to the protective role of pleura during inflammatory reactions.

  Medical hypotheses 20070101

• Physiological and biochemical responses to acute ozone-induced oxidative stress in Medicago truncatula.

  Plant physiology and biochemistry : PPB 20070101

• A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease.

  BMC musculoskeletal disorders 20070101

• Sparing effects of selenium and ascorbic acid on vitamin C and E in guinea pig tissues.

  Nutrition journal 20070101

• Effect of cigarette smoking on the oxidant/antioxidant balance in healthy subjects.

  American journal of therapeutics 20070101

• Measurement of reduced, oxidized and total ascorbate content in plants.

  Nature protocols 20070101

• Effect of L-carnitine on skeletal muscle lipids and oxidative stress in rats fed high-fructose diet.

  Experimental diabetes research 20070101

• Formation of furan and methylfuran from ascorbic acid in model systems and food.

  Food additives and contaminants 20070101

• Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake.

  Molecular cancer 20070101

• Microglial cells in astroglial cultures: a cautionary note.

  Journal of neuroinflammation 20070101

• Dehydroascorbate uptake is impaired in the early response of Arabidopsis plant cell cultures to cadmium.

  Journal of experimental botany 20070101

• Mitochondrial recycling of ascorbic acid as a mechanism for regenerating cellular ascorbate.

  BioFactors (Oxford, England) 20070101

• Human erythrocyte membranes contain a cytochrome b561 that may be involved in extracellular ascorbate recycling.

  The Journal of biological chemistry 20061229

• Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes.

  Glycobiology 20061201

• On the mechanism of the ascorbic acid-induced release of nitric oxide from N-nitrosated tryptophan derivatives: scavenging of NO by ascorbyl radicals.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20061124

• Differing effects of metoprolol and propranolol on large vessel and microvessel responsiveness in a porcine model of coronary spasm.

  Coronary artery disease 20061101

• Seasonal profiles of leaf ascorbic acid content and redox state in ozone-sensitive wildflowers.

  Environmental pollution (Barking, Essex : 1987) 20061001

• Copper-induced changes in the growth, oxidative metabolism, and saponin production in suspension culture roots of Panax ginseng in bioreactors.

  Plant cell reports 20061001

• The effect of intracellular ascorbate on the susceptibility of HL60 and Jurkat cells to chemotherapy agents.

  Apoptosis : an international journal on programmed cell death 20061001

• Inhibition of dehydroascorbic acid transport across the rat blood-retinal and -brain barriers in experimental diabetes.

  Biological & pharmaceutical bulletin 20061001

• Oxidative stress, α-tocopherol, ascorbic acid and reduced glutathione status in schizophrenics.

  Indian journal of clinical biochemistry : IJCB 20060901

• A cerebroprotective dose of intravenous citrate/sorbitol-stabilized dehydroascorbic acid is correlated with increased cerebral ascorbic acid and inhibited lipid peroxidation after murine reperfused stroke.

  Neurosurgery 20060801

• Ascorbate and H2O2 induced oxidative DNA damage in Jurkat cells.

  Free radical biology & medicine 20060615

• Enhanced expression of glucose transporter 1 on erythrocyte membrane in hemodialysis patients: the possible role in erythrocyte ascorbate recycling.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20060601

• Influence of glutathione fructosylation on its properties.

  Archives of biochemistry and biophysics 20060515

• Ascorbic acid enhances the inhibitory effect of aspirin on neuronal cyclooxygenase-2-mediated prostaglandin E2 production.

  Journal of neuroimmunology 20060501

• Fast analysis of sugars, fruit acids, and vitamin C in sea buckthorn (Hippophaë rhamnoides L.) varieties.

  Journal of agricultural and food chemistry 20060405

• Antioxidant composition in cherry and high-pigment tomato cultivars.

  Journal of agricultural and food chemistry 20060405

• Heterologous expression of dehydroascorbate reductase from rice and its application to determination of dehydroascorbate concentrations.

  Journal of nutritional science and vitaminology 20060401

• Degradation kinetics of the antioxidant additive ascorbic acid in packed table olives during storage at different temperatures.

  Journal of agricultural and food chemistry 20060322

• Coenzyme Q(1) depletes NAD(P)H and impairs recycling of ascorbate in astrocytes.

  Brain research 20060317

• Measuring nitric oxide in single neurons by capillary electrophoresis with laser-induced fluorescence: use of ascorbate oxidase in diaminofluorescein measurements.

  Analytical chemistry 20060315

• Reduction of vanadium(V) by L-ascorbic acid at low and neutral pH: kinetic, mechanistic, and spectroscopic characterization.

  Inorganic chemistry 20060220

• Preventive effects of phosphorylated ascorbate on ultraviolet-B induced apoptotic cell death and DNA strand cleavage through enrichment of intracellular vitamin C in skin epidermal keratinocytes.

  Free radical research 20060201

• Free zinc inhibits transport of vitamin C in differentiated HL-60 cells during respiratory burst.

  Free radical biology & medicine 20060201

• [Influence of gastric juice pH on the metabolism of vitamin C in gastric mucosa and juice].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060201

• Rapid high-performance liquid chromatographic method for Vitamin C determination in human milk versus an enzymatic method.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102

• Ca2+-mediated ascorbate release from coronary artery endothelial cells.

  British journal of pharmacology 20060101

• Water-soluble vitamins.

  Journal of AOAC International 20060101

• Safety and tolerance of ester-C compared with regular ascorbic acid.

  Advances in therapy 20060101

• Antioxidant protection during the menstrual cycle: the effects of estradiol on ascorbic-dehydroascorbic acid plasma levels and total antioxidant plasma status in eumenorrhoic women during the menstrual cycle.

  Acta obstetricia et gynecologica Scandinavica 20060101

• Macrophage uptake and recycling of ascorbic acid: response to activation by lipopolysaccharide.

  Free radical biology & medicine 20051201

• Vitamin C transiently arrests cancer cell cycle progression in S phase and G2/M boundary by modulating the kinetics of activation and the subcellular localization of Cdc25C phosphatase.

  Journal of cellular physiology 20051101

• Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats.

  Journal of pineal research 20051101

• Sepsis inhibits recycling and glutamate-stimulated export of ascorbate by astrocytes.

  Free radical biology & medicine 20051015

• Ascorbate is particularly effective against LDL oxidation in the presence of iron(III) and homocysteine/cystine at acidic pH.

  Biochimica et biophysica acta 20051001

• Vitamin C enters mitochondria via facilitative glucose transporter 1 (Glut1) and confers mitochondrial protection against oxidative injury.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051001

• High-throughput analysis of vitamin C in human plasma with the use of HPLC with monolithic column and UV-detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

• Diabetic changes in the redox status of the microsomal protein folding machinery.

  Biochemical and biophysical research communications 20050902

• Direct fluorimetric determination of ascorbic acid by the supramolecular system of AA with beta-cyclodextrin derivative.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050901

• Dehydroascorbate transport in human chondrocytes is regulated by hypoxia and is a physiologically relevant source of ascorbic acid in the joint.

  Arthritis and rheumatism 20050901

• Ascorbate uptake and antioxidant function in peritoneal macrophages.

  Archives of biochemistry and biophysics 20050815

• Association between hydrogen peroxide-dependent byproducts of ascorbic acid and increased hepatic acetyl-CoA carboxylase activity.

  Clinical chemistry 20050801

• Ozonated water extends the shelf life of fresh-cut lettuce.

  Journal of agricultural and food chemistry 20050713

• White matter injury following prolonged free radical formation in the 0.65 gestation fetal sheep brain.

  Pediatric research 20050701

• Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases.

  Pharmacogenetics and genomics 20050701

• Chondrocyte transport and concentration of ascorbic acid is mediated by SVCT2.

  Biochimica et biophysica acta 20050630

• The influence of oxygenated water on the immune status, liver enzymes, and the generation of oxygen radicals: a prospective, randomised, blinded clinical study.

  Clinical nutrition (Edinburgh, Scotland) 20050601

• [Determination of oxidation-reduction level in patients with rheumatoid arthritis].

  Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050601

• Atomic absorption spectrometry for the automatic indirect determination of ascorbic acid based on-the reduction of manganese dioxide.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050601

• Kinetic and thermodynamic characterization of the cobalt and manganese oxyhydroxide cores formed in horse spleen ferritin.

  Inorganic chemistry 20050516

• Vitamin C protects HL60 and U266 cells from arsenic toxicity.

  Blood 20050515

• Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation.

  Free radical biology & medicine 20050515

• Ascorbate depletion: a critical step in nickel carcinogenesis?

  Environmental health perspectives 20050501

• Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat.

  Neurochemistry international 20050401

• Vitamin C homeostasis in skeletal muscle cells.

  Free radical biology & medicine 20050401

• Generation and destruction of unstable reagent in flow injection system: determination of acetylcysteine in pharmaceutical formulations using bromine as reagent.

  Journal of pharmaceutical and biomedical analysis 20050401

• [Malondialdehyde and reduced glutathione increase in patients with chronic stable ischaemic cardiopathy].

  Medicina clinica 20050319

• Cloning, sequencing, and characterization of alternatively spliced glutaredoxin 1 cDNA and its genomic gene: chromosomal localization, mrna stability, and origin of pseudogenes.

  The Journal of biological chemistry 20050318

• Spectrophotometric determination of ascorbic acid using copper(II)-neocuproine reagent in beverages and pharmaceuticals.

  Talanta 20050315

• Dehydroascorbic acid prevents oxidative cell death through a glutathione pathway in primary astrocytes.

  Journal of neuroscience research 20050301

• Evaluation of a sunscreen photoprotective effect by ascorbic acid assessment in human dermis using microdialysis and gas chromatography mass spectrometry.

  Experimental dermatology 20050301

• Ascorbate uptake in pig coronary artery endothelial cells.

  Molecular and cellular biochemistry 20050301

• 6-Bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+-dependent vitamin C transporter but not glucose transporter pathways.

  The Journal of biological chemistry 20050218

• Preparation of dehydro-L-ascorbic acid dimer by air oxidation of L-ascorbic acid in the presence of catalytic amounts of copper(II) acetate and pyridine.

  Carbohydrate research 20050207

• Changes in intracellular and apoplastic peroxidase activity, ascorbate redox status, and root elongation induced by enhanced ascorbate content in Allium cepa L.

  Journal of experimental botany 20050201

• Transport and intracellular accumulation of vitamin C in endothelial cells: relevance to collagen synthesis.

  Archives of biochemistry and biophysics 20050201

• Protective role of dehydroascorbate in rat liver ischemia-reperfusion injury.

  The Journal of surgical research 20050201

• Modulation of cadmium-induced oxidative stress in Ceratophyllum demersum by zinc involves ascorbate-glutathione cycle and glutathione metabolism.

  Plant physiology and biochemistry : PPB 20050201

• Stability of copigmented anthocyanins and ascorbic acid in a grape juice model system.

  Journal of agricultural and food chemistry 20050112

• Vitamin C uptake and recycling among normal and tumor cells from the central nervous system.

  Journal of neuroscience research 20050101

• Furan precursors in food: a model study and development of a simple headspace method for determination of furan.

  Journal of AOAC International 20050101

• Use of ascorbate-rich dialysate to attenuate oxidative stress in maintenance hemodialysis patients.

  Renal failure 20050101

• [The contents of ascorbic acid and its oxidized forms at the aging of red blood cells produced in conditions of the normal and intense of erythropoesis].

  Biomeditsinskaia khimiia 20050101

• Regulation of vitamin C transport.

  Annual review of nutrition 20050101

• Hyperglycemia inhibits the uptake of dehydroascorbate in tubular epithelial cell.

  American journal of nephrology 20050101

• [Determination of ascorbic and dehydroascorbic acid concentration using HPLC method in smokers with stable coronary artery disease scheduled for coronary artery bypass grafting (CABG)].

  Przeglad lekarski 20050101

• Expression of superoxide dismutase in hyperglycemic focal cerebral ischemia in the rat.

  Neurochemistry international 20041201

• Localization of ascorbic acid, ascorbic acid oxidase, and glutathione in roots of Cucurbita maxima L.

  Journal of experimental botany 20041201

• Measurement of nitric oxide by 4,5-diaminofluorescein without interferences.

  The Analyst 20041201

• Seawater irrigation: antioxidant defence responses in leaves and roots of a sunflower (Helianthus annuus L.) ecotype.

  Journal of plant physiology 20041201

• Ascorbic acid recycling by cultured beta cells: effects of increased glucose metabolism.

  Free radical biology & medicine 20041115

• Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts.

  Free radical biology & medicine 20041101

• Ascorbate modulation of H(2)O(2) and camptothecin-induced cell death in Jurkat cells.

  Cancer chemotherapy and pharmacology 20041001

• Oxidative stress in limpets exposed to different environmental conditions in the Beagle Channel.

  Aquatic toxicology (Amsterdam, Netherlands) 20040920

• Nitric oxide-induced oxidant stress in endothelial cells: amelioration by ascorbic acid.

  Archives of biochemistry and biophysics 20040901

• Plasma ascorbate deficiency is associated with impaired reduction of sulfamethoxazole-nitroso in HIV infection.

  Journal of acquired immune deficiency syndromes (1999) 20040815

• Ascorbate distribution during hibernation is independent of ascorbate redox state.

  Free radical biology & medicine 20040815

• UV light increases vitamin C uptake by bovine lens epithelial cells.

  Molecular vision 20040806

• Facilitated glucose and dehydroascorbate transport in plant mitochondria.

  Archives of biochemistry and biophysics 20040801

• Cellular vitamin C accumulation in the presence of copper.

  Biological trace element research 20040801

• Oxidative decomposition of vitamin C in drinking water.

  Free radical research 20040801

• Plasma 8-isoprostane is increased in preterm infants who develop bronchopulmonary dysplasia or periventricular leukomalacia.

  Pediatric research 20040701

• [Levels of serum ascorbate and its metabolites in hemodialysis patients].

  Nihon Jinzo Gakkai shi 20040701

• Characterization and quantitation of antioxidant constituents of sweet pepper (Capsicum annuum L.).

  Journal of agricultural and food chemistry 20040616

• Ascorbate-mediated enhancement of reactive oxygen species generation from polymorphonuclear leukocytes: modulatory effect of nitric oxide.

  Journal of leukocyte biology 20040601

• The ascorbic acid redox state controls guard cell signaling and stomatal movement.

  The Plant cell 20040501

• Human erythrocyte recycling of ascorbic acid: relative contributions from the ascorbate free radical and dehydroascorbic acid.

  The Journal of biological chemistry 20040409

• Vitamin C transport in oxidized form across the rat blood-retinal barrier.

  Investigative ophthalmology & visual science 20040401

• Preparation of dehydro-l-(+)-ascorbic acid dimer by oxidation of ascorbic acid with arsenic acid/iodine and formation of complexes between arsenious acid and ascorbic acid.

  Journal of inorganic biochemistry 20040401

• Dehydroascorbate influences the plant cell cycle through a glutathione-independent reduction mechanism.

  Plant physiology 20040401

• Deep hypothermia during ischemia improves functional recovery and reduces free-radical generation in isolated reperfused rat heart.

  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20040401

• Vitamin C: basic metabolism and its function as an index of oxidative stress.

  Current medicinal chemistry 20040401

• The methanol method for the quantification of ascorbic acid and dehydroascorbic acid in biological samples.

  Journal of biochemical and biophysical methods 20040331

• Enhancing effects of intracellular ascorbic acid on peroxynitrite-induced U937 cell death are mediated by mitochondrial events resulting in enhanced sensitivity to peroxynitrite-dependent inhibition of complex III and formation of hydrogen peroxide.

  The Biochemical journal 20040315

• The effect of Botrytis cinerea infection on the antioxidant profile of mitochondria from tomato leaves.

  Journal of experimental botany 20040301

• Micronutrient concentrations in patients with malignant disease: effect of the inflammatory response.

  Annals of clinical biochemistry 20040301

• Characterization and detection of lysine-arginine cross-links derived from dehydroascorbic acid.

  Carbohydrate research 20040225

• Ebselen is a dehydroascorbate reductase mimic, facilitating the recycling of ascorbate via mammalian thioredoxin systems.

  Antioxidants & redox signaling 20040201

• The p38 pathway partially mediates caspase-3 activation induced by reactive oxygen species in Fanconi anemia C cells.

  Biochemical pharmacology 20040201

• Breath condensate hydrogen peroxide correlates with both airway cytology and epithelial lining fluid ascorbic acid concentration in the horse.

  Free radical research 20040201

• Ascorbic acid in blood serum of patients with pulmonary tuberculosis and pneumonia.

  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20040201

• Evaluation of the hepatic reduction of a nitroxide radical in rats receiving ascorbic acid, glutathione or ascorbic acid oxidase by in vivo electron spin resonance study.

  Journal of gastroenterology and hepatology 20040101

• Light-induced byproducts of vitamin C in multivitamin solutions.

  Clinical chemistry 20040101

• Iron supplements: the quick fix with long-term consequences.

  Nutrition journal 20040101

• Hopes, disillusions and more hopes from vitamin C.

  Cellular and molecular life sciences : CMLS 20040101

• Changes in vitamin C concentrations in plasma and milk from dairy cows after an intramammary infusion of Escherichia coli.

  Journal of dairy science 20040101

• Effects of multilayered bags vs ethylvinyl-acetate bags on oxidation of parenteral nutrition.

  JPEN. Journal of parenteral and enteral nutrition 20040101

• Capacity of ascorbyl palmitate to produce the ascorbyl radical in vitro: an electron spin resonance investigation.

  Physiological research 20040101

• Long-distance transport of L-ascorbic acid in potato.

  BMC plant biology 20040101

• Synergistic effect of dehydroascorbic acid and mixtures with vitamin E and beta-carotene on mitomycin C efficiency under irradiation in vitro.

  In vivo (Athens, Greece) 20040101

• Effect of imipramine treatment on plasma dopamine beta-hydroxylase activity in chronic mild stress in rats.

  Polish journal of pharmacology 20040101

• Chromatographic study of photolysis of aqueous cyanocobalamin solution in presence of vitamins B and C.

  Pakistan journal of pharmaceutical sciences 20040101

• Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes.

  Brain research 20031212

• Functional studies of threonine 310 mutations in Glut1: T310I is pathogenic, causing Glut1 deficiency.

  The Journal of biological chemistry 20031205

• Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo.

  Free radical biology & medicine 20031201

• Molecular and catalytic properties of a peroxiredoxin-glutaredoxin hybrid from Neisseria meningitidis.

  FEBS letters 20031106

• Role of nitric oxide in ethanol-induced ascorbic acid release in striatum of freely moving mice.

  Toxicology letters 20031101

• Sugar hydrazone-metal complexes: transition- and non-transition metal complexes of monosaccharide S-alkylhydrazonecarbodithioates and dehydro-L-ascorbic acid bis(S-alkylhydrazonecarbodithioates).

  Carbohydrate research 20031031

• Solid-phase iodine as an oxidant in flow injection analysis: determination of ascorbic acid in pharmaceuticals and foods by background correction.

  Talanta 20031017

• Vitamin C recycling is enhanced in the adaptive response to leptin-induced oxidative stress in keratinocytes.

  The Journal of investigative dermatology 20031001

• Role of ascorbate in the regulation of nitric oxide generation by polymorphonuclear leukocytes.

  Biochemical and biophysical research communications 20030912

• Dehydroascorbate uptake activity correlates with cell growth and cell division of tobacco bright yellow-2 cell cultures.

  Plant physiology 20030901

• Vitamin E supplementation does not increase the vitamin C radical concentration at rest and after exhaustive exercise in healthy male subjects.

  European journal of nutrition 20030801

• Effects of ascorbic acid and analogs on the activity of testicular hyaluronidase and hyaluronan lyase on hyaluronan.

  Journal of enzyme inhibition and medicinal chemistry 20030801

• Ascorbic acid concentration in Cv. conference pears during fruit development and postharvest storage.

  Journal of agricultural and food chemistry 20030730

• L-galactono-gamma-lactone dehydrogenase aand vitamin C content in fresh-cut potatoes stored under controlled atmospheres.

  Journal of agricultural and food chemistry 20030716

• Elevated carbon dioxide increases contents of antioxidant compounds in field-grown strawberries.

  Journal of agricultural and food chemistry 20030716

• Vitamin C inhibits FAS-induced apoptosis in monocytes and U937 cells.

  Blood 20030701

• The effect of UVA light on the anaerobic oxidation of ascorbic acid and the glycation of lens proteins.

  Investigative ophthalmology & visual science 20030701

• Ascorbic acid spares alpha-tocopherol and decreases lipid peroxidation in neuronal cells.

  Biochemical and biophysical research communications 20030606

• Vitamin C metabolomic mapping in experimental diabetes with 6-deoxy-6-fluoro-ascorbic acid and high resolution 19F-nuclear magnetic resonance spectroscopy.

  Metabolism: clinical and experimental 20030601

• Recycling of vitamin C from its oxidized forms by human endothelial cells.

  Biochimica et biophysica acta 20030512

• Rocket-powered high-performance liquid chromatographic analysis of plant ascorbate and glutathione.

  Analytical biochemistry 20030501

• Vitamin C metabolomic mapping in the lens with 6-deoxy-6-fluoro-ascorbic acid and high-resolution 19F-NMR spectroscopy.

  Investigative ophthalmology & visual science 20030501

• Role of ascorbic acid in the modulation of inhibition of platelet aggregation by polymorphonuclear leukocytes.

  Thrombosis research 20030501

• Non-protein-bound transition metals and hydroxyl radical generation in cerebrospinal fluid of newborn infants with hypoxic ischemic encephalopathy.

  Pediatric research 20030401

• Vitamin C protects low-density lipoprotein from homocysteine-mediated oxidation.

  Free radical biology & medicine 20030401

• Effects of processing treatment and sorbate addition on the flavor characteristics of apple cider.

  Journal of agricultural and food chemistry 20030326

• Recycling of vitamin C by a bystander effect.

  The Journal of biological chemistry 20030321

• Isolation and characterization of a new advanced glycation endproduct of dehydroascorbic acid and lysine.

  Biochimica et biophysica acta 20030317

• Up-regulation and polarized expression of the sodium-ascorbic acid transporter SVCT1 in post-confluent differentiated CaCo-2 cells.

  The Journal of biological chemistry 20030314

• Ascorbic acid blunts oxidant stress due to menadione in endothelial cells.

  Archives of biochemistry and biophysics 20030301

• An oxidative mechanism of interferon induced priming of the Fas pathway in Fanconi anemia cells.

  Biochemical pharmacology 20030301

• Modification of analytical procedures for determining vitamin C enzyme (L-gulonolactone oxidase) activity in swine liver.

  The Journal of nutritional biochemistry 20030301

• Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes.

  Archives of biochemistry and biophysics 20030201

• Zonal changes in ascorbate and hydrogen peroxide contents, peroxidase, and ascorbate-related enzyme activities in onion roots.

  Plant physiology 20030201

• Biochemical changes in arthritic rats: dehydroascorbic and ascorbic acid levels.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030201

• Effects of leaf ascorbate content on defense and photosynthesis gene expression in Arabidopsis thaliana.

  Antioxidants & redox signaling 20030201

• Dehydroascorbic acid in urine as a possible indicator of surgical stress.

  Annals of nutrition & metabolism 20030101

• Determination of total vitamin C in fruit juices and related products by liquid chromatography: interlaboratory study.

  Journal of AOAC International 20030101

• Total and corrected antioxidant capacity in hemodialyzed patients.

  BMC nephrology 20030101

• Role of ascorbate in oxidative protein folding.

  BioFactors (Oxford, England) 20030101

• Vitamin C in human health and disease is still a mystery? An overview.

  Nutrition journal 20030101

• Peroxynitrous acid--where is the hydroxyl radical?

  IUBMB life 20030101

• The correlation between markers of oxidative stress and risk factors of coronary artery disease in Thai patients.

  Clinical hemorheology and microcirculation 20030101

• Vitamin C: from popular food supplement to specific drug.

  Forum of nutrition 20030101

• Effects of glutamate on dehydroascorbate uptake and its enhanced vulnerability to the peroxidation in cerebral cortical slices.

  Experimental & molecular medicine 20021231

• Interfering with nitric oxide measurements. 4,5-diaminofluorescein reacts with dehydroascorbic acid and ascorbic acid.

  The Journal of biological chemistry 20021213

• Hyperbaric oxygen enhances apoptosis in hematopoietic cells.

  Apoptosis : an international journal on programmed cell death 20021201

• Impaired ascorbic acid metabolism in streptozotocin-induced diabetic rats.

  Free radical biology & medicine 20021101

• Sensorial and chemical quality of gamma-irradiated fresh-cut iceberg lettuce in modified atmosphere packages.

  Journal of food protection 20021101

• Ascorbic acid assays of individual neurons and neuronal tissues using capillary electrophoresis with laser-induced fluorescence detection.

  Analytical chemistry 20021101

• Vitamin C suppresses TNF alpha-induced NF kappa B activation by inhibiting I kappa B alpha phosphorylation.

  Biochemistry 20021029

• Determination of bovine blood oleandrin by high-performance liquid chromatography and postcolumn derivatization.

  Journal of chromatographic science 20021001

• Analysis of glycated and ascorbylated proteins by gas chromatography-mass spectrometry.

  Journal of agricultural and food chemistry 20020925

• The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes.

  The Journal of biological chemistry 20020913

• The physiological role of dehydroascorbic acid.

  FEBS letters 20020911

• Bioavailability of oxidized vitamin C (dehydroascorbic acid).

  Journal of the American Dietetic Association 20020901

• Bioavailability of oxidized vitamin C (dehydroascorbic acid).

  Journal of the American Dietetic Association 20020901

• Accumulation of intracellular ascorbate from dehydroascorbic acid by astrocytes is decreased after oxidative stress and restored by propofol.

  Glia 20020801

• Ascorbyl free radical and dehydroascorbate formation in rat liver endoplasmic reticulum.

  Journal of bioenergetics and biomembranes 20020801

• Effect of zinc on antioxidant response in maize (Zea mays L.) leaves.

  Indian journal of experimental biology 20020801

• Measurement of ascorbic acid and dehydroascorbic acid in biological samples.

  Current protocols in toxicology 20020801

• Mitochondrial recycling of ascorbic acid from dehydroascorbic acid: dependence on the electron transport chain.

  Archives of biochemistry and biophysics 20020701

• Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells.

  Free radical biology & medicine 20020701

• Ascorbic acid and flavonoid-peroxidase reaction as a detoxifying system of H(2)O(2) in grapevine leaves.

  Phytochemistry 20020701

• Nicotinamide is not a substrate of the facilitative hexose transporter GLUT1.

  Biochemistry 20020625

• Are diabetic neuropathy, retinopathy and nephropathy caused by hyperglycemic exclusion of dehydroascorbate uptake by glucose transporters?

  Journal of theoretical biology 20020607

• A photoprotective role for O(2) as an alternative electron sink in photosynthesis?

  Current opinion in plant biology 20020601

• Heat stress- and heat shock transcription factor-dependent expression and activity of ascorbate peroxidase in Arabidopsis.

  Plant physiology 20020601

• Recycling processes of cellular ascorbate generate oxidative stress in pancreatic tissues in in vitro system.

  Endocrine 20020601

• Differential regulation of hydrogen peroxide and Fas-dependent apoptosis pathways by dehydroascorbate, the oxidized form of vitamin C.

  Antioxidants & redox signaling 20020601

• Oxidation of ferulic acid or arabinose-esterified ferulic acid by wheat germ peroxidase.

  Journal of agricultural and food chemistry 20020522

• Catalytic properties, thiol pK value, and redox potential of Trypanosoma brucei tryparedoxin.

  The Journal of biological chemistry 20020517

• Vitamin C prevents DNA mutation induced by oxidative stress.

  The Journal of biological chemistry 20020510

• Alpha-tocopherol protects cultured human cells from the acute lethal cytotoxicity of dioxin.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20020501

• Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigs.

  Free radical research 20020501

• Sepsis inhibits reduction of dehydroascorbic acid and accumulation of ascorbate in astroglial cultures: intracellular ascorbate depletion increases nitric oxide synthase induction and glutamate uptake inhibition.

  Journal of neurochemistry 20020401

• Carcinogenic chromium(VI) induces cross-linking of vitamin C to DNA in vitro and in human lung A549 cells.

  Biochemistry 20020305

• Dehydroascorbic acid uptake by coronary artery smooth muscle: effect of intracellular acidification.

  The Biochemical journal 20020301

• Ebselen has dehydroascorbate reductase and thioltransferase-like activities.

  Biochemical and biophysical research communications 20020301

• Inhibition of human breast carcinoma cell proliferation by ascorbate and copper.

  Puerto Rico health sciences journal 20020301

• Determination of vitamin C in plasma and dialysate from uremia patients by high performance liquid chromatography with electrochemical detection.

  Se pu = Chinese journal of chromatography 20020301

• Exploring the active site of plant glutaredoxin by site-directed mutagenesis.

  FEBS letters 20020130

• Very low vitamin C activity of orally administered L-dehydroascorbic acid.

  Journal of agricultural and food chemistry 20020102

• Intracellular flavonoids as electron donors for extracellular ferricyanide reduction in human erythrocytes.

  Free radical biology & medicine 20020101

• Hydroponically cultivated radish fed L-galactono-1,4-lactone exhibit increased tolerance to ozone.

  Planta 20020101

• Recycling of vitamin C by mammalian thioredoxin reductase.

  Methods in enzymology 20020101

• Analysis of transmembrane redox reactions: interaction of intra- and extracellular ascorbate species.

  Methods in enzymology 20020101

• Preventing the common cold with a vitamin C supplement: a double-blind, placebo-controlled survey.

  Advances in therapy 20020101

• Physical characteristics of total parenteral nutrition bags significantly affect the stability of vitamins C and B1: a controlled prospective study.

  JPEN. Journal of parenteral and enteral nutrition 20020101

• The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats.

  International journal of experimental diabetes research 20020101

• GSH is required to recycle ascorbic acid in cultured liver cell lines.

  Antioxidants & redox signaling 20011201

• Selenium spares ascorbate and alpha-tocopherol in cultured liver cell lines under oxidant stress.

  FEBS letters 20011123

• Mechanism of vitamin C inhibition of cell death induced by oxidative stress in glutathione-depleted HL-60 cells.

  The Journal of biological chemistry 20011102

• Relationships among dietary roasted soybeans, milk components, and spontaneous oxidized flavor of milk.

  Journal of dairy science 20011101

• Interactions among ascorbate, dehydroascorbate and glucose transport in cultured hippocampal neurons and glia.

  Brain research 20011019

• Mechanisms of ascorbic acid recycling in human erythrocytes.

  Biochimica et biophysica acta 20011003

• Requirement for GSH in recycling of ascorbic acid in endothelial cells.

  Biochemical pharmacology 20011001

• Quality of irradiated alfalfa sproutst.

  Journal of food protection 20011001

• Autosomal dominant glut-1 deficiency syndrome and familial epilepsy.

  Annals of neurology 20011001

• Dehydroascorbic acid reduction in several tissues and cultured hepatocytes of the chicken.

  Bioscience, biotechnology, and biochemistry 20011001

• Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke.

  Proceedings of the National Academy of Sciences of the United States of America 20010925

• Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats.

  Diabetologia 20010901

• Glucose transporter type 1 deficiency syndrome (Glut1DS): methylxanthines potentiate GLUT1 haploinsufficiency in vitro.

  Pediatric research 20010801

• A comparative study of glutathione and ascorbate metabolism during germination of Pinus pinea L. seeds.

  Journal of experimental botany 20010801

• High-affinity sodium-vitamin C co-transporters (SVCT) expression in embryonic mouse neurons.

  Journal of neurochemistry 20010801

• Short- and long-term effects of dehydroascorbate in Lupinus albus and Allium cepa roots.

  Plant & cell physiology 20010801

• Fluorimetric determination of total ascorbic acid by a stopped-flow mixing technique.

  The Analyst 20010801

• Identification of 3,4-dihydroxy-2-oxo-butanal (L-threosone) as an intermediate compound in oxidative degradation of dehydro-L-ascorbic acid and 2,3-diketo-L-gulonic acid in a deuterium oxide phosphate buffer.

  Bioscience, biotechnology, and biochemistry 20010801

• Reduction of dehydroerythorbic acid in vitamin C-deficient guinea pigs.

  Journal of nutritional science and vitaminology 20010801

• Ceruloplasmin as low-density lipoprotein oxidase: activation by ascorbate and dehydroascorbate.

  FEBS letters 20010713

• In vivo detection of tobacco mosaic virus-induced local and systemic oxidative burst by electron paramagnetic resonance spectroscopy.

  Plant & cell physiology 20010701

• Involvement of oxidative stress in ascorbate-induced proapoptotic death of PC12 cells.

  Experimental neurology 20010601

• Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells.

  The Biochemical journal 20010601

• Antioxidant defense systems of two lipidopteran insect cell lines.

  Free radical biology & medicine 20010601

• Degradation of dehydroascorbic acid in parenteral nutrition mixtures.

  Journal of pharmaceutical and biomedical analysis 20010601

• Alterations in intragastric nitrite and vitamin C levels during acid inhibitory therapy.

  Best practice & research. Clinical gastroenterology 20010601

• Inactivation of protein farnesyltransferase by active-site-targeted dicarbonyl compounds.

  Archiv der Pharmazie 20010601

• Role of biological antioxidants in benzanthrone toxicity.

  Archives of toxicology 20010601

• Quercetin prevents glutathione depletion induced by dehydroascorbic acid in rabbit red blood cells.

  Free radical research 20010601

• Blood transfusion increases radical promoting non-transferrin bound iron in preterm infants.

  Archives of disease in childhood. Fetal and neonatal edition 20010501

• Water-soluble antioxidants inhibit macrophage recognition of oxidized erythrocytes.

  Biological & pharmaceutical bulletin 20010501

• Quantification of L-ascorbic acid and total ascorbic acid in fruits and spinach by capillary zone electrophoresis.

  Electrophoresis 20010501

• Chloroplastic ascorbate peroxidase is the primary target of methylviologen-induced photooxidative stress in spinach leaves: its relevance to monodehydroascorbate radical detected with in vivo ESR.

  Biochimica et biophysica acta 20010402

• Oxidative stress induced by ascorbate causes neuronal damage in an in vitro system.

  Brain research 20010323

• Dehydroascorbic acid and oxidative stress in haemodialysis patients.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20010301

• Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells.

  Journal of natural products 20010301

• Changes in oxygen-scavenging systems and membrane lipid peroxidation during maturation and ripening in blackberry.

  Journal of agricultural and food chemistry 20010301

• Mitochondrial uptake and recycling of ascorbic acid.

  Archives of biochemistry and biophysics 20010301

• Reduction of dehydroascorbic acid by homocysteine.

  Biochimica et biophysica acta 20010216

• Minor role of oxidative stress during intermediate phase of acute pancreatitis in rats.

  Free radical biology & medicine 20010201

• Topical L-ascorbic acid: percutaneous absorption studies.

  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20010201

• Immunohistochemical evidence and ultrastructural compartmentalization of a new antioxidant enzyme in the rat substantia nigra.

  Journal of neurocytology 20010201

• The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.

  The Journal of biological chemistry 20010126

• Direct inhibition of the hexose transporter GLUT1 by tyrosine kinase inhibitors.

  Biochemistry 20010123

• Influences of process parameters on preparation of microparticle used as a carrier system for omega - 3 unsaturated fatty acid ethyl esters used in supplementary nutrition.

  Journal of microencapsulation 20010101

• Vitamin C transport systems of mammalian cells.

  Molecular membrane biology 20010101

• Routine analysis of ascorbic acid in citrus juice using capillary electrophoresis.

  Journal of AOAC International 20010101

• Biochemical parameters as biomarkers for the early recognition of environmental pollution on Scots pine trees. II. The antioxidative metabolites ascorbic acid, glutathione, alpha-tocopherol and the enzymes superoxide dismutase and glutathione reductase.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20010101

• Characterization of dehydroascorbic acid solutions by liquid chromatography/mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20010101

• A family of mammalian Na+-dependent L-ascorbic acid transporters.

  Nature 19990506

• Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters.

  The Journal of clinical investigation 19971201

• Protective action of dehydroascorbic acid on the Ah receptor-dependent and receptor-independent induction of lipid peroxidation in adipose tissue of male guinea pig caused by TCDD administration.

  Journal of biochemical toxicology 19960101

• Effect of combined ascorbic acid and B-12 on survival of mice with implanted Ehrlich carcinoma and L1210 leukemia.

  The American journal of clinical nutrition 19911201

• Glucose-independent transport of dehydroascorbic acid in human erythrocytes.

  Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19860301