491-78-1 | 5-Hydroxyflavone

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$33.00	$23.00
250mg	98%	in stock	$50.00	$35.00
1g	98%	in stock	$126.00	$88.00
5g	98%	in stock	$452.00	$316.00

Description

• Catalog Number: AB69310
• Chemical Name: 5-Hydroxyflavone
• CAS Number: 491-78-1
• Molecular Formula: C15H10O3
• Molecular Weight: 238.2381
• MDL Number: MFCD00016944
• SMILES: Oc1cccc2c1c(=O)cc(o2)c1ccccc1
• NSC Number: 26745

Computed Properties

• Complexity: 355
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 18
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 2.5

Literature

• In vitro effects of some flavones on human pyruvate kinase isoenzyme M2.

  Journal of biochemical and molecular toxicology 20150301

• Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.

  Journal of medicinal chemistry 20130523

• Mutagenicity of flavonoids assayed by bacterial reverse mutation (Ames) test.

  Molecules (Basel, Switzerland) 20120507

• Microbial transformations of 7-hydroxyflavanone.

  TheScientificWorldJournal 20120101

• Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.

  Bioorganic & medicinal chemistry letters 20111015

• Fisetin lowers methylglyoxal dependent protein glycation and limits the complications of diabetes.

  PloS one 20110101

• A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease.

  PloS one 20110101

• Spectroscopic study of solvent effects on the electronic absorption spectra of flavone and 7-hydroxyflavone in neat and binary solvent mixtures.

  International journal of molecular sciences 20110101

• Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.

  Chemical research in toxicology 20101220

• Multivariate QSAR study on the antimutagenic activity of flavonoids against 3-NFA on Salmonella typhimurium TA98.

  European journal of medicinal chemistry 20101001

• Excited state intramolecular proton transfer in 3-hydroxy flavone and 5-hydroxy flavone: a DFT based comparative study.

  Journal of molecular modeling 20100501

• Potent inhibitor scaffold against Trypanosoma cruzi trans-sialidase.

  Bioorganic & medicinal chemistry 20100215

• Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids.

  Bioorganic & medicinal chemistry 20100101

• Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

  Bioorganic & medicinal chemistry letters 20090815

• Metabolism and pharmacokinetics of 3,3',4',7-tetrahydroxyflavone (fisetin), 5-hydroxyflavone, and 7-hydroxyflavone and antihemolysis effects of fisetin and its serum metabolites.

  Journal of agricultural and food chemistry 20090114

• Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle.

  Journal of experimental botany 20080701

• Microbial metabolism part 9. Structure and antioxidant significance of the metabolites of 5,7-dihydroxyflavone (chrysin), and 5- and 6-hydroxyflavones.

  Chemical & pharmaceutical bulletin 20080401

• A fluorescent fluoride ion probe based on a self-organized ensemble of 5-hydroxyflavone-Al(III) complex.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080101

• Permeability profile estimation of flavonoids and other phenolic compounds by biopartitioning micellar capillary chromatography.

  Journal of agricultural and food chemistry 20071017

• 2-Styrylchromones: novel strong scavengers of reactive oxygen and nitrogen species.

  Bioorganic & medicinal chemistry 20070915

• Fragmentation of 3-hydroxyflavone; a computational and mass spectrometric study.

  Rapid communications in mass spectrometry : RCM 20070101

• Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

  Journal of molecular graphics & modelling 20061101

• Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids.

  Journal of medicinal chemistry 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Towards a photophysical model for 5-hydroxyflavone.

  The Journal of chemical physics 20060314

• Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

  Steroids 20050901

• Time dependent density functional theory study of electronic absorption properties of lead(II) complexes with a series of hydroxyflavones.

  The journal of physical chemistry. A 20050804

• Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

  Steroids 20050801

• Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

  Naunyn-Schmiedeberg's archives of pharmacology 20041001

• Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives.

  Bioorganic & medicinal chemistry letters 20040308

• Biological effects of epicuticular flavonoids from Primula denticulata on human leukemia cells.

  Journal of agricultural and food chemistry 20040128

• Flavonoids and nitric oxide synthase.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20021201

• 7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate.

  Xenobiotica; the fate of foreign compounds in biological systems 20020701

• Steroid hormone activity of flavonoids and related compounds.

  Breast cancer research and treatment 20000701

• Structure-activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA(A) receptor complex.

  Journal of medicinal chemistry 19991021

• Interactions of flavonoids and other phytochemicals with adenosine receptors.

  Journal of medicinal chemistry 19960202

• Inhibition of HIV-1 integrase by flavones, caffeic acid phenethyl ester (CAPE) and related compounds.

  Biochemical pharmacology 19940803

• Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases.

  European journal of biochemistry 19900705