-
Synthesis and comparison of antiplasmodial activity of (+), (-) and racemic 7-chloro-4-(N-lupinyl)aminoquinoline.
Bioorganic & medicinal chemistry 20121001
-
Asymmetric synthesis of trans-2,3-disubstituted indoline derivatives.
The Journal of organic chemistry 20120106
-
[Derivatives of lupinin and epilupinin as ligands of various cholinesterases].
Zhurnal evoliutsionnoi biokhimii i fiziologii 20120101
-
[Isomeric derivatives of lupinine and epilupinine--organophosphorus inhibitors of cholinesterases].
Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20120101
-
[Reversible lupininin inhibitors of cholinesterases of mammalian blood and of optical ganglia of individuals of the commander squid Berryteuthis magister from different zones of species areal].
Zhurnal evoliutsionnoi biokhimii i fiziologii 20120101
-
Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications.
The Journal of organic chemistry 20110805
-
Total syntheses of (-) epilupinine and (-)-tashiromine using imino-aldol reactions.
Organic letters 20110805
-
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry 20110714
-
Synthesis of the azaphilones (+)-sclerotiorin and (+)-8-O-methylsclerotiorinamine utilizing (+)-sparteine surrogates in copper-mediated oxidative dearomatization.
The Journal of organic chemistry 20110415
-
Total synthesis of (+)-epilupinine via an intramolecular nitrile oxide-alkene cycloaddition.
The Journal of organic chemistry 20110107
-
Development and application of a method to investigate drug-metabolizing enzyme inhibitors using sparteine for probe of cytochrome P450 2D6 and tris(2,2'-bipyridine)ruthenium(II)-electrogenerated chemiluminescence detection.
Chemical & pharmaceutical bulletin 20110101
-
Experimental and computational study of a direct O2-coupled Wacker oxidation: water dependence in the absence of Cu salts.
Journal of the American Chemical Society 20100901
-
Can the genotype or phenotype of two polymorphic drug metabolising cytochrome P450-enzymes identify oral lichenoid drug eruptions?
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100701
-
Characterization of a rhodium-sparteine complex, [((-)-sparteine)Rh(eta4-COD)]+: crystal structure and DNMR/DFT studies on ligand-rotation dynamics.
Dalton transactions (Cambridge, England : 2003) 20100321
-
Short access to (+)-lupinine and (+)-epiquinamide via double hydroformylation.
Organic letters 20100205
-
Asymmetric catalysis of homo-coupling of 3-substituted naphthylamine and hetero-coupling with 3-substituted naphthol leading to 3,3'-dimethyl-2,2'-diaminobinaphthyl and -2-amino-2'-hydroxybinaphthyl.
Chirality 20100201
-
Estimation of the interindividual variability of cytochrome 2D6 activity from urinary metabolic ratios in the literature.
Drug metabolism and pharmacokinetics 20100101
-
Reactions of (-)-sparteine with alkali metal HMDS complexes: conventional meets the unconventional.
Chemical communications (Cambridge, England) 20091021
-
Optically active (aR)- and (aS)-linear and vaulted biaryl ligands: deracemization versus oxidative dimerization.
Journal of the American Chemical Society 20091014
-
Enantiomerization dynamics and a catalytic dynamic resolution of N-trimethylallyl-2-lithiopyrrolidine.
Journal of the American Chemical Society 20090527
-
Epiquinamide: a poison that wasn't from a frog that was.
Journal of natural products 20090227
-
Total synthesis of (+/-)-alpha-isosparteine, (+/-)-beta-isosparteine, and (+/-)-sparteine from a common tetraoxobispidine intermediate.
The Journal of organic chemistry 20081017
-
A new catalytic Cu(II)/sparteine oxidant system for beta,beta-phenolic couplings of styrenyl phenols: synthesis of carpanone and unnatural analogs.
Organic letters 20080918
-
A direct stereoselective approach to trans-2,3-disubstituted piperidines: application in the synthesis of 2-Epi-CP-99,994 and (+)-epilupinine.
Organic letters 20080619
-
A new sparteine surrogate for asymmetric deprotonation of N-Boc pyrrolidine.
Organic letters 20080403
-
Basic instinct: design, synthesis and evaluation of (+)-sparteine surrogates for asymmetric synthesis.
Chemical communications (Cambridge, England) 20080214
-
Asymmetric lithiation-substitution of amines involving rearrangement of borates.
Organic letters 20080103
-
Cholinesterase hydrolysis of substituted lupinine benzoates.
Doklady. Biochemistry and biophysics 20080101
-
Bactericidal and fungicidal activities of Calia secundiflora (Ort.) Yakovlev.
Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101
-
Stereocontrolled synthesis and alkylation of cyclic beta-amino esters: asymmetric synthesis of a (-)-sparteine surrogate.
Organic & biomolecular chemistry 20071121
-
A (-)-sparteine-directed highly enantioselective synthesis of boroproline. Solid- and solution-state structure and properties.
The Journal of organic chemistry 20070803
-
A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.
Drug metabolism and disposition: the biological fate of chemicals 20070801
-
Hypoglycaemic effect of quinolizidine alkaloids--lupanine and 2-thionosparteine on non-diabetic and streptozotocin-induced diabetic rats.
European journal of pharmacology 20070622
-
[Phenotypes of oxidation and acetylation in Alzheimer's disease--preliminary report].
Psychiatria polska 20070101
-
Enantioselective nitroaldol (Henry) reaction using copper(II) complexes of (-)-sparteine.
Chemical communications (Cambridge, England) 20061021
-
Neuronal damage and changes in the expression of muscarinic acetylcholine receptor subtypes in the neonatal rat cerebral cortical upon exposure to sparteine, a quinolizidine alkaloid.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20061001
-
Pd(II)-catalyzed conversion of styrene derivatives to acetals: impact of (-)-sparteine on regioselectivity.
Organic letters 20060316
-
Pd(II)-catalyzed enantioselective oxidative tandem cyclization reactions. Synthesis of indolines through C-N and C-C bond formation.
Journal of the American Chemical Society 20060315
-
Asymmetric synthesis of 4,5,6- and 3,4,5,6-substituted azepanes by a highly diastereoselective and enantioselective lithiation-conjugate addition sequence.
Journal of the American Chemical Society 20060222
-
[Clinical significance of oxidation and acetylation genetic polymorphism in patients with hyperthyreosis].
Endokrynologia Polska 20060101
-
Origin of enantioselection in chiral alcohol oxidation catalyzed by Pd[(-)-sparteine]Cl2.
Journal of the American Chemical Society 20051026
-
A practical synthesis of (+/-)-alpha-isosparteine from a tetraoxobispidine core.
Organic letters 20051013
-
Stereocontrolled total synthesis of (-)-kainic acid. Regio- and stereoselective lithiation of pyrrolidine ring with the (+)-sparteine surrogate.
Organic letters 20050929
-
Enantioselective lithiation of O-alkyl and O-alk-2-enyl Carbamates in the presence of (-)-sparteine and (-)-alpha-isosparteine. A theoretical study.
The Journal of organic chemistry 20050527
-
Cascade iminium ion reactions for the facile synthesis of quinolizidines. Concise syntheses of (+/-)-epilupinine and (-)-epimyrtine.
Organic letters 20050512
-
A synthesis of (+/-)-sparteine.
Organic & biomolecular chemistry 20050421
-
Absolute configuration of 2-(tributylstannyl)pyrrolidine by anomalous dispersion X-ray analysis.
The Journal of organic chemistry 20050107
-
[Synthesis of lupinine derivatives of flavonoids].
Bioorganicheskaia khimiia 20050101
-
Is the A-ring of sparteine essential for high enantioselectivity in the asymmetric lithiation-substitution of N-Boc-pyrrolidine?
Journal of the American Chemical Society 20041201
-
An experimental and computational study of the enantioselective lithiation of N-Boc-pyrrolidine using sparteine-like chiral diamines.
Journal of the American Chemical Society 20041201
-
Comparison of plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis or clinically normal calves.
American journal of veterinary research 20041101
-
Total synthesis of (-)-alpha-kainic acid by (-)-sparteine-mediated asymmetric deprotonation-cycloalkylation.
Organic letters 20041014
-
Effect of ligand structure on the asymmetric cyclization of achiral olefinic organolithiums.
The Journal of organic chemistry 20040903
-
Synthesis of a new N-acetyl thiazolidinethione reagent and its application to a highly selective asymmetric acetate aldol reaction.
Organic letters 20040902
-
Concise asymmetric synthesis of (-)-sparteine.
Chemical communications (Cambridge, England) 20040821
-
Evaluation of (+)-sparteine-like diamines for asymmetric synthesis.
The Journal of organic chemistry 20040820
-
A short synthesis of (+/-)-cytisine.
Organic & biomolecular chemistry 20040707
-
Double ring-closing metathesis reaction of nitrogen-containing tetraenes: efficient construction of bicyclic alkaloid skeletons and synthetic application to four stereoisomers of lupinine and their derivatives.
Chemistry (Weinheim an der Bergstrasse, Germany) 20040705
-
A computational model relating structure and reactivity in enantioselective oxidations of secondary alcohols by (-)-sparteine-Pd(II) complexes.
Journal of the American Chemical Society 20040630
-
[Application of bisalkaloid derivatives of dicarboxylic acids based on lupinine, anabasine and cytisine as cholinesterase inhibitors of various origin].
Zhurnal evoliutsionnoi biokhimii i fiziologii 20040101
-
Palladium-catalyzed aerobic oxidative kinetic resolution of alcohols with an achiral exogenous base.
The Journal of organic chemistry 20030919
-
Mechanistic investigations of the palladium-catalyzed aerobic oxidative kinetic resolution of secondary alcohols using (-)-sparteine.
Journal of the American Chemical Society 20030611
-
Scope of enantioselective palladium(II)-catalyzed aerobic alcohol oxidations with (-)-sparteine.
The Journal of organic chemistry 20030530
-
Synthetic applications of lithiated N-Boc allylic amines as asymmetric homoenolate equivalents.
The Journal of organic chemistry 20030221
-
Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.
Journal of medicinal chemistry 20030102
-
Bisalkaloid derivatives of dicarboxylic acids on the basis of lupinine, anabasine, and cytisine as reversible cholinesterase inhibitors.
Doklady. Biochemistry and biophysics 20030101
-
A readily-accessible (+)-sparteine surrogate.
Journal of the American Chemical Society 20021009
-
Enantioselective synthesis of 2-substituted 2-phenylethylamines by lithiation-substitution sequences: synthetic development and mechanistic pathway.
The Journal of organic chemistry 20020920
-
Control of the conformational equilibria in aza-cis-decalins: structural modification, solvation, and metal chelation.
The Journal of organic chemistry 20020906
-
First asymmetric total synthesis of (+)-sparteine.
Organic letters 20020725
-
Practical and highly selective oxazolidinethione-based asymmetric acetate aldol reactions with aliphatic aldehydes.
Organic letters 20020627
-
Thesinine-4'-O-beta-D-glucoside the first glycosylated plant pyrrolizidine alkaloid from Borago officinalis.
Phytochemistry 20020601
-
Lobocyclamide B from Lyngbya confervoides. Configuration and asymmetric synthesis of beta-hydroxy-alpha-amino acids by (-)-sparteine-mediated aldol addition.
Organic letters 20020530
-
Conformational control of flexible molecules: design and synthesis of novel chiral 1,5-diaza-cis-decalins.
The Journal of organic chemistry 20020503
-
Bacterial removal of quinolizidine alkaloids and other carbon sources from a Lupinus albus aqueous extract.
Journal of agricultural and food chemistry 20020410
-
Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans.
Clinical pharmacology and therapeutics 20020401
-
An experimental and computational investigation of the enantioselective deprotonation of Boc-piperidine.
Journal of the American Chemical Society 20020306
-
Effect of growth hormone on hepatic cytochrome P450 activity in healthy elderly men.
Clinical pharmacology and therapeutics 20020301
-
Pharmacokinetics of therapeutic doses of tropisetron in healthy volunteers.
British journal of clinical pharmacology 20011201
-
Dose-dependent inhibition of the CYP2D6 catalyzed oxidation of sparteine by mepyramine in healthy volunteers.
Pharmacology & toxicology 20011201
-
Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test.
Clinical pharmacology and therapeutics 20011001
-
Indolizidine and quinolizidine alkaloids.
Natural product reports 20011001
-
Chiral diamines 4: a computational study of the enantioselective deprotonation of Boc-pyrrolidine with an alkyllithium in the presence of a chiral diamine.
Journal of the American Chemical Society 20010829
-
Absorption and disposition of levocetirizine, the eutomer of cetirizine, administered alone or as cetirizine to healthy volunteers.
Fundamental & clinical pharmacology 20010801
-
Influence of CYP2D6 genotype and medication on the sparteine metabolic ratio of psychiatric patients.
European journal of clinical pharmacology 20010701
-
Kinetics and mechanism of the (-)-sparteine-mediated deprotonation of (E)-N-Boc-N-(p-methoxyphenyl)-3-cyclohexylallylamine.
Journal of the American Chemical Society 20010530
-
Novel sparteine-mediated enantio-dichotomic formal synthesis of R-(-)- and S-(+)-curcuphenol.
The Journal of organic chemistry 20010420
-
Synthesis of enantiomerically enriched allenes by (-)-sparteine-mediated lithiation of alkynyl carbamates.
Organic letters 20010419
-
Moving toward genetic profiling in patient care: the scope and rationale of pharmacogenetic/ecogenetic investigation.
Drug metabolism and disposition: the biological fate of chemicals 20010401
-
2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine.
Farmaco (Societa chimica italiana : 1989) 20010301
-
Asymmetric aldol additions: use of titanium tetrachloride and (-)-sparteine for the soft enolization of N-acyl oxazolidinones, oxazolidinethiones, and thiazolidinethiones.
The Journal of organic chemistry 20010209
-
Immunolocalization of alkaloids and X-ray microanalysis of elements in lupin seeds.
Protoplasma 20010101
-
Drug metabolism and genetic polymorphism in subjects with previous halothane hepatitis.
Scandinavian journal of gastroenterology 19930801
-
Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal of natural products 19910101
-
Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.
Klinische Wochenschrift 19871215
-
Screening for new compounds with antiherpes activity.
Antiviral research 19841001
-
Antifibrillatory, cardiovascular and toxic effects of sparteine, butylsparteine and pentylsparteine.
Arzneimittel-Forschung 19800101
-
[Effect of sparteine sulfate on the predamaged conduction system of the heart].
Zeitschrift fur Kardiologie 19750501
