496-15-1 | Indoline

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$6.00	$4.00
10g	97%	in stock	$7.00	$5.00
25g	97%	in stock	$9.00	$6.00
100g	97%	in stock	$15.00	$11.00
500g	97%	in stock	$72.00	$51.00

Description

• Catalog Number: AI51093
• Chemical Name: Indoline
• CAS Number: 496-15-1
• Molecular Formula: C8H9N
• Molecular Weight: 119.1638
• MDL Number: MFCD00005705
• SMILES: C1CNC2=CC=CC=C21

Computed Properties

• Complexity: 101
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• XLogP3: 1.9

Upstream Synthesis Route

Indoline is a versatile compound that finds wide application in various fields of chemical synthesis. In the realm of pharmaceuticals, it serves as a key building block for the synthesis of numerous biologically active compounds. Its unique structure and reactivity make it a valuable intermediate in the production of various drugs and medicinal compounds.In organic synthesis, indoline plays a crucial role in the construction of complex molecular structures. Its scaffold is often used as a starting material for the synthesis of natural products, dyes, and advanced materials. Indoline derivatives can undergo various functionalizations, allowing chemists to create diverse chemical libraries for drug discovery and material science applications.Additionally, indoline derivatives are utilized in the synthesis of agrochemicals and specialty chemicals. Their ability to undergo diverse chemical transformations makes them valuable tools in the design and development of new compounds with specific properties and functions. In the field of materials science, indoline derivatives have been studied for their potential applications in optoelectronic devices, such as organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).Overall, the versatility and reactivity of indoline make it a valuable building block in chemical synthesis, with applications ranging from pharmaceuticals to materials science.

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• Asymmetric synthesis of indolines through intramolecular shifting of aromatic sulfinyl groups. Role of the pi,pi-stacking interactions in these unusual S(N)Ar processes.

  Journal of the American Chemical Society 20090708

• In vitro metabolism of the novel, highly selective oral angiogenesis inhibitor motesanib diphosphate in preclinical species and in humans.

  Drug metabolism and disposition: the biological fate of chemicals 20090701

• Thiourea-catalyzed highly enantio- and diastereoselective additions of oxindoles to nitroolefins: application to the formal synthesis of (+)-physostigmine.

  Journal of the American Chemical Society 20090701

• 5-Bromo-1-methyl-indolin-2-one.

  Acta crystallographica. Section E, Structure reports online 20090701

• 4'-(4-Methoxy-phen-yl)-1,1',1''-trimethyl-dispiro-[indoline-3,2'-pyrrolidine-3',3''-pyrrolidine]-2,2'',5''-trione.

  Acta crystallographica. Section E, Structure reports online 20090701

• 2-(4-{3-[1-(3-Bromo-prop-yl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-yl-idene]prop-1-en-yl}-3-cyano-5,5-dimethyl-2,5-dihydro-furan-2-yl-idene)malononitrile.

  Acta crystallographica. Section E, Structure reports online 20090601

• Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases.

  Organic & biomolecular chemistry 20090521

• Palladium-catalyzed highly diastereoselective oxidative cascade cyclization reactions.

  Organic letters 20090507

• Differentiating solvation mechanisms at polar solid/liquid interfaces.

  Journal of the American Chemical Society 20090506

• Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics.

  Journal of the American Chemical Society 20090408

• Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20090315

• Discovery of indoline-based, natural-product-like compounds as probes of focal adhesion kinase signaling pathways.

  Journal of combinatorial chemistry 20090309

• Dehydrogenation of the indoline-containing drug 4-chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (indapamide) by CYP3A4: correlation with in silico predictions.

  Drug metabolism and disposition: the biological fate of chemicals 20090301

• 1-(2,6-Dichloro-phen-yl)indolin-2-one.

  Acta crystallographica. Section E, Structure reports online 20090301

• Palladium-catalyzed annulation of haloanilines and halobenzamides using norbornadiene as an acetylene synthon: a route to functionalized indolines, isoquinolinones, and indoles.

  The Journal of organic chemistry 20090220

• Asymmetric C2-C3 cyclopentannulation of the indole ring.

  Journal of the American Chemical Society 20090218

• 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.

  Journal of medicinal chemistry 20090212

• Glycogen synthase kinase-3 inhibition by 3-anilino-4-phenylmaleimides: insights from 3D-QSAR and docking.

  Journal of computer-aided molecular design 20090201

• (Z)-3-[(E)-3-Phenyl-allyl-idene]indolin-2-one.

  Acta crystallographica. Section E, Structure reports online 20090201

• Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation.

  The Journal of biological chemistry 20090102

• Synthesis of 2-substituted indoles and indolines via Suzuki-Miyaura coupling/5-endo-trig cyclization strategies.

  The Journal of organic chemistry 20090102

• General approach to the total synthesis of 9-methoxy-substituted indole alkaloids: synthesis of mitragynine, as well as 9-methoxygeissoschizol and 9-methoxy-N(b)-methylgeissoschizol.

  The Journal of organic chemistry 20090102

• Structure-based CoMFA and CoMSIA study of indolinone inhibitors of PDK1.

  Journal of computer-aided molecular design 20090101

• Asymmetric radical and anionic cyclizations of axially chiral carbamates.

  Organic letters 20090101

• Highly efficient and regioselective platinum(II)-catalyzed tandem synthesis of multiply substituted indolines and tetrahydroquinolines.

  Angewandte Chemie (International ed. in English) 20090101

• A study of 3-substituted benzylidene-1,3-dihydro-indoline derivatives as antimicrobial and antiviral agents.

  Zeitschrift fur Naturforschung. C, Journal of biosciences 20090101

• Palladium-catalyzed amidation of unactivated C(sp(3))-H bonds: from anilines to indolines.

  Angewandte Chemie (International ed. in English) 20090101

• Catalytic enantioselective stereoablative alkylation of 3-halooxindoles: facile access to oxindoles with C3 all-carbon quaternary stereocenters.

  Angewandte Chemie (International ed. in English) 20090101

• Catalytic asymmetric 6pi electrocyclization: enantioselective synthesis of functionalized indolines.

  Angewandte Chemie (International ed. in English) 20090101

• Production of H2 from combined endothermic and exothermic hydrogen carriers.

  Journal of the American Chemical Society 20081217

• A high efficiency indoline-sensitized solar cell based on a nanocrystalline TiO(2) surface doped with copper.

  Nanotechnology 20081203

• Experimental and computational study on the molecular energetics of indoline and indole.

  The journal of physical chemistry. A 20081127

• In silico optimization of merocyanine-spiropyran compounds as second-order nonlinear optical molecular switches.

  Physical chemistry chemical physics : PCCP 20081107

• High-conversion-efficiency organic dye-sensitized solar cells with a novel indoline dye.

  Chemical communications (Cambridge, England) 20081107

• Building skeletally diverse architectures on the Indoline Scaffold: the discovery of a chemical probe of focal adhesion kinase signaling networks.

  Bioorganic & medicinal chemistry 20081101

• Ethyl 4'-ethenyl-2'-oxo-4-phenyl-2-(3,4,5-trimethoxy-phen-yl)spiro-[pyrrolidine-3,3'-indoline]-5-carboxyl-ate monohydrate.

  Acta crystallographica. Section E, Structure reports online 20081101

• 1-(3-Chloro-benz-yl)-5-iodo-indoline-2,3-dione.

  Acta crystallographica. Section E, Structure reports online 20081101

• Conversion efficiency versus sensitizer for electrospun TiO(2) nanorod electrodes in dye-sensitized solar cells.

  Nanotechnology 20081022

• Structure and orientation of puroindolines into wheat galactolipid monolayers.

  Langmuir : the ACS journal of surfaces and colloids 20081007

• Titanocene(III)-catalyzed formation of indolines and azaindolines.

  Organic letters 20081002

• Synthesis and biological evaluation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors.

  Journal of medicinal chemistry 20080911

• Synthesis and evaluation of indolinyl- and indolylphenylacetylenes as PET imaging agents for beta-amyloid plaques.

  Bioorganic & medicinal chemistry letters 20080901

• Novel synthesis of cinnolines and 1-aminoindolines via Cu-catalyzed intramolecular N-arylation of hydrazines and hydrazones prepared from 3-haloaryl-3-hydroxy-2-diazopropanoates.

  The Journal of organic chemistry 20080815

• Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.

  Journal of medicinal chemistry 20080814

• 5',6-Dichloro-1',3',3'-trimethyl-spiro-[2H-1-benzopyran-2,2'-indoline].

  Acta crystallographica. Section E, Structure reports online 20080801

• Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid.

  The Journal of organic chemistry 20080704

• Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction.

  Organic letters 20080703

• Facile and general synthesis of quaternary 3-aminooxindoles.

  Organic letters 20080703

• Electronic tera-order stabilization of photoinduced metastable species: structure of the photochromic product of spiropyran determined with in situ single crystal X-ray photodiffraction.

  The journal of physical chemistry. A 20080703

• 1-Acetyl-5,6-dimethoxy-indoline at 123 K.

  Acta crystallographica. Section E, Structure reports online 20080701

• Interplay of hydrogenation and dehydrogenation in isoindoline and indoline isomers: a density functional theory study.

  The journal of physical chemistry. A 20080612

• A highly sensitive and selective chemosensor for cyanide.

  Talanta 20080515

• Palladium-catalyzed intramolecular C-arylation of benzylic carbon: synthesis of 3-benzoxazolylisoindolinones by a sequence of Ugi-4CR/postfunctionalization.

  The Journal of organic chemistry 20080502

• Palladium-catalyzed sp(3) CH activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines.

  Organic letters 20080501

• 1-Allyl-3,3-di-p-tolyl-indolin-2-one.

  Acta crystallographica. Section E, Structure reports online 20080501

• Free radical-mediated aryl amination: convergent two- and three-component couplings to chiral 2,3-disubstituted indolines.

  The Journal of organic chemistry 20080418

• Preparation of the isomeric azaindoline family by intramolecular carbolithiation.

  Organic letters 20080320

• A new route to indolines by the Cu-catalyzed cyclization reaction of 2-ethynylanilines with sulfonyl azides.

  Organic letters 20080320

• CYP2D6-Mediated metabolism of a novel acyl coenzyme A:cholesterol acyltransferase inhibitor, pactimibe, and its unique plasma metabolite, R-125528.

  Drug metabolism and disposition: the biological fate of chemicals 20080301

• Studies on the SAR and pharmacophore of milnacipran derivatives as monoamine transporter inhibitors.

  Bioorganic & medicinal chemistry letters 20080215

• Orthogonal synthesis of indolines and isoquinolines via aryne annulation.

  Journal of the American Chemical Society 20080206

• Organic dye-sensitized ionic liquid based solar cells: remarkable enhancement in performance through molecular design of indoline sensitizers.

  Angewandte Chemie (International ed. in English) 20080101

• Reagent-based, modular, tandem Michael approach for obtaining different indoline alkaloid-inspired polycyclic architectures.

  Journal of combinatorial chemistry 20080101

• Gold-catalyzed synthesis of chroman, dihydrobenzofuran, dihydroindole, and tetrahydroquinoline derivatives.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Synthesis of indolines and tetrahydroisoquinolines from arylethylamines by Pd(II)-catalyzed C-H activation reactions.

  Angewandte Chemie (International ed. in English) 20080101

• Anionic-anionic asymmetric tandem reactions: one-pot synthesis of optically pure fluorinated indolines from 2-p-tolylsulfinyl alkylbenzenes.

  Angewandte Chemie (International ed. in English) 20080101

• Efficient singlet-state deactivation of cyano-substituted indolines in protic solvents via CN--HO hydrogen bonds.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20071221

• Design, structure-activity relationship, and pharmacokinetic profile of pyrazole-based indoline factor Xa inhibitors.

  Bioorganic & medicinal chemistry letters 20071201

• Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

  Bioorganic & medicinal chemistry letters 20071201

• One-pot cyclization of 2-aminophenethyl alcohols: a novel and direct approach to the synthesis of N-acyl indolines.

  The Journal of organic chemistry 20071123

• 5'-Phenyl-3'H-spiro[indoline-3,2'-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (aggrecanase-2).

  Bioorganic & medicinal chemistry letters 20071015

• Catalytic activation of the leaving group in the S(N)2 reaction.

  Organic letters 20070927

• 1'-Methylcyclooctane-1-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-2,2''-dione and 1,1'-dimethylpiperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-2'',4-dione.

  Acta crystallographica. Section C, Crystal structure communications 20070901

• Acido-triggered nonlinear optical switches: benzazolo-oxazolidines.

  The journal of physical chemistry. B 20070823

• Strategies for the synthesis of 2-substituted indoles and indolines starting from acyclic alpha-phosphoryloxy enecarbamates.

  Organic letters 20070816

• Dehydrogenation of indoline by cytochrome P450 enzymes: a novel 'aromatase' process.

  The Journal of pharmacology and experimental therapeutics 20070801

• Practical synthesis of 7-prenylindole.

  The Journal of organic chemistry 20070720

• Synthesis of substituted 1,2-dihydroquinolines and quinolines from aromatic amines and alkynes by gold(I)-catalyzed tandem hydroamination-hydroarylation under microwave-assisted conditions.

  Organic letters 20070705

• Synthesis and properties of novel porphyrin spin probes containing isoindoline nitroxides.

  Free radical biology & medicine 20070701

• Selective inhibition of carboxylesterases by isatins, indole-2,3-diones.

  Journal of medicinal chemistry 20070419

• Polyhydroxylated indolines and oxindoles from C-glycosides via sequential Henry reaction, Michael addition, and reductive amination/amidation.

  The Journal of organic chemistry 20070330

• Indoline derivatives II: synthesis and factor Xa (FXa) inhibitory activities.

  Chemical & pharmaceutical bulletin 20070301

• Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors.

  Bioorganic & medicinal chemistry 20070115

• Non-metathesis reactions of ruthenium carbene catalysts and their application to the synthesis of nitrogen-containing heterocycles.

  Chemical record (New York, N.Y.) 20070101

• New procedure to mask the 2,3-pi bond of the indole nucleus and its application to the preparation of potent opioid receptor agonists with a Corynanthe skeleton.

  Organic letters 20061207

• Exploration of the diketoacid integrase inhibitor chemotype leading to the discovery of the anilide-ketoacids chemotype.

  Bioorganic & medicinal chemistry letters 20061115

• Kinetic resolutions of indolines by a nonenzymatic acylation catalyst.

  Journal of the American Chemical Society 20061108

• Studies in sigmatropic rearrangements of N-prenylindole derivatives--a formal enantiomerically pure synthesis of tryprostatin B.

  Organic & biomolecular chemistry 20061107

• Biophysical characterization of an indolinone inhibitor in the ATP-binding site of DNA gyrase.

  Biochemical and biophysical research communications 20061103

• DNA interstrand crosslinking agents: synthesis, DNA interactions, and cytotoxicity of dimeric achiral seco-amino-CBI and conjugates of achiral seco-amino-CBI with pyrrolobenzodiazepine (PBD).

  Bioorganic & medicinal chemistry letters 20061101

• A metal-free approach to the synthesis of indoline derivatives by a phenyliodine(III) bis(trifluoroacetate)-mediated amidohydroxylation reaction.

  The Journal of organic chemistry 20061013

• [Asymmetric intramolecular conjugate addition of chiral enolates via non-equilibrium].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20060801

• [Recent advances in the study of pharmacological activities and solid-phase synthesis of indoles and their analogues].

  Yao xue xue bao = Acta pharmaceutica Sinica 20060801

• A phase I study with oral SU5416 in patients with advanced solid tumors: a drug inducing its clearance.

  Investigational new drugs 20060701

• 2-thioindoles as precursors to spiro-fused indolines: synthesis of (+/-)-dehaloperophoramidine.

  Angewandte Chemie (International ed. in English) 20060626

• Efficient synthesis of achiral seco-cyclopropylbenz[2,3-e]indoline analogues: [4-amino-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl chloride and [4-hydroxy-2-(5,6,7-trimethoxyindole-2-carboxamido)naphthalen-1-yl]ethyl chloride.

  The Journal of organic chemistry 20060609

• Preparation of 7-Halo-indoles by Thallation of N-formylindoline and their attempted use for synthesis of the right-hand segment of chloropeptin.

  Chemical & pharmaceutical bulletin 20060601

• Synthesis of tricyclic pyrano[2,3-e]isoindolin-3-ones as the core structure of stachybotrin A, B, and C.

  Chemical communications (Cambridge, England) 20060514

• Design and synthesis of 8-octyl-benzolactam-V9, a selective activator for protein kinase C epsilon and eta.

  Journal of medicinal chemistry 20060504

• Pd(II)-catalyzed enantioselective oxidative tandem cyclization reactions. Synthesis of indolines through C-N and C-C bond formation.

  Journal of the American Chemical Society 20060315

• Indoline derivatives I: synthesis and factor Xa (FXa) inhibitory activities.

  Chemical & pharmaceutical bulletin 20060201

• Chromogenic oxazines for cyanide detection.

  The Journal of organic chemistry 20060120

• Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives.

  European journal of medicinal chemistry 20060101

• Solution- and solid-phase, modular approaches for obtaining different natural product-like polycyclic architectures from an aminoindoline scaffold for combinatorial chemistry.

  Journal of combinatorial chemistry 20060101

• Synergistic effects on escape of a ligand from the closed tryptophan synthase bienzyme complex.

  Biochemistry 20051227

• Scope and mechanistic study of the ruthenium-catalyzed ortho-C-H bond activation and cyclization reactions of arylamines with terminal alkynes.

  Journal of the American Chemical Society 20051207

• Inhibitors of tripeptidyl peptidase II. 3. Derivation of butabindide by successive structure optimizations leading to a potential general approach to designing exopeptidase inhibitors.

  Journal of medicinal chemistry 20051117

• Synthesis, structure and DNA interaction of cobalt(III) bis-complexes of 1,3-bis(2-pyridylimino)isoindoline and 1,4,7-triazacyclononane.

  Journal of inorganic biochemistry 20051101

• A domino amidation route to indolines and indoles: rapid syntheses of anhydrolycorinone, hippadine, oxoassoanine, and pratosine.

  Organic letters 20051013

• Fast and stable photochromic oxazines.

  The Journal of organic chemistry 20050930

• Indole- and indoline-based kainate analogues with antagonist activity at ionotropic glutamate receptors.

  Bioorganic & medicinal chemistry letters 20050901

• Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their beta1-, beta2-adrenergic receptor binding studies.

  Bioorganic chemistry 20050801

• Scavenging of reactive oxygen species by novel indolin-2-one and indoline-2-thione derivatives.

  Biopolymers 20050701

• Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles.

  The Journal of organic chemistry 20050624

• Prediction of genotoxicity of chemical compounds by statistical learning methods.

  Chemical research in toxicology 20050601

• Design and synthesis of subtype-selective cyclooxygenase (COX) inhibitors derived from thalidomide.

  Bioorganic & medicinal chemistry 20050502

• Molecular diversity via amino acid derived alpha-amino nitriles: synthesis of spirocyclic 2,6-dioxopiperazine derivatives.

  The Journal of organic chemistry 20050429

• A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline.

  Organic letters 20050303

• Solvent-dependent vibrational frequencies and reorganization energies of two merocyanine chromophores.

  The journal of physical chemistry. A 20050303

• Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides.

  Bioorganic & medicinal chemistry 20050301

• Stereocontrolled solid-phase synthesis of a 90-membered library of indoline-alkaloid-like polycycles from an enantioenriched aminoindoline scaffold.

  Angewandte Chemie (International ed. in English) 20050218

• Regio- and stereoselective synthesis of isoindolin-1-ones via electrophilic cyclization.

  The Journal of organic chemistry 20050218

• Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

  Bioorganic & medicinal chemistry letters 20050201

• The diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates.

  The Journal of organic chemistry 20050121

• Asymmetric synthesis of a prostaglandin D2 receptor antagonist.

  The Journal of organic chemistry 20050107

• Regioselective glycosylation: synthesis of alpha-indoline nucleosides.

  Nucleosides, nucleotides & nucleic acids 20050101

• Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists.

  Bioorganic & medicinal chemistry letters 20041220

• The design and enzyme-bound crystal structure of indoline based peptidomimetic inhibitors of hepatitis C virus NS3 protease.

  Journal of medicinal chemistry 20041216

• Asymmetric synthesis of pyrrolidinoindolines. Application for the practical total synthesis of (-)-phenserine.

  Journal of the American Chemical Society 20041103

• Conformational insights into furo- and thieno[2,3-b]indolines derived from coupling constants and molecular modeling.

  Magnetic resonance in chemistry : MRC 20041101

• High efficiency of dye-sensitized solar cells based on metal-free indoline dyes.

  Journal of the American Chemical Society 20041006

• A new indolinepeptide from Paecilomyces sp. J300.

  Archives of pharmacal research 20040601

• Synthesis of phakellistatin 13 and oxidation to phakellistatin 3 and isophakellistatin 3.

  Organic letters 20040527

• Indoline derivatives as 5-HT(2C) receptor agonists.

  Bioorganic & medicinal chemistry letters 20040503

• Synthesis and evaluation of some new spiro indoline-based heterocycles as potentially active antimicrobial agents.

  Bioorganic & medicinal chemistry 20040501

• Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.

  Acta crystallographica. Section D, Biological crystallography 20040401

• Novel non-peptidic neuropeptide Y Y2 receptor antagonists.

  Bioorganic & medicinal chemistry letters 20040308

• Spirobipyridopyrans, spirobinaphthopyrans, indolinospiropyridopyrans, indolinospironaphthopyrans and indolinospironaphtho-1,4-oxazines: synthesis, study of X-ray crystal structure, antitumoral and antiviral evaluation.

  Bioorganic & medicinal chemistry 20040301

• Unexpected syntheses of seco-cyclopropyltetrahydroquinolines - from a radical 5-exo-trig cyclization reaction: analogs of CC-1065 and the duocarmycins.

  Molecules (Basel, Switzerland) 20040227

• Highly-efficient metal-free organic dyes for dye-sensitized solar cells.

  Chemical communications (Cambridge, England) 20031221

• Aptamers switch on fluorescence of triphenylmethane dyes.

  Journal of the American Chemical Society 20031203

• The effect of remote chirality on the antibacterial activity of indolinyl, tetrahydroquinolyl and dihydrobenzoxazinyl oxazolidinones.

  Bioorganic & medicinal chemistry letters 20031201

• A convergent synthetic approach to the nucleoside-type liposidomycin antibiotics.

  Organic letters 20031016

• Stereospecific construction of contiguous quaternary and tertiary stereocenters by rearrangement from indoline-2-methanol to 2,2,3-trisubstituted tetrahydroquinoline: application to an efficient total synthesis of natural virantmycin.

  Angewandte Chemie (International ed. in English) 20030606

• Total synthesis of the duocarmycins.

  Journal of the American Chemical Society 20030604

• Preparation and pharmacological profile of 7-(alpha-azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors.

  Bioorganic & medicinal chemistry letters 20030505

• Cardioselective anti-ischemic ATP-sensitive potassium channel (KATP) openers: benzopyranyl indoline and indole analogues.

  European journal of medicinal chemistry 20030501

• Synthesis of 6H-pyrrolo[3',4':2,3][1,4]diazepino[6,7,1-hi]indole-8,10(7H,9H)-diones using 3-bromo-4-(indol-1-yl)maleimide scaffold.

  Organic & biomolecular chemistry 20030307

• Sulfur ylide-initiated thio-claisen rearrangements. The synthesis of highly substituted indolines.

  The Journal of organic chemistry 20030207

• Novel strategies for the solid phase synthesis of substituted indolines and indoles.

  Bioorganic & medicinal chemistry 20030206

• The reaction of cyclic carbinol amides with triflic anhydride as a method to prepare alpha-trifluoromethyl-sulfonamido furans.

  Organic letters 20030123

• Free radical-mediated aryl amination and its use in a convergent [3 + 2] strategy for enantioselective indoline alpha-amino acid synthesis.

  Journal of the American Chemical Society 20030108

• Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.

  Bioorganic & medicinal chemistry letters 20021104

• Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.

  Bioorganic & medicinal chemistry letters 20021104

• Novel furano analogues of duocarmycin C1 and C2: design, synthesis, and biological evaluation of seco-iso-cyclopropylfurano[2,3-e]indoline (seco-iso-CFI) and seco-cyclopropyltetrahydrofurano[2,3-f]quinoline (seco-CFQ) analogues.

  Bioorganic & medicinal chemistry 20020901

• A convergent approach to 3-substituted-5-methoxyindoles. Application to the synthesis of melatonin [correction].

  Chemical communications (Cambridge, England) 20020821

• Intermediate trapping via a conformational switch in the Na(+)-activated tryptophan synthase bienzyme complex.

  Biochemistry 20020806

• A new strychnobrasiline base of Strychnos mattogrossensis.

  Natural product letters 20020801

• Nature of non-radiative processes involved in the excited state of 9-cyanoanthracene in presence of 2-methylindole/2-methylindoline quenchers. A laser flash photolysis study to reveal the medium effects.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020601

• Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline.

  Journal of natural products 20020401

• Erythropoietin mimetics derived from solution phase combinatorial libraries.

  Journal of the American Chemical Society 20020130

• Theoretical elucidation on structure-antioxidant activity relationships for indolinonic hydroxylamines.

  Bioorganic & medicinal chemistry letters 20020121

• Design, synthesis, and biological activity of diiminoisoindolines as complement component 3a antagonists.

  Bioorganic & medicinal chemistry letters 20011105

• Multiple mutations at the active site of naphthalene dioxygenase affect regioselectivity and enantioselectivity.

  Journal of industrial microbiology & biotechnology 20010801

• The discovery of linezolid, the first oxazolidinone antibacterial agent.

  Current drug targets. Infectious disorders 20010801

• Asymmetric synthesis of novel isoindolines: azasaccharide mimics as potential enzyme inhibitors.

  The Journal of pharmacy and pharmacology 20010701

• Beta D305A mutant of tryptophan synthase shows strongly perturbed allosteric regulation and substrate specificity.

  Biochemistry 20010626

• A new and general synthetic pathway to strychnos indole alkaloids: total syntheses of (-)-dehydrotubifoline and (-)-tubifoline by palladium-catalyzed asymmetric allylic substitution.

  Organic letters 20010614

• A novel series of thromboxane A2 synthetase inhibitors with free radical scavenging and anti-peroxidative activities.

  Chemical & pharmaceutical bulletin 20010501

• N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.

  Bioorganic & medicinal chemistry letters 20010326

• 1-Nitroindoline.

  Acta crystallographica. Section C, Crystal structure communications 20010301

• Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.

  Bioorganic & medicinal chemistry letters 20010212

• Trapping of the putative cationic intermediate in the Morin rearrangement with carbon nucleophiles.

  The Journal of organic chemistry 20010209

• [[Intramolecular alkylation of aromatic compounds. 35. Di- and tetrahydropyridinemethylindolines as potential precursors of ergolines] ].

  Die Pharmazie 20010101