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Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol.
Toxicology and applied pharmacology 20180915
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Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.
Toxicology letters 20180601
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Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats.
Toxicology letters 20170205
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Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms.
The journals of gerontology. Series A, Biological sciences and medical sciences 20160601
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Resveratrol via sirtuin-1 downregulates RE1-silencing transcription factor (REST) expression preventing PCB-95-induced neuronal cell death.
Toxicology and applied pharmacology 20151101
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BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses.
Chembiochem : a European journal of chemical biology 20150901
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Resveratrol improves hepatic steatosis by inducing autophagy through the cAMP signaling pathway.
Molecular nutrition & food research 20150801
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Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.
Nature medicine 20150501
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Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis.
The Journal of physiology 20150415
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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Cell metabolism 20141104
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Discovery of potent and selective sirtuin 2 (SIRT2) inhibitors using a fragment-based approach.
Journal of medicinal chemistry 20141023
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Non-specific SIRT inhibition as a mechanism for the cytotoxicity of ginkgolic acids and urushiols.
Toxicology letters 20140902
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SIRT1 inhibition restores apoptotic sensitivity in p53-mutated human keratinocytes.
Toxicology and applied pharmacology 20140615
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Des-acyl ghrelin protects microvascular endothelial cells from oxidative stress-induced apoptosis through sirtuin 1 signaling pathway.
Metabolism: clinical and experimental 20140401
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Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease.
Basic & clinical pharmacology & toxicology 20140201
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Sesamin ameliorates doxorubicin-induced cardiotoxicity: involvement of Sirt1 and Mn-SOD pathway.
Toxicology letters 20140113
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Resveratrol differentially regulates NAMPT and SIRT1 in Hepatocarcinoma cells and primary human hepatocytes.
PloS one 20140101
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Resveratrol induces a mitochondrial complex I-dependent increase in NADH oxidation responsible for sirtuin activation in liver cells.
The Journal of biological chemistry 20131220
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Resveratrol suppresses the STAT3 signaling pathway and inhibits proliferation of high glucose-exposed HepG2 cells partly through SIRT1.
Oncology reports 20131201
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Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway.
Autophagy 20131201
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Identification of potent Yes1 kinase inhibitors using a library screening approach.
Bioorganic & medicinal chemistry letters 20130801
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Age-associated changes in gene expression and developmental competence of bovine oocytes, and a possible countermeasure against age-associated events.
Molecular reproduction and development 20130701
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Resveratrol protects HUVECs from oxidized-LDL induced oxidative damage by autophagy upregulation via the AMPK/SIRT1 pathway.
Cardiovascular drugs and therapy 20130601
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Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
Journal of medicinal chemistry 20130509
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SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging.
Biochemical pharmacology 20130501
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Resveratrol improves cardiomyopathy in dystrophin-deficient mice through SIRT1 protein-mediated modulation of p300 protein.
The Journal of biological chemistry 20130222
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Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice.
Free radical biology & medicine 20130101
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Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress.
PloS one 20130101
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Activation of SIRT1 protects pancreatic β-cells against palmitate-induced dysfunction.
Biochimica et biophysica acta 20121101
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Role of deleted in breast cancer 1 (DBC1) protein in SIRT1 deacetylase activation induced by protein kinase A and AMP-activated protein kinase.
The Journal of biological chemistry 20120706
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Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.
Journal of medicinal chemistry 20120628
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Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway.
Acta pharmacologica Sinica 20120501
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SIRT1 overexpression decreases cisplatin-induced acetylation of NF-κB p65 subunit and cytotoxicity in renal proximal tubule cells.
Biochemical and biophysical research communications 20120309
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Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.
Vascular pharmacology 20120101
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Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: a possible cause for reduced osteogenesis and increased adipogenesis in older individuals.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20111101
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SIRT1 overexpression in the rheumatoid arthritis synovium contributes to proinflammatory cytokine production and apoptosis resistance.
Annals of the rheumatic diseases 20111001
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SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.
American journal of physiology. Renal physiology 20110801
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After the grape rush: sirtuins as epigenetic drug targets in neurodegenerative disorders.
Bioorganic & medicinal chemistry 20110615
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The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin.
Diabetes 20110401
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Fructose induces gluconeogenesis and lipogenesis through a SIRT1-dependent mechanism.
The Journal of endocrinology 20110301
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Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.
The Journal of biological chemistry 20110225
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Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.
Molecular bioSystems 20110101
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Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells.
PloS one 20110101
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Resveratrol prevents RANKL-induced osteoclast differentiation of murine osteoclast progenitor RAW 264.7 cells through inhibition of ROS production.
Biochemical and biophysical research communications 20101022
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SIRT1 modulates expression of matrix metalloproteinases in human dermal fibroblasts.
The British journal of dermatology 20101001
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Acetylation of tau inhibits its degradation and contributes to tauopathy.
Neuron 20100923
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Agrp neurons mediate Sirt1's action on the melanocortin system and energy balance: roles for Sirt1 in neuronal firing and synaptic plasticity.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20100901
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Early apoptotic vascular signaling is determined by Sirt1 through nuclear shuttling, forkhead trafficking, bad, and mitochondrial caspase activation.
Current neurovascular research 20100501
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SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
Molecular cancer therapeutics 20100401
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N(epsilon)-thioacetyl-lysine-containing tri-, tetra-, and pentapeptides as SIRT1 and SIRT2 inhibitors.
Journal of medicinal chemistry 20090409
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Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.
Journal of medicinal chemistry 20080814
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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.
Molecular and cellular biology 20060101
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Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1.
Journal of medicinal chemistry 20051215
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The Sir2 family of protein deacetylases.
Annual review of biochemistry 20040101