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Hinokitiol induces autophagy in murine breast and colorectal cancer cells.
Environmental toxicology 20160101
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Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors.
ACS medicinal chemistry letters 20130808
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The furan route to tropolones: probing the antiproliferative effects of β-thujaplicin analogs.
Organic & biomolecular chemistry 20121121
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Synthesis and electrochemistry of organometallic cobaltadithiaazulenes.
Inorganic chemistry 20121015
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In vitro and in vivo anti-plasmodial activity of essential oils, including hinokitiol.
The Southeast Asian journal of tropical medicine and public health 20120301
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Topical hypopigmenting agents for pigmentary disorders and their mechanisms of action.
Annals of dermatology 20120201
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Effects of a combination of hinokitiol (β-thujaplicin) and an organic acid mixture on ruminal fermentation in heifers fed a high-grain diet.
Animal science journal = Nihon chikusan Gakkaiho 20120101
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Preventive effects of β-thujaplicin against UVB-induced MMP-1 and MMP-3 mRNA expressions in skin fibroblasts.
The American journal of Chinese medicine 20120101
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In vitro and in vivo therapeutics of β-thujaplicin on LPS-induced inflammation in macrophages and septic shock in mice.
International journal of immunopathology and pharmacology 20120101
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A 13-week subchronic toxicity study of hinokitiol administered in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801
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trans-Bis(hinokitiolato)copper(II) trans-bis(hinokitiolato)palladium(II) cocrystals with (5/1) and (3/2) formulations.
Acta crystallographica. Section C, Crystal structure communications 20110401
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Identifying chelators for metalloprotein inhibitors using a fragment-based approach.
Journal of medicinal chemistry 20110127
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The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.
International journal of molecular sciences 20110101
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Cytoplasmic Skp2 expression is increased in human melanoma and correlated with patient survival.
PloS one 20110101
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Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts, supported by scanning electron microscopy.
Parasites & vectors 20110101
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Effect of oral care gel on the quality of life for oral lichen planus in patients with chronic HCV infection.
Virology journal 20110101
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Inhibitory effects of hinokitiol on tyrosinase activity and melanin biosynthesis and its antimicrobial activities.
Journal of enzyme inhibition and medicinal chemistry 20101201
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Structural insights into the hot spot amino acid residues of mushroom tyrosinase for the bindings of thujaplicins.
Bioorganic & medicinal chemistry 20101115
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Bioorganic & medicinal chemistry letters 20101101
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Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture.
PLoS pathogens 20101101
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catena-Poly[(μ(3)-2-hy-droxy-4-isopropyl-cyclo-hepta-2,4,6-trien-1-onato)(μ(2)-2-hy-droxy-4-isopropyl-cyclo-hepta-2,4,6-trien-1-onato)lead(II)].
Acta crystallographica. Section E, Structure reports online 20101101
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A urea adduct of bis(hinokitiolato)copper(II).
Acta crystallographica. Section C, Crystal structure communications 20101001
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Bis(hinokitiolato)copper(II): modification (III).
Acta crystallographica. Section C, Crystal structure communications 20100601
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Hinokitiol activates the hypoxia-inducible factor (HIF) pathway through inhibition of HIF hydroxylases.
Biochemical and biophysical research communications 20100528
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Non-classical anticancer agents: synthesis and biological evaluation of zinc(II) heteroleptic complexes.
Dalton transactions (Cambridge, England : 2003) 20100507
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In vitro skin permeation of hinokitiol loaded in vesicles composed of behenyltrimethylammonium chloride and stearic acid.
Drug development and industrial pharmacy 20100501
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Time-kill assay results for a linalool-hinokitiol-based eyelid cleanser for lid hygiene.
Cornea 20100501
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Synthesis of tropolone derivatives and evaluation of their in vitro neuroprotective activity.
European journal of medicinal chemistry 20100301
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Zinc-dependent effects of small molecules on the insulin-sensitive transcription factor FOXO1a and gluconeogenic genes.
Metallomics : integrated biometal science 20100301
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Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells.
BMC biology 20100101
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p27-Associated G1 arrest induced by hinokitiol in human malignant melanoma cells is mediated via down-regulation of pRb, Skp2 ubiquitin ligase, and impairment of Cdk2 function.
Cancer letters 20091228
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Antimicrobial activity of fullerenes and their hydroxylated derivatives.
Biocontrol science 20090601
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Volatile and non-volatile monoterpenes produced by elicitor-stimulated Cupressus lusitanica cultured cells.
Journal of plant physiology 20090501
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High-performance liquid chromatography with dual-wavelength ultraviolet detection for measurement of hinokitiol in personal care products.
Journal of cosmetic science 20090101
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Harnessing gene expression to identify the genetic basis of drug resistance.
Molecular systems biology 20090101
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High production of beta-thujaplicin glycosides by immobilized plant cells of Nicotiana tabacum.
Acta biologica Hungarica 20080901
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In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(epsilon-caprolacton) nanocapsules.
Journal of microencapsulation 20080801
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Antifungal properties of ethanolic extract and its active compounds from Calocedrus macrolepis var. formosana (Florin) heartwood.
Bioresource technology 20080701
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Hinokitiol, a natural tropolone derivative, inhibits TNF-alpha production in LPS-activated macrophages via suppression of NF-kappaB.
Planta medica 20080601
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Antifungal mechanism of hinokitiol against Candida albicans.
Biological & pharmaceutical bulletin 20080401
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In vitro permeation study of hinokitiol: effects of vehicles and enhancers.
Drug delivery 20080101
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The mechanism of the bactericidal activity of hinokitiol.
Biocontrol science 20070901
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Growth inhibitory effect of shelf life extending agents on Bacillus subtilis IAM 1026.
Biocontrol science 20070601
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UV-visible and 1H or 13C NMR spectroscopic studies on the specific interaction between lithium ions and the anion from tropolone or 4-isopropyltropolone (hinokitiol) and on the formation of protonated tropolones in acetonitrile or other solvents.
The journal of physical chemistry. B 20070222
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Baicalein induction of hydroxyl radical formation via 12-lipoxygenase in human platelets: an ESR study.
Journal of agricultural and food chemistry 20070207
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Reactive oxygen species, nitric oxide, and their interactions play different roles in Cupressus lusitanica cell death and phytoalexin biosynthesis.
The New phytologist 20070101
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Hinokitiol, a metal chelator derived from natural plants, suppresses cell growth and disrupts androgen receptor signaling in prostate carcinoma cell lines.
Biochemical and biophysical research communications 20061208
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Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.
Journal of molecular graphics & modelling 20061101
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Lack of hinokitiol (beta-thujaplicin) carcinogenicity in F344/DuCrj rats.
The Journal of toxicological sciences 20061001
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Differential regulation of melanosomal proteins after hinokitiol treatment.
Journal of dermatological science 20060901
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The excellence of Aomori Hiba (Hinokiasunaro) in its use as building materials of Buddhist temples and Shinto shrines.
Biocontrol science 20060601
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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Preferential inhibition of the magnesium-dependent strand transfer reaction of HIV-1 integrase by alpha-hydroxytropolones.
Molecular pharmacology 20060401
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Therapeutic effects of beta-thujaplicin eardrops on canine Malassezia-related otitis externa.
The Journal of veterinary medical science 20060401
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Searching for a new anti-HCV therapy: synthesis and properties of tropolone derivatives.
Biochemical and biophysical research communications 20060310
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Signal transduction and metabolic flux of beta-thujaplicin and monoterpene biosynthesis in elicited Cupressus lusitanica cell cultures.
Metabolic engineering 20060101
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Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species.
Biological & pharmaceutical bulletin 20060101
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Arachidonate 12-lipoxygenases with reference to their selective inhibitors.
Biochemical and biophysical research communications 20051209
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Inhibitory effects of 4-n-butylresorcinol on tyrosinase activity and melanin synthesis.
Biological & pharmaceutical bulletin 20051201
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Prooxidant action of hinokitiol: hinokitiol-iron dependent generation of reactive oxygen species.
Basic & clinical pharmacology & toxicology 20051201
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Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa.
The Journal of veterinary medical science 20051201
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Mosquito larvicidal activity of active constituent derived from Chamaecyparis obtusa leaves against 3 mosquito species.
Journal of the American Mosquito Control Association 20051201
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Oxidative stress in plant cell culture: a role in production of beta-thujaplicin by Cupresssus lusitanica suspension culture.
Biotechnology and bioengineering 20050605
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Acaricidal activity of active constituent isolated in Chamaecyparis obtusa leaves against Dermatophagoides spp.
Journal of agricultural and food chemistry 20050323
-
Fungal diversity from western redcedar fences and their resistance to beta-thujaplicin.
Antonie van Leeuwenhoek 20050201
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Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones.
Nucleic acids research 20050101
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Interaction of silver nanoparticles with HIV-1.
Journal of nanobiotechnology 20050101
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Biological activity of beta-dolabrin, gamma-thujaplicin, and 4-acetyltropolone, hinokitiol-related compounds.
Biological & pharmaceutical bulletin 20041001
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Biological activity of alpha-thujaplicin, the isomer of hinokitiol.
Biological & pharmaceutical bulletin 20040601
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Rapid accumulation and metabolism of polyphosphoinositol and its possible role in phytoalexin biosynthesis in yeast elicitor-treated Cupressus lusitanica cell cultures.
Planta 20040501
-
Jasmonate and ethylene signalling and their interaction are integral parts of the elicitor signalling pathway leading to beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.
Journal of experimental botany 20040501
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Beta-thujaplicin: new quantitative CZE method and adsorption to goethite.
Journal of agricultural and food chemistry 20040324
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Evaluation of developmental toxicity of beta-thujaplicin (hinokitiol) following oral administration during organogenesis in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040301
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(-)-Epigallocatechin-3-gallate and hinokitiol reduce melanin synthesis via decreased MITF production.
Archives of pharmacal research 20040301
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Synthesis and structural characterization of silver(I), aluminium(III) and cobalt(II) complexes with 4-isopropyltropolone (hinokitiol) showing noteworthy biological activities. Action of silver(I)-oxygen bonding complexes on the antimicrobial activities.
Journal of inorganic biochemistry 20040101
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Transmission electron microscopy of Schistosoma mansoni cercariae treated with hinokitiol (beta-thujaplicin), a compound for potential skin application against cercarial penetration.
The Tohoku journal of experimental medicine 20040101
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Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines.
Anticancer research 20040101
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[Antimicrobial activity of hinokitiol against Legionella pneumophila].
Journal of UOEH 20031201
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Biological activity of tropolone.
Biological & pharmaceutical bulletin 20031001
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Generation of reactive oxygen species from Hinokitiol under near-UV irradiation.
Bioscience, biotechnology, and biochemistry 20030901
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Multiple signalling pathways mediate fungal elicitor-induced beta-thujaplicin biosynthesis in Cupressus lusitanica cell cultures.
Journal of experimental botany 20030201
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Antibacterial effect of beta-thujaplicin on staphylococci isolated from atopic dermatitis: relationship between changes in the number of viable bacterial cells and clinical improvement in an eczematous lesion of atopic dermatitis.
The Journal of antimicrobial chemotherapy 20030101
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Biological activity of 4-acetyltropolone, the minor component of Thujopsis dolabrata SIeb. et Zucc. hondai Mak.
Biological & pharmaceutical bulletin 20020801
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Feedback regulation of beta-thujaplicin production and formation of its methyl ether in a suspension culture of Cupressus lusitanica.
Phytochemistry 20020701
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New lanostanoids, elfvingic acids A-H, from the fruit body of Elfvingia applanata.
Journal of natural products 20020401
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Fungicidal activity of beta-thujaplicin analogues.
Pest management science 20010901
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Synthesis and structural characterization of tin(II) and zinc(II) derivatives of cyclic alpha-hydroxyketones, including the structures of Sn(maltol)(2), Sn(tropolone)(2), Zn(tropolone)(2), and Zn(hinokitiol)(2).
Inorganic chemistry 20010813
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Cytotoxic effects of beta-thujaplicin on rat thymocytes and prevention by the compound in tributyltin-induced thymocyte damage.
Bulletin of environmental contamination and toxicology 20010701
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Biological activity of alpha-thujaplicin, the minor component of Thujopsis dolabrata SIEB. et ZUCC. var. hondai MAKINO.
Biological & pharmaceutical bulletin 20010601
-
Production of beta-thujaplicin in Cupressus lusitanica suspension cultures fed with organic acids and monoterpenes.
Bioscience, biotechnology, and biochemistry 20010501
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Improved beta-thujaplicin production in Cupressus lusitanica suspension cultures by fungal elicitor and methyl jasmonate.
Applied microbiology and biotechnology 20010401
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Cytotoxicity of the hinokitiol-related compounds, gamma-thujaplicin and beta-dolabrin.
Biological & pharmaceutical bulletin 20010301
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Induction of apoptosis by hinokitiol, a potent iron chelator, in teratocarcinoma F9 cells is mediated through the activation of caspase-3.
Cell proliferation 19990201
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Thujaplicin-copper chelates inhibit replication of human influenza viruses.
Antiviral research 19980801
