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Quinolone-3-diarylethers: a new class of antimalarial drug.
Science translational medicine 20130320
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Efficacy and safety of atovaquone-proguanil in treating imported malaria in Japan: the second report from the research group.
Parasitology international 20120901
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A cluster of Plasmodium vivax malaria in an expedition group to Ethiopia: prophylactic efficacy of atovaquone/proguanil on liver stages of P. vivax.
The Journal of infection 20120901
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Cloning and heterologous expression of Plasmodium ovale dihydrofolate reductase-thymidylate synthase gene.
Parasitology international 20120601
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Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K.
The Journal of pharmacology and experimental therapeutics 20120601
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Standby emergency treatment of malaria in travelers: experience to date and new developments.
Expert review of anti-infective therapy 20120501
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Dosing rationale for fixed-dose combinations in children: shooting from the hip?
Clinical pharmacology and therapeutics 20120401
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Bridging strategies for drug combinations in pediatric indications.
Clinical pharmacology and therapeutics 20120401
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Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression.
The Journal of biological chemistry 20120323
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Mosquito infection studies with Aotus monkeys and humans infected with the Chesson strain of Plasmodiun vivax.
The American journal of tropical medicine and hygiene 20120301
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Anti-malarial chemoprophylaxis following evacuation from Afghanistan.
Journal of the Royal Army Medical Corps 20120301
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Prolonged protection provided by a single dose of atovaquone-proguanil for the chemoprophylaxis of Plasmodium falciparum malaria in a human challenge model.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120115
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Randomized, prospective, three-arm study to confirm the auditory safety and efficacy of artemether-lumefantrine in Colombian patients with uncomplicated Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 20120101
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Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria.
Malaria journal 20120101
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Therapy of uncomplicated falciparum malaria in Europe: MALTHER - a prospective observational multicentre study.
Malaria journal 20120101
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A longitudinal trial comparing chloroquine as monotherapy or in combination with artesunate, azithromycin or atovaquone-proguanil to treat malaria.
PloS one 20120101
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Focused Screening and Treatment (FSAT): a PCR-based strategy to detect malaria parasite carriers and contain drug resistant P. falciparum, Pailin, Cambodia.
PloS one 20120101
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Review: Malaria chemoprophylaxis for travelers to Latin America.
The American journal of tropical medicine and hygiene 20111201
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Malaria therapy in HIV: drug interactions between nevirapine and quinine.
International journal of STD & AIDS 20111201
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[Atovaquone-proguanil treatment failure in Plasmodium falciparum].
Presse medicale (Paris, France : 1983) 20111101
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Pharmacokinetics of antimalarials in pregnancy: a systematic review.
Clinical pharmacokinetics 20111101
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Prophylactic use of antimalarials during pregnancy.
Canadian family physician Medecin de famille canadien 20111101
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Prolonged administration of proguanil induces reproductive toxicity in male rats.
The Journal of toxicological sciences 20111001
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Community management of anti-malarials in Africa and iatrogenic risk.
Journal of tropical pediatrics 20110601
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Severe hypersensitivity reaction as acute eosinophilic pneumonia and skin eruption induced by proguanil.
The European respiratory journal 20110601
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Improvements in compliance with medical force protection measures by simplification of the anti-malarial chemoprophylaxis regime.
Journal of the Royal Army Medical Corps 20110601
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Exploring QSAR, pharmacophore mapping and docking studies and virtual library generation for cycloguanil derivatives as PfDHFR-TS inhibitors.
Medicinal chemistry (Shariqah (United Arab Emirates)) 20110501
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Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacartâ„¢) tablets.
Journal of pharmaceutical and biomedical analysis 20110220
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Azithromycin for treating uncomplicated malaria.
The Cochrane database of systematic reviews 20110216
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Atovaquone-proguanil use in early pregnancy and the risk of birth defects.
Archives of internal medicine 20110214
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[Post-malaria neurological syndrome complicating a relapse of Plasmodium falciparum malaria after atovaquone-proguanil treatment].
Medecine et maladies infectieuses 20110101
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Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis.
Malaria journal 20110101
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Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum.
PloS one 20110101
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Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia.
PloS one 20110101
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Frequency of glucose-6-phosphate dehydrogenase deficiency in malaria patients from six African countries enrolled in two randomized anti-malarial clinical trials.
Malaria journal 20110101
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Antimalarial chemoprophylaxis in a deployed Naval Unit.
Journal of the Royal Naval Medical Service 20110101
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[Duodenal ulcers caused by chloroquine-proguanil association].
Medecine tropicale : revue du Corps de sante colonial 20101201
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Localization of artesunate and its derivatives in the pregnant rat and fetus following oral administration and relationship to developmental toxicity.
Birth defects research. Part B, Developmental and reproductive toxicology 20101001
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The rise and fall of the antimalarial Lapdap: a lesson in pharmacogenetics.
Lancet (London, England) 20100828
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Pancytopenia due to proguanil toxicity in a returning traveller with fever.
European journal of clinical pharmacology 20100801
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Do 5-fluorouracil therapies alter CYP2C19 metaboliser status?
Cancer chemotherapy and pharmacology 20100701
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Lower atovaquone/proguanil concentrations in patients taking efavirenz, lopinavir/ritonavir or atazanavir/ritonavir.
AIDS (London, England) 20100515
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Letter to the editor of travel medicine and infectious disease.
Travel medicine and infectious disease 20100501
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Quantitative structure-activity relationships for cycloguanil analogs as PfDHFR inhibitors using mathematical molecular descriptors.
SAR and QSAR in environmental research 20100401
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Chronic malaria infections increase family inequalities and reduce parental fitness: experimental evidence from a wild bird population.
Journal of evolutionary biology 20100301
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Alteration of pharmacokinetics of proguanil in healthy volunteers following concurrent administration of efavirenz.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219
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Shape- and chemical feature-based 3D-pharmacophore model generation and virtual screening: identification of potential leads for P. falciparum DHFR enzyme inhibition.
Chemical biology & drug design 20100101
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Duration of protection against clinical malaria provided by three regimens of intermittent preventive treatment in Tanzanian infants.
PloS one 20100101
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Intermittent preventive treatment in infants for the prevention of malaria in rural Western kenya: a randomized, double-blind placebo-controlled trial.
PloS one 20100101
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Alternatives for malaria prophylaxis during the first trimester of pregnancy: our personal view.
Journal of travel medicine 20100101
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Assessment of adherence to atovaquone-proguanil prophylaxis in travelers.
Journal of travel medicine 20100101
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Different mutation patterns of Plasmodium falciparum among patients in Jimma University Hospital, Ethiopia.
Malaria journal 20100101
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Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface.
Analytical chemistry 20091215
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Chlorproguanil-dapsone-artesunate versus chlorproguanil-dapsone: a randomized, double-blind, phase III trial in African children, adolescents, and adults with uncomplicated Plasmodium falciparum malaria.
The American journal of tropical medicine and hygiene 20091201
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3D-QSAR analysis of cycloguanil derivatives as inhibitors of A16V + S108T mutant Plasmodium falciparum dihydrofolate reductase enzyme.
Journal of molecular graphics & modelling 20091101
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Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.
Travel medicine and infectious disease 20091101
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Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.
Lancet (London, England) 20091031
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Mefloquine has more adverse effects than other drugs for malaria prophylaxis.
BMJ (Clinical research ed.) 20091013
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Drugs for preventing malaria in travellers.
The Cochrane database of systematic reviews 20091007
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Pharmacokinetics of chlorproguanil, dapsone, artesunate and their major metabolites in patients during treatment of acute uncomplicated Plasmodium falciparum malaria.
European journal of clinical pharmacology 20091001
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Plasmodium relictum (lineage P-SGS1): Further observation of effects on experimentally infected passeriform birds, with remarks on treatment with Malarone.
Experimental parasitology 20091001
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Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090915
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Drug impurity profiling by capillary electrophoresis/mass spectrometry using various ionization techniques.
Rapid communications in mass spectrometry : RCM 20090901
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Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.
Pharmacogenomics 20090901
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Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.
Journal of chemical information and modeling 20090701
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Atovaquone + proguanil: new indication. For children weighing as little as 5 kg; an inconvenient form. A flavoured syrup would be better suited to infants and young children.
Prescrire international 20090601
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Interactions between cycloguanil derivatives and wild type and resistance-associated mutant Plasmodium falciparum dihydrofolate reductases.
Journal of computer-aided molecular design 20090401
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A novel in silico approach to drug discovery via computational intelligence.
Journal of chemical information and modeling 20090401
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[Fever in returning travellers].
Praxis 20090318
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Short report: comparison of chlorproguanil-dapsone with a combination of sulfadoxine-pyrimethamine and chloroquine in children with malaria in northcentral Nigeria.
The American journal of tropical medicine and hygiene 20090201
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Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.
Journal of travel medicine 20090101
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Randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and SP for malaria in pregnancy in Tanzania.
PloS one 20090101
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Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria.
PloS one 20090101
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Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.
Malaria journal 20090101
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Influence of the genetic polymorphisms in the 5' flanking and exonic regions of CYP2C19 on proguanil oxidation.
Drug metabolism and pharmacokinetics 20090101
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Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents.
Bioorganic & medicinal chemistry letters 20081215
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Bone marrow aplasia following acute poisoning with chloroquine-proguanil.
Clinical toxicology (Philadelphia, Pa.) 20081201
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Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.
Military medicine 20081201
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Bullous erythema multiforme after treatment with Malarone, a combination antimalarial composed of atovaquone and proguanil hydrochloride.
Tropical doctor 20080701
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Atovaquone-proguanil resistance in imported falciparum malaria in a young child.
The Pediatric infectious disease journal 20080601
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Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.
Parasitology research 20080501
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A randomised trial to assess the efficacy and safety of chlorproguanil/dapsone + artesunate for the treatment of uncomplicated Plasmodium falciparum malaria.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20080501
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Failure of atovaquone/proguanil to prevent Plasmodium ovale malaria in traveler returning from Cameroon.
Travel medicine and infectious disease 20080501
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Artemether + lumefantrine: new drug. An alternative to atovaquone + proguanil.
Prescrire international 20080401
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A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda.
Journal of infection in developing countries 20080401
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[Tolerance and efficacy of atovaquone-proguanil for the treatment of paediatric imported Plasmodium falciparum malaria in France: clinical practice in a university hospital in Paris].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20080301
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Role of specific cytochrome P450 isoforms in the conversion of phenoxypropoxybiguanide analogs in human liver microsomes to potent antimalarial dihydrotriazines.
Drug metabolism and disposition: the biological fate of chemicals 20080201
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Plasmodium falciparum malaria and atovaquone-proguanil treatment failure.
Emerging infectious diseases 20080201
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An investigation into the native-like properties of de novo designed cavitand-based four-helix bundle proteins.
Biopolymers 20080101
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In vitro atovaquone/proguanil susceptibility and characterization of the cytochrome b gene of Plasmodium falciparum from different endemic regions of Thailand.
Malaria journal 20080101
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Open-label comparative clinical study of chlorproguanil-dapsone fixed dose combination (Lapdap) alone or with three different doses of artesunate for uncomplicated Plasmodium falciparum malaria.
PloS one 20080101
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Escalating Plasmodium falciparum antifolate drug resistance mutations in Macha, rural Zambia.
Malaria journal 20080101
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An open label, randomised trial of artesunate+amodiaquine, artesunate+chlorproguanil-dapsone and artemether-lumefantrine for the treatment of uncomplicated malaria.
PloS one 20080101
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Ototoxicity of artemether/lumefantrine in the treatment of falciparum malaria: a randomized trial.
Malaria journal 20080101
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Trends in antimalarial prescriptions in Australia 2002 to 2005.
Journal of travel medicine 20080101
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Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil.
Malaria journal 20080101
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Pharmacodynamic interaction between monodesbutyl-benflumetol and artemisinin as well as proguanil in Plasmodium falciparum in vitro.
Wiener klinische Wochenschrift 20080101
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High risk of severe anaemia after chlorproguanil-dapsone+artesunate antimalarial treatment in patients with G6PD (A-) deficiency.
PloS one 20080101
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Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071215
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The risk of antimalarials in patients with renal failure.
Postgraduate medical journal 20071201
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Inadequate chemoprophylaxis and the risk of malaria.
Australian family physician 20071201
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Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.
The American journal of tropical medicine and hygiene 20071201
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Selective ambulatory management of Plasmodium falciparum malaria in paediatric refugees.
Archives of disease in childhood 20071101
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A systematic review and meta-analysis of the effectiveness and safety of atovaquone proguanil (Malarone) for chemoprophylaxis against malaria.
The Journal of antimicrobial chemotherapy 20071101
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Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.
Clinical pharmacology and therapeutics 20071101
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Clinical efficacy of antiparasite treatments against intestinal helminths and haematic protozoa in Gallotia caesaris (lizards).
Experimental parasitology 20070801
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Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment.
Molecular biology and evolution 20070801
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The role of tryptophan-48 in catalysis and binding of inhibitors of Plasmodium falciparum dihydrofolate reductase.
International journal for parasitology 20070601
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Chloroquine-resistant Plasmodium falciparum infections among UK travellers returning with malaria after chloroquine prophylaxis.
The Journal of antimicrobial chemotherapy 20070601
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Sulfadoxine-pyrimethamine, chlorproguanil-dapsone, or chloroquine for the treatment of Plasmodium vivax malaria in Afghanistan and Pakistan: a randomized controlled trial.
JAMA 20070523
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Effect of honey on CYP3A4, CYP2D6 and CYP2C19 enzyme activity in healthy human volunteers.
Basic & clinical pharmacology & toxicology 20070401
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Quality evaluation of chloroquine, quinine, sulfadoxine-pyrimethamine and proguanil formulations sold on the market in East Congo DR.
Journal of clinical pharmacy and therapeutics 20070401
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Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand.
The American journal of tropical medicine and hygiene 20070401
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Cerebral malaria in spite of peripheral parasite clearance in a patient treated with atovaquone/proguanil.
Parasitology research 20070301
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Analyses of cytochrome b mutations in Plasmodium falciparum isolates in Thai-Myanmar border.
Travel medicine and infectious disease 20070301
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Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum.
Nature 20070301
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Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography.
Journal of pharmaceutical and biomedical analysis 20070219
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Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).
The American journal of tropical medicine and hygiene 20070201
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The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].
Journal of travel medicine 20070101
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Hodgkin lymphoma in a child with sickle cell anemia.
Pediatric hematology and oncology 20070101
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A man with tropical travel history, fever, and pulmonary infiltrates.
Comprehensive therapy 20070101
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Relapsing vivax malaria after 6 months of daily atovaquone/proguanil in Afghanistan: the case for expanded use of primaquine as a causal prophylactic.
Journal of travel medicine 20070101
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Outpatient treatment of malaria in recently arrived African migrants.
The Medical journal of Australia 20061201
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A randomised, double-blind, placebo-controlled trial of atovaquone-proguanil vs. sulphadoxine-pyrimethamine in the treatment of malarial anaemia in Zambian children.
Tropical medicine & international health : TM & IH 20061101
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Plasmodium falciparum malaria associated with mefloquine failure in Gambia.
Pharmacotherapy 20061001
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Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs.
The American journal of tropical medicine and hygiene 20061001
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Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061001
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Clinical atovaquone-proguanil resistance of Plasmodium falciparum associated with cytochrome b codon 268 mutations.
Microbes and infection 20060901
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Randomized, double-blind, placebo-controlled study of Malarone for malaria prophylaxis in non-immune Colombian soldiers.
The American journal of tropical medicine and hygiene 20060901
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Evaluation of the bio-efficacy of three brands of repellents against wild populations of anthropophilic mosquitoes.
Tanzania health research bulletin 20060901
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Resisting resistance: dealing with the irrepressible problem of malaria.
British journal of clinical pharmacology 20060601
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Folic acid treatment of Zambian children with moderate to severe malaria anemia.
The American journal of tropical medicine and hygiene 20060601
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Pharmacokinetics of dihydroartemisinin following oral artesunate treatment of pregnant women with acute uncomplicated falciparum malaria.
European journal of clinical pharmacology 20060501
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Efficacy of chloroquine-proguanil malaria prophylaxis in a non-immune population in Bangui, Central African Republic: a case-control study.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20060401
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[Malaria: a medical and economic problem].
Presse medicale (Paris, France : 1983) 20060401
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[Retrospective analysis of 107 imported adult cases of malaria. Experience report of uncomplicated falciparum malaria treatment in adults with oral atovaquone-proguanil].
Presse medicale (Paris, France : 1983) 20060401
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Multiple synergistic interactions between atovaquone and antifolates against Plasmodium falciparum in vitro: a rational basis for combination therapy.
Acta tropica 20060301
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Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone.
British journal of clinical pharmacology 20060301
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Sensitive method for the quantitative determination of proguanil and its metabolites in rat blood and plasma by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060118
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Apparent absence of atovaquone/proguanil resistance in 477 Plasmodium falciparum isolates from untreated French travellers.
The Journal of antimicrobial chemotherapy 20060101
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[Cytochrome P-450 and the response to antimalarial drugs].
Revista panamericana de salud publica = Pan American journal of public health 20060101
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Detection of atovaquone-proguanil resistance conferring mutations in Plasmodium falciparum cytochrome b gene in Luanda, Angola.
Malaria journal 20060101
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Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.
Malaria journal 20060101
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[Severe imported malaria. The experience of the military hospital of Marrakech].
Annales de biologie clinique 20060101
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Tertian malaria (Plasmodium vivax and Plasmodium ovale) in two travelers despite atovaquone-proguanil prophylaxis.
Journal of travel medicine 20060101
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Molecular surveillance of mutations in the cytochrome b gene of Plasmodium falciparum in Gabon and Ethiopia.
Malaria journal 20060101
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Pharmacodynamic interaction between atovaquone and other antimalarial compounds against Plasmodium falciparum in vitro.
Wiener klinische Wochenschrift 20060101
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[Severe imported malaria: the experience of the Avicenna military hospital of Marrakech].
Sante (Montrouge, France) 20060101
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Atovaquone/proguanil for the prophylaxis and treatment of malaria.
Expert review of anti-infective therapy 20051201
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Malaria: prevention in travellers.
Clinical evidence 20051201
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Plasmodium falciparum: interaction of shikimate analogues with antimalarial drugs.
Experimental parasitology 20051101
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[Ineffective change of antimalaria prophylaxis to Artemisia vulgaris in a group travelling to West Africa].
Ugeskrift for laeger 20051024
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Atovaquone-proguanil for treating uncomplicated malaria.
The Cochrane database of systematic reviews 20051019
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[Malaria chemoprophylaxis].
Ugeskrift for laeger 20051017
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[Malaria prophylaxis for long-term travellers and expatriates].
Ugeskrift for laeger 20051017
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A simple dual selection for functionally active mutants of Plasmodium falciparum dihydrofolate reductase with improved solubility.
Protein engineering, design & selection : PEDS 20051001
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Susceptibility studies of Malaysian Plasmodium falciparum clones to type II antifolate drugs after 3 years of continuous in vitro culture.
Chemotherapy 20051001
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The pharmacokinetics and pharmacodynamics of atovaquone and proguanil for the treatment of uncomplicated falciparum malaria in third-trimester pregnant women.
European journal of clinical pharmacology 20050901
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A randomized comparison of artesunate-atovaquone-proguanil versus quinine in treatment for uncomplicated falciparum malaria during pregnancy.
The Journal of infectious diseases 20050901
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Consumption of charcoal-broiled meat as an experimental tool for discerning CYP1A2-mediated drug metabolism in vivo.
Basic & clinical pharmacology & toxicology 20050901
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Hepatotoxicity associated with the use of a fixed combination of chloroquine and proguanil.
International journal of antimicrobial agents 20050801
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Short report: no evidence of cardiotoxicity of atovaquone-proguanil alone or in combination with artesunate.
The American journal of tropical medicine and hygiene 20050801
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Effectiveness of antimalarial drugs.
The New England journal of medicine 20050728
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Shikimate and folate pathways in the protozoan parasite, Perkinsus olseni.
Molecular and biochemical parasitology 20050701
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The chemotherapy of rodent malaria. LXIII. Drug combinations to impede the selection of drug resistance, part 6: the potential value of chlorproguanil and dapsone in combination, and with the addition of artesunate.
Annals of tropical medicine and parasitology 20050701
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Occult Plasmodium vivax infection diagnosed by a polymerase chain reaction-based detection system: a case report.
The American journal of tropical medicine and hygiene 20050701
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Prediction of genotoxicity of chemical compounds by statistical learning methods.
Chemical research in toxicology 20050601
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Malaria: uncomplicated, caused by Plasmodium falciparum.
Clinical evidence 20050601
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In vitro metabolism of phenoxypropoxybiguanide analogues in human liver microsomes to potent antimalarial dihydrotriazines.
Journal of medicinal chemistry 20050421
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Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa.
The American journal of tropical medicine and hygiene 20050401
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[Color reaction of chlorhexidine and proguanil with hypobromite].
Die Pharmazie 20050401
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Stoichiometric selection of tight-binding inhibitors by wild-type and mutant forms of malarial (Plasmodium falciparum) dihydrofolate reductase.
Analytical chemistry 20050301
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A randomized open label clinical trial to compare the efficacy and safety of intravenous quinine followed by oral malarone vs. intravenous quinine followed by oral quinine in the treatment of severe malaria.
Journal of tropical pediatrics 20050201
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Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20050201
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Artesunate-dapsone-proguanil treatment of falciparum malaria: genotypic determinants of therapeutic response.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20050201
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Syntheses of 2,4,6-trisubstituted triazines as antimalarial agents.
Bioorganic & medicinal chemistry letters 20050201
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A malaria outbreak following a British military deployment to Sierra Leone.
The Journal of infection 20050201
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In vitro recrudescence of Plasmodium falciparum parasites suppressed to dormant state by atovaquone alone and in combination with proguanil.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20050101
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Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil.
Molecular and biochemical parasitology 20050101
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Simultaneous quantitation of the highly lipophilic atovaquone and hydrophilic strong basic proguanil and its metabolites using a new mixed-mode SPE approach and steep-gradient LC.
Journal of chromatographic science 20050101
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Malaria prophylaxis for aircrew: safety of atovaquone/proguanil in healthy volunteers under aircraft cabin pressure conditions.
Journal of travel medicine 20050101
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Acute hepatitis and atovaquone/proguanil.
Journal of travel medicine 20050101
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Pfcrt K76T mutation and its associations in imported Plasmodium falciparum malaria cases.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20041201
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Developmental toxicity of artesunate and an artesunate combination in the rat and rabbit.
Birth defects research. Part B, Developmental and reproductive toxicology 20041201
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The chemotherapy of rodent malaria. LXII. Drug combinations to impede the selection of drug resistance, part 5: rates of development of resistance to some inhibitors of folate metabolism and to artesunate.
Annals of tropical medicine and parasitology 20041201
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Rare, highly pyrimethamine-resistant alleles of the Plasmodium falciparum dihydrofolate reductase gene from 5 African sites.
The Journal of infectious diseases 20041115
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Screening for mutations related to atovaquone/proguanil resistance in treatment failures and other imported isolates of Plasmodium falciparum in Europe.
The Journal of infectious diseases 20041101
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Chlorproguanil-dapsone for malaria.
Lancet (London, England) 20041101
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Chlorproguanil-dapsone for treating uncomplicated malaria.
The Cochrane database of systematic reviews 20041018
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Quinine-resistant severe falciparum malaria effectively treated with atovaquone and proguanil hydrochloride combination therapy.
Internal medicine (Tokyo, Japan) 20040701
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[Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].
MMW Fortschritte der Medizin 20040617
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Atovaquone-proguanil versus chloroquine-proguanil for malaria prophylaxis in nonimmune pediatric travelers: results of an international, randomized, open-label study.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040615
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Chlorproguanil-dapsone for malaria in Africa.
Lancet (London, England) 20040605
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Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children: double-blind randomised controlled trial.
Lancet (London, England) 20040605
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Malaria: prevention in travellers.
Clinical evidence 20040601
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Short communication: Prevalence of mutations associated with resistance to atovaquone and to the antifolate effect of proguanil in Plasmodium falciparum isolates from northern Ghana.
Tropical medicine & international health : TM & IH 20040301
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A malaria outbreak following a British military deployment to Sierra Leone.
The Journal of infection 20040201
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CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.
Tropical medicine & international health : TM & IH 20040201
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Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
Journal of medicinal chemistry 20040129
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Susceptibility of Plasmodium falciparum to the drugs used to treat severe malaria (quinine) and to prevent malaria (mefloquine, cycloguanil) in Comoros Union and Madagascar.
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20040101
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[Pharmaceutical care for international voyagers: prophylaxis including chloroquine plus proguanil].
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101
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Malaria journal 20040101
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Journal of travel medicine 20040101
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Journal of travel medicine 20040101
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031201
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Military aviators, special operations forces, and causal malaria prophylaxis.
Military medicine 20031201
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Clinical evidence 20031201
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115
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Angewandte Chemie (International ed. in English) 20031110
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European journal of clinical pharmacology 20031101
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Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.
Pharmacogenetics 20031101
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Pregnancy and use of oral contraceptives reduces the biotransformation of proguanil to cycloguanil.
European journal of clinical pharmacology 20031001
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European journal of clinical pharmacology 20031001
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Presse medicale (Paris, France : 1983) 20030906
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The Annals of pharmacotherapy 20030901
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Nature medicine 20030901
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Annals of tropical medicine and parasitology 20030901
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Professional nurse (London, England) 20030901
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The American journal of tropical medicine and hygiene 20030901
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BMJ (Clinical research ed.) 20030816
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Biochemical pharmacology 20030815
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Genetic confirmation of atovaquone-proguanil-resistant Plasmodium falciparum malaria acquired by a nonimmune traveler to East Africa.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030801
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The Journal of antimicrobial chemotherapy 20030701
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030701
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The impact of Malarone and primaquine on psychomotor performance.
Aviation, space, and environmental medicine 20030701
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Deutsche medizinische Wochenschrift (1946) 20030606
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Journal of travel medicine 20030501
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Journal of travel medicine 20030501
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Journal of travel medicine 20030501
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The Annals of pharmacotherapy 20030401
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The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum.
Fundamental & clinical pharmacology 20030401
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The new drug combinations: their place in the treatment of uncomplicated Plasmodium falciparum malaria.
Fundamental & clinical pharmacology 20030401
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Fundamental & clinical pharmacology 20030401
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The Pediatric infectious disease journal 20030401
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Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20030401
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BMJ (Clinical research ed.) 20030322
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The Lancet. Infectious diseases 20030301
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Parassitologia 20030301
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Nederlands tijdschrift voor geneeskunde 20030215
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Pharmacy world & science : PWS 20030201
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Presse medicale (Paris, France : 1983) 20030125
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Bioorganic & medicinal chemistry 20030117
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Archives of biochemistry and biophysics 20030101
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The American journal of tropical medicine and hygiene 20030101
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Drugs 20030101
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Malaria journal 20030101
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Acta dermato-venereologica 20030101
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The efficacy of chemoprophylaxis against malaria with chloroquine plus proguanil, mefloquine, and atovaquone plus proguanil in travelers from Denmark.
Journal of travel medicine 20030101
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Journal of travel medicine 20030101
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Journal of travel medicine 20030101
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BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20030101
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Detection of atovaquone and Malarone resistance conferring mutations in Plasmodium falciparum cytochrome b gene (cytb).
Molecular and cellular probes 20030101
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Bulletin of the World Health Organization 20030101
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Variation of malaria transmission and morbidity with altitude in Tanzania and with introduction of alphacypermethrin treated nets.
Malaria journal 20030101
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Journal of travel medicine 20030101
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Journal of travel medicine 20030101
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Scandinavian journal of infectious diseases 20030101
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Malaria prophylaxis in post renal transplant recipients in the tropics: is it necessary?
The Central African journal of medicine 20030101
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Pharmacodynamic interactions among atovaquone, proguanil and cycloguanil against Plasmodium falciparum in vitro.
Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101
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Transactions of the Royal Society of Tropical Medicine and Hygiene 20030101
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Acta medica portuguesa 20030101
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The Journal of infectious diseases 20021215
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215
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Journal of clinical pharmacy and therapeutics 20021201
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Parassitologia 20021201
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The Southeast Asian journal of tropical medicine and public health 20021201
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021115
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Atovaquone/proguanil therapy for Plasmodium falciparum and Plasmodium vivax malaria in Indonesians who lack clinical immunity.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021101
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Tropical medicine & international health : TM & IH 20021101
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European journal of clinical pharmacology 20021101
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The Pediatric infectious disease journal 20021101
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Lancet (London, England) 20021012
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Prescrire international 20021001
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MMW Fortschritte der Medizin 20020919
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Presse medicale (Paris, France : 1983) 20020907
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Lakartidningen 20020627
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501
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The American journal of tropical medicine and hygiene 20020501
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European journal of clinical pharmacology 20020401
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Consumer reports 20020301
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The Journal of infectious diseases 20020201
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Annals of emergency medicine 20020101
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Medecine tropicale : revue du Corps de sante colonial 20020101
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Malaria journal 20020101
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Bioequivalence evaluation of a fixed combination of chloroquine and proguanil in a capsule formulation versus a standard medication.
Arzneimittel-Forschung 20020101
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Journal of travel medicine 20020101
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Medecine tropicale : revue du Corps de sante colonial 20020101
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Medecine tropicale : revue du Corps de sante colonial 20020101
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Medecine tropicale : revue du Corps de sante colonial 20020101
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Medecine tropicale : revue du Corps de sante colonial 20020101
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Bulletin of the World Health Organization 20020101
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The Journal of infectious diseases 20011215
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011101
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Tropical medicine & international health : TM & IH 20011101
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Lancet (London, England) 20011013
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011001
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Pediatrics in review 20011001
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Drug and therapeutics bulletin 20011001
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Journal of the Royal Army Medical Corps 20011001
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Molecular and biochemical parasitology 20010928
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JAMA 20010815
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Biophysical chemistry 20010724
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MMWR. Morbidity and mortality weekly report 20010720
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010715
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[Expanded arsenal for prevention and therapy. What is the value of the new malaria drugs? (interview by Waltraut Paukstadt)].
MMW Fortschritte der Medizin 20010705
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010701
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A political analysis of corporate drug donations: the example of Malarone in Kenya.
Health policy and planning 20010601
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Microbial drug resistance and the roles of the new antibiotics.
Cleveland Clinic journal of medicine 20010601
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[Malaria--chemoprophylaxis 2001].
Therapeutische Umschau. Revue therapeutique 20010601
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Analysis of proguanil and its metabolites by application of the sweeping technique in micellar electrokinetic chromatography.
Journal of chromatography. A 20010504
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Lancet (London, England) 20010421
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Memorias do Instituto Oswaldo Cruz 20010401
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Atovaquone and proguani hydrochloride compared with chloroquine or pyrimethamine/sulfodaxine for treatment of acute Plasmodium falciparum malaria in Peru.
The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20010401
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Mode of action and mechanisms of resistance for antimalarial drugs.
Pharmacology & therapeutics 20010201
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Drug metabolism and disposition: the biological fate of chemicals 20010101
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Therapie 20010101
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Studies of the complexation of chloranilic acid with proguanil.
Bollettino chimico farmaceutico 20010101
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Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101
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Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101
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Medecine tropicale : revue du Corps de sante colonial 20010101
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Medecine tropicale : revue du Corps de sante colonial 20010101
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Lancet (London, England) 20001202
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The Journal of infectious diseases 20000601
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Journal of travel medicine 20000101
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Antimicrobial agents and chemotherapy 19990601
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The American journal of tropical medicine and hygiene 19990601
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European journal of clinical pharmacology 19970101
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European journal of clinical pharmacology 19970101
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BMJ (Clinical research ed.) 19961214
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Antimicrobial agents and chemotherapy 19960901
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BMJ (Clinical research ed.) 19960831
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Antimicrobial agents and chemotherapy 19950801
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Experimental parasitology 19950501
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Antimicrobial agents and chemotherapy 19950401
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The Journal of infectious diseases 19941001
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Antimicrobial agents and chemotherapy 19940601
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Antimicrobial agents and chemotherapy 19930701
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Lancet (London, England) 19930619
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The British journal of psychiatry : the journal of mental science 19910701
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In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs.
Antimicrobial agents and chemotherapy 19900801
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CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 19871001
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South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 19750125