500579-04-4 | GANT 61

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$11.00	$8.00
5mg	98%	in stock	$22.00	$16.00
10mg	98%	in stock	$33.00	$23.00
50mg	98%	in stock	$140.00	$98.00
250mg	98%	in stock	$198.00	$138.00
1g	98%	in stock	$502.00	$352.00

Description

• Catalog Number: AD21680
• Chemical Name: GANT 61
• CAS Number: 500579-04-4
• Molecular Formula: C27H35N5
• Molecular Weight: 429.6003
• MDL Number: MFCD14635408
• SMILES: CN(c1ccccc1CN1CCCN(C1c1ccncc1)Cc1ccccc1N(C)C)C
• NSC Number: 136476

Computed Properties

• Complexity: 508
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 7
• XLogP3: 4.2

Literature

• Hedgehog pathway dysregulation contributes to the pathogenesis of human gastrointestinal stromal tumors via GLI-mediated activation of KIT expression.

  Oncotarget 20161129

• Targeting of the Hedgehog signal transduction pathway suppresses survival of malignant pleural mesothelioma cells in vitro.

  The Journal of thoracic and cardiovascular surgery 20140101

• Identification of hepatitis C virus inhibitors targeting different aspects of infection using a cell-based assay.

  Antimicrobial agents and chemotherapy 20121201

• Gli inhibitor GANT61 causes apoptosis in myeloid leukemia cells and acts in synergy with rapamycin.

  Leukemia research 20120601

• Transcriptional responses of zebrafish embryos exposed to potential sonic hedgehog pathway interfering compounds deviate from expression profiles of cyclopamine.

  Reproductive toxicology (Elmsford, N.Y.) 20120401

• Hedgehog pathway signaling regulates human colon carcinoma HT-29 epithelial cell line apoptosis and cytokine secretion.

  PloS one 20120101

• Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth.

  International journal of oncology 20111001

• Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.

  Cancer research 20110901

• The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer.

  Oncotarget 20110801

• HH/GLI signalling as a new therapeutic target for patients with oral squamous cell carcinoma.

  Oral oncology 20110601

• Redundant and differential roles of transcription factors Gli1 and Gli2 in the development of mouse fetal Leydig cells.

  Biology of reproduction 20110501

• Hedgehog signaling drives cellular survival in human colon carcinoma cells.

  Cancer research 20110201

• Modulators of the hedgehog signaling pathway.

  Bioorganic & medicinal chemistry 20100915

• Inhibition of GLI, but not Smoothened, induces apoptosis in chronic lymphocytic leukemia cells.

  Oncogene 20100902

• Gli2 expression and human bladder transitional carcinoma cell invasiveness.

  The Journal of urology 20100701

• Amide conjugates of ketoprofen and indole as inhibitors of Gli1-mediated transcription in the Hedgehog pathway.

  Bioorganic & medicinal chemistry 20100701