509093-47-4 | IRAK-1-4 Inhibitor I

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$10.00	$7.00
5mg	98%	in stock	$22.00	$16.00
10mg	98%	in stock	$33.00	$23.00
50mg	98%	in stock	$93.00	$65.00
100mg	98%	in stock	$158.00	$111.00

Description

• Catalog Number: AD20379
• Chemical Name: IRAK-1-4 Inhibitor I
• CAS Number: 509093-47-4
• Molecular Formula: C20H21N5O4
• Molecular Weight: 395.4118
• MDL Number: MFCD09752602
• SMILES: O=C(c1cccc(c1)[N+](=O)[O-])Nc1nc2c(n1CCN1CCOCC1)cccc2

Computed Properties

• Complexity: 580
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 2

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

  The Biochemical journal 20130415

• Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

  Nature biotechnology 20111101

• Discovery and initial SAR of inhibitors of interleukin-1 receptor-associated kinase-4.

  Bioorganic & medicinal chemistry letters 20060601

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419