5108-96-3 | 1-Pyrrolidinecarbodithioic acid ammonium salt

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$16.00	$11.00
5g	95%	in stock	$20.00	$14.00
25g	95%	in stock	$21.00	$15.00
100g	95%	in stock	$72.00	$51.00
500g	95%	in stock	$260.00	$182.00

Description

• Catalog Number: AB49311
• Chemical Name: 1-Pyrrolidinecarbodithioic acid ammonium salt
• CAS Number: 5108-96-3
• Molecular Formula: C5H12N2S2
• Molecular Weight: 164.2922
• MDL Number: MFCD00012720
• SMILES: [S-]C(=S)N1CCCC1.[NH4+]

Computed Properties

• Complexity: 91.1
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1

Upstream Synthesis Route

Ammonium pyrrolidinedithiocarbamate is a versatile chemical reagent commonly used in chemical synthesis processes. Its unique properties make it a valuable tool for various applications in the field of organic chemistry. In synthesis, ammonium pyrrolidinedithiocarbamate is utilized as a source of dithiocarbamate ligands, which can coordinate with a variety of metal ions to form stable complexes. These complexes play a crucial role in catalyzing a wide range of reactions, including polymerization, cross-coupling, and oxidation reactions. Additionally, ammonium pyrrolidinedithiocarbamate can act as a sulfur transfer reagent, facilitating sulfur incorporation into organic molecules. Its ability to facilitate diverse chemical transformations makes it an essential reagent for synthetic chemists seeking to develop novel compounds and materials.

Literature

• Resveratrol inhibits oxygen-glucose deprivation-induced MMP-3 expression and cell apoptosis in primary cortical cells via the NF-κB pathway.

  Molecular medicine reports 20140801

• [Intervention of pyrrolidine dithiocarbamate on expressions of connective tissue growth factor, type I collagen, and type III collage in acute paraquat poisoned rats].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20130101

• Functional characterization of TNF-α in grass carp head kidney leukocytes: induction and involvement in the regulation of NF-κB signaling.

  Fish & shellfish immunology 20121101

• NF-κΒ inhibition is ineffective in blocking cytokine-induced IL-8 production but P38 and STAT1 inhibitors are effective.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120901

• Involvement of 15-lipoxygenase in the inflammatory arthritis.

  Journal of cellular biochemistry 20120701

• Foxp3 expression in A549 cells is regulated by Toll-like receptor 4 through nuclear factor-κB.

  Molecular medicine reports 20120701

• Sphingosine-1-phosphate is a mediator of TNF-α action on the Na+/K+ ATPase in HepG2 cells.

  Journal of cellular biochemistry 20120601

• Chronic inhibition of nuclear factor kappa B attenuates aldosterone/salt-induced renal injury.

  Life sciences 20120420

• Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-κB/bFGF signaling.

  World journal of gastroenterology 20120414

• High glucose-induced expression of inflammatory cytokines and reactive oxygen species in cultured astrocytes.

  Neuroscience 20120127

• Mechanism of P-glycoprotein expression in the SGC7901 human gastric adenocarcinoma cell line induced by cyclooxygenase-2.

  Asian Pacific journal of cancer prevention : APJCP 20120101

• Suppression of NF-κB reduces myocardial no-reflow.

  PloS one 20120101

• Inhibition of NF-κB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells.

  Experimental & molecular medicine 20111231

• Down-regulation of matrix metalloproteinase-9 by pyrrolidine dithiocarbamate prevented retinal ganglion cell death after transection of optic nerve in rats.

  Current eye research 20111101

• Bezafibrate prevents palmitate-induced apoptosis in osteoblastic MC3T3-E1 cells through the NF-κB signaling pathway.

  International journal of molecular medicine 20111001

• An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism.

  Cellular signalling 20110901

• Inhibition of NF-κB signaling commits resveratrol-treated medulloblastoma cells to apoptosis without neuronal differentiation.

  Journal of neuro-oncology 20110801

• 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes.

  Prostaglandins & other lipid mediators 20110801

• Nuclear factor-kappaB (NF-kappaB) p65 interacts with Stat5b in growth plate chondrocytes and mediates the effects of growth hormone on chondrogenesis and on the expression of insulin-like growth factor-1 and bone morphogenetic protein-2.

  The Journal of biological chemistry 20110715

• Programmed hypertension in rats treated with a NF-κB inhibitor during nephrogenesis: renal mechanisms.

  Hypertension research : official journal of the Japanese Society of Hypertension 20110601

• [The impact of PDTC on circulating tumor cells of laryngocarcinoma in nude mice model].

  Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20110501

• Nitric oxide in enteric nervous system mediated the inhibitory effect of vasopressin on the contraction of circular muscle strips from colon in male rats.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110301

• Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives.

  Bioorganic & medicinal chemistry letters 20110201

• Nuclear factor kappa B pathway down-regulates aquaporin 5 in the nasal mucosa of rats with allergic rhinitis.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110101

• Inhibition of nuclear factor κB regresses cardiac hypertrophy by modulating the expression of extracellular matrix and adhesion molecules.

  Free radical biology & medicine 20110101

• The influence of passive stretch and NF-κB inhibitors on the morphology of dystrophic muscle fibers.

  Anatomical record (Hoboken, N.J. : 2007) 20110101

• Angiotensin II induces the expression of c-reactive protein via MAPK-dependent signal pathway in U937 macrophages.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101

• Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway.

  PloS one 20110101

• Nuclear factor-κB inhibitors alleviate nivalenol-induced cytotoxicity in HL60 cells.

  Environmental toxicology and pharmacology 20110101

• Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage.

  Journal of neuroinflammation 20110101

• Characterization of polysaccharide from Astragalus radix as the macrophage stimulator.

  Cellular immunology 20110101

• TNFα-induced necroptosis and autophagy via supression of the p38-NF-κB survival pathway in L929 cells.

  Journal of pharmacological sciences 20110101

• Expressions of lymphotactin and its receptor, XCR, in Lewis rats with experimental autoimmune anterior uveitis.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20101201

• Shock wave induces chronic renal lesion through activation of the nuclear factor kappa B signaling pathway.

  World journal of urology 20101001

• 5-aminoimidazole-4-carboxamide ribonucleoside and AMP-activated protein kinase inhibit signalling through NF-κB.

  Immunology and cell biology 20101001

• C-reactive protein triggers inflammatory responses partly via TLR4/IRF3/NF-κB signaling pathway in rat vascular smooth muscle cells.

  Life sciences 20100911

• Nitric oxide regulates stretch-induced proliferation in C2C12 myoblasts.

  Journal of muscle research and cell motility 20100901

• [Study about cardiomyocyte apoptosis in myocardial ischemic-reperfusion injury of rats and NF-κB p65, iNOS expression].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100901

• Effects of NF-kappaB inhibitor on titanium particulate-induced inflammation in a murine model.

  The Journal of surgical research 20100801

• Involvement of NF-kappaB activation in the apoptosis induced by extracellular adenosine in human hepatocellular carcinoma HepG2 cells.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20100801

• Inhibition of immune-mediated concanavalin a-induced liver damage by free-radical scavengers.

  Digestive diseases and sciences 20100201

• Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion.

  Cardiovascular research 20100101

• SLC/CCR7 stimulates the proliferation of BMDCs by the pNF-kappaB p65 pathway.

  Anatomical record (Hoboken, N.J. : 2007) 20100101

• Hypoxia activates heparanase expression in an NF-kappaB dependent manner.

  Oncology reports 20100101

• Amyloid-β induces cyclooxygenase-2 and PGE2 release in human astrocytes in NF-κ B dependent manner.

  Journal of Alzheimer's disease : JAD 20100101

• TGF-β1 induces podocyte injury through Smad3-ERK-NF-κB pathway and Fyn-dependent TRPC6 phosphorylation.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• The effect of microenvironmental CD40 signals on TRAIL- and drug-induced apoptosis in follicular lymphoma cells.

  Scandinavian journal of immunology 20091201

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.

  Archives of biochemistry and biophysics 20090901

• Increased expression and activity of MMP-9 in C-reactive protein- induced human THP-1 mononuclear cells is related to activation of nuclear factor kappa-B.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090801

• Bilirubin effect on endothelial adhesion molecules expression is mediated by the NF-kappaB signaling pathway.

  Bioscience trends 20090801

• Toll-like receptor 9 agonists promote IL-8 and TGF-beta1 production via activation of nuclear factor kappaB in PC-3 cells.

  Cancer genetics and cytogenetics 20090715

• PDTC enables type I TRAIL signaling in type II follicular lymphoma cells.

  Leukemia research 20090601

• Osteopontin increases lung cancer cells migration via activation of the alphavbeta3 integrin/FAK/Akt and NF-kappaB-dependent pathway.

  Lung cancer (Amsterdam, Netherlands) 20090601

• Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension.

  Cardiovascular research 20090601

• Comparative effects of fatty acids on proinflammatory gene cyclooxygenase 2 and inducible nitric oxide synthase expression in retinal pigment epithelial cells.

  Molecular nutrition & food research 20090601

• The effects of PDTC on interleukin-1beta-induced nitric oxide production in chondrocytes.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20090601

• Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway.

  European journal of pharmacology 20090128

• Regulation of the trigeminal NR1 subunit expression induced by inflammation of the temporomandibular joint region in rats.

  Pain 20090101

• Cocaine induces cell death and activates the transcription nuclear factor kappa-B in PC12 cells.

  Molecular brain 20090101

• Anti-angiogenic actions of pyrrolidine dithiocarbamate, a nuclear factor kappa B inhibitor.

  Angiogenesis 20090101

• Notch2 signaling sensitizes endothelial cells to apoptosis by negatively regulating the key protective molecule survivin.

  PloS one 20090101

• Protection of capsaicin against hypoxia-reoxygenation-induced apoptosis of rat hippocampal neurons.

  Canadian journal of physiology and pharmacology 20081101

• Role of NF-kappaB and PI 3-kinase/Akt in TNF-alpha-induced cytotoxicity in microvascular endothelial cells.

  American journal of physiology. Renal physiology 20081001

• Prednisolone inhibits PDGF-induced nuclear translocation of NF-kappaB in human pulmonary artery smooth muscle cells.

  American journal of physiology. Lung cellular and molecular physiology 20081001

• [Research of signaling pathway of vascular endothelial growth factor regulating by hepatitis B virus X protein].

  Zhonghua wai ke za zhi [Chinese journal of surgery] 20080715

• Inhibitory effect of zinc on hypoxic HIF-1 activation in astrocytes.

  Neuroreport 20080702

• The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080701

• Atorvastatin downregulates BMP-2 expression induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells.

  Circulation journal : official journal of the Japanese Circulation Society 20080501

• TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-kappa B pathways.

  Molecular immunology 20080301

• The role of metals in modulating metalloprotease activity in the AD brain.

  European biophysics journal : EBJ 20080301

• Relationship between carbachol hyperstimulation-induced pancreatic intracellular trypsinogen and NF-kappa B activation in rats in vitro.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080201

• HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study.

  BMC infectious diseases 20080101

• NF-kappaB and AP-1 are key signaling pathways in the modulation of NAD(P)H:quinone oxidoreductase 1 gene by mercury, lead, and copper.

  Journal of biochemical and molecular toxicology 20080101

• Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells.

  Journal of nephrology 20080101

• [Inhibition of NF-kappa B activity enhanced apoptosis induced by matrine in hepatocellular carcinoma cells].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20071201

• Nuclear factor-kappaB p65 facilitates longitudinal bone growth by inducing growth plate chondrocyte proliferation and differentiation and by preventing apoptosis.

  The Journal of biological chemistry 20071116

• Role of Rel A and IkappaB of nuclear factor kappaB in the release of interleukin-8 by cyclic mechanical strain in human alveolar type II epithelial cells A549.

  Respirology (Carlton, Vic.) 20071101

• Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070901

• Bee venom and melittin reduce proinflammatory mediators in lipopolysaccharide-stimulated BV2 microglia.

  International immunopharmacology 20070801

• Siderophores in fluorescent pseudomonads: new tricks from an old dog.

  Future microbiology 20070801

• Activation of HGF/c-Met pathway contributes to the reactive oxygen species generation and motility of small cell lung cancer cells.

  American journal of physiology. Lung cellular and molecular physiology 20070601

• YC-1 attenuates LPS-induced proinflammatory responses and activation of nuclear factor-kappaB in microglia.

  British journal of pharmacology 20070601

• Relaxin-induced matrix metalloproteinase-9 expression is associated with activation of the NF-kappaB pathway in human THP-1 cells.

  Journal of leukocyte biology 20070501

• Endogenously generated hydrogen peroxide induces apoptosis via mitochondrial damage independent of NF-kappaB and p53 activation in bovine embryos.

  Theriogenology 20070415

• Role of nuclear factor kappa B (NF-kappaB) in oxidative stress-induced defective dopamine D1 receptor signaling in the renal proximal tubules of Sprague-Dawley rats.

  Free radical biology & medicine 20070315

• [Effects of lead acetate on transcription activity of nuclear factor-kappaB in PC12 cells].

  Wei sheng yan jiu = Journal of hygiene research 20070301

• Huperzine A protects C6 rat glioma cells against oxygen-glucose deprivation-induced injury.

  FEBS letters 20070220

• Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils.

  Journal of leukocyte biology 20070201

• Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase.

  American journal of physiology. Heart and circulatory physiology 20070201

• Ameliorative effect of pyrrolidinedithiocarbamate on acetic acid-induced colitis in rats.

  European journal of pharmacology 20070105

• Plantainoside D protects adriamycin-induced apoptosis in H9c2 cardiac muscle cells via the inhibition of ROS generation and NF-kappaB activation.

  Life sciences 20070102

• Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behçet's disease.

  The Journal of investigative dermatology 20070101

• [Establishment of a transgenic cell model for preliminary screening of chemopreventive agents].

  Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20070101

• UVB-induced IL-18 production in human keratinocyte cell line NCTC 2544 through NF-kappaB activation.

  Cytokine 20070101

• Tumor necrosis factor alpha alters Na+-K+ ATPase activity in rat cardiac myocytes: involvement of NF-kappaB, AP-1 and PGE2.

  Life sciences 20061214

• [Signaling pathways in expression of inducible nitric oxide synthase induced by high mobility group box 1 in rat alveolar macrophages].

  Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20061201

• Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.

  Journal of cellular biochemistry 20061101

• [Expression of inducible nitric oxide synthase was regulated by activating nuclear factor kappaB in mouse macrophages stimulated with ureaplasma urealyticum lipid-associated membrane proteins].

  Wei sheng wu xue bao = Acta microbiologica Sinica 20061001

• Small-molecule screening identifies the selanazal drug ebselen as a potent inhibitor of DMT1-mediated iron uptake.

  Chemistry & biology 20060901

• Reciprocal and coordinate regulation of serum amyloid A versus apolipoprotein A-I and paraoxonase-1 by inflammation in murine hepatocytes.

  Arteriosclerosis, thrombosis, and vascular biology 20060801

• P53 status influences regulation of HSPs and ribosomal proteins by PDTC and radiation.

  Biochemical and biophysical research communications 20060505

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway.

  Cellular signalling 20060301

• Deregulation of cyclin-dependent kinase 2 activity correlates with UVC-induced apoptosis in Chinese hamster ovary cells.

  Journal of cellular biochemistry 20060301

• Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway.

  Growth factors (Chur, Switzerland) 20060301

• Nuclear factor kappa-B blockade reduces skeletal muscle degeneration and enhances muscle function in Mdx mice.

  Experimental neurology 20060301

• Lipopolysaccharide-induced c-Src expression plays a role in nitric oxide and TNFalpha secretion in macrophages.

  Molecular immunology 20060201

• Involvement of NF-kappaB and glutathione in cytotoxic effects of nitric oxide and taxol on human leukemia cells.

  Leukemia research 20060201

• Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells.

  International immunopharmacology 20060201

• Changes in the human peritoneal mesothelial cells during aging.

  Kidney international 20060101

• Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through phosphatidylinositol 3'-kinase pathway.

  Biology of reproduction 20051201

• [Inhibition of rat corneal neovascularization by inhibitor of nuclear factor-kappaB].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20051201

• Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro.

  American journal of physiology. Cell physiology 20051101

• NF-kappaB and Hsp70 are involved in the phospholipase Cgamma1 signaling pathway in colorectal cancer cells.

  Life sciences 20051014

• Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats.

  The Journal of pharmacology and experimental therapeutics 20051001

• Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation.

  The European journal of neuroscience 20051001

• Redox regulation of cytokine-mediated inhibition of myelin gene expression in human primary oligodendrocytes.

  Free radical biology & medicine 20050915

• Motorcycle exhaust particles induce IL-8 production through NF-kappaB activation in human airway epithelial cells.

  Journal of toxicology and environmental health. Part A 20050901

• Lovastatin reduces nuclear factor kappaB activation induced by C-reactive protein in human vascular endothelial cells.

  Biological & pharmaceutical bulletin 20050901

• HIV-1 Tat protein-induced VCAM-1 expression in human pulmonary artery endothelial cells and its signaling.

  American journal of physiology. Lung cellular and molecular physiology 20050801

• Human immunodeficiency virus type 1 envelope glycoprotein 120 induces cyclooxygenase-2 expression in neuroblastoma cells through a nuclear factor-kappaB and activating protein-1 mediated mechanism.

  Journal of neurochemistry 20050801

• Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells.

  Kidney international 20050801

• FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.

  The Journal of biological chemistry 20050729

• Involvement of the NMDA receptor, NO-cyclic GMP and nuclear factor K-beta in an animal model of repeated trauma.

  Human psychopharmacology 20050701

• Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis.

  Molecular vision 20050701

• Brain microvessel endothelial cell responses to tumor necrosis factor-alpha involve a nuclear factor kappa B (NF-kappaB) signal transduction pathway.

  Brain research 20050628

• Signaling pathways involved in tumor necrosis factor alpha-induced upregulation of the taurine transporter in Caco-2 cells.

  FEBS letters 20050606

• [Inhibitory effect of daunorubicin enhanced by PDTC on drug-resistant leukemic cells in vitro].

  Zhongguo shi yan xue ye xue za zhi 20050601

• Paclitaxel probably enhances cytotoxicity of natural killer cells against breast carcinoma cells by increasing perforin production.

  Cancer immunology, immunotherapy : CII 20050501

• Inhibiton of NF-kappaB activation during ischemia reduces hepatic ischemia/reperfusion injury in rats.

  The Journal of toxicological sciences 20050501

• [Role of nitric oxide-nuclear factor kappaB signal pathway in functional expression of T lymphocytes from asthmatic patients].

  Zhonghua nei ke za zhi 20050501

• PPAR-gamma activation inhibits angiogenesis by blocking ELR+CXC chemokine production in non-small cell lung cancer.

  Neoplasia (New York, N.Y.) 20050301

• Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-kappaB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell.

  Biochemical pharmacology 20050215

• [Homocysteine induces macrophage inflammatory protein-1alpha expression by activating NF-kappaB in THP-1 monocytes].

  Zhonghua bing li xue za zhi = Chinese journal of pathology 20050201

• Adenosine kinase inhibitor attenuates the expression of inducible nitric oxide synthase in glial cells.

  Neuropharmacology 20050101

• Effect of 17beta-estradiol on tumor necrosis factor-alpha-induced cytotoxicity in the human peripheral T lymphocytes.

  The Journal of endocrinology 20050101

• Antiandrogen-like actions of an antioxidant on survivin, Bcl-2 and PSA in human prostate cancer cells.

  Cancer detection and prevention 20050101

• Effects of a redox-active agent on lymphocyte activation and early gene expression patterns.

  Free radical biology & medicine 20041115

• NF-kappaB activation is required for the development of cardiac hypertrophy in vivo.

  American journal of physiology. Heart and circulatory physiology 20041001

• Hyporesponsiveness in alloreactive T-cells by NF-kappaB inhibitor-treated dendritic cells: resistance to calcineurin inhibition.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040901

• YC-1-induced cyclooxygenase-2 expression is mediated by cGMP-dependent activations of Ras, phosphoinositide-3-OH-kinase, Akt, and nuclear factor-kappaB in human pulmonary epithelial cells.

  Molecular pharmacology 20040901

• Homocysteine increases the production of asymmetric dimethylarginine in cultured neurons.

  Journal of neuroscience research 20040701

• Allergen activates peripheral blood eosinophil nuclear factor-kappaB to generate granulocyte macrophage-colony stimulating factor, tumour necrosis factor-alpha and interleukin-8.

  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040701

• Inhibition of nuclear factor-kappa B prevents staphylococcal enterotoxin A-induced fever.

  Molecular and cellular biochemistry 20040701

• A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20040630

• Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition.

  The Biochemical journal 20040501

• The signal transduction pathway that mediates the effect of interleukin-1 beta on the Na+-K+-ATPase in LLC-PK1 cells.

  Pflugers Archiv : European journal of physiology 20040501

• Increase of cyclooxygenase-2 expression by interleukin 15 in rheumatoid synoviocytes.

  The Journal of rheumatology 20040501

• A new antimalarial quassinoid from Simaba orinocensis.

  Journal of natural products 20040501

• TWEAK can induce pro-inflammatory cytokines and matrix metalloproteinase-9 in macrophages.

  Circulation journal : official journal of the Japanese Circulation Society 20040401

• Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney.

  Kidney international 20040401

• [Effect of protein kinase C-nuclear factor-kappa B signal transduction pathway on proliferation and expression of vascular endothelial growth factor in human pulmonary artery smooth muscle cells].

  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20040401

• PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase.

  Journal of cellular physiology 20040201

• Laminar shear stress up-regulates inducible nitric oxide synthase in the endothelium.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040201

• Endotoxin releases a precursor to vasodilation from large veins in an NF-kappaB-dependent manner.

  The Journal of surgical research 20040101

• NF-kappaB inhibition restores sensitivity to Fas-mediated apoptosis in lymphoma cell lines.

  Annals of the New York Academy of Sciences 20031201

• NF-kappaB in critical diseases: a bad guy?

  Intensive care medicine 20031101

• Protection of mitochondrial perturbation by human T-lymphotropic virus type 1 tax through induction of Bcl-xL expression.

  The Journal of laboratory and clinical medicine 20031101

• Decrease in activity of smooth muscle L-type Ca2+ channels and its reversal by NF-kappaB inhibitors in Crohn's colitis model.

  American journal of physiology. Gastrointestinal and liver physiology 20030901

• Induction of cyclooxygenase-2 accounts for restraint stress-induced oxidative status in rat brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030901

• Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid beta peptides.

  Free radical research 20030901

• Fractalkine (CX3CL1) stimulated by nuclear factor kappaB (NF-kappaB)-dependent inflammatory signals induces aortic smooth muscle cell proliferation through an autocrine pathway.

  The Biochemical journal 20030715

• IGF-1 potentiation of IL-4-induced CD23/Fc(epsilon)RII expression in human B cells.

  Molecules and cells 20030630

• Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor kappa B transcriptional activity.

  Cancer research 20030615

• Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway.

  American journal of physiology. Lung cellular and molecular physiology 20030601

• Activation of selective transcription factors and cytokines by water-soluble extract from Lentinus lepideus.

  Experimental biology and medicine (Maywood, N.J.) 20030601

• Production of nitric oxide and tumor necrosis factor-alpha by Smilacis rhizoma in mouse peritoneal macrophages.

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20030601

• Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells.

  Endocrinology 20030501

• Alcohol consumption decreases IL-2-induced NF-kappaB activity in enriched NK cells from C57BL/6 mice.

  Toxicological sciences : an official journal of the Society of Toxicology 20030501

• Pyrrolidine dithiocarbamate provides protection against hypothermic preservation and transplantation injury in the rat liver: the role of heme oxygenase-1.

  Surgery 20030501

• Metal ions induce bone-resorbing cytokine production through the redox pathway in synoviocytes and bone marrow macrophages.

  Biomaterials 20030401

• Modulation of IkappaB kinase autophosphorylation and activity following brain ischemia.

  Acta pharmacologica Sinica 20030401

• Antioxidant amplifies antibiotic protection in the cecal ligation and puncture model of microbial sepsis through interleukin-10 production.

  Shock (Augusta, Ga.) 20030301

• RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappa B signaling pathway.

  The Journal of clinical endocrinology and metabolism 20030201

• Cyclooxygenase-2 inhibitor NS-398 suppresses cell growth and constitutive production of granulocyte-colony stimulating factor and granulocyte macrophage-colony stimulating factor in lung cancer cells.

  Cancer science 20030201

• Redox-regulated mechanisms of IL-4-induced MCP-1 expression in human vascular endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20030101

• Glucocorticoids aggravate hyperoxia-induced lung injury through decreased nuclear factor-kappa B activity.

  American journal of physiology. Lung cellular and molecular physiology 20030101

• Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium.

  Investigative ophthalmology & visual science 20030101

• TNF alpha down-regulates CD105 expression in vascular endothelial cells: a comparative study with TGF beta 1.

  Anticancer research 20030101

• Cytokine action and oxidative stress response in differentiated neuroblastoma SH-SY5Y cells.

  Acta biochimica Polonica 20030101

• Pro-inflammatory cytokine-induced matrix metalloproteinase-1 (MMP-1) secretion in human pancreatic periacinar myofibroblasts.

  Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20030101

• Modulation of the activation of extracellular signal-regulated kinase (ERK) and the production of inflammatory mediators by ADP-ribosylation inhibitors.

  Biological chemistry 20030101

• Activation time course of activator protein-1 and effect of proline dithiocarbamate during ischemia-reperfusion in rat skeletal muscle.

  Annals of plastic surgery 20021201

• Constitutively active NFkappa B is required for the survival of S-type neuroblastoma.

  The Journal of biological chemistry 20021101

• Suppression of cerulein-induced cytokine expression by antioxidants in pancreatic acinar cells.

  Laboratory investigation; a journal of technical methods and pathology 20021001

• Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets.

  The Journal of clinical investigation 20020915

• [In vitro study of the apoptosis effect of DNR on HL-60 cells and its relationship with ROS, CER and NF-kappaB].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020901

• DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way.

  Oncogene 20020829

• Up-regulation of CD13/aminopeptidase N induced by phorbol ester is involved in redox regulation and tumor necrosis factor alpha production in HL-60 cells.

  Inflammation 20020801

• NF-kappaB p50 and p52 expression is not required for RANK-expressing osteoclast progenitor formation but is essential for RANK- and cytokine-mediated osteoclastogenesis.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20020701

• Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.

  The Journal of clinical endocrinology and metabolism 20020701

• IL-17 stimulates inflammatory responses via NF-kappaB and MAP kinase pathways in human colonic myofibroblasts.

  American journal of physiology. Gastrointestinal and liver physiology 20020601

• Potential role of nuclear factor kappaB and reactive oxygen species in cAMP and cytokine regulation of surfactant protein-A gene expression in lung type II cells.

  Molecular endocrinology (Baltimore, Md.) 20020601

• Induction of iNOS expression in skeletal muscle by IL-1beta and NFkappaB activation: an in vitro and in vivo study.

  Cardiovascular research 20020401

• Differential induction of mafF, mafG and mafK expression by electrophile-response-element activators.

  The Biochemical journal 20020115

• Angiotensin II induced inflammation in the kidney and in the heart of double transgenic rats.

  BMC cardiovascular disorders 20020101

• Testosterone is a potential augmentor of antioxidant-induced apoptosis in human prostate cancer cells.

  Cancer detection and prevention 20020101

• Inhibition of nuclear factor kappaB induces apoptosis following treatment with tumor necrosis factor alpha and an antioxidant in human prostate cancer cells.

  Cancer detection and prevention 20020101

• Nuclear factor kappa B is involved in lipopolysaccharide-stimulated induction of interferon regulatory factor-1 and GAS/GAF DNA-binding in human umbilical vein endothelial cells.

  British journal of pharmacology 20011201

• Antioxidants increase lipopolysaccharide-stimulated TNF alpha release in murine macrophages: role for altered TNF alpha mRNA stability.

  Shock (Augusta, Ga.) 20011101

• TGF-beta-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes.

  International journal of molecular medicine 20010901

• Cyclooxygenase-2 gene expression and regulation in human retinal pigment epithelial cells.

  Investigative ophthalmology & visual science 20010901

• Regulation of MARCKS and MARCKS-related protein expression in BV-2 microglial cells in response to lipopolysaccharide.

  Journal of neurochemistry 20010801

• Mechanism of colon cancer cell apoptosis mediated by pyropheophorbide-a methylester photosensitization.

  Oncogene 20010705

• High constitutive level of NF-kappaB is crucial for viability of adenocarcinoma cells.

  Cell death and differentiation 20010601

• Inhibition of the initial wave of NF-kappaB activity in rat muscle reduces ischemia/reperfusion injury.

  Muscle & nerve 20010401

• Hypoxia/reoxygenation promotes myocardial angiogenesis via an NF kappa B-dependent mechanism in a rat model of chronic myocardial infarction.

  Journal of molecular and cellular cardiology 20010201

• Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response.

  Hypertension (Dallas, Tex. : 1979) 20010201

• S-nitrosoglutathione inhibits TNF-alpha-induced NFkappaB activation in neutrophils.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010201

• Antioxidant therapy attenuates JNK activation and apoptosis in the remote noninfarcted myocardium after large myocardial infarction.

  Biochemical and biophysical research communications 20010112

• Cholesterol-induced upregulation of angiotensin II and its effects on monocyte-endothelial interaction and superoxide production.

  Vascular medicine (London, England) 20010101

• Induction of stromelysin gene expression by tumor necrosis factor alpha is inhibited by dexamethasone, salicylate, and N-acetylcysteine in synovial fibroblasts.

  The Journal of pharmacology and experimental therapeutics 19990601

• Sulfasalazine: a potent and specific inhibitor of nuclear factor kappa B.

  The Journal of clinical investigation 19980301

• Regulation of RANTES and ICAM-1 expression in murine mesangial cells.

  Journal of the American Society of Nephrology : JASN 19970401