512-56-1 | Trimethyl phosphate

Packsize	Purity	Availability	Price	Discounted Price
25g	99%	in stock	$12.00	$8.00
100g	99%	in stock	$15.00	$10.00
250g	99%	in stock	$16.00	$11.00

Description

• Catalog Number: AB80066
• Chemical Name: Trimethyl phosphate
• CAS Number: 512-56-1
• Molecular Formula: C3H9O4P
• Molecular Weight: 140.0749
• MDL Number: MFCD00008348
• SMILES: COP(=O)(OC)OC
• NSC Number: 58985

Computed Properties

• Complexity: 82.4
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• XLogP3: -0.5

Upstream Synthesis Route

Trimethyl phosphate is a versatile compound widely used in various chemical synthesis applications. As a methylating agent, it serves as a crucial building block in organic synthesis, particularly in the production of pharmaceuticals, pesticides, and specialty chemicals. By facilitating methyl group transfer reactions, trimethyl phosphate enables the modification of molecules to enhance their properties or create new substances. Its high reactivity and compatibility with a range of substrates make it a valuable tool for controlling the structure and functionality of organic compounds in the laboratory. Additionally, trimethyl phosphate is utilized as a solvent in the synthesis of complex organic molecules, where its unique properties help drive reactions towards desired products. Its ability to act as both a reagent and a solvent underscores its significance in chemical synthesis processes, contributing to the development of innovative materials and pharmaceuticals.

Literature

• Affinities of organophosphate flame retardants to tumor suppressor gene p53: an integrated in vitro and in silico study.

  Toxicology letters 20150122

• A method for simultaneous quantification of phospholipid species by routine 31P NMR.

  Journal of pharmaceutical and biomedical analysis 20121101

• Oxidation of phosphorus centers by ferrate(VI): spectral observation of an intermediate.

  Inorganic chemistry 20120618

• The synthesis of 2'-methylseleno adenosine and guanosine 5'-triphosphates.

  Bioorganic & medicinal chemistry 20120401

• Development of an ultra-high-performance liquid chromatography-tandem mass spectrometry method for high throughput determination of organophosphorus flame retardants in environmental water.

  Journal of chromatography. A 20110923

• Brominated and organophosphate flame retardants in selected consumer products on the Japanese market in 2008.

  Journal of hazardous materials 20110915

• Conformations of trimethyl phosphite: a matrix isolation infrared and ab initio study.

  The journal of physical chemistry. A 20110908

• Adsorption of trimethyl phosphate on maghemite, hematite, and goethite nanoparticles.

  The journal of physical chemistry. A 20110818

• Adsorption of organophosphates into microporous and mesoporous NaX zeolites and subsequent chemistry.

  Environmental science & technology 20110401

• Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model.

  PloS one 20110101

• Gas-phase synchrotron FTIR spectroscopy of weakly volatile alkyl phosphonate and alkyl phosphate compounds: vibrational and conformational analysis in the terahertz/far-IR spectral domain.

  The journal of physical chemistry. B 20101223

• Mechanistic and computational study of a palladacycle-catalyzed decomposition of a series of neutral phosphorothioate triesters in methanol.

  Journal of the American Chemical Society 20101124

• 3-Methyl-quinoxaline-2-carb-oxy-lic acid 4-oxide monohydrate.

  Acta crystallographica. Section E, Structure reports online 20100701

• Facile small scale synthesis of nucleoside 5'-phosphate mixtures.

  Nucleosides, nucleotides & nucleic acids 20100101

• The diatomic dication PO2+.

  Physical chemistry chemical physics : PCCP 20090807

• Kinetics and mechanism for degradation of dichlorvos by permanganate in drinking water treatment.

  Water research 20090801

• Rapid estimation of trace organophosphonate used as a scale inhibitor in aqueous systems by reactive pyrolysis-gas chromatography/mass spectrometry.

  Journal of chromatography. A 20090703

• Gas-phase vibrational spectroscopy and ab initio study of organophosphorus compounds: discrimination between species and conformers.

  The journal of physical chemistry. B 20081002

• Phosphorescent organic light-emitting devices: working principle and iridium based emitter materials.

  International journal of molecular sciences 20080801

• Hydroxyapatite coating on Ti6Al4V alloy by a sol-gel method.

  Journal of materials science. Materials in medicine 20080601

• A tetra-substituted chrysene: orientation of multiple electrophilic substitution and use of a tetra-substituted chrysene as a blue emitter for OLEDs.

  Chemical communications (Cambridge, England) 20080528

• Are there pi* shape resonances in electron scattering from phosphate groups?

  The journal of physical chemistry. A 20080501

• A simple model for metal cation-phosphate interactions in nucleic acids in the gas phase: alkali metal cations and trimethyl phosphate.

  Journal of the American Society for Mass Spectrometry 20080201

• Mechanism of SN2 disulfide bond cleavage by phosphorus nucleophiles. Implications for biochemical disulfide reducing agents.

  The Journal of organic chemistry 20071026

• Synthesis and biological evaluation of phosphate prodrugs of 4-phospho-D-erythronohydroxamic acid, an inhibitor of 6-phosphogluconate dehydrogenase.

  ChemMedChem 20070813

• Liquid chromatography/tandem mass spectrometry determination of organophosphorus flame retardants and plasticizers in drinking and surface waters.

  Rapid communications in mass spectrometry : RCM 20070101

• Mononuclear Schiff base boron halides: synthesis, characterization, and dealkylation of trimethyl phosphate.

  Inorganic chemistry 20061113

• Air sampling with Empore solid phase extraction membranes and online single-channel desorption/liquid chromatography/mass spectrometry analysis: determination of volatile and semi-volatile organophosphate esters.

  Journal of chromatography. A 20060929

• Total dissociative electron attachment cross sections for molecular constituents of DNA.

  The Journal of chemical physics 20060807

• Synthesis, structural characterization and the first electroluminescent properties of tris- and bis-cycloiridiated complexes of sterically hindered electron-poor 2-(3,5-bis(trifluoromethyl)phenyl)-4-trifluoromethylpyridine.

  Dalton transactions (Cambridge, England : 2003) 20060528

• Five-coordinate aluminum bromides: synthesis, structure, cation formation, and cleavage of phosphate ester bonds.

  Journal of the American Chemical Society 20060201

• J-coupling nuclear magnetic resonance spectroscopy of liquids in nT fields.

  Journal of the American Chemical Society 20060125

• Theoretical studies of the hydroxide-catalyzed P-O cleavage reactions of neutral phosphate triesters and diesters in aqueous solution: examination of the changes induced by H/Me substitution.

  The journal of physical chemistry. B 20051201

• Tris(thioimidazolyl)borate-zinc-thiolate complexes for the modeling of biological thiolate alkylations.

  Inorganic chemistry 20051114

• Does phosphoryl protonation occurs in aqueous phosphoesters solutions.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20051101

• Expression of mucin genes in the human testis and its relationship to spermatogenesis.

  Yonsei medical journal 20051031

• The structure of an enzyme-product complex reveals the critical role of a terminal hydroxide nucleophile in the bacterial phosphotriesterase mechanism.

  Biochimica et biophysica acta 20050831

• Thiolysis and alcoholysis of phosphate tri- and monoesters with alkyl and aryl leaving groups. An ab initio study in the gas phase.

  The journal of physical chemistry. A 20050630

• Effect of the TBP and water on the complexation of uranyl nitrate and the dissolution of nitric acid into supercritical CO2. A Theoretical Study.

  The journal of physical chemistry. A 20050616

• Zinc-thiolate complexes of the bis(pyrazolyl)(thioimidazolyl)hydroborate tripods for the modeling of thiolate alkylating enzymes.

  Inorganic chemistry 20050516

• Gas-phase reactivity of the O=P(OCH3)2 + phosphonium ion towards alpha,beta-unsaturated esters in a quadrupole ion trap.

  Journal of mass spectrometry : JMS 20050401

• Uranyl extraction by beta-diketonate ligands to SC-CO2: theoretical studies on the effect of ligand fluorination and on the synergistic effect of TBP.

  The journal of physical chemistry. B 20050113

• Preparation of (cyanomethylene)trimethylphosphorane as a new Mitsunobu-type reagent.

  Chemical & pharmaceutical bulletin 20030401

• Trimethyl phosphite as a trap for alkoxy radicals formed from the ring opening of oxiranylcarbinyl radicals. Conversion to alkenes. Mechanistic applications to the study of C-C versus C-O ring cleavage.

  Journal of the American Chemical Society 20030319

• Zinc mediated methyl transfer from trimethyl phosphate to chelating and non-chelating alkyl thiols. Model for Zn-dependent methyltransferases.

  Journal of inorganic biochemistry 20030201

• Gas chromatography-mass spectrometry assay of the (18)o enrichment of water as trimethyl phosphate.

  Analytical biochemistry 20020715

• Chemistry. Whisper of magnetism tells molecules apart.

  Science (New York, N.Y.) 20020322

• Overview of studies on rat sperm motion analysis using a Hamilton-Thorne Sperm Analyzer--collaborative working study.

  The Journal of toxicological sciences 20011201

• Functional modeling of cobalamine-independent methionine synthase with pyrazolylborate-zinc-thiolate complexes.

  Inorganic chemistry 20011119

• Synthesis of (S)-isoprenoid thiodiphosphates as substrates and inhibitors.

  The Journal of organic chemistry 20011005

• Methylation of neutral pseudotetrahedral zinc thiolate complexes: model reactions for alkyl group transfer to sulfur by zinc-containing enzymes.

  Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20010101