51639-49-7 | 1-(3-chlorophenyl)piperazine DiHCl

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Description

• Catalog Number: AI51577
• Chemical Name: 1-(3-chlorophenyl)piperazine DiHCl
• CAS Number: 51639-49-7
• Molecular Formula: C10H15Cl3N2
• Molecular Weight: 269.5985
• MDL Number: MFCD00012764
• SMILES: Clc1cccc(c1)N1CCNCC1.Cl.Cl

Computed Properties

• Complexity: 157
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 15
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 1

Literature

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• BF-1--a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs.

  European journal of pharmacology 20150315

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• Methamphetamine, amphetamine, MDMA ('ecstasy'), MDA and mCPP modulate electrical and cholinergic input in PC12 cells.

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  Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 20120201

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  Neuropharmacology 20110901

• Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels.

  Neuron 20110811

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  Pakistan journal of pharmaceutical sciences 20110701

• The trazodone metabolite meta-chlorophenylpiperazine can cause false-positive urine amphetamine immunoassay results.

  Journal of analytical toxicology 20110701

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• The autonomic stress-induced hyperthermia response is not enhanced by several anxiogenic drugs.

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• Separation of positional CPP isomers by chiral HPLC-DAD of seized tablets.

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• Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.

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  Journal of clinical pharmacology 20101201

• Blockade of 5-HT2A/2C-type receptors impairs learning in female rats in the course of estrous cycle.

  Bulletin of experimental biology and medicine 20101201

• Trazodone, meta-chlorophenylpiperazine (an hallucinogenic drug and trazodone metabolite), and the hallucinogen trifluoromethylphenylpiperazine cross-react with the EMIT®II ecstasy immunoassay in urine.

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• [Behavioral effects of m-CPP and ketanserine during ovarian cycle in female rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20101101

• Hypothalamic orexin and pro-opiomelanocortin activities are essential for the anorexic effects of m-chlorophenylpiperazine in mice.

  The international journal of neuropsychopharmacology 20101001

• Multiple anxiogenic drugs recruit a parvalbumin-containing subpopulation of GABAergic interneurons in the basolateral amygdala.

  Progress in neuro-psychopharmacology & biological psychiatry 20101001

• 5-HT2C receptor activation prevents stress-induced enhancement of brain 5-HT turnover and extracellular levels in the mouse brain: modulation by chronic paroxetine treatment.

  Journal of neurochemistry 20101001

• Detection of 1-benzylpiperazine, 1-(3-trifluoromethylphenyl)-piperazine, and 1-(3-chlorophenyl)-piperazine in 3,4-methylenedioxymethamphetamine-positive urine samples.

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• Tolerance to 3,4-methylenedioxymethamphetamine is associated with impaired serotonin release.

  Addiction biology 20100701

• Acute SSRI-induced anxiogenic and brain metabolic effects are attenuated 6 months after initial MDMA-induced depletion.

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• The effects of the 5-HT2C agonist m-chlorophenylpiperazine on elite athletes with unexplained underperformance syndrome (overtraining).

  British journal of sports medicine 20100301

• Acquisition session length modulates consolidation effects produced by 5-HT2C ligands in a mouse autoshaping-operant procedure.

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• Role of spinal serotonergic pathways in sneeze-induced urethral continence reflex in rats.

  American journal of physiology. Renal physiology 20091001

• Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

  Nature chemical biology 20091001

• Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice.

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• Individual differences in the sensitivity to serotonergic drugs: a pharmacobehavioural approach using rats selected on the basis of their response to novelty.

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• Fluvoxamine exerts anorexic effect in 5-HT2C receptor mutant mice with heterozygous mutation of beta-endorphin gene.

  The international journal of neuropsychopharmacology 20090501

• Selective serotonin reuptake inhibitors modify physiological gastrointestinal motor activities via 5-HT2c receptor and acyl ghrelin.

  Biological psychiatry 20090501

• 1-(m-Chlorophenyl)piperazine induces depressogenic-like behaviour in rodents by stimulating the neuronal 5-HT(2A) receptors: proposal of a modified rodent antidepressant assay.

  European journal of pharmacology 20090417

• Synergistic actions of apomorphine and m-chlorophenylpiperazine on ejaculation, but not penile erection in rats.

  Biomedical research (Tokyo, Japan) 20090401

• Behavioral and neurochemical profile of m-CPP following exposure to single restraint stress in rat.

  Acta neurologica Belgica 20090301

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  Theriogenology 20090201

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  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101

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  International immunopharmacology 20081210

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  Psychopharmacology 20081101

• Relationship of the serotonin transporter with prolactin response to meta-chlorophenylpiperazine in cocaine dependence.

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• Effects of chemotherapeutic agents 5-fluorouracil and methotrexate alone and combined in a mouse model of learning and memory.

  Psychopharmacology 20080901

• Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo.

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• HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.

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• High throughput and sensitive determination of trazodone and its primary metabolite, m-chlorophenylpiperazine, in human plasma by liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080801

• Exercise is associated with reduction in the anxiogenic effect of mCPP on acoustic startle.

  Behavioral neuroscience 20080801

• 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.

  European journal of pharmacology 20080728

• Serotonin systems upregulate the expression of hypothalamic NUCB2 via 5-HT2C receptors and induce anorexia via a leptin-independent pathway in mice.

  Biochemical and biophysical research communications 20080718

• Behavioral effects of 1-(m-chlorophenyl)piperazine (m-CPP) in a rat model of tardive dyskinesia.

  Pakistan journal of pharmaceutical sciences 20080701

• Antagonism of AMPA receptors produces anxiolytic-like behavior in rodents: effects of GYKI 52466 and its novel analogues.

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• Rikkunshito, an herbal medicine, suppresses cisplatin-induced anorexia in rats via 5-HT2 receptor antagonism.

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• Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine (m-CPP) in patients with generalized social anxiety disorder, panic disorder and healthy controls.

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• Adrenergic and serotoninergic regulation of myocardial contractility in patients with various morphofunctional changes in the heart resulting from chronic heart failure.

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• Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake: use as adulterant of cocaine resulting in drug-drug interactions?

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• Trazodone inhibits T-type calcium channels.

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  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070701

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• High-throughput quantitation of nefazodone and its metabolites in human plasma by high flow direct-injection LC-MS/MS.

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• Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 rats.

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• Hyperphagia alters expression of hypothalamic 5-HT2C and 5-HT1B receptor genes and plasma des-acyl ghrelin levels in Ay mice.

  Endocrinology 20061201

• Serotonin dysfunction in pathological gamblers: increased prolactin response to oral m-CPP versus placebo.

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• Measurement and characterization of energy intake in the mouse.

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• m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat.

  Pharmacology 20050201

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  Neuroscience 20050101

• Anxiety-like state associates with taste to produce conditioned taste aversion.

  Biological psychiatry 20041201

• Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor.

  Pharmacopsychiatry 20041101

• Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice.

  Psychopharmacology 20041001

• Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001

• Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders.

  The international journal of neuropsychopharmacology 20040901

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  Progress in neuro-psychopharmacology & biological psychiatry 20040901

• A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits.

  Physiology & behavior 20040801

• Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats.

  Pharmacology, biochemistry, and behavior 20040801

• Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile.

  Pharmacopsychiatry 20040701

• Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats.

  Pharmacology 20040601

• Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders.

  The Journal of clinical psychiatry 20040601

• mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes.

  Neuropharmacology 20040401

• The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system.

  Journal of psychopharmacology (Oxford, England) 20040301

• m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptor.

  Behavioral neuroscience 20040201

• Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls.

  Psychiatry research 20040101

• Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution.

  Molecular psychiatry 20040101

• Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function.

  Psychological medicine 20040101

• Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan.

  Neuropsychobiology 20040101

• 5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy.

  Experimental neurology 20031201

• Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa.

  Psychiatry research 20031015

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  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030901

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  Life sciences 20030801

• Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze.

  European journal of pharmacology 20030725

• Neuroendocrine response to the serotonin agonist M-chlorophenylpiperazine in women with menstrual status migrainosus.

  Neuroendocrinology 20030701

• m-CPP-induced self-grooming is mediated by 5-HT2C receptors.

  Behavioural brain research 20030616

• Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats.

  Neuropharmacology 20030601

• Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia.

  Psychopharmacology 20030501

• Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test.

  Methods and findings in experimental and clinical pharmacology 20030501

• Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons.

  Brain research 20030418

• Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.

  Cephalalgia : an international journal of headache 20030301

• Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity.

  Neuropharmacology 20030301

• Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs.

  Biological psychiatry 20030215

• Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice.

  Physiology & behavior 20030201

• Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101

• 5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function.

  The European journal of neuroscience 20030101

• Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone.

  Journal of analytical toxicology 20030101

• Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice.

  Polish journal of pharmacology 20030101

• Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression.

  Psychiatry research 20021215

• Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat.

  European journal of pharmacology 20021122

• 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine].

  The Journal of pharmacology and experimental therapeutics 20021101

• 5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze.

  Psychopharmacology 20021101

• The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021101

• Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers.

  Pharmacopsychiatry 20021101

• Effects of GABA(A) compounds on mCPP drug discrimination in rats.

  Life sciences 20021018

• mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids.

  Pharmacology, biochemistry, and behavior 20021001

• p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro.

  Journal of neurochemistry 20020901

• 5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI.

  Neuroreport 20020827

• Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients.

  Therapeutic drug monitoring 20020801

• Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats.

  International journal of impotence research 20020801

• The effects of serotonin agonists on the hypothalamic regulation of sexual receptivity in Syrian hamsters.

  Hormones and behavior 20020801

• Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats.

  Pharmacology, biochemistry, and behavior 20020701

• Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression.

  Archives of general psychiatry 20020701

• Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms.

  Psychopharmacology 20020601

• Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents.

  Psychopharmacology 20020501

• Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine.

  Synapse (New York, N.Y.) 20020401

• Serotonin 2C receptor agonists and the behavioural satiety sequence in mice.

  Pharmacology, biochemistry, and behavior 20020401

• Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats.

  Pharmacology, biochemistry, and behavior 20020401

• Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat.

  Progress in neuro-psychopharmacology & biological psychiatry 20020401

• Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.

  Neuropharmacology 20020201

• Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration.

  Psychopharmacology 20020201

• Perturbations of plasma cortisol and DHEA-S following discontinuation of cocaine use in cocaine addicts.

  Psychoneuroendocrinology 20020101

• The subjective effects of MDMA and mCPP in moderate MDMA users.

  Drug and alcohol dependence 20011201

• The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia.

  Journal of clinical psychopharmacology 20011201

• The 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) inhibits 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats.

  Biological & pharmaceutical bulletin 20011201

• Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635.

  The international journal of neuropsychopharmacology 20011201

• m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors.

  Behavioural pharmacology 20011201

• Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment.

  Brain research 20011019

• Association of serotonin and cortisol indices with childhood abuse in bulimia nervosa.

  Archives of general psychiatry 20010901

• Mapping of brain activation in response to pharmacological agents using fMRI in the rat.

  Magnetic resonance imaging 20010901

• Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells.

  Biochemical pharmacology 20010815

• Self-destructiveness and serotonin function in bulimia nervosa.

  Psychiatry research 20010805

• Pedophilia is accompanied by increased plasma concentrations of catecholamines, in particular epinephrine.

  Psychiatry research 20010805

• Tryptophan hydroxylase gene and major psychoses.

  Psychiatry research 20010805

• Altered response to meta-chlorophenylpiperazine in anorexia nervosa: support for a persistent alteration of serotonin activity after short-term weight restoration.

  The International journal of eating disorders 20010701

• Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat.

  Pharmacopsychiatry 20010701

• The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections.

  Experimental neurology 20010601

• A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation.

  Psychopharmacology 20010601

• 1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501

• Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors.

  Neuroscience research 20010501

• Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome.

  Psychological medicine 20010501

• Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients.

  Pharmacology & toxicology 20010501

• Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects.

  Psychopharmacology 20010501

• Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder.

  Psychoneuroendocrinology 20010201

• Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons.

  Pharmacology, biochemistry, and behavior 20010201

• Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC).

  Cephalalgia : an international journal of headache 20010201

• Low versus standard dose mCPP challenge in obsessive-compulsive patients.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

• Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101

• Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa.

  Psychological medicine 20010101

• Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.

  Psychopharmacology 20010101

• m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors.

  Neuroscience 20010101

• Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.

  European journal of pharmacology 20000707

• Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions.

  Psychopharmacology 19991001

• Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.

  Psychopharmacology 19990701

• Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.

  Drug metabolism and disposition: the biological fate of chemicals 19980601

• Effect of fenfluramine challenge on cocaine craving in addicted male users.

  The American journal on addictions 19980101

• The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons.

  European journal of pharmacology 19970501

• SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist.

  Neuropharmacology 19970101

• In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties.

  British journal of pharmacology 19960201

• Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats.

  Psychopharmacology 19950801

• Trazodone treatment increases plasma prolactin concentrations in depressed patients.

  International clinical psychopharmacology 19950601

• Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission.

  European journal of pharmacology 19940811

• Prolonged penile erections induced by hydroxyzine: possible mechanism of action.

  Neuropsychobiology 19940101

• d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors.

  European journal of pharmacology 19930921

• Trazodone induction of migraine headache through mCPP.

  The American journal of psychiatry 19920501

• A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease.

  Biological psychiatry 19910715

• Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment.

  Archives of general psychiatry 19880201

• 1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole.

  The Journal of pharmacy and pharmacology 19821001