51773-92-3 | (R)-[2,8-bis(trifluoromethyl)quinolin-4-yl](2S)-piperidin-2-ylmethanol hydrochloride

Packsize	Purity	Availability	Price	Discounted Price
25mg	97%	in stock	$44.00	$31.00
250mg	97%	in stock	$48.00	$33.00
1g	97%	in stock	$95.00	$66.00
5g	97%	in stock	$326.00	$228.00
25g	97%	in stock	$1,319.00	$923.00

Description

• Catalog Number: AI51597
• Chemical Name: (R)-[2,8-bis(trifluoromethyl)quinolin-4-yl](2S)-piperidin-2-ylmethanol hydrochloride
• CAS Number: 51773-92-3
• Molecular Formula: C17H17ClF6N2O
• Molecular Weight: 414.7730991999998
• MDL Number: MFCD00797519
• SMILES: O[C@@H](c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)[C@H]1CCCCN1.Cl

Computed Properties

• Complexity: 483
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 2

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• Neuropeptides modulate compound postsynaptic potentials in basolateral amygdala.

  Neuroscience 20091229

• Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.

  Journal of medicinal chemistry 20091210

• Mode of action and choice of antimalarial drugs for intermittent preventive treatment in infants.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20091201

• Further study on mefloquine concerning several aspects in experimental treatment of mice and hamsters infected with Schistosoma japonicum.

  Parasitology research 20091201

• The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum.

  Parasitology research 20091201

• Therapeutic efficacy and effects of artesunate-mefloquine and mefloquine alone on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in southwest Nigeria.

  The American journal of tropical medicine and hygiene 20091201

• Mefloquine blockade of Pannexin1 currents: resolution of a conflict.

  Cell communication & adhesion 20091201

• From serendipity to rational antituberculosis drug discovery of mefloquine-isoxazole carboxylic acid esters.

  Journal of medicinal chemistry 20091126

• Histopathological alteration of juvenile Schistosoma japonicum in mice following treatment with single-dose mefloquine.

  Parasitology research 20091101

• Use of resazurin to detect mefloquine as an efflux-pump inhibitor in Pseudomonas aeruginosa and Escherichia coli.

  Journal of microbiological methods 20091101

• Effectiveness of malaria chemoprophylaxis against Plasmodium falciparum infection in UK travellers: retrospective observational data.

  Travel medicine and infectious disease 20091101

• Early diagnosis and treatment of falciparum malaria in Cambodian trauma patients.

  The Southeast Asian journal of tropical medicine and public health 20091101

• Protective efficacy and safety of three antimalarial regimens for intermittent preventive treatment for malaria in infants: a randomised, double-blind, placebo-controlled trial.

  Lancet (London, England) 20091031

• Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.

  Organic & biomolecular chemistry 20091021

• Mefloquine has more adverse effects than other drugs for malaria prophylaxis.

  BMJ (Clinical research ed.) 20091013

• Drugs for preventing malaria in travellers.

  The Cochrane database of systematic reviews 20091007

• Plasmodium berghei-infection induces volume-regulated anion channel-like activity in human hepatoma cells.

  Cellular microbiology 20091001

• In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors.

  Acta tropica 20091001

• Pharmacodynamic interaction between mefloquine and retinol in Plasmodium falciparum in vitro.

  Wiener klinische Wochenschrift 20091001

• Travelers on beta-blockers: is malaria chemoprophylaxis dangerous?

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20091001

• Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine.

  The Journal of infectious diseases 20090915

• Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice.

  Parasitology research 20090901

• Childhood mefloquine-induced mania and psychosis: a case report.

  Journal of child neurology 20090801

• Mefloquine: interstitial pneumonia: rare events.

  Prescrire international 20090801

• Artemisinin resistance in Plasmodium falciparum malaria.

  The New England journal of medicine 20090730

• Mixed Plasmodium falciparum and Plasmodium vivax malaria in orthotopic liver transplant recipient.

  Transplantation 20090727

• [Malaria--current diagnosis and therapy].

  Medizinische Klinik (Munich, Germany : 1983) 20090715

• Artemisinin-based combination therapy for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20090708

• Dose-response relationships and tegumental surface alterations in Opisthorchis viverrini following treatment with mefloquine in vivo and in vitro.

  Parasitology research 20090701

• Case 4-2009: a pregnant woman with fever after a trip to Africa.

  The New England journal of medicine 20090604

• Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine.

  Parasitology research 20090601

• Drug resistance and in vitro susceptibility of Plasmodium falciparum in Thailand during 1988-2003.

  The Korean journal of parasitology 20090601

• MCC 'tardy' as couple suffer Mefliam 'nightmare'.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20090601

• [Therapeutic efficacy of a regimen of artesunate-mefloquine-primaquine treatment for Plasmodium falciparum malaria and treatment effects on gametocytic development].

  Biomedica : revista del Instituto Nacional de Salud 20090601

• Pannexin 1: the molecular substrate of astrocyte 'hemichannels'.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527

• Two-step liquid-phase microextraction and high-performance liquid chromatography for the simultaneous analysis of the enantiomers of mefloquine and its main metabolite carboxymefloquine in plasma.

  Analytical and bioanalytical chemistry 20090301

• Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.

  Journal of medicinal chemistry 20090226

• Influence of chitosan crosslinking on bitterness of mefloquine hydrochloride microparticles using central composite design.

  Journal of pharmaceutical sciences 20090201

• Mefloquine--an aminoalcohol with promising antischistosomal properties in mice.

  PLoS neglected tropical diseases 20090101

• Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern Cambodia.

  Malaria journal 20090101

• Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia.

  Malaria journal 20090101

• Swedish traveller with Plasmodium knowlesi malaria after visiting Malaysian Borneo.

  Malaria journal 20090101

• Mefloquine neurotoxicity: a literature review.

  Travel medicine and infectious disease 20090101

• Evaluation of mood profiles during malaria chemoprophylaxis: a randomized, double-blind, four-arm study.

  Journal of travel medicine 20090101

• Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment.

  PloS one 20090101

• Impact of cerebral malaria on brain distribution of mefloquine.

  Drug metabolism letters 20090101

• Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.

  Malaria journal 20090101

• Distinct patterns of gene and protein expression elicited by organophosphorus pesticides in Caenorhabditis elegans.

  BMC genomics 20090101

• Epileptogenic potential of mefloquine chemoprophylaxis: a pathogenic hypothesis.

  Malaria journal 20090101

• The neurological assessment in young children treated with artesunate monotherapy or artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria.

  Malaria journal 20090101

• Analysis of the direct and indirect costs of treatment of imported malaria in the Slovak Republic.

  Revista da Sociedade Brasileira de Medicina Tropical 20090101

• Travel health care for immigrant children visiting friends and relatives abroad: retrospective analysis of a hospital-based travel health service in a US urban underserved area.

  Journal of travel medicine 20090101

• Post-malaria neurological syndrome: a case report and review of the literature.

  Journal of travel medicine 20090101

• Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children.

  Malaria journal 20090101

• [Case report: two imported Plasmodium falciparum cases].

  Turkiye parazitolojii dergisi 20090101

• Modafinil increases arousal determined by P13 potential amplitude: an effect blocked by gap junction antagonists.

  Sleep 20081201

• Well-tolerated chemoprophylaxis uniformly prevented Swedish soldiers from Plasmodium falciparum malaria in Liberia, 2004-2006.

  Military medicine 20081201

• Blockade by mefloquine of intercellular electrical coupling between vascular endothelial cells in the guinea-pig mesenteric arteries.

  Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20081201

• Elevated pressure triggers a physiological release of ATP from the retina: Possible role for pannexin hemichannels.

  Neuroscience 20081119

• Lack of multiple copies of pfmdr1 gene in Papua New Guinea.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20081101

• A randomized trial of artesunate-mefloquine versus artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Mali.

  The American journal of tropical medicine and hygiene 20081101

• Drugs for treating uncomplicated malaria in pregnant women.

  The Cochrane database of systematic reviews 20081008

• Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia.

  Emerging infectious diseases 20081001

• [Cerebral malaria in a pregnant woman].

  Medicina intensiva 20081001

• Protection of retinal cells from ischemia by a novel gap junction inhibitor.

  Biochemical and biophysical research communications 20080905

• P2X7 receptor-Pannexin1 complex: pharmacology and signaling.

  American journal of physiology. Cell physiology 20080901

• Effect of artemisinins and amino alcohol partner antimalarials on mammalian sarcoendoplasmic reticulum calcium adenosine triphosphatase activity.

  Basic & clinical pharmacology & toxicology 20080901

• Schistosomicidal activity of the antimalarial drug, mefloquine, in Schistosoma mansoni-infected mice.

  Travel medicine and infectious disease 20080901

• Clinical practice. Malaria prevention in short-term travelers.

  The New England journal of medicine 20080807

• Neuronal coupling via connexin36 contributes to spontaneous synaptic currents of striatal medium-sized spiny neurons.

  Journal of neuroscience research 20080801

• Artemisinin derivatives and malaria: useful, in combination with other antimalarials.

  Prescrire international 20080801

• Mixed tetraoxanes containing the acetone subunit as antimalarials.

  Bioorganic & medicinal chemistry 20080715

• Design and optimization of mefloquine hydrochloride microparticles for bitter taste masking.

  AAPS PharmSciTech 20080601

• Gametocyte clearance in uncomplicated and severe Plasmodium falciparum malaria after artesunate-mefloquine treatment in Thailand.

  The Korean journal of parasitology 20080601

• Psychotic mania associated with mefloquine in a bipolar patient.

  Southern medical journal 20080501

• Declining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand border.

  Emerging infectious diseases 20080501

• A woman from Honduras with a painful forearm and fever.

  The American journal of tropical medicine and hygiene 20080501

• New combined pill to treat malaria is launched.

  BMJ (Clinical research ed.) 20080419

• Liquid-phase microextraction combined with high-performance liquid chromatography for the enantioselective analysis of mefloquine in plasma samples.

  Journal of pharmaceutical and biomedical analysis 20080414

• Antimalarial drugs inhibit human 5-HT(3) and GABA(A) but not GABA(C) receptors.

  British journal of pharmacology 20080401

• Studies on antimalarial drug susceptibility in Colombia, in relation to Pfmdr1 and Pfcrt.

  Parasitology 20080401

• [Tolerance and efficacy of mefloquine as the first line treatment of uncomplicated P. falciparum malaria in children].

  Pathologie-biologie 20080201

• Hyper-reactive malarial splenomegaly in a patient with human immunodeficiency virus.

  The American journal of tropical medicine and hygiene 20080201

• Prolonged Plasmodium falciparum infection in immigrants, Paris.

  Emerging infectious diseases 20080201

• WITHDRAWN: Mefloquine for preventing malaria in non-immune adult travellers.

  The Cochrane database of systematic reviews 20080123

• Clinical inquiries. What is the most effective and safe malaria prophylaxis during pregnancy?

  The Journal of family practice 20080101

• Prevalence of contraindications to mefloquine use among USA military personnel deployed to Afghanistan.

  Malaria journal 20080101

• Clinically uncomplicated Plasmodium falciparum malaria with high schizontaemia: a case report.

  Malaria journal 20080101

• Cost of increasing access to artemisinin combination therapy: the Cambodian experience.

  Malaria journal 20080101

• Efficacy of Artequick versus artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.

  The Southeast Asian journal of tropical medicine and public health 20080101

• Efficacy, safety and tolerability of artesunate-mefloquine in the treatment of uncomplicated Plasmodium falciparum malaria in four geographic zones of Nigeria.

  Malaria journal 20080101

• Auditory assessment of patients with acute uncomplicated Plasmodium falciparum malaria treated with three-day mefloquine-artesunate on the north-western border of Thailand.

  Malaria journal 20080101

• Trends in antimalarial prescriptions in Australia 2002 to 2005.

  Journal of travel medicine 20080101

• Mefloquine-induced eosinophilic pneumonia.

  Pharmacotherapy 20071201

• Inadequate chemoprophylaxis and the risk of malaria.

  Australian family physician 20071201

• Assessment of the relative advantage of various artesunate-based combination therapies by a multi-treatment Bayesian random-effects meta-analysis.

  The American journal of tropical medicine and hygiene 20071201

• Malaria chemoprophylaxis: what do the travelers choose, and how does pretravel consultation influence their final decision.

  The American journal of tropical medicine and hygiene 20071201

• Malaria in Egypt, Saudi Arabia and Yemen: a clinical pilot study.

  Journal of the Egyptian Society of Parasitology 20071201

• Selective ambulatory management of Plasmodium falciparum malaria in paediatric refugees.

  Archives of disease in childhood 20071101

• Design, synthesis, and pharmacological evaluation of mefloquine-based ligands as novel antituberculosis agents.

  ChemMedChem 20071101

• Pharmacokinetics of two paediatric artesunate mefloquine drug formulations in the treatment of uncomplicated falciparum malaria in Gabon.

  The Journal of antimicrobial chemotherapy 20071101

• Pharmacologic advances in the global control and treatment of malaria: combination therapy and resistance.

  Clinical pharmacology and therapeutics 20071101

• Clinical inquiries. When should travelers begin malaria prophylaxis?

  The Journal of family practice 20071101

• Reversible hearing loss in temporal association with chemoprophylactic mefloquine use.

  Travel medicine and infectious disease 20071101

• Study on the biochemical basis of mefloquine resistant Plasmodium falciparum.

  Experimental parasitology 20071001

• An analytical method with a single extraction procedure and two separate high performance liquid chromatographic systems for the determination of artesunate, dihydroartemisinin and mefloquine in human plasma for application in clinical pharmacological studies of the drug combination.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071001

• Self-reported adverse events associated with antimalarial chemoprophylaxis in peace corps volunteers.

  American journal of preventive medicine 20070901

• Mefloquine versus 3-day oral quinine-clindamycin in uncomplicated imported falciparum malaria.

  Travel medicine and infectious disease 20070901

• Lariam and Halfan.

  Journal of the Royal Society of Medicine 20070801

• Adaptation of a multi-drug resistant strain of Plasmodium falciparum from Peru to Aotus lemurinus griseimembra, A. nancymaae, and A. vociferans monkeys.

  The American journal of tropical medicine and hygiene 20070801

• Anemia and antibodies to the 19-kDa fragment of MSP1 during Plasmodium falciparum infection in Aotus monkeys.

  Comparative medicine 20070801

• A non-radiolabeled heme-GSH interaction test for the screening of antimalarial compounds.

  Experimental parasitology 20070701

• Effect of Plasmodium yoelii nigeriensis infection on hepatic and splenic glutathione-S-transferase(s) in Swiss albino and db/+ mice: efficacy of mefloquine and menadione in antimalarial chemotherapy.

  Parasitology 20070701

• The antimalarial drugs quinine, chloroquine and mefloquine are antagonists at 5-HT3 receptors.

  British journal of pharmacology 20070701

• The in-vitro susceptibilities of Ghanaian Plasmodium falciparum to antimalarial drugs.

  Annals of tropical medicine and parasitology 20070701

• Dramatically decreased therapeutic efficacy of chloroquine and sulfadoxine-pyrimethamine, but not mefloquine, in southern Benin.

  Tropical medicine & international health : TM & IH 20070701

• Clinical efficacy of high dose monotherapy of oral dihydroartemisinin in uncomplicated falciparum malaria in viet nam.

  Japanese journal of infectious diseases 20070701

• HTS, chemical hybridization, and drug design identify a chemically unique antituberculosis agent-coupling serendipity and rational approaches to drug discovery.

  ChemMedChem 20070601

• Prevalent pfmdr1 n86y mutant Plasmodium falciparum in Madagascar despite absence of pfcrt mutant strains.

  The American journal of tropical medicine and hygiene 20070601

• [Polymorphisms of the pfmdr1 gene in field samples of Plasmodium falciparum and their association with therapeutic response to antimalarial drugs and severe malaria in Colombia].

  Biomedica : revista del Instituto Nacional de Salud 20070601

• Controversies and misconceptions in malaria chemoprophylaxis for travelers.

  JAMA 20070523

• Behavioral synergism between D(1) and D(2) dopamine receptors in mice does not depend on gap junctions.

  Synapse (New York, N.Y.) 20070501

• Roxithromycin potentiates the effects of chloroquine and mefloquine on multidrug-resistant Plasmodium falciparum in vitro.

  Experimental parasitology 20070401

• A lesson learnt: the rise and fall of Lariam and Halfan.

  Journal of the Royal Society of Medicine 20070401

• Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border.

  The American journal of tropical medicine and hygiene 20070401

• Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin.

  European journal of pharmacology 20070308

• Raman spectroscopic investigation of the antimalarial agent mefloquine.

  Analytical and bioanalytical chemistry 20070301

• Population pharmacokinetics of mefloquine in military personnel for prophylaxis against malaria infection during field deployment.

  European journal of clinical pharmacology 20070301

• Comparative study of the effectiveness and pharmacokinetics of two rectal artesunate/oral mefloquine combination regimens for the treatment of uncomplicated childhood falciparum malaria.

  Annals of tropical paediatrics 20070301

• Pharmacokinetics of mefloquine with dihydroartemisinin as 2-day regimens in patients with uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20070301

• Recurrent gene amplification and soft selective sweeps during evolution of multidrug resistance in malaria parasites.

  Molecular biology and evolution 20070201

• American Society of Tropical Medicine and Hygiene--55th Annual Meeting. 12-16 November 2006, Atlanta, GA, USA.

  IDrugs : the investigational drugs journal 20070201

• Current malaria status and distribution of drug resistance in East and Southeast Asia with special focus to Thailand.

  The Tohoku journal of experimental medicine 20070201

• Mefloquine treatment for uncomplicated falciparum malaria in young children 6-24 months of age in northern Ghana.

  The American journal of tropical medicine and hygiene 20070201

• In vitro antimalarial drug susceptibility and pfcrt mutation among fresh Plasmodium falciparum isolates from the Lao PDR (Laos).

  The American journal of tropical medicine and hygiene 20070201

• A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.

  Tropical medicine & international health : TM & IH 20070201

• [Acute hepatitis associated with mefloquine therapy].

  Gastroenterologia y hepatologia 20070201

• Maculopathy associated with mefloquine (Lariam) therapy for malaria prophylaxis.

  Canadian journal of ophthalmology. Journal canadien d'ophtalmologie 20070201

• Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach.

  Malaria journal 20070101

• The safety and tolerance of atovaquone/proguanil for the long-term prophylaxis of plasmodium falciparum malaria in non-immune travelers and expatriates [corrected].

  Journal of travel medicine 20070101

• Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated Plasmodium falciparum malaria in Senegal.

  Malaria journal 20070101

• DNA cleavage induced by photoexcited antimalarial drugs: a photophysical and photobiological study.

  Photochemistry and photobiology 20070101

• Malaria and mefloquine prophylaxis use among Japan Ground Self-Defense Force personnel deployed in East Timor.

  Journal of travel medicine 20070101

• Screening of gap junction antagonists on dye coupling in the rabbit retina.

  Visual neuroscience 20070101

• A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.

  PloS one 20070101

• Susceptibility to chloroquine, mefloquine and artemisinin of Plasmodium vivax in northwestern Thailand.

  Wiener klinische Wochenschrift 20070101

• Relapsing vivax malaria after 6 months of daily atovaquone/proguanil in Afghanistan: the case for expanded use of primaquine as a causal prophylactic.

  Journal of travel medicine 20070101

• The prevalence and degree of resistance of Plasmodium falciparum to first-line antimalarial drugs: an in vitro study from a malaria endemic region in Yemen.

  Annals of Saudi medicine 20070101

• Effect of mefloquine on the mechanical activity of the mouse isolated rectal smooth muscle.

  Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria 20070101

• The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro.

  Brain research bulletin 20061211

• Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia.

  Tropical medicine & international health : TM & IH 20061201

• In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003.

  Tropical medicine & international health : TM & IH 20061201

• An open label randomized comparison of mefloquine-artesunate as separate tablets vs. a new co-formulated combination for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.

  Tropical medicine & international health : TM & IH 20061101

• Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor.

  Movement disorders : official journal of the Movement Disorder Society 20061001

• Plasmodium falciparum malaria associated with mefloquine failure in Gambia.

  Pharmacotherapy 20061001

• MDR1 gene polymorphisms are associated with neuropsychiatric adverse effects of mefloquine.

  Clinical pharmacology and therapeutics 20061001

• Fluoxetine potentiates chloroquine and mefloquine effect on multidrug-resistant Plasmodium falciparum in vitro.

  Japanese journal of infectious diseases 20061001

• Interaction studies of omeprazole with mefloquine, pyrimethamine and sulfadoxine.

  Pakistan journal of pharmaceutical sciences 20061001

• Efficacy and safety of atovaquone-proguanil compared with mefloquine in the treatment of nonimmune patients with uncomplicated P. falciparum malaria in Japan.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061001

• [A plasmodium alciparum malaria case originated from Mozambique: clues for the diagnosis and therapy].

  Mikrobiyoloji bulteni 20061001

• Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in Cambodia.

  Tropical medicine & international health : TM & IH 20060901

• An unusual cutaneous manifestation with mefloquine.

  The American journal of emergency medicine 20060901

• Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin.

  The Journal of infectious diseases 20060815

• An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).

  Tropical medicine & international health : TM & IH 20060801

• An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil.

  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20060801

• Connexin-36 gap junctions mediate electrical coupling between ventral tegmental area GABA neurons.

  Synapse (New York, N.Y.) 20060701

• Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance.

  Cellular and molecular life sciences : CMLS 20060701

• Artemisinin combination therapies.

  Lancet (London, England) 20060624

• Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.

  Lancet (London, England) 20060624

• Mefloquine toxicity presenting with polyneuropathy - a report of two cases in India.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060601

• Mefloquine enhances nigral gamma-aminobutyric acid release via inhibition of cholinesterase.

  The Journal of pharmacology and experimental therapeutics 20060601

• Deployment of early diagnosis and mefloquine-artesunate treatment of falciparum malaria in Thailand: the Tak Malaria Initiative.

  PLoS medicine 20060601

• Mefloquine-induced mania in a 22-year-old Chinese man.

  Singapore medical journal 20060601

• In vitro study assessing the response of plasmodium falciparum malaria to chloroquine, sulfadoxine/pyrimethamine, quinine and mefloquine in Wad Medani District, Sudan.

  Saudi medical journal 20060601

• Design, synthesis, and SAR studies of mefloquine-based ligands as potential antituberculosis agents.

  ChemMedChem 20060601

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Mefloquine use and hospitalizations among US service members, 2002-2004.

  The American journal of tropical medicine and hygiene 20060501

• [Relapse of Plasmodium falciparum malaria in a patient treated with artesunate].

  Medecine et maladies infectieuses 20060501

• [Spectacular suicide associated with mefloquine].

  Presse medicale (Paris, France : 1983) 20060501

• [Atypical course of falciparum malaria in an asplenic patient].

  Presse medicale (Paris, France : 1983) 20060501

• Malaria. 'One step forward, two steps back'.

  East African medical journal 20060501

• Efficacy and safety of an artesunate/mefloquine combination, (artequin) in the treatment of uncomplicated P. falciparum malaria in Kenya.

  East African medical journal 20060501

• Mefloquine is highly efficacious against chloroquine-resistant Plasmodium vivax malaria and Plasmodium falciparum malaria in Papua, Indonesia.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060415

• Emerging chloroquine-resistant Plasmodium vivax (Benign Tertian) malaria: the need for alternative drug treatment.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060415

• Predictors of the failure of treatment with pyrimethamine-sulfadoxine in children with uncomplicated falciparum malaria.

  Acta tropica 20060401

• Mefloquine.

  Nursing times 20060401

• Mefloquine selectively increases asynchronous acetylcholine release from motor nerve terminals.

  Neuropharmacology 20060301

• Stimulation of choline/Mg2+ antiport in rat erythrocytes by mefloquine.

  Magnesium research 20060301

• [Coartem and fansimef in the treatment of falciparum malaria].

  Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20060227

• Conformation stability and organization of mefloquine molecules in different environments.

  Bioorganic & medicinal chemistry letters 20060215

• A randomized trial comparing the efficacy of four treatment regimens for uncomplicated falciparum malaria in Assam state, India.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20060201

• In vivo sensitivity monitoring of mefloquine monotherapy and artesunate-mefloquine combinations for the treatment of uncomplicated falciparum malaria in Thailand in 2003.

  Tropical medicine & international health : TM & IH 20060201

• Thrombotic-thrombocytopenic purpura following malaria prophylaxis with mefloquine.

  The Journal of antimicrobial chemotherapy 20060101

• Methodological concerns regarding the relation between mefloquine and serious psychiatric events in females.

  The Journal of clinical psychiatry 20060101

• Successful treatment of imported cerebral malaria with artesunate-mefloquine combination therapy.

  Journal of the Formosan Medical Association = Taiwan yi zhi 20060101

• [Cytochrome P-450 and the response to antimalarial drugs].

  Revista panamericana de salud publica = Pan American journal of public health 20060101

• Acute respiratory distress syndrome in Plasmodium vivax malaria in traveler returning from Venezuela.

  Journal of travel medicine 20060101

• Mefloquine-induced pneumonitis.

  Journal of travel medicine 20060101

• [Improvement of epidemiological surveillance of malaria among frontier guards in Tadjukistan].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20060101

• Drug interactions and pharmacogenetic reactions are the basis for chloroquine and mefloquine-induced psychosis.

  Medical hypotheses 20060101

• Psychosis with paranoid delusions after a therapeutic dose of mefloquine: a case report.

  Malaria journal 20060101

• [Severe imported malaria. The experience of the military hospital of Marrakech].

  Annales de biologie clinique 20060101

• Quinoline-resistance reversing agents for the malaria parasite Plasmodium falciparum.

  Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20060101

• Mefloquine effects on the lens suggest cooperative gating of gap junction channels.

  The Journal of membrane biology 20060101

• [Severe imported malaria: the experience of the Avicenna military hospital of Marrakech].

  Sante (Montrouge, France) 20060101

• Chemoprophylaxis according to the guidelines on malaria prevention for Japanese overseas travelers.

  The Southeast Asian journal of tropical medicine and public health 20060101

• Are we losing artemisinin combination therapy already?

  Lancet (London, England) 20051203

• Mefloquine inhibits cholinesterases at the mouse neuromuscular junction.

  Neuropharmacology 20051201

• Fatty food does not alter blood mefloquine concentrations in the treatment of falciparum malaria.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20051201

• Malaria: prevention in travellers.

  Clinical evidence 20051201

• Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon.

  The Journal of infectious diseases 20051115

• Transcriptional profiling of mefloquine-induced disruption of calcium homeostasis in neurons in vitro.

  Genomics 20051101

• [Ineffective change of antimalaria prophylaxis to Artemisia vulgaris in a group travelling to West Africa].

  Ugeskrift for laeger 20051024

• Artesunate plus mefloquine versus mefloquine for treating uncomplicated malaria.

  The Cochrane database of systematic reviews 20051019

• [Malaria chemoprophylaxis].

  Ugeskrift for laeger 20051017

• [Malaria prophylaxis for long-term travellers and expatriates].

  Ugeskrift for laeger 20051017

• [Painless jaundice after holidays in Tanzania].

  Der Internist 20051001

• Efficacy of chloroquine + sulfadoxine--pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20051001

• The efficacy and tolerability of doxycycline and mefloquine in malaria prophylaxis of the ISAF troops in Afghanistan.

  The Journal of infection 20051001

• In vitro synergy and enhanced murine brain penetration of saquinavir coadministered with mefloquine.

  The Journal of pharmacology and experimental therapeutics 20050901

• Malaria in an eastern screech owl (Otus asio).

  Avian diseases 20050901

• An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20050901

• Interactions of mefloquine with ABC proteins, MRP1 (ABCC1) and MRP4 (ABCC4) that are present in human red cell membranes.

  Biochemical pharmacology 20050815

• A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815

• First-time diagnosis of severe depression: induced by mefloquine?

  Journal of clinical psychopharmacology 20050801

• Molecular epidemiology of drug resistance markers of Plasmodium falciparum malaria in Thailand.

  Tropical medicine & international health : TM & IH 20050801

• pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.

  Molecular microbiology 20050801

• Questionnaire-based analysis of mefloquine chemoprophylaxis for malaria in a Japanese population.

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20050801

• Effectiveness of antimalarial drugs.

  The New England journal of medicine 20050728

• Drugs for treating uncomplicated malaria in pregnant women.

  The Cochrane database of systematic reviews 20050720

• Gamma-aminobutyric acid and mefloquine-induced seizures in mice.

  Progress in neuro-psychopharmacology & biological psychiatry 20050701

• Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers.

  Journal of clinical pharmacy and therapeutics 20050601

• Malaria: uncomplicated, caused by Plasmodium falciparum.

  Clinical evidence 20050601

• ATPase activity of purified plasma membranes and digestive vacuoles from Plasmodium falciparum.

  Molecular and biochemical parasitology 20050501

• pfmdr1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border.

  The American journal of tropical medicine and hygiene 20050501

• Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria.

  Parasitology 20050501

• An open, randomized trial of three-day treatment with artesunate combined with a standard dose of mefloquine divided over either two or three days, for acute, uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20050501

• Life-saving rectal artesunate for complicated malaria in children.

  The Southeast Asian journal of tropical medicine and public health 20050501

• Effectiveness of antimalarial drugs.

  The New England journal of medicine 20050414

• Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules.

  Chembiochem : a European journal of chemical biology 20050401

• [Mefloquine versus halofantrine in children suffering from acute uncomplicated falciparum malaria].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20050401

• [Relative bioavailability of an optimised galenical formulation of mefloquine].

  Praxis 20050330

• [Relapse of Plasmodium malariae malaria 20 years after living in an endemic area].

  Presse medicale (Paris, France : 1983) 20050312

• Absence of nucleotide polymorphism in a Plasmodium vivax multidrug resistance gene after failure of mefloquine prophylaxis in French Guyana.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050301

• Efficacies of mefloquine alone and of artesunate followed by mefloquine, for the treatment of uncomplicated, Plasmodium falciparum malaria in eastern Sudan.

  Annals of tropical medicine and parasitology 20050301

• Mefloquine and doxycycline malaria prophylaxis in Australian soldiers in East Timor.

  The Medical journal of Australia 20050221

• Efficacy of antimalarial chemoprophylaxis among French residents travelling to Africa.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20050201

• Identification of putative Plasmodium falciparum mefloquine resistance genes.

  Molecular and biochemical parasitology 20050201

• A malaria outbreak following a British military deployment to Sierra Leone.

  The Journal of infection 20050201

• Mefloquine increases the risk of serious psychiatric events during travel abroad: a nationwide case-control study in the Netherlands.

  The Journal of clinical psychiatry 20050201

• [Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].

  Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20050201

• [Neuropsychiatric symptoms caused by mefloquine (report of several cases)].

  Orvosi hetilap 20050116

• In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002.

  Acta tropica 20050101

• Syndromic management of prolonged fever: a cost-effective approach.

  Tropical doctor 20050101

• Pharmacokinetics of the four combination regimens of dihydroartemisinin/mefloquine in acute uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20050101

• Investigation of bioavailability, pharmacokinetics and safety of new pediatric formulations of artesunate and mefloquine.

  The Southeast Asian journal of tropical medicine and public health 20050101

• Pharmacodynamic analysis of antimalarials used in Plasmodium falciparum imported malaria in northern Italy.

  Journal of travel medicine 20050101

• In vitro antimalarial drug susceptibility in Thai border areas from 1998-2003.

  Malaria journal 20050101

• A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand.

  Malaria journal 20050101

• Antimalarial multi-drug resistance in Asia: mechanisms and assessment.

  Current topics in microbiology and immunology 20050101

• In vitro susceptibility and genetic variations for chloroquine and mefloquine in Plasmodium falciparum isolates from Thai-Myanmar border.

  The Southeast Asian journal of tropical medicine and public health 20050101

• Fake antimalarials in Southeast Asia are a major impediment to malaria control: multinational cross-sectional survey on the prevalence of fake antimalarials.

  Tropical medicine & international health : TM & IH 20041201

• Malaria: prevention in travellers.

  Clinical evidence 20041201

• Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.

  The Journal of infectious diseases 20041115

• Australian army faces legal action over mefloquine.

  BMJ (Clinical research ed.) 20041106

• Therapeutic efficacy of artemether-lumefantrine and artesunate-mefloquine for treatment of uncomplicated Plasmodium falciparum malaria in Luang Namtha Province, Lao People's Democratic Republic.

  Tropical medicine & international health : TM & IH 20041101

• Comparison of chloroquine, sulfadoxine/pyrimethamine, mefloquine and mefloquine-artesunate for the treatment of falciparum malaria in Kachin State, North Myanmar.

  Tropical medicine & international health : TM & IH 20041101

• Randomized comparison of chloroquine plus sulfadoxine-pyrimethamine versus artesunate plus mefloquine versus artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in the Lao People's Democratic Republic.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041015

• Mefloquine in the treatment of falciparum malaria during pregnancy in Eastern Sudan.

  Saudi medical journal 20041001

• 'Serious' and 'severe' adverse drug reactions need defining.

  BMJ (Clinical research ed.) 20040904

• The relationship between body weight and tolerance to mefloquine prophylaxis in non-immune adults: results of a questionnaire-based study.

  Annals of tropical medicine and parasitology 20040901

• The sensitivities of yeast strains deficient in PDR ABC transporters, to quinoline-ring antimalarial drugs.

  Annals of tropical medicine and parasitology 20040901

• SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease.

  Antimicrobial agents and chemotherapy 20040901

• Declining mefloquine sensitivity of Plasmodium falciparum along the Thai-Myanmar border.

  The Southeast Asian journal of tropical medicine and public health 20040901

• Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

  Bioorganic & medicinal chemistry letters 20040802

• Artesunate with mefloquine at various intervals for non-severe Plasmodium falciparum malaria.

  The American journal of tropical medicine and hygiene 20040801

• The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.

  Antimicrobial agents and chemotherapy 20040701

• Safety of mefloquine in infants with acute falciparum malaria.

  The Pediatric infectious disease journal 20040701

• [Malaria: prophylaxis, treatment, stand-by medication. A single mosquito bite suffices].

  MMW Fortschritte der Medizin 20040617

• Babesia microti infection in Europe.

  Current microbiology 20040601

• The in-vitro antimalarial activity of ferrochloroquine, measured against Cambodian isolates of Plasmodium falciparum.

  Annals of tropical medicine and parasitology 20040601

• [Combined antimalarial therapy using artemisinin].

  Parassitologia 20040601

• Malaria: prevention in travellers.

  Clinical evidence 20040601

• Mefloquine--its 20 years in the Thai Malaria Control Program.

  The Southeast Asian journal of tropical medicine and public health 20040601

• Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum.

  Biochemistry 20040504

• Polymorphism of the Plasmodium falciparum multidrug resistance and chloroquine resistance transporter genes and in vitro susceptibility to aminoquinolines in isolates from the Peruvian Amazon.

  The American journal of tropical medicine and hygiene 20040501

• Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice.

  British journal of pharmacology 20040401

• Low body mass index is associated with an increased risk of neuropsychiatric adverse events and concentration impairment in women on mefloquine.

  British journal of clinical pharmacology 20040401

• Optimising operational use of artesunate-mefloquine: a randomised comparison of four treatment regimens.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20040301

• Genetic and biochemical aspects of drug resistance in malaria parasites.

  Current drug targets. Infectious disorders 20040301

• Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions.

  Photochemistry and photobiology 20040301

• Artesunate combinations for malaria.

  Lancet (London, England) 20040227

• A malaria outbreak following a British military deployment to Sierra Leone.

  The Journal of infection 20040201

• Mefloquine for preventing malaria in nonimmune adult travelers.

  American family physician 20040201

• Efficacy of mefloquine and mefloquine-artesunate for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon region of Bolivia.

  Tropical medicine & international health : TM & IH 20040201

• Malaria during pregnancy in a reference centre from the Brazilian Amazon: unexpected increase in the frequency of Plasmodium falciparum infections.

  Memorias do Instituto Oswaldo Cruz 20040201

• FDA requires warnings on anti-malaria drug Lariam.

  Consumer reports 20040101

• Susceptibility of Plasmodium falciparum to the drugs used to treat severe malaria (quinine) and to prevent malaria (mefloquine, cycloguanil) in Comoros Union and Madagascar.

  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20040101

• [Cerebral Malaria in Ceará: a case report].

  Revista da Sociedade Brasileira de Medicina Tropical 20040101

• Is quartan malaria safely prevented by mefloquine prophylaxis?

  Journal of travel medicine 20040101

• The effect of mefloquine and volume-regulated anion channel inhibitors on induced transport in Plasmodium falciparum-infected human red blood cells.

  Blood cells, molecules & diseases 20040101

• Drug-induced depression: a systematic review to inform clinical practice.

  Psychotherapy and psychosomatics 20040101

• Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.

  Lancet (London, England) 20040101

• Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru.

  Revista da Sociedade Brasileira de Medicina Tropical 20040101

• Resistance reversal action of ketoconazole against mefloquine resistance of Plasmodium yoelii nigeriensis.

  Experimental parasitology 20040101

• Long-term malaria prophylaxis for travelers.

  Journal of travel medicine 20040101

• Comparative study of the in vitro sensitivity of Plasmodium falciparum to artemisinin in two border areas of Thailand.

  Wiener klinische Wochenschrift 20040101

• In vitro sensitivity of Plasmodium falciparum to lumefantrine in north-western Thailand.

  Wiener klinische Wochenschrift 20040101

• Impact of the national protocol for malaria treatment on prescribing patterns in Gezira state, Sudan.

  Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20040101

• Genetic analysis of mefloquine-resistant mechanism of Plasmodium falciparum.

  Nucleic acids symposium series (2004) 20040101

• Randomised efficacy and safety study of two 3-day artesunate rectal capsule/mefloquine regimens versus artesunate alone for uncomplicated malaria in Ecuadorian children.

  Acta tropica 20031201

• Military aviators, special operations forces, and causal malaria prophylaxis.

  Military medicine 20031201

• [Treatment of uncomplicated Plasmodium falciparum malaria in children: comparison of halofantrine with mefloquine].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20031201

• Malaria: prevention in travellers.

  Clinical evidence 20031201

• Diagnosis and treatment of malaria in children.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20031115

• Delayed onset of malaria--implications for chemoprophylaxis in travelers.

  The New England journal of medicine 20031016

• [Mefloquine treatment in infants and children with Plasmodium falciparum malaria: an efficient and well tolerated treatment].

  Pathologie-biologie 20031001

• Malaria in a cohort of Javanese migrants to Indonesian Papua.

  Annals of tropical medicine and parasitology 20030901

• Atovaquone-proguanil for recrudescent Plasmodium falciparum in Vietnam.

  Annals of tropical medicine and parasitology 20030901

• Malaria and children: the risks, precautions, and the nurse's role.

  Professional nurse (London, England) 20030901

• A cost-effectiveness analysis of three antimalarial treatments for acute, uncomplicated Plasmodium falciparum malaria in Mumbai, India.

  The Journal of the Association of Physicians of India 20030901

• Monitoring the therapeutic efficacy of antimalarials against uncomplicated falciparum malaria in Thailand.

  The Southeast Asian journal of tropical medicine and public health 20030901

• Six-years monitoring the efficacy of the combination of artesunate and mefloquine for the treatment of uncomplicated falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20030901

• In vitro susceptibility of Plasmodium falciparum isolates to chloroquine and mefloquine in southeastern Mindanao Island, the Philippines.

  The Southeast Asian journal of tropical medicine and public health 20030901

• [A randomized comparative study of naphtoquine, mefloquine and artsunate in the treatment of falciparum malaria].

  Zhonghua yi xue za zhi 20030825

• Mapping of the Plasmodium falciparum multidrug resistance gene 5'-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites.

  Molecular microbiology 20030801

• Postmalaria neurological syndrome after treatment of Plasmodium falciparum malaria in the United States.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030715

• Asymptomatic, recrudescent, chloroquine-resistant Plasmodium falciparum infections in Nigerian children: clinical and parasitological characteristics and implications for the transmission of drug-resistant parasites.

  Annals of tropical medicine and parasitology 20030701

• Mefloquine, moxifloxacin, and ethambutol are a triple-drug alternative to macrolide-containing regimens for treatment of Mycobacterium avium disease.

  The Journal of infectious diseases 20030615

• [Malaria--case report].

  Deutsche medizinische Wochenschrift (1946) 20030606

• Failure of a chloroquine chemoprophylaxis program to adequately prevent malaria during pregnancy in Koupéla District, Burkina Faso.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030601

• Efficacy of mefloquine and a mefloquine-artesunate combination therapy for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon Basin of Peru.

  The American journal of tropical medicine and hygiene 20030501

• The efficacy of combined mefloquine-artesunate versus mefloquine-primaquine on subsequent development of Plasmodium falciparum gametocytemia.

  The American journal of tropical medicine and hygiene 20030501

• Enantioseparation of erythro-mefloquine and its analogues in capillary electrophoresis.

  Journal of pharmaceutical and biomedical analysis 20030424

• Prophylaxis failure due to probable mefloquine resistant P falciparum from Tanzania.

  Acta tropica 20030401

• Malaria in Austria 1990-2000.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20030401

• The chemotherapy of rodent malaria. LXI. Drug combinations to impede the selection of drug resistance, part 4: the potential role of 8-aminoquinolines.

  Annals of tropical medicine and parasitology 20030401

• [Convulsions and shock during antimalarial chemoprophylaxis with mefloquine].

  Presse medicale (Paris, France : 1983) 20030308

• The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adults.

  American journal of respiratory and critical care medicine 20030301

• Ceramide mediates growth inhibition of the Plasmodium falciparum parasite.

  Cellular and molecular life sciences : CMLS 20030301

• Treatment of imported uncomplicated malaria: a medical emergency.

  Prescrire international 20030201

• Drug-resistant malaria in Bangladesh: an in vitro assessment.

  The American journal of tropical medicine and hygiene 20030201

• Descriptive study on the efficacy and safety of artesunate suppository in combination with other antimalarials in the treatment of severe malaria in Sudan.

  The American journal of tropical medicine and hygiene 20030201

• Utilisation of malaria prophylaxis: the effect of changes in guidelines in The Netherlands, 1993-1998.

  Pharmacy world & science : PWS 20030201

• [Antiprotozoal drugs].

  Nihon rinsho. Japanese journal of clinical medicine 20030201

• In vitro activity of chloroquine, quinine, mefloquine and halofantrine against Gabonese isolates of Plasmodium falciparum.

  Tropical medicine & international health : TM & IH 20030101

• Lack of prediction of mefloquine and mefloquine-artesunate treatment outcome by mutations in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene for P. falciparum malaria in Peru.

  The American journal of tropical medicine and hygiene 20030101

• Efficacy of chloroquine, sulfadoxine-pyrimethamine, and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria on the north coast of Peru.

  The American journal of tropical medicine and hygiene 20030101

• Effect of sample size and P-value filtering techniques on the detection of transcriptional changes induced in rat neuroblastoma (NG108) cells by mefloquine.

  Malaria journal 20030101

• The efficacy of chemoprophylaxis against malaria with chloroquine plus proguanil, mefloquine, and atovaquone plus proguanil in travelers from Denmark.

  Journal of travel medicine 20030101

• Trends in antimalarial drugs prescribed in Australia 1992 to 1998.

  Journal of travel medicine 20030101

• Mefloquine and anticoagulant interaction.

  Journal of travel medicine 20030101

• Trends in antimalarial drugs prescribed in New Zealand 1993 to 1998.

  Journal of travel medicine 20030101

• [Efficacy and tolerance of mefloquine in the treatment of infants and children with Plasmodium falciparum malaria].

  Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20030101

• Curses, madness, and mefloquine.

  Psychosomatics 20030101

• The acute neurotoxicity of mefloquine may be mediated through a disruption of calcium homeostasis and ER function in vitro.

  Malaria journal 20030101

• [Mefloquine resistance in Plasmodium falciparum malaria].

  Recenti progressi in medicina 20030101

• Antimosquito precautions and medical chemoprophylaxis in French children with malaria.

  Journal of travel medicine 20030101

• Evaluation of malaria chemoprophylaxis in Bahrain.

  Journal of travel medicine 20030101

• Consumer guide for malaria drug.

  FDA consumer 20030101

• Effects of mefloquine usage on genetic polymorphism of Plasmodium falciparum in Thai-Myanmarese border.

  The Kobe journal of medical sciences 20030101

• Discovery of novel targets of quinoline drugs in the human purine binding proteome.

  Molecular pharmacology 20021201

• In vitro sensitivity of Plasmodium falciparum to amodiaquine compared with other major antimalarials in Madagascar.

  Parassitologia 20021201

• Mefloquine: contraindicated in patients with mood, psychotic or seizure disorders.

  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20021112

• Haem polymerase as a novel target of antimalarial action of cyproheptadine.

  Biochemical pharmacology 20021101

• Drug-resistant Plasmodium falciparum infection in immigrants and non-immune travellers.

  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20021101

• Pancytopenia resulting from hemophagocytosis in malaria.

  The Pediatric infectious disease journal 20021101

• Artesunate and mefloquine given simultaneously for three days via a prepacked blister is equally effective and tolerated as a standard sequential treatment of uncomplicated acute Plasmodium falciparum malaria: randomized, double-blind study in Thailand.

  The American journal of tropical medicine and hygiene 20021101

• Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.

  Science (New York, N.Y.) 20021004

• Atovaquone + proguanil: new preparation. Second-line antimalarial combination.

  Prescrire international 20021001

• Synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives designed as mefloquine analogues.

  Farmaco (Societa chimica italiana : 1989) 20021001

• Use of nested PCR for differential diagnosis of falciparum malaria reinfection and relapse in drug-resistant patients.

  Bulletin of experimental biology and medicine 20021001

• [Blackwater fever].

  Presse medicale (Paris, France : 1983) 20020907

• Atovaquone plus chloroguanide versus mefloquine for malaria prophylaxis: a focus on neuropsychiatric adverse events.

  Clinical pharmacology and therapeutics 20020901

• Mefloquine-induced paranoid psychosis and subsequent major depression in a 25-year-old student.

  Pharmacopsychiatry 20020901

• Neuropsychiatric events during prophylactic use of mefloquine before travelling.

  European journal of clinical pharmacology 20020901

• Clinical practice: antimalarial prophylaxis in patients with epilepsy [corrected].

  Epilepsy research 20020901

• [Malaria of native Africans after returning home from European residence].

  Orvosi hetilap 20020901

• An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.

  The Southeast Asian journal of tropical medicine and public health 20020901

• A comparative clinical trial of combinations of dihydroartemisinin plus azithromycin and dihydroartemisinin plus mefloquine for treatment of multidrug resistant falciparum malaria.

  The Southeast Asian journal of tropical medicine and public health 20020901

• Impact of microscopy error on estimates of protective efficacy in malaria-prevention trials.

  The Journal of infectious diseases 20020815

• Population pharmacokinetic and pharmacodynamic modelling of artemisinin and mefloquine enantiomers in patients with falciparum malaria.

  European journal of clinical pharmacology 20020801

• [Senegal and malaria. True prophylactic failure of mefloquine].

  Presse medicale (Paris, France : 1983) 20020713

• Profile and evolution of the chemosusceptibility of falciparum malaria imported into France in 2000.

  Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 20020701

• [Many travellers suffer of side-effects of malaria prophylaxis].

  Lakartidningen 20020627

• Design, synthesis, and evaluation of new chemosensitizers in multi-drug-resistant Plasmodium falciparum.

  Journal of medicinal chemistry 20020620

• Resistant malaria in a neonate.

  Indian pediatrics 20020601

• Anemia in parasite- and recombinant protein-immunized aotus monkeys infected with Plasmodium falciparum.

  The American journal of tropical medicine and hygiene 20020601

• Tolerability of antimalaria drugs.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020501

• Relationships between mefloquine blood levels, gender, and adverse reactions.

  The American journal of tropical medicine and hygiene 20020501

• Relationships between mefloquine blood levels, gender, and adverse reactions.

  The American journal of tropical medicine and hygiene 20020501

• In-vitro sensitivity of Plasmodium falciparum to chloroquine, halofantrine, mefloquine and quinine in Madagascar.

  East African medical journal 20020501

• Safety evaluation of the drugs available to prevent malaria.

  Expert opinion on drug safety 20020501

• Treatment of imported malaria in an ambulatory setting: prospective study.

  BMJ (Clinical research ed.) 20020413

• Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology.

  Therapeutic drug monitoring 20020401

• Efficacy of scopadulcic acid A against Plasmodium falciparum in vitro.

  Journal of natural products 20020401

• Successful treatment of refractory disseminated Mycobacterium avium complex infection with the addition of linezolid and mefloquine.

  The Journal of infection 20020401

• A rapid spectrophotometric method for the determination of mefloquine hydrochloride.

  Journal of pharmaceutical and biomedical analysis 20020301

• Lariam's legacy.

  Consumer reports 20020301

• The influence of body weight on the pharmacokinetics of mefloquine.

  British journal of clinical pharmacology 20020301

• An outbreak of cutaneous leishmaniasis among soldiers in Belém, Pará State, Brazil, caused by Leishmania (Viannia) lindenbergi n. sp. A new leishmanial parasite of man in the Amazon region.

  Parasite (Paris, France) 20020301

• Malaria remains a military medical problem--MJ World. Published in Vol 147, Number 3, October 2001.

  Journal of the Royal Army Medical Corps 20020301

• Unexpected frequency, duration and spectrum of adverse events after therapeutic dose of mefloquine in healthy adults.

  Acta tropica 20020201

• Does mefloquine prophylaxis affect electroencephalographic patterns?

  The American journal of medicine 20020201

• Differential effects of 4-aminoquinoline-containing antimalarial drugs on hemoglobin digestion in Plasmodium falciparum-infected erythrocytes.

  Biochemical pharmacology 20020201

• Mathematical modelling of malaria chemotherapy: combining artesunate and mefloquine.

  Parasitology 20020101

• Adverse effects of the antimalaria drug, mefloquine: due to primary liver damage with secondary thyroid involvement?

  BMC public health 20020101

• Malaria recurrence caused by Plasmodium falciparum.

  The Journal of the American Board of Family Practice 20020101

• Fever, anemia, and emesis...whazzup?

  Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners 20020101

• Trends in antimalarial drugs prescribed in New Zealand 1993 to 1998.

  Journal of travel medicine 20020101

• [Efficacy of mefloquine, halofantrine, and coarteme in the treatment of tropical malaria].

  Meditsinskaia parazitologiia i parazitarnye bolezni 20020101

• Multifocal myoclonus associated with mefloquine chemoprophylaxis.

  Clinical neuropharmacology 20020101

• Molecular characterisation of drug-resistant Plasmodium falciparum from Thailand.

  Malaria journal 20020101

• Malaria during a multinational military deployment: the comparative experience of the Italian, British and Australian Armed Forces in East Timor.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101

• Epidemiology of malaria from East Timor among Australian Defence Force personnel.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101

• A randomized, double-blind study on the efficacy and safety of a practical three-day regimen with artesunate and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in Africa.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20020101

• Plasmodium falciparum: effect of anti-malarial drugs on the production and secretion characteristics of histidine-rich protein II.

  Experimental parasitology 20020101

• Episodic see-saw nystagmus in spino-cerebellar ataxia type 2 (SCA-2).

  Cerebellum (London, England) 20020101

• Genomic analysis of mefloquine-resistant Plasmodium falciparum.

  Nucleic acids research. Supplement (2001) 20020101

• Side effects of and compliance with malaria prophylaxis in children.

  Journal of travel medicine 20020101

• Trends in malaria chemoprophylaxis prescription in South Africa 1994 to 2000.

  Journal of travel medicine 20020101

• Paranoid psychosis related to mefloquine antimalarial prophylaxis.

  Papua and New Guinea medical journal 20020101

• Treatment of falciparum malaria in Vietnamese children: the need for combination therapy and optimized dosage regimens.

  Annals of tropical paediatrics 20011201

• Efficacy of mefloquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated Plasmodium falciparum infection in Machinga District, Malawi, 1998.

  The American journal of tropical medicine and hygiene 20011201

• In vivo-in vitro model for the assessment of clinically relevant antimalarial cross-resistance.

  The American journal of tropical medicine and hygiene 20011201

• Community-based program for malaria case management in the Brazilian Amazon.

  The American journal of tropical medicine and hygiene 20011201

• Current drugs for antimalarial chemoprophylaxis: a review of efficacy and safety.

  Journal of travel medicine 20011201

• In vitro susceptibility of Plasmodium falciparum isolates from Myanmar to antimalarial drugs.

  The American journal of tropical medicine and hygiene 20011101

• Pulmonary toxicity with mefloquine.

  The European respiratory journal 20011101

• Atovaquone-proguanil versus mefloquine for malaria prophylaxis in nonimmune travelers: results from a randomized, double-blind study.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011001

• Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK and HERG.

  The Journal of pharmacology and experimental therapeutics 20011001

• Pharmacokinetic-pharmacodynamic modelling of the antimalarial activity of mefloquine.

  Parasitology 20011001

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  Journal of the Royal Army Medical Corps 20011001

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  Presse medicale (Paris, France : 1983) 20010929

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  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010901

• Serious adverse events of mefloquine in relation to blood level and gender.

  The American journal of tropical medicine and hygiene 20010901

• Development of stereoselective nonaqueous capillary electrophoresis system for the resolution of cationic and amphoteric analytes.

  Electrophoresis 20010901

• The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase.

  Pharmaceutical research 20010901

• Randomized trial of artesunate and mefloquine in comparison with quinine sulfate to treat P. falciparum malaria pregnant women.

  Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20010901

• Mefloquine-induced trigeminal sensory neuropathy.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010801

• Reversal of chloroquine and mefloquine resistance in Plasmodium falciparum by the two monoindole alkaloids, icajine and isoretuline.

  Planta medica 20010801

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  Canada communicable disease report = Releve des maladies transmissibles au Canada 20010715

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  MMW Fortschritte der Medizin 20010705

• Pharmacokinetic interaction between mefloquine and ritonavir in healthy volunteers.

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• Efficacy of dihydroartemisinin-mefloquine on acute uncomplicated falciparum malaria.

  Chinese medical journal 20010601

• Antimalarial drugs exacerbate rat liver microsomal lipid peroxidation in the presence of oxidants.

  Bioscience reports 20010601

• Bipolar disorder after mefloquine treatment.

  Journal of psychiatry & neuroscience : JPN 20010501

• From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000.

  JAMA 20010411

• Madagascan isolates of Plasmodium falciparum showing low sensitivity to artemether in vitro.

  Annals of tropical medicine and parasitology 20010401

• Use of the DELI-microtest to determine the drug sensitivity of Plasmodium falciparum in Burkina Faso.

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• Fake antimalaria drugs in Cambodia.

  Lancet (London, England) 20010317

• Sudden death in a traveler following halofantrine administration--Togo, 2000.

  MMWR. Morbidity and mortality weekly report 20010309

• Acute respiratory distress syndrome complicating Plasmodium vivax malaria.

  Critical care medicine 20010301

• Drug resistant malaria on the Thai-Myanmar and Thai-Cambodian borders.

  The Southeast Asian journal of tropical medicine and public health 20010301

• Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity.

  The Pediatric infectious disease journal 20010201

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  Releve epidemiologique hebdomadaire 20010126

• Declining chloroquine resistance of Plasmodium falciparum in Lambaréné, Gabon from 1992 to 1998.

  Wiener klinische Wochenschrift 20010115

• Potentiation of halofantrine-induced QTc prolongation by mefloquine: correlation with blood concentrations of halofantrine.

  British journal of pharmacology 20010101

• Antimalarial chemoprophylaxis in infants and children.

  Paediatric drugs 20010101

• Cognitive and neuropsychiatric side effects of mefloquine.

  The Journal of neuropsychiatry and clinical neurosciences 20010101

• Malaria antibodies and mefloquine levels among United Nations troops in Angola.

  Journal of travel medicine 20010101

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  Journal of travel medicine 20010101

• Resistance of Plasmodium falciparum to antimalarial drugs in a highly endemic area of southern Viet Nam: a study in vivo and in vitro.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• Plasmodium falciparum: emerging mefloquine resistance in vitro in Para State, north Brazil.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• How can we do pharmacokinetic studies in the tropics?

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• The Italian army standpoint on malaria chemoprophylaxis.

  Medecine tropicale : revue du Corps de sante colonial 20010101

• The malaria threat.

  Medecine tropicale : revue du Corps de sante colonial 20010101

• Experiences with malaria chemoprophylaxis in Dutch troops.

  Medecine tropicale : revue du Corps de sante colonial 20010101

• Assessment of susceptibility of Plasmodium falciparum to chloroquine, quinine, mefloquine, sulfadoxine-pyrimethamine and artemisinin in southern Viet Nam.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• A randomized controlled trial on the efficacy of alternative treatment regimens for uncomplicated falciparum malaria in a multidrug-resistant falciparum area of Bangladesh--narrowing the options for the National Malaria Control Programme?

  Transactions of the Royal Society of Tropical Medicine and Hygiene 20010101

• Analysis of Pfmdr 1 gene in mefloquine-resistant Plasmodium falciparum.

  Nucleic acids research. Supplement (2001) 20010101

• Preliminary assessment of the efficacy of mefloquine/-sulphadoxine/ pyrimethamine combination in the treatment of uncomplicated malaria in children in North Eastern Nigeria.

  African journal of medicine and medical sciences 20010101

• Mefloquine-induced acute hepatitis.

  Pharmacotherapy 20001201

• Antimicrobial activities of mefloquine and a series of related compounds.

  Antimicrobial agents and chemotherapy 20000401

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  The National medical journal of India 20000101

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  L'Encephale 20000101

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  Journal of travel medicine 20000101

• Another case of achalasia-microcephaly syndrome.

  Clinical dysmorphology 19991001

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  Psychiatrische Praxis 19990901

• Mefloquine is active in vitro and in vivo against Mycobacterium avium complex.

  Antimicrobial agents and chemotherapy 19990801

• Dermatological adverse effects with the antimalarial drug mefloquine: a review of 74 published case reports.

  Clinical and experimental dermatology 19990701

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  Transactions of the Royal Society of Tropical Medicine and Hygiene 19990101

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• A unique case of mefloquine-induced psoriasis.

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  Tropical medicine & international health : TM & IH 19980201

• Case study: neuropsychiatric symptoms associated with the antimalarial agent mefloquine.

  Journal of the American Academy of Child and Adolescent Psychiatry 19971101

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  British journal of clinical pharmacology 19970701

• Tolerance of mefloquine by SwissAir trainee pilots.

  The American journal of tropical medicine and hygiene 19970201

• Neuro-psychiatric effects of antimalarials.

  European journal of clinical pharmacology 19970101

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  European journal of clinical pharmacology 19970101

• Immune hemolytic anemia associated with mefloquine.

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  BMJ (Clinical research ed.) 19961214

• Atrial flutter with 1:1 conduction after administration of the antimalarial drug mefloquine.

  Clinical cardiology 19961201

• Mefloquine induced grand mal seizure in a case of uncomplicated falciparum malaria.

  The Journal of the Association of Physicians of India 19961001

• Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers.

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  Annals of emergency medicine 19960601

• Cutaneous vasculitis associated with mefloquine.

  Annals of internal medicine 19951201

• Adverse reaction to mefloquine associated with ethanol ingestion.

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  Transactions of the Royal Society of Tropical Medicine and Hygiene 19950101

• Acute psychosis after mefloquine. Report of six cases.

  Tropical and geographical medicine 19950101

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• Severe psychiatric side effects observed during prophylaxis and treatment with mefloquine.

  Archives of internal medicine 19941024

• Seizure associated with mefloquine for malaria prophylaxis.

  The Medical journal of Australia 19941003

• Central anticholinergic syndrome with the antimalarial drug mefloquine.

  The New England journal of medicine 19940707

• Quinine toxicity when given with doxycycline and mefloquine.

  The Southeast Asian journal of tropical medicine and public health 19940601

• In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii.

  Antimicrobial agents and chemotherapy 19940601

• Efficacy and tolerance of extended-dose halofantrine for drug-resistant falciparum malaria in Thailand.

  The American journal of tropical medicine and hygiene 19940201

• Aplastic anemia during malarial prophylaxis with mefloquine.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 19940201

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  International journal of dermatology 19930701

• Mefloquine.

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  La Revue de medecine interne 19930101

• Abnormal circulatory control in falciparum malaria: the effects of antimalarial drugs.

  European journal of clinical pharmacology 19930101

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  Annals of internal medicine 19921215

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  The American journal of psychiatry 19920501

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  Der Nervenarzt 19920501

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  The Southeast Asian journal of tropical medicine and public health 19920301

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  Der Nervenarzt 19911201

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  Immunitat und Infektion 19910601

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  Annals of internal medicine 19910601

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  Annales de medecine interne 19910101

• Structure-activity relationships of analogs of pentamidine against Plasmodium falciparum and Leishmania mexicana amazonensis.

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  Therapie 19900101

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  The New England journal of medicine 19891116

• Acute psychosis after mefloquine.

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• Tolerance of mefloquine alone and in combination with sulfadoxine-pyrimethamine in the prophylaxis of malaria.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 19890101